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L

Leying Guan

yale school of public health

15H-index
86Paper Count
1.4KCitation Count
Published Papers 19
Publication Date
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Virus reactivation in acute and long COVID-19
errNature
IF48.5
err2026-08-05
err0
errOAAI
errCole Maguire; Jing Chen; Nadine Rouphael; Brinkley A. Morse; Annmarie Hoch; Harry Pickering; Hoang Van Phan; Abigail Glascock; Victoria Chu; Ravi Dandekar; David Corry; Farrah Kheradmand; Lindsey R. Baden; Rafick-Pierre Sekaly; Grace A. McComsey; Elias K. Haddad; Charles B. Cairns; Bali Pulendran; Ana Fernandez-Sesma; Viviana Simon; Jordan P. Metcalf; Nelson I. Agudelo Higuita; William B. Messer; Mark M. Davis; Kari C. Nadeau; Monica Kraft; Chris Bime; Joanna Schaenman; David Erle; Carolyn S. Calfee; Mark A. Atkinson; Scott C. Brakenridge; Lauren I. R. Ehrlich; Ruth R. Montgomery; Albert Shaw; Catherine L. Hough; David Hafler; Alison D. Augustine; Patrice M. Becker; Bjoern Peters; Al Ozonoff; Seunghee Kim-Schulze; Florian Krammer; Steven E. Bosinger; Walter Eckalbar; Matthew C. Altman; Michael Wilson; Leying Guan; Steven H. Kleinstein; Kinga K. Smolen; Elaine F. Reed; Ofer Levy; Holden Maecker; Peter Hunt; Hanno Steen; Joann Diray-Arce; Charles R. Langelier; Esther Melamed
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MIXPRS enables multi-population and multi-method polygenic risk scores using summary statistics
errNature Genetics
IF29
err2026-06-09
err0
errOAAI
errLeqi Xu; Yikai Dong; Xiaowei Zeng; Zeyu Bian; Geyu Zhou; Leying Guan; Hongyu Zhao
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Author Correction: Machine learning models predict long COVID outcomes based on baseline clinical and immunologic factors
errCommunications Medicine
IF6.3
err2026-02-23
err0
errOAAI
errNaresh Doni Jayavelu; Hady Samaha; Sonia Tandon Wimalasena; Annmarie Hoch; Jeremy P. Gygi; Gisela Gabernet; Al Ozonoff; Shanshan Liu; Carly E. Milliren; Ofer Levy; Lindsey R. Baden; Esther Melamed; Lauren I. R. Ehrlich; Grace A. McComsey; Rafick P. Sekaly; Charles B. Cairns; Elias K. Haddad; Joanna Schaenman; Albert C. Shaw; David A. Hafler; Ruth R. Montgomery; David B. Corry; Farrah Kheradmand; Mark A. Atkinson; Scott C. Brakenridge; Nelson I. Agudelo Higuit; Jordan P. Metcalf; Catherine L. Hough; William B. Messer; Bali Pulendran; Kari C. Nadeau; Mark M. Davis; Linda N. Geng; Ana Fernandez Sesma; Viviana Simon; Florian Krammer; Monica Kraft; Chris Bime; Carolyn S. Calfee; David J. Erle; Charles R. Langelier; Leying Guan; Holden T. Maecker; Bjoern Peters; Steven H. Kleinstein; Elaine F. Reed; Alison D. Augustine; Joann Diray-Arce; Patrice M. Becker; Nadine Rouphael; Matthew C. Altman
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Machine learning models predict long COVID outcomes based on baseline clinical and immunologic factors
errCommunications Medicine
IF6.3
err2026-01-03
err0
errOAAI
