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Ken J. Ishii

the university of tokyo

82H-index
482Paper Count
3.3WCitation Count
Published Papers 188
Publication Date
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Gut Microbiota-Derived Bacterial Extracellular Vesicles in COVID-19: Their Signature and Immunological Impact
errJournal of Extracellular Vesicles
IF14.5
err2026-07-28
err0
errOAAI
errAya Ishizaka; Michiko Koga; Tomoya Hayashi; Ken J Ishii; Hiroyuki Yamamoto; Hiroshi Yotsuyanagi; Taketoshi Mizutani
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A distinct antigen presentation pathway drives potent T cell immunity in lipid nanoparticle–based mRNA vaccines
errScience Advances
IF12.5
err2026-07-17
err0
errOAAI
errRyunosuke Muro; Suqi Wang; Taku Ito-Kureha; Hung Hiep Huynh; Kouji Kobiyama; Takuya Sugita; Kazuo Okamoto; Kenta Nakano; Tadashi Okamura; Masato Kubo; Ken J. Ishii; Takeshi Nitta; Hiroshi Takayanagi
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STING agonists as next-generation vaccine adjuvants: mechanisms, opportunities, and challenges
errCurrent Opinion in Virology
IF5.1
err2026-05-01
err0
errOAAI
errBurcu Temizoz; Ken J Ishii
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errSave
Efficacy of intranasal adenovirus vector vaccine is attenuated by type I IFN-induced NK cell activation
errMOLECULAR THERAPY ADVANCES
IF0
err2026-05-01
err0
PREAI
errNakatani, Hayato; Tachibana, Masashi; Onishi, Rika; Nakagaki, Takato; Ishii, Ken J.; Shimizu, Kahori; Sakurai, Fuminori; Mizuguchi, Hiroyuki
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A poorly reactogenic lipid nanoparticle-mRNA vaccine unveils an innate immune pathway for adverse reactions
errnpj Vaccines
IF6.5
err2026-04-16
err0
errOAAI
errTomohiro Takano; Keigo Kumagai; Hitoshi Iuchi; Kazutaka Terahara; Aya Mizuike; Eita Sasaki; Yu Adachi; Ryutaro Kotaki; Saya Moriyama; Shinichiro Ota; Mizuki Fujisawa; Tomoharu Mizukami; Kyoko Saito; Masanori Isogawa; Kohei Soga; Haruyo Nakajima-Adachi; Satoshi Hachimura; Kouji Kobiyama; Ken J. Ishii; Michiaki Hamada; Masayoshi Fukasawa; Masaharu Shinkai; Takayuki Matsumura; Yoshimasa Takahashi
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IL-1 delineates squalene-based adjuvant efficacy and reactogenicity in a cell-type-specific manner
errnpj Vaccines
IF6.5
err2026-03-30
err0
errOAAI
errYuya Yoshioka; Anri Nishinaka-Yoshioka; Kouji Kobiyama; Tomoya Hayashi; Yujiro Kidani; Yosuke Yanagida; Junpei Kasahara; Kenichiro Tsujii; Yoshiji Asaoka; Norikazu Kuroda; Akira Kugimiya; Hiroaki Osawa; Akimasa Yoshimura; Motoyasu Onishi; Takayuki Nakagawa; Satoru Ishida; Shinya Omoto; Morio Nagira; Cevayir Coban; Ken J. Ishii
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errSave
cGAS-IFN-I responses by extracting nuclear DNA from dying cells via nucleocytosis
errNature Communications
IF15.7
err2026-02-18
err0
errOAAI
errHideo Negishi; Yusuke Wada; Yoshitaka Shirasaki; Tomoya Hayashi; Yuji Kubota; Tomio Iwasaki; Mina Kurosawa; Tatsuma Ban; Daisuke Muto; Yusuke Suenaga; Taichi Kojima; Yuzuki Matsuda; Sean Lord Irish; Kosuke Dodo; Toru Suzuki; Mai Yamagishi; Burcu Temizoz; Atsushi Yoshimori; Chisato Kanai; Yoji Nagasaki; Masaki Ohmuraya; Tomohiko Tamura; Atsushi Iwama; Toshifumi Inada; Etsushi Kuroda; Kouji Kobiyama; Noriko Toyama-Sorimachi; Mutsuhiro Takekawa; Cevayir Coban; Ken J. Ishii
