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D

David M. Sabatini

Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences

149H-index
533Paper Count
15.4WCitation Count
Published Papers 178
Publication Date
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Atlas of lysosomal aging reveals a metabolite signature shared with lysosomal storage disorders
errScience
IF45.8
err2026-07-30
err0
PREAI
errAnna M. Puszynska; Thao P. Nguyen; Andrew L. Cangelosi; Andrea Armani; Justin M. Roberts; Kristin A. Singh; James C. Cameron; Tenzin Tseyang; Grace Y. Liu; Steven Lai; Hans-Georg Sprenger; Jason Yang; William N. Colgan; Jibril F. Kedir; Kathrin M. Kajderowicz; Theodore K. Esantsi; Yuancheng Ryan Lu; Millenia Waite; Tenzin Kunchok; Caroline A. Lewis; Fabian Schulte; George W. Bell; David M. Sabatini; Jonathan S. Weissman
errShare
errSave
Structural basis for the recruitment and selective phosphorylation of Akt by mTORC2
errScience
IF45.8
err2025-11-27
err0
PREAI
errMartin S. Taylor; Maggie Chen; Matthew Hancock; Maximilian Wranik; Bryant D. Miller; Timothy R. O’Meara; Brad A. Palanski; Scott B. Ficarro; Brian J. Groendyke; Yufei Xiang; Kazuma T. Kondo; Karen Y. Linde-Garelli; Michelle J. Lee; Dibyendu Mondal; Daniel Freund; Samantha Congreve; Kaay Matas; Maximiliaan Hennink; Kera Xibinaku; Max L. Valenstein; Trevor van Eeuwen; Jarrod A. Marto; Andrej Sali; Yi Shi; Nathanael S. Gray; David M. Sabatini; Nam Chu; Kacper B. Rogala; Philip A. Cole
errShare
errSave
Structural basis for the dynamic regulation of mTORC1 by amino acids
errNature
IF48.5
err2025-08-20
err0
errOAAI
errMax L. Valenstein; Maximilian Wranik; Pranav V. Lalgudi; Karen Y. Linde-Garelli; Yuri Choi; Raghu R. Chivukula; David M. Sabatini; Kacper B. Rogala
errShare
errSave
Polyglycine-mediated aggregation of FAM98B disrupts tRNA processing in GGC repeat disorders
errScience
IF45.8
err2025-07-17
err0
PREAI
errJason Yang; Yunhan Xu; David R. Ziehr; Martin S. Taylor; Max L. Valenstein; Evgeni M. Frenkel; Jack R. Bush; Kate Rutter; Igor Stevanovski; Charlie Y. Shi; Maheswaran Kesavan; Ricardo Mouro Pinto; Ira Deveson; David P. Bartel; David M. Sabatini; Raghu R. Chivukula
errShare
errSave
Ergothioneine controls mitochondrial function and exercise performance via direct activation of MPST
errCELL METABOLISM
IF30.9
err2025-02-01
err0
PREAI
errSprenger, Hans-Georg; Mittenbuhler, Melanie J.; Sun, Yizhi; Van Vranken, Jonathan G.; Schindler, Sebastian; Jayaraj, Abhilash; Khetarpal, Sumeet A.; Smythers, Amanda L.; Vargas-Castillo, Ariana; Puszynska, Anna M.; Spinelli, Jessica B.; Armani, Andrea; Kunchok, Tenzin; Ryback, Birgitta; Seo, Hyuk-Soo; Song, Kijun; Sebastian, Luke; O'Young, Coby; Braithwaite, Chelsea; Dhe-Paganon, Sirano; Burger, Nils; Mills, Evanna L.; Gygi, Steven P.; Paulo, Joao A.; Arthanari, Haribabu; Chouchani, Edward T.; Sabatini, David M.; Spiegelman, Bruce M.
errShare
errSave
Rhodoquinone carries electrons in the mammalian electron transport chain
errCELL
IF42.5
err2025-02-01
err1
errOAAI