errNaresh Doni Jayavelu; Hady Samaha; Sonia Tandon Wimalasena; Annmarie Hoch; Jeremy P. Gygi; Gisela Gabernet; Al Ozonoff; Shanshan Liu; Carly E. Milliren; Ofer Levy; Lindsey R. Baden; Esther Melamed; Lauren I. R. Ehrlich; Grace A. McComsey; Rafick P. Sekaly; Charles B. Cairns; Elias K. Haddad; Joanna Schaenman; Albert C. Shaw; David A. Hafler; Ruth R. Montgomery; David B. Corry; Farrah Kheradmand; Mark A. Atkinson; Scott C. Brakenridge; Nelson I. Agudelo Higuit; Jordan P. Metcalf; Catherine L. Hough; William B. Messer; Bali Pulendran; Kari C. Nadeau; Mark M. Davis; Linda N. Gen; Ana Fernandez Sesma; Viviana Simon; Florian Krammer; Monica Kraft; Chris Bime; Carolyn S. Calfee; David J. Erle; Charles R. Langelier; Leying Guan; Holden T. Maecker; Bjoern Peters; Steven H. Kleinstein; Elaine F. Reed; Alison D. Augustine; Joann Diray-Arce; Patrice M. Becker; Nadine Rouphael; Matthew C. Altman
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errSave
A multiomics recovery factor predicts long COVID in the IMPACC study
errJOURNAL OF CLINICAL INVESTIGATION
IF13.6
err2025-11-03
err0
errOAAI
errGabernet, Gisela; Maciuch, Jessica; Gygi, Jeremy P.; Moore, John F.; Hoch, Annmarie; Syphurs, Caitlin; Chu, Tianyi; Jayavelu, Naresh Doni; Corry, David B.; Kheradmand, Farrah; Baden, Lindsey R.; Sekaly, Rafick-Pierre; McComsey, Grace A.; Haddad, Elias K.; Cairns, Charles B.; Rouphael, Nadine; Fernandez-Sesma, Ana; Simon, Viviana; Metcalf, Jordan P.; Higuita, Nelson I. Agudelo; Hough, Catherine L.; Messer, William B.; Davis, Mark M.; Nadeau, Kari C.; Pulendran, Bali; Kraft, Monica; Bime, Chris; Reed, Elaine F.; Schaenman, Joanna; Erle, David J.; Calfee, Carolyn S.; Atkinson, Mark A.; Brakenridge, Scott C.; Melamed, Esther; Shaw, Albert C.; Hafler, David A.; Augustine, Alison D.; Becker, Patrice M.; Ozonoff, Al; Bosinger, Steven E.; Eckalbar, Walter; Maecker, Holden T.; Kim-Schulze, Seunghee; Steen, Hanno; Krammer, Florian; Westendorf, Kerstin; Peters, Bjoern; Fourati, Slim; Altman, Matthew C.; Levy, Ofer; Smolen, Kinga K.; Montgomery, Ruth R.; Diray-Arce, Joann; Kleinstein, Steven H.; Guan, Leying; Ehrlich, Lauren I. R.
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errSave
Circulating endothelial signatures correlate with worse outcomes in COVID-19, respiratory failure and ARDS
errCritical Care
IF9.3
err2025-10-15
err0
errOAAI
errAna C. Costa Monteiro; Harry Pickering; Aartik Sarma; Clove S. Taylor; Meagan M. Jenkins; Fei-Man Hsu; Brian Nadel; Ofer Levy; Lindsey R. Baden; Esther Melamed; Lauren I. R. Ehrlich; Grace A. McComsey; Rafick P. Sekaly; Charles B. Cairns; Elias K. Haddad; Albert C. Shaw; David A. Hafler; Ruth R. Montgomery; David B. Corry; Farrah Kheradmand; Mark A. Atkinson; Scott C. Brakenridge; Nelson I. Agudelo Higuita; Jordan P. Metcalf; Catherine L. Hough; William B. Messer; Bali Pulendran; Kari C. Nadeau; Mark M. Davis; Linda N. Geng; Ana Fernandez-Sesma; Viviana Simon; Florian Krammer; Monica Kraft; Chris Bime; Carolyn S. Calfee; David J. Erle; Steve Bosinger; Walter Eckalbar; Holden Maecker; Adeeb Rahman; Leying Guan; Bjoern Peters; Steven H. Kleinstein; Alison D. Augustine; Joann Diray-Arce; Patrice M. Becker; Nadine Rouphael; Michael Agus; Hrishikesh Kulkarni; Joanna M. Schaenmann; Ramin Salehi-Rad; Michael A. Matthay; Elaine F. Reed; Anil Sapru
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Cerebrospinal fluid immune phenotyping reveals distinct immunotypes of myalgic encephalomyelitis/chronic fatigue syndrome