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Identification of Histone Deacetylase Inhibitor Targeting Type I Interferon and B Cell Abnormalities in Systemic Lupus Erythematosus
errArthritis & Rheumatology
IF10.9
err2026-02-01
err0
errOAAI
errHirayama, Takehiro; Konaka, Hachiro; Kato, Yasuhiro; Shibahara, Takayuki; Nishizawa, Chisato; Tsujimoto, Kohei; Park, Jeonghoon; Itotagawa, Eri; Jo, Tatsunori; Nishide, Masayuki; Nishida, Sumiyuki; Shima, Yoshihito; Narazaki, Masashi; Aoki, Wataru; Ishii, Ken J.; Takamatsu, Hyota; Kumanogoh, Atsushi
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Long-term immunoprophylaxis by TLR9 ligand mediates macrophage-ILC cross-talk against respiratory viral infection
errScience Advances
IF12.5
err2026-01-01
err0
PREAI
errAsuka Joy Tobuse; Kouji Kobiyama; Jun Tsuchida; Masamitsu N. Asaka; Daichi Utsumi; Mariana Silva Almeida; Yaeko Nakajima‐Takagi; Motohiko Oshima; Tomoya Hayashi; Burcu Temizoz; Etsushi Kuroda; Cevayir Coban; Yasuhiro Yasutomi; Atsushi Iwama; Ken J. Ishii
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Resident alveolar macrophages are highly susceptible to the induction of RIPK1/RIPK3-mediated necroptosis which promote efficient pulmonary immune response
errCell Death & Disease
IF9.6
err2025-12-22
err0
errOAAI
errTakumi Adachi; Kazufumi Matsushita; Koubun Yasuda; Masakiyo Nakahira; Mai Imasaka; Michihiko Sugimoto; Zhuohao Yang; Kouji Kobiyama; Tomoya Hayashi; Ken J. Ishii; Yasuo Yoshioka; Masaki Ohmuraya; Yoshitaka Shirasaki; Etsushi Kuroda
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errSave
NOX2-Dependent Phagocyte Signaling Mediates Silica-Induced Murine Lung Injury via Macrophage-Neutrophil Interactions
errInflammation
IF5
err2025-12-17
err0
errOAAI
errMasahiro Kusaka; Koji Sakamoto; Yoshiki Ikeyama; Yuki Kondo; Tomoya Hayashi; Akira Ando; Yuta Mori; Tomonori Sato; Miyoko Matsushima; Atsushi Suzuki; Saeka Fujita; Yukihiro Shiraki; Tsutomu Kawabe; Atsushi Enomoto; Ken J. Ishii; Naozumi Hashimoto; Makoto Ishii
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errSave
Discovery of DS79540454 via fragment-based drug discovery strategy: New scaffolds of hypoxia-inducible factor prolyl hydroxylase inhibitor
errBioorganic & Medicinal Chemistry Letters
IF2.2
err2025-11-19
err0
PREAI
errTakeshi Fukuda; Tatsuya Nishi; Takashi Ishiyama; Ryoko Kitazawa; Ken Ishii; Shinichi Takahashi; Yuki Kawabata; Kyoji Yamaguchi; Daichi Baba; Shuichiro Ito; Naoki Tanaka
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errSave
Antagonistic stem cell fates under stress govern decisions between hair greying and melanoma
errNature Cell Biology
IF19.1
err2025-10-06
err0
PREAI
errYasuaki Mohri; Jialiang Nie; Hironobu Morinaga; Tomoki Kato; Takahiro Aoto; Takashi Yamanashi; Daisuke Nanba; Hiroyuki Matsumura; Sakura Kirino; Kouji Kobiyama; Ken J. Ishii; Masahiro Hayashi; Tamio Suzuki; Takeshi Namiki; Jun Seita; Emi K. Nishimura
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The chitosan nanoparticle-based adjuvant CH-100 orchestrates multifaceted innate immune activation via STING-dependent and -independent pathways
errInternational Immunology
IF3.2
err2025-10-01
err3
PREAI
errNagai, Eri; Ori, Daisuke; Kano, Norisuke; Ikegawa, Moe; Kobiyama, Kouji; Ishii, Ken J.; Kawasaki, Takumi; Kawai, Taro
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Vaccine adjuvants as stand-alone immunoprophylaxis in strategies for 100-day rapid responses to future pandemics
