Not logged in A Novel Confocal Scanning Protein-Protein Interaction Assay (PPI-CONA) Reveals Exceptional Selectivity and Specificity of CC0651, a Small Molecule Binding Enhancer of the Weak Interaction between the E2 Ubiquitin-Conjugating Enzyme CDC34A and Ubiquitin Koszela, Joanna; Pham, Nhan T.; Shave, Steven; St-Cyr, Daniel; Ceccarelli, Derek F.; Orlicky, Steven; Marinier, Anne; Sicheri, Frank; Tyers, Mike; Auer, Manfred Share Save
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Discovery and Structural Characterization of Small Molecule Binders of the Human CTLH E3 Ligase Subunit GID4 Chana, Chetan K.; Maisonneuve, Pierre; Posternak, Ganna; Grinberg, Nicolas G. A.; Poirson, Juline; Ona, Samara M.; Ceccarelli, Derek F.; Mader, Pavel; St-Cyr, Daniel J.; Pau, Victor; Kurinov, Igor; Tang, Xiaojing; Deng, Dongjing; Cui, Weiren; Su, Wenji; Kuai, Letian; Soll, Richard; Tyers, Mike; Rost, Hannes L.; Batey, Robert A.; Taipale, Mikko; Gingras, Anne-Claude; Sicheri, Frank Share Save
Identification and optimization of molecular glue compounds that inhibit a noncovalent E2 enzyme-ubiquitin complex St-Cyr, Daniel; Ceccarelli, Derek F.; Orlicky, Stephen; van der Sloot, Almer M.; Tang, Xiaojing; Kelso, Susan; Moore, Susan; James, Clint; Posternak, Ganna; Coulombe-Huntington, Jasmin; Bertomeu, Thierry; Marinier, Anne; Sicheri, Frank; Tyers, Mike Share Save
A substrate binding model for the KEOPS tRNA modifying complex Beenstock, Jonah; Ona, Samara Mishelle; Porat, Jennifer; Orlicky, Stephen; Wan, Leo C. K.; Ceccarelli, Derek F.; Maisonneuve, Pierre; Szilard, Rachel K.; Yin, Zhe; Setiaputra, Dheva; Mao, Daniel Y. L.; Khan, Morgan; Raval, Shaunak; Schriemer, David C.; Bayfield, Mark A.; Durocher, Daniel; Sicheri, Frank Share Save
Persistence of serum and saliva antibody responses to SARS-CoV-2 spike antigens in COVID-19 patients Isho, Baweleta; Abe, Kento T.; Zuo, Michelle; Jamal, Alainna J.; Rathod, Bhavisha; Wang, Jenny H.; Li, Zhijie; Chao, Gary; Rojas, Olga L.; Bang, Yeo Myong; Pu, Annie; Christie-Holmes, Natasha; Gervais, Christian; Ceccarelli, Derek; Samavarchi-Tehrani, Payman; Guvenc, Furkan; Budylowski, Patrick; Li, Angel; Paterson, Aimee; Yue, Feng Yun; Marin, Lina M.; Caldwell, Lauren; Wrana, Jeffrey L.; Colwill, Karen; Sicheri, Frank; Mubareka, Samira; Gray-Owen, Scott D.; Drews, Steven J.; Siqueira, Walter L.; Barrios-Rodiles, Miriam; Ostrowski, Mario; Rini, James M.; Durocher, Yves; McGeer, Allison J.; Gommerman, Jennifer L.; Gingras, Anne-Claude Share Save
Functional characterization of a PROTAC directed against BRAF mutant V600E Posternak, Ganna; Tang, Xiaojing; Maisonneuve, Pierre; Jin, Ting; Lavoie, Hugo; Daou, Salima; Orlicky, Stephen; de Rugy, Theo Goullet; Caldwell, Lauren; Chan, Kin; Aman, Ahmed; Prakesch, Michael; Poda, Gennady; Mader, Pavel; Wong, Cassandra; Maier, Stefan; Kitaygorodsky, Julia; Larsen, Brett; Colwill, Karen; Yin, Zhe; Ceccarelli, Derek F.; Batey, Robert A.; Taipale, Mikko; Kurinov, Igor; Uehling, David; Wrana, Jeff; Durocher, Daniel; Gingras, Anne-Claude; Al-Awar, Rima; Therrien, Marc; Sicheri, Frank Share Save
Monoubiquitination of ASXLs controls the deubiquitinase activity of the tumor suppressor BAP1 Daou, Salima; Barbour, Haithem; Ahmed, Oumaima; Masclef, Louis; Baril, Caroline; Sen Nkwe, Nadine; Tchelougou, Damehan; Uriarte, Maxime; Bonneil, Eric; Ceccarelli, Derek; Mashtalir, Nazar; Tanji, Mika; Masson, Jean-Yves; Thibault, Pierre; Sicheri, Frank; Yang, Haining; Carbone, Michele; Therrien, Marc; Affar, El Bachir Share Save
