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SaveTissue Organoid Cultures Metabolize Dietary Carcinogens Proficiently and Are Effective Models for DNA Adduct Formation
Garcia, Angela L. Caipa; Kucab, Jill E.; Al-Serori, Halh; Beck, Rebekah S. S.; Bellamri, Madjda; Turesky, Robert J.; Groopman, John D.; Francies, Hayley E.; Garnett, Mathew J.; Huch, Meritxell; Drost, Jarno; Zilbauer, Matthias; Arlt, Volker M.; Phillips, David H. Share Save Mutagenicity of 2-hydroxyamino-1-methyl-6-phenylimidazo [4,5-b] pyridine (N-OH-PhIP) in human TP53 knock-in (Hupki) mouse embryo fibroblastsHolzl-Armstrong, Lisa; Moody, Sarah; Kucab, Jill E.; Zwart, Edwin P.; Bellamri, Medjda; Luijten, Mirjam; Turesky, Robert J.; Stratton, Michael R.; Arlt, Volker M.; Phillips, David H. Share Save Mutagenicity of acrylamide and glycidamide in humanTP53knock-in (Hupki) mouse embryo fibroblastsHolzl-Armstrong, Lisa; Kucab, Jill E.; Moody, Sarah; Zwart, Edwin P.; Loutkotova, Lucie; Duffy, Veronica; Luijten, Mirjam; da Costa, Goncalo Gamboa; Stratton, Michael R.; Phillips, David H.; Arlt, Volker M. Share Save The impact of p53 on aristolochic acid I-induced nephrotoxicity and DNA damage in vivo and in vitroSborchia, Mateja; De Prez, Eric G.; Antoine, Marie-Helene; Bienfait, Lucie; Indra, Radek; Valbuena, Gabriel; Phillips, David H.; Nortier, Joelle L.; Stiborova, Marie; Keun, Hector C.; Arlt, Volker M. Share Save Share Save Application of hepatic cytochrome b5/P450 reductase null (HBRN) mice to study the role of cytochrome b5 in the cytochrome P450-mediated bioactivation of the anticancer drug ellipticineReed, Lindsay; Indra, Radek; Mrizova, Iveta; Moserova, Michaela; Schmeiser, Heinz H.; Wolf, C. Roland; Henderson, Colin J.; Stiborova, Marie; Phillips, David H.; Arlt, Volker M. Share Save Share Save Bulky DNA adducts, microRNA profiles, and lipid biomarkers in Norwegian tunnel finishing workers occupationally exposed to diesel exhaustRynning, Iselin; Arlt, Volker M.; Vrbova, Kristyna; Neca, Jiri; Rossner, Pavel, Jr.; Klema, Jiri; Ulvestad, Bente; Petersen, Elisabeth; Skare, Oivind; Haugen, Aage; Phillips, David H.; Machala, Miroslav; Topinka, Jan; Mollerup, Steen Share Save Share Save α-actinin accounts for the bioactivity of actin preparations in inducing STAT target genes in Drosophila melanogasterGordon, Oliver; Henry, Conor M.; Srinivasan, Naren; Ahrens, Susan; Franz, Anna; Deddouche, Safia; Chakravarty, Probir; Phillips, David; George, Roger; Kjaer, Svend; Frith, David; Snijders, Ambrosius P.; Valente, Rita S.; da Silva, Carolina J. Simoes; Teixeira, Luis; Thompson, Barry; Dionne, Marc S.; Wood, Will; Reis e Sousa, Caetano Share Save Share Save The impact of chemotherapeutic drugs on the CYP1A1-catalysed metabolism of the environmental carcinogen benzo [a] pyrene: Effects in human colorectal HCT116 TP53(+/+), TP53(+/-) and TP53(-/-) cellsWillis, Alexandra J.; Indra, Radek; Wohak, Laura E.; Sozeri, Osman; Feser, Kerstin; Mrizova, Iveta; Phillips, David H.; Stiborova, Marie; Arlt, Volker M. Share Save Share Save EXPOsOMICS: final policy workshop and stakeholder consultationTurner, Michelle C.; Vineis, Paolo; Seleiro, Eduardo; Dijmarescu, Michaela; Balshaw, David; Bertollini, Roberto; Chadeau-Hyam, Marc; Gant, Timothy; Gulliver, John; Jeong, Ayoung; Kyrtopoulos, Soterios; Martuzzi, Marco; Miller, Gary W.; Nawrot, Timothy; Nieuwenhuijsen, Mark; Phillips, David H.; Probst-Hensch, Nicole; Samet, Jonathan; Vermeulen, Roel; Vlaanderen, Jelle; Vrijheid, Martine; Wild, Christopher; Kogevinas, Manolis Share Save Differentiation-associated urothelial cytochrome P450 oxidoreductase predicates the xenobiotic-metabolizing activity of luminal muscle-invasive bladder cancersBaker, Simon C.; Arlt, Volker M.; Indra, Radek; Joel, Madeleine; Stiborova, Marie; Eardley, Ian; Ahmad, Niaz; Otto, Wolfgang; Burger, Maximilian; Rubenwolf, Peter; Phillips, David H.; Southgate, Jennifer Share Save Cytochrome b5 impacts on cytochrome P450-mediated metabolism of benzo[a]pyrene and its DNA adduct formation: studies in hepatic cytochrome b5/P450 reductase null (HBRN) miceReed, Lindsay; Mrizova, Iveta; Barta, Frantisek; Indra, Radek; Moserova, Michaela; Kopka, Klaus; Schmeiser, Heinz H.; Wolf, C. Roland; Henderson, Colin J.; Stiborova, Marie; Phillips, David H.; Arlt, Volker M. Share Save Share Save From the exposome to mechanistic understanding of chemical-induced adverse effectsEscher, Beate I.; Hackermuller, Joerg; Polte, Tobias; Scholz, Stefan; Aigner, Achim; Altenburger, Rolf; Boehme, Alexander; Bopp, Stephanie K.; Brack, Werner; Busch, Wibke; Chadeau-Hyam, Marc; Covaci, Adrian; Eisentraeger, Adolf; Galligan, James J.; Garcia-Reyero, Natalia; Hartung, Thomas; Hein, Michaela; Herberth, Gunda; Jahnke, Annika; Kleinjans, Jos; Kluever, Nils; Krauss, Martin; Lamoree, Marja; Lehmann, Irina; Luckenbach, Till; Miller, Gary W.; Mueller, Andrea; Phillips, David H.; Reemtsma, Thorsten; Rolle-Kampczyk, Ulrike; Schueuermann, Gerrit; Schwikowski, Benno; Tan, Yu-Mei; Trump, Saskia; Walter-Rohde, Susanne; Wambaugh, John F. Share Save Share Save 
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