errJOURNAL OF IMMUNOLOGY
IF3.4
err2025-05-15
err0
errOAAI
errBastos, Victoria C.; Greene, Kerrie A.; Tabachnikova, Alexandra; Bhattacharjee, Bornali; Sjogren, Per; Bertilson, Bo; Reifert, Jack; Zhang, Minlu; Kamath, Kathy; Shon, John; Gehlhausen, Jeff R.; Guan, Leying; VanElzakker, Michael; Proal, Amy; Bragee, Bjorn
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JointPRS: A data-adaptive framework for multi-population genetic risk prediction incorporating genetic correlation
errNATURE COMMUNICATIONS
IF15.7
err2025-04-24
err0
errOAAI
errXu, Leqi; Zhou, Geyu; Jiang, Wei; Zhang, Haoyu; Dong, Yikai; Guan, Leying
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A CONFORMAL TEST OF LINEAR MODELS VIA PERMUTATION-AUGMENTED REGRESSIONS
errANNALS OF STATISTICS
IF3.7
err2024-10-01
err0
errOAAI
errGuan, Leying
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A systems vaccinology resource to develop and test computational models of immunity
errJOURNAL OF IMMUNOLOGY
IF3.4
err2024-05-01
err0
errOAAI
errShinde, Pramod; Willemsen, Lisa; Orfield, Shelby; Kojima, Mari; Reyna, Joaquin; Ha, Brendan; Greenbaum, Jason; Overton, James; Nili, Somayeh; Rasmussen, Mikkel; Gygi, Jeremy; Antunes, Ricardo da Silva; Sette, Alessandro; Olsen, Lars Ronn; Grant, Barry; Konstorum, Anna; Guan, Leying
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errSave
Host-microbe multiomic profiling reveals age-dependent immune dysregulation associated with COVID-19 immunopathology
errSCIENCE TRANSLATIONAL MEDICINE
IF14.6
err2024-04-17
err1
errOAAI
errPhan, Hoang Van; Tsitsiklis, Alexandra; Maguire, Cole; Haddad, Elias; Becker, Patrice; Kim-Schulze, Seunghee; Lee, Brian; Chen, Jing; Hoch, Annmarie; Pickering, Harry; van Zalm, Patrick; Altman, Matthew; Augustine, Alison; Calfee, Carolyn; Bosinger, Steve; Cairns, Charles; Eckalbar, Walter; Guan, Leying; Jayavelu, Naresh Doni; Kleinstein, Steven; Krammer, Florian; Maecker, Holden; Ozonoff, Al; Peters, Bjoern; Rouphael, Nadine; Montgomery, Ruth; Reed, Elaine; Schaenman, Joanna; Steen, Hanno; Levy, Ofer; Diray-Arce, Joann; Langelier, Charles
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errSave
A multi-omics systems vaccinology resource to develop and test computational models of immunity
errCELL REPORTS METHODS
IF4.5
err2024-03-01
err0
errOAAI
errShinde, Pramod; Soldevila, Ferran; Reyna, Joaquin; Aoki, Minori; Rasmussen, Mikkel; Willemsen, Lisa; Kojima, Mari; Ha, Brendan; Greenbaum, Jason A.; Overton, James A.; Guzman-Orozco, Hector; Nili, Somayeh; Orfield, Shelby; Gygi, Jeremy P.; Antunes, Ricardo da Silva; Sette, Alessandro; Grant, Barry; Olsen, Lars Ronn; Konstorum, Anna; Guan, Leying; Ay, Ferhat; Kleinstein, Steven H.; Peters, Bjoern
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errSave
Predictive overfitting in immunological applications: Pitfalls and solutions
errHUMAN VACCINES & IMMUNOTHERAPEUTICS
IF3.5
err2023-09-12
err9
errOAAI
errGygi, Jeremy P.; Kleinstein, Steven H.; Guan, Leying
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errSave
Prediction and outlier detection in classification problems
errJOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES B-STATISTICAL METHODOLOGY
IF3.6
err2022-02-15
err20
errOAAI
errGuan, Leying; Tibshirani, Robert
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errSave
Immunophenotyping assessment in a COVID-19 cohort (IMPACC): A prospective longitudinal study
errSCIENCE IMMUNOLOGY
IF16.3
err2021-08-10
err23
errOAAI
errRouphael, Nadine; Maecker, Holden; Montgomery, Ruth R.; Diray-Arce, Joann; Kleinstein, Steven H.; Altman, Matthew C.; Bosinger, Steven E.; Eckalbar, Walter; Guan, Leying; Hough, Catherine L.; Krammer, Florian; Langelier, Charles; Levy, Ofer; McEnaney, Kerry; Peters, Bjoern; Rahman, Adeeb; Rajan, Jayant, V; Sigelman, Steven; Steen, Hanno; van Bakel, Harm; Ward, Alyssa; Wilson, Michael R.; Woodruff, Prescott; Zamecnik, Colin R.; Augustine, Alison D.; Ozonoff, Al; Reed, Elaine F.; Becker, Patrice M.; Higuita, Nelson Agudelo; Altman, Matthew C.; Atkinson, Mark A.; Baden, Lindsey R.; Bime, Christian; Brakenridge, Scott C.; Calfee, Carolyn S.; Cairns, Charles B.; Corry, David; Davis, Mark M.; Ehrlich, Lauren I. R.; Haddad, Elias K.; Erle, David J.; Fernandez-Sesma, Ana; Hafler, David A.; Kheradmand, Farrah; Kraft, Monica; McComsey, Grace A.; Melamed, Esther; Messer, William; Metcalf, Jordan; Nadeau, Kari C.; Pulendran, Bali; Rouphaell, Nadine; Sarwal, Minnie; Schaenman, Joanna; Sekaly, Rafick; Shaw, Albert C.; Simon, Viviana
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Increased T Cell Differentiation and Cytolytic Function in Bangladeshi Compared to American Children
errFRONTIERS IN IMMUNOLOGY
IF5.9
err2019-09-20
err14
errOAAI
errWager, Lisa E.; Bolen, Christopher R.; Sigel, Natalia; Angel, Cesar J. Lopez; Guan, Leying; Kirkpatrick, Beth D.; Haque, Rashidul; Tibshirani, Robert J.; Parsonnet, Julie; Petri, William A., Jr.; Davis, Mark M.
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Detecting Strong Signals in Gene Perturbation Experiments: An Adaptive Approach With Power Guarantee and FDR Control
errJOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION
IF3
err2019-08-14
err1
errOAAI
errGuan, Leying; Chen, Xi; Wong, Wing Hung
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errSave
APPROXIMATE l0-PENALIZED ESTIMATION OF PIECEWISE-CONSTANT SIGNALS ON GRAPHS
errANNALS OF STATISTICS
IF3.7
err2018-12-02
err19
errOAAI
errFan, Zhou; Guan, Leying
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errSave
Big data modeling to predict platelet usage and minimize wastage in a tertiary care system
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2017-10-09
err47
errOAAI
errGuan, Leying; Tian, Xiaoying; Gombar, Saurabh; Zemek, Allison J.; Krishnan, Gomathi; Scott, Robert; Narasimhan, Balasubramanian; Tibshirani, Robert J.; Pham, Tho D.
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Research Directions

No research directions
Co-authors
Cooperation Journals
A
Alessandro Sette
H-index: 174 · Papers: 1.4K
M
Mark M. Davis
H-index: 173 · Papers: 988
R
Robert Tibshirani
H-index: 160 · Papers: 1.0K
D
David A. Hafler
H-index: 132 · Papers: 684
M
Mark A. Atkinson
H-index: 126 · Papers: 1.1K
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