Higher-Order Assembly of BRCC36-KIAA0157 Is Required for DUB Activity and Biological Function Zeqiraj, Elton; Tian, Lei; Piggott, Christopher A.; Pillon, Monica C.; Duffy, Nicole M.; Ceccarelli, Derek F.; Keszei, Alexander F. A.; Lorenzen, Kristina; Kurinov, Igor; Orlicky, Stephen; Gish, Gerald D.; Heck, Albert J. R.; Guarne, Alba; Greenberg, Roger A.; Sicheri, Frank Share Save
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Dimeric Structure of Pseudokinase RNase L Bound to 2-5A Reveals a Basis for Interferon-Induced Antiviral Activity Huang, Hao; Zeqiraj, Elton; Dong, Beihua; Jha, Babal Kant; Duffy, Nicole M.; Orlicky, Stephen; Thevakumaran, Neroshan; Talukdar, Manisha; Pillon, Monica C.; Ceccarelli, Derek F.; Wan, Leo C. K.; Juang, Yu-Chi; Mao, Daniel Y. L.; Gaughan, Christina; Brinton, Margo A.; Perelygin, Andrey A.; Kourinov, Igor; Guarne, Alba; Silverman, Robert H.; Sicheri, Frank Share Save
E2 enzyme inhibition by stabilization of a low-affinity interface with ubiquitin Huang, Hao; Ceccarelli, Derek F.; Orlicky, Stephen; St-Cyr, Daniel J.; Ziemba, Amy; Garg, Pankaj; Plamondon, Serge; Auer, Manfred; Sidhu, Sachdev; Marinier, Anne; Kleiger, Gary; Tyers, Mike; Sicheri, Frank Share Save
STK25 Protein Mediates TrkA and CCM2 Protein-dependent Death in Pediatric Tumor Cells of Neural Origin Costa, Barbara; Kean, Michelle J.; Ast, Volker; Knight, James D. R.; Mett, Alice; Levy, Zehava; Ceccarelli, Derek F.; Badillo, Beatriz Gonzalez; Eils, Roland; Koenig, Rainer; Gingras, Anne-Claude; Fainzilber, Mike Share Save
OTUB1 Co-opts Lys48-Linked Ubiquitin Recognition to Suppress E2 Enzyme Function (vol 45, pg 384, 2012) Juang, Yu-Chi; Landry, Marie-Claude; Sanches, Mario; Vittal, Vinayak; Leung, Charles; Ceccarelli, Derek F.; Mateo, Abigail-Rachele F.; Pruneda, Jonathan N.; Mao, Dan; Szilard, Rachel K.; Orlicky, Stephen; Munro, Meagan; Brzovic, Peter S.; Klevit, Rachel E.; Sicheri, Frank; Durocher, Daniel Share Save
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OTUB1 Co-opts Lys48-Linked Ubiquitin Recognition to Suppress E2 Enzyme Function Juang, Yu-Chi; Landry, Marie-Claude; Sanches, Mario; Vittal, Vinayak; Leung, Charles C. Y.; Ceccarelli, Derek F.; Mateo, Abigail-Rachele F.; Pruneda, Jonathan N.; Mao, Daniel Y. L.; Szilard, Rachel K.; Orlicky, Stephen; Munro, Meagan; Brzovic, Peter S.; Klevit, Rachel E.; Sicheri, Frank; Durocher, Daniel Share Save
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CCM3/PDCD10 Heterodimerizes with Germinal Center Kinase III (GCKIII) Proteins Using a Mechanism Analogous to CCM3 Homodimerization Ceccarelli, Derek F.; Laister, Rob C.; Mulligan, Vikram Khipple; Kean, Michelle J.; Goudreault, Marilyn; Scott, Ian C.; Derry, W. Brent; Chakrabartty, Avijit; Gingras, Anne-Claude; Sicheri, Frank Share Save
Structure-Function Analysis of Core STRIPAK Proteins A SIGNALING COMPLEX IMPLICATED IN GOLGI POLARIZATION Kean, Michelle J.; Ceccarelli, Derek F.; Goudreault, Marilyn; Sanches, Mario; Tate, Stephen; Larsen, Brett; Gibson, Lucien C. D.; Derry, W. Brent; Scott, Ian C.; Pelletier, Laurence; Baillie, George S.; Sicheri, Frank; Gingras, Anne-Claude Share Save
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