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Ligand distances as key predictors of pathogenicity and function in NMDA receptors Montanucci, Ludovica; Bruenger, Tobias; Bhattarai, Nisha; Bosselmann, Christian M.; Kim, Sukhan; Allen, James P.; Zhang, Jing; Kloeckner, Chiara; Krey, Ilona; Fariselli, Piero; May, Patrick; Lemke, Johannes R.; Myers, Scott J.; Yuan, Hongjie; Traynelis, Stephen F.; Lal, Dennis Share Save
De novo GRIN variants in M3 helix associated with neurological disorders control channel gating of NMDA receptor Xu, Yuchen; Song, Rui; Perszyk, Riley E.; Chen, Wenjuan; Kim, Sukhan; Park, Kristen L.; Allen, James P.; Nocilla, Kelsey A.; Zhang, Jing; Xiangwei, Wenshu; Tankovic, Anel; McDaniels, Ellington D.; Sheikh, Rehan; Mizu, Ruth K.; Karamchandani, Manish M.; Hu, Chun; Kusumoto, Hirofumi; Pecha, Joseph; Cappuccio, Gerarda; Gaitanis, John; Sullivan, Jennifer; Shashi, Vandana; Petrovski, Slave; Jauss, Robin-Tobias; Lee, Hyun Kyung; Bozarth, Xiuhua; Lynch, David R.; Helbig, Ingo; Pierson, Tyler Mark; Boerkoel, Cornelius F.; Myers, Scott J.; Lemke, Johannes R.; Benke, Timothy A.; Yuan, Hongjie; Traynelis, Stephen F. Share Save
Clinical features, functional consequences, and rescue pharmacology of missense GRID1 and GRID2 human variants Allen, James P.; Garber, Kathryn B.; Perszyk, Riley; Khayat, Cara T.; Kell, Steven A.; Kaneko, Maki; Quindipan, Catherine; Saitta, Sulagna; Ladda, Roger L.; Hewson, Stacy; Inbar-Feigenberg, Michal; Prasad, Chitra; Prasad, Asuri N.; Olewiler, Leah; Mu, Weiyu; Rosenthal, Liana S.; Scala, Marcello; Striano, Pasquale; Zara, Federico; McCullock, Tyler W.; Jauss, Robin-Tobias; Lemke, Johannes R.; MacLean, David M.; Zhu, Cheng; Yuan, Hongjie; Myers, Scott J.; Traynelis, Stephen F. Share Save
Clinical and functional consequences of GRIA variants in patients with neurological diseases XiangWei, Wenshu; Perszyk, Riley E.; Liu, Nana; Xu, Yuchen; Bhattacharya, Subhrajit; Shaulsky, Gil H.; Smith-Hicks, Constance; Fatemi, Ali; Fry, Andrew E.; Chandler, Kate; Wang, Tao; Vogt, Julie; Cohen, Julie S.; Paciorkowski, Alex R.; Poduri, Annapurna; Zhang, Yuehua; Wang, Shuang; Wang, Yuping; Zhai, Qiongxiang; Fang, Fang; Leng, Jie; Garber, Kathryn; Myers, Scott J.; Jauss, Robin-Tobias; Park, Kristen L.; Benke, Timothy A.; Lemke, Johannes R.; Yuan, Hongjie; Jiang, Yuwu; Traynelis, Stephen F. Share Save
Intrathecal magnesium delivery for Mg plus plus -insensitive NMDA receptor activity due to GRIN1 mutation Lewis, Sara A.; Shetty, Sheetal; Gamble, Sean; Heim, Jennifer; Zhao, Ningning; Stitt, Gideon; Pankratz, Matthew; Mangum, Tara; Marku, Iris; Rosenberg, Robert B.; Wilfong, Angus A.; Fahey, Michael C.; Kim, Sukhan; Myers, Scott J.; Appavu, Brian; Kruer, Michael C. Share Save
Classification of missense variants in the N-methyl-d-aspartate receptor GRIN gene family as gain- or loss-of-function Myers, Scott J.; Yuan, Hongjie; Perszyk, Riley E.; Zhang, Jing; Kim, Sukhan; Nocilla, Kelsey A.; Allen, James P.; Bain, Jennifer M.; Lemke, Johannes R.; Lal, Dennis; Benke, Timothy A.; Traynelis, Stephen F. Share Save
Functional effects of disease-associated variants reveal that the S1-M1 linker of the NMDA receptor critically controls channel opening Xie, Lingling; McDaniel, Miranda J.; Perszyk, Riley E.; Kim, Sukhan; Cappuccio, Gerarda; Shapiro, Kevin A.; Munoz-Cabello, Beatriz; Sanchez-Lara, Pedro A.; Grand, Katheryn; Zhang, Jing; Nocilla, Kelsey A.; Sheikh, Rehan; Armengol, Lluis; Romano, Roberta; Pierson, Tyler Mark; Yuan, Hongjie; Myers, Scott J.; Traynelis, Stephen F. Share Save
Novel GluN2B-Selective NMDA Receptor Negative Allosteric Modulator Possesses Intrinsic Analgesic Properties and Enhances Analgesia of Morphine in a Rodent Tail Flick Pain Model Harris, Lynnea D.; Regan, Michael C.; Myers, Scott J.; Nocilla, Kelsey A.; Akins, Nicholas S.; Tahirovic, Yesim A.; Wilson, Lawrence J.; Dingledine, Ray; Furukawa, Hiro; Traynelis, Stephen F.; Liotta, Dennis C. Share Save