errValeros, Jonathan; Jerome, Madison; Tseyang, Tenzin; Vo, Paula; Do, Thang; Palomino, Diana Fajardo; Grotehans, Nils; Kunala, Manisha; Jerrett, Alexandra E.; Hathiramani, Nicolai R.; Mireku, Michael; Magesh, Rayna Y.; Yenilmez, Batuhan; Rosen, Paul C.; Mann, Jessica L.; Myers, Jacob W.; Kunchok, Tenzin; Manning, Tanner L.; Boercker, Lily N.; Carr, Paige E.; Bin Munim, Muhammad; Lewis, Caroline A.; Sabatini, David M.; Kelly, Mark; Xie, Jun; Czech, Michael P.; Gao, Guangping; Shepherd, Jennifer N.; Walker, Amy K.; Kim, Hahn; V. Watson, Emma; Spinelli, Jessica B.
errShare
errSave
SLC25A38 is required for mitochondrial pyridoxal 5'-phosphate (PLP) accumulation
errNATURE COMMUNICATIONS
IF15.7
err2025-01-24
err0
errOAAI
errPena, Izabella A.; Shi, Jeffrey S.; Chang, Sarah M.; Yang, Jason; Block, Samuel; Adelmann, Charles H.; Keys, Heather R.; Ge, Preston; Bathla, Shveta; Witham, Isabella H.; Sienski, Grzegorz; Nairn, Angus C.; Sabatini, David M.; Lewis, Caroline A.; Kory, Nora; Vander Heiden, Matthew G.
errShare
errSave
An evolutionary mechanism to assimilate new nutrient sensors into the mTORC1 pathway
errNATURE COMMUNICATIONS
IF15.7
err2024-03-21
err7
errOAAI
errLiu, Grace Y.; Jouandin, Patrick; Bahng, Raymond E.; Perrimon, Norbert; Sabatini, David M.
errShare
errSave
Organelle proteomic profiling reveals lysosomal heterogeneity in association with longevity
errELIFE
IF0
err2024-01-19
err4
errOAAI
errYu, Yong; Gao, Shihong M.; Guan, Youchen; Hu, Pei-Wen; Zhang, Qinghao; Liu, Jiaming; Jing, Bentian; Zhao, Qian; Sabatini, David M.; Abu-Remaileh, Monther; Jung, Sung Yun; Wang, Meng C.
errShare
errSave
Enumeration of the simian virus 40 early region elements necessary for human cell transformation
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-28
err611
errOAAI
errHahn, WC; Dessain, SK; Brooks, MW; King, JE; Elenbaas, B; Sabatini, DM; DeCaprio, JA; Weinberg, RA
errShare
errSave
The immuno suppress ant rapamycin mimics a starvation-like signal distinct from amino acid and glucose deprivation
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-27
err419
errOAAI
errPeng, T; Golub, TR; Sabatini, DM
errShare
errSave
Collateral deletion of the mitochondrial AAA plus ATPase ATAD1 sensitizes cancer cells to proteasome dysfunction
errELIFE
IF0
err2022-11-21
err7
errOAAI
errWinter, Jacob M.; Fresenius, Heidi L.; Cunningham, Corey N.; Wei, Peng; Keys, Heather R.; Berg, Jordan; Bott, Alex; Yadav, Tarun; Ryan, Jeremy; Sirohi, Deepika; Tripp, Sheryl R.; Barta, Paige; Agarwal, Neeraj; Letai, Anthony; Sabatini, David M.; Wohlever, Matthew L.; Rutter, Jared
errShare
errSave
GCN2 adapts protein synthesis to scavenging-dependent growth
errCELL SYSTEMS
IF7.7
err2022-02-01
err17
errOAAI
errNofal, Michel; Wang, Tim; Yang, Lifeng; Jankowski, Connor S. R.; Li, Sophia Hsin-Jung; Han, Seunghun; Parsons, Lance; Frese, Alexander N.; Gitai, Zemer; Anthony, Tracy G.; Wuhr, Martin; Sabatini, David M.; Rabinowitz, Joshua D.
errShare
errSave
Limited survival and impaired hepatic fasting metabolism in mice with constitutive Rag GTPase signaling
errNATURE COMMUNICATIONS
IF15.7
err2021-06-16
err16
errOAAI
errde la Calle Arregui, Celia; Belen Plata-Gomez, Ana; Deleyto-Seldas, Nerea; Garcia, Fernando; Ortega-Molina, Ana; Abril-Garrido, Julio; Rodriguez, Elena; Nemazanyy, Ivan; Tribouillard, Laura; de Martino, Alba; Caleiras, Eduardo; Campos-Olivas, Ramon; Mulero, Francisca; Laplante, Mathieu; Munoz, Javier; Pende, Mario; Sabio, Guadalupe; Sabatini, David M.; Efeyan, Alejo