errInternational Immunology
IF3.2
err2025-09-01
err2
errOAAI
errKavian, Niloufar; Kobiyama, Kouji; Ishii, Ken J.; Coban, Cevayir
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An adjuvant database for preclinical evaluation of vaccines and immunotherapeutics
errCell Chemical Biology
IF7.2
err2025-08-11
err0
errOAAI
errYayoi Natsume-Kitatani; Kouji Kobiyama; Yoshinobu Igarashi; Taiki Aoshi; Noriyuki Nakatsu; Lokesh P. Tripathi; Junichi Ito; Johan Nyström-Persson; Yuji Kosugi; Rodolfo S. Allendes Osorio; Chioko Nagao; Burcu Temizoz; Etsushi Kuroda; Daron M. Standley; Hiroshi Kiyono; Kenji Nakanishi; Satoshi Uematsu; Isao Hamaguchi; Yasuhiro Yasutomi; Jun Kunisawa; Sho Yamasaki; Cevayir Coban; Hiroshi Yamada; Kenji Mizuguchi; Ken J. Ishii
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OTUD3 prevents ulcerative colitis by inhibiting microbiota-mediated STING activation
errScience Immunology
IF16.3
err2025-07-18
err0
PREAI
errBo Li; Taiki Sakaguchi; Haruka Tani; Takayoshi Ito; Mari Murakami; Ryu Okumura; Masao Kobayashi; Daisuke Okuzaki; Daisuke Motooka; Hiroki Ikeuchi; Takayuki Ogino; Tsunekazu Mizushima; Seiichi Hirota; Yuriko Otake-Kasamoto; Toshihiro Kishikawa; Shota Nakamura; Kouji Kobiyama; Ken J. Ishii; Takao Hashiguchi; Taro Kawai; Etsushi Kuroda; Shinichiro Shinzaki; Wataru Ise; Tomohiro Kurosaki; Akira Kikuchi; Yoshihiko Tomofuji; Yukinori Okada; Kiyoshi Takeda; Hisako Kayama
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Immunological analysis of LC16m8 vaccine: preclinical and early clinical insights into mpox
errEBIOMEDICINE
IF10.8
err2025-05-01
err0
PREAI
errKobiyama, Kouji; Utsumi, Daichi; Kaku, Yu; Sasaki, Eita; Yasui, Fumihiko; Okamura, Tomotaka; Onodera, Taishi; Tobuse, Asuka Joy; Sakkour, Areej; Amiry, Ahmad Faisal; Hayashi, Tomoya; Temizoz, Burcu; Liu, Kaiwen; Negishi, Hideo; Toyama-Sorimachi, Noriko; Kohara, Michinori; Sawasaki, Tatsuya; Takagi, Junichi; Sato, Kei; Takahashi, Yoshimasa; Yasutomi, Yasuhiro; Ishii, Ken J.
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Immunogenicity, safety, and tolerability of a β-glucan-CpG-adjuvanted respiratory syncytial virus vaccine in Japanese healthy participants aged 60 to 80 years: A phase 2, randomized, double-blind, dose-finding study
errHUMAN VACCINES & IMMUNOTHERAPEUTICS
IF3.5
err2025-04-21
err0
errOAAI
errTetsuo Nakayama; Makoto Iwanami; Sachiko Sakakibara; Ryuta Mukasa; Aisaku Ota; Kei Furihata; Yuko Honda; Ken J. Ishii
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miR-147-3p in pathogenic CD4 T cells controls chemokine receptor expression for the development of experimental autoimmune diseases
errJOURNAL OF AUTOIMMUNITY
IF7
err2024-12-01
err0
errOAAI
errIijima, Norifumi; Yamaguchi, Masaya; Hayashi, Tomoya; Rui, Yuxiang; Ohira, Yuta; Miyamoto, Yoichi; Niino, Masaaki; Okuno, Tatsusada; Suzuki, Osamu; Oka, Masahiro; Ishii, Ken J.
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Research Directions

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Co-authors
Cooperation Journals
S
Shizuo Akira
H-index: 269 · Papers: 1.5K
M
Marco Colonna
H-index: 170 · Papers: 849
H
Hideo Yagita∥
H-index: 144 · Papers: 1.3K
Y
Yoichiro Iwakura
H-index: 143 · Papers: 947
K
Katherine A. Fitzgerald
H-index: 136 · Papers: 609
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