Novel neuroactive steroids as positive allosteric modulators of NMDA receptors: mechanism, site of action, and rescue pharmacology on GRIN variants associated with neurological conditions Tang, Weiting; Beckley, Jacob T.; Zhang, Jin; Song, Rui; Xu, Yuchen; Kim, Sukhan; Quirk, Michael C.; Robichaud, Albert J.; Diaz, Eva Sarai; Myers, Scott J.; Doherty, James J.; Ackley, Michael A.; Traynelis, Stephen F.; Yuan, Hongjie Share Save
Compound-heterozygous GRIN2A null variants associated with severe developmental and epileptic encephalopathy Strehlow, Vincent; Rieubland, Claudine; Gallati, Sabina; Kim, Sukhan; Myers, Scott J.; Peterson, Vincent; Ramsey, Amy J.; Teuscher, Daniel D.; Traynelis, Stephen F.; Lemke, Johannes R. Share Save
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A Glutamate N-Methyl-D-Aspartate (NMDA) Receptor Subunit 2B-Selective Inhibitor of NMDA Receptor Function with Enhanced Potency at Acidic pH and Oral Bioavailability for Clinical Use Myers, Scott J.; Ruppa, Kamalesh P.; Wilson, Lawrence J.; Tahirovic, Yesim A.; Lyuboslavsky, Polina; Menaldino, David S.; Dentmon, Zackery W.; Koszalka, George W.; Zaczek, Robert; Dingledine, Raymond J.; Traynelis, Stephen F.; Liotta, Dennis C. Share Save
Modelling and treating GRIN2A developmental and epileptic encephalopathy in mice Amador, Ariadna; Bostick, Christopher D.; Olson, Heather; Peters, Jurrian; Camp, Chad R.; Krizay, Daniel; Chen, Wenjuan; Han, Wei; Tang, Weiting; Kanber, Ayla; Kim, Sukhan; Teoh, JiaJie; Sah, Megha; Petri, Sabrina; Paek, Hunki; Kim, Ana; Lutz, Cathleen M.; Yang, Mu; Myers, Scott J.; Bhattacharya, Subhrajit; Yuan, Hongjie; Goldstein, David B.; Poduri, Annapurna; Boland, Michael J.; Traynelis, Stephen F.; Frankel, Wayne N. Share Save
The GRIA3 c.2477G > A Variant Causes an Exaggerated Startle Reflex, Chorea, and Multifocal Myoclonus Piard, Juliette; Bereau, Matthieu; XiangWei, Wenshu; Wirth, Thomas; Amsallem, Daniel; Buisson, Lauren; Richard, Philippe; Liu, Nana; Xu, Yuchen; Myers, Scott J.; Traynelis, Stephen F.; Chelly, Jameleddine; Anheim, Mathieu; Raynaud, Martine; Van Maldergem, Lionel; Yuan, Hongjie Share Save
De novo GRIN variants in NMDA receptor M2 channel pore-forming loop are associated with neurological diseases Li, Jia; Zhang, Jin; Tang, Weiting; Mizu, Ruth K.; Kusumoto, Hirofumi; XiangWei, Wenshu; Xu, Yuchen; Chen, Wenjuan; Amin, Johansen B.; Hu, Chun; Kannan, Varun; Keller, Stephanie R.; Wilcox, William R.; Lemke, Johannes R.; Myers, Scott J.; Swanger, Sharon A.; Wollmuth, Lonnie P.; Petrovski, Slave; Traynelis, Stephen F.; Yuan, Hongjie Share Save
Heterogeneous clinical and functional features of GRIN2D-related developmental and epileptic encephalopathy XiangWei, Wenshu; Kannan, Varun; Xu, Yuchen; Kosobucki, Gabrielle J.; Schulien, Anthony J.; Kusumoto, Hirofumi; El Achkar, Christelle Moufawad; Bhattacharya, Subhrajit; Lesca, Gaetan; Nguyen, Sylvie; Helbig, Katherine L.; Cuisset, Jean-Marie; Fenger, Christina Duhring; Marjanovic, Dragan; Schuler, Elisabeth; Wu, Ye; Bao, Xinhua; Zhang, Yuehua; Dirkx, Nina; Schoonjans, An-Sofie; Syrbe, Steffen; Myers, Scott J.; Poduri, Annapurna; Aizenman, Elias; Traynelis, Stephen F.; Lemke, Johannes R.; Yuan, Hongjie; Jiang, Yuwu Share Save
Synthesis and Preliminary Evaluations of a Triazole-Cored Antagonist as a PET Imaging Probe ([18F]N2B-0518) for GluN2B Subunit in the Brain Fu, Hualong; Tang, Weiting; Chen, Zhen; Belov, Vasily V.; Zhang, Genwei; Shao, Tuo; Zhang, Xiaofei; Yu, Qingzhen; Rong, Jian; Deng, Xiaoyun; Han, Wei; Myers, Scott J.; Giffenig, Pilar; Wang, Lu; Josephson, Lee; Shao, Yihan; Davenport, April T.; Daunais, James B.; Papisov, Mikhail; Yuan, Hongjie; Li, Zijing; Traynelis, Stephen F.; Liang, Steven H. Share Save
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