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errSave
CRISPR screens in physiologic medium reveal conditionally essential genes in human cells
errCELL METABOLISM
IF30.9
err2021-06-01
err64
errOAAI
errRossiter, Nicholas J.; Huggler, Kimberly S.; Adelmann, Charles H.; Keys, Heather R.; Soens, Ross W.; Sabatini, David M.; Cantor, Jason R.
errShare
errSave
APOE4 disrupts intracellular lipid homeostasis in human iPSC-derived glia
errSCIENCE TRANSLATIONAL MEDICINE
IF14.6
err2021-03-03
err183
errOAAI
errSienski, Grzegorz; Narayan, Priyanka; Bonner, Julia Maeve; Kory, Nora; Boland, Sebastian; Arczewska, Aleksandra A.; Ralvenius, William T.; Akay, Leyla; Lockshin, Elana; He, Liang; Milo, Blerta; Graziosi, Agnese; Baru, Valeriya; Lewis, Caroline A.; Kellis, Manolis; Sabatini, David M.; Tsai, Li-Huei; Lindquist, Susan
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errSave
Genome-wide CRISPR screens reveal multitiered mechanisms through which mTORC1 senses mitochondrial dysfunction
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2021-01-22
err78
errOAAI
errCondon, Kendall J.; Orozco, Jose M.; Adelmann, Charles H.; Spinelli, Jessica B.; van der Helm, Pim W.; Roberts, Justin M.; Kunchok, Tenzin; Sabatini, David M.
errShare
errSave
Metabolic determinants of cellular fitness dependent on mitochondrial reactive oxygen species
errSCIENCE ADVANCES
IF12.5
err2020-11-06
err35
errOAAI
errKong, Hyewon; Reczek, Colleen R.; McElroy, Gregory S.; Steinert, Elizabeth M.; Wang, Tim; Sabatini, David M.; Chandel, Navdeep S.
errShare
errSave
MCART1/SLC25A51 is required for mitochondrial NAD transport
errSCIENCE ADVANCES
IF12.5
err2020-10-23
err117
errOAAI
errKory, Nora; de Bos, Jelmi Uit; van der Rijt, Sanne; Jankovic, Nevena; Gura, Miriam; Arp, Nicholas; Pena, Izabella A.; Prakash, Gyan; Chan, Sze Ham; Kunchok, Tenzin; Lewis, Caroline A.; Sabatini, David M.
errShare
errSave
Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition
errCANCER DISCOVERY
IF33.3
err2020-09-01
err166
errOAAI
errNgo, Bryan; Kim, Eugenie; Osorio-Vasquez, Victoria; Doll, Sophia; Bustraan, Sophia; Liang, Roger J.; Luengo, Alba; Davidson, Shawn M.; Ali, Ahmed; Ferraro, Gino B.; Fischer, Grant M.; Eskandari, Roozbeh; Kang, Diane S.; Ni, Jing; Plasger, Ariana; Rajasekhar, Vinagolu K.; Kastenhuber, Edward R.; Bacha, Sarah; Sriram, Roshan K.; Stein, Benjamin D.; Bakhoum, Samuel F.; Snuderl, Matija; Cotzia, Paolo; Healey, John H.; Mainolfi, Nello; Suri, Vipin; Friedman, Adam; Manfredi, Mark; Sabatini, David M.; Jones, Drew R.; Yu, Min; Zhao, Jean J.; Jain, Rakesh K.; Keshari, Kayvan R.; Davies, Michael A.; Vander Heiden, Matthew G.; Hernando, Eva; Mann, Matthias; Cantley, Lewis C.; Pacold, Michael E.
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errSave

Research Directions

No research directions
Co-authors
Cooperation Journals
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Eric S. Lander
H-index: 271 · Papers: 897
M
Matthias Mann
H-index: 250 · Papers: 1.4K
G
Gordon B. Mills
H-index: 231 · Papers: 3.5K
S
Solomon H. Snyder
H-index: 222 · Papers: 1.2K
L
Lewis C. Cantley
H-index: 214 · Papers: 1.4K
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