Ken J. Ishii - Publications, H-index & Citations

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Ken J. Ishii

The University of Tokyo

82H-index

480Paper Count

3.3WCitation Count

Published Papers 186

Publication Date

Gut Microbiota-Derived Bacterial Extracellular Vesicles in COVID-19: Their Signature and Immunological Impact

Journal of Extracellular Vesicles

IF14.5

2026-07-28

OAAI

Aya Ishizaka; Michiko Koga; Tomoya Hayashi; Ken J Ishii; Hiroyuki Yamamoto; Hiroshi Yotsuyanagi; Taketoshi Mizutani

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A distinct antigen presentation pathway drives potent T cell immunity in lipid nanoparticle–based mRNA vaccines

Science Advances

IF12.5

2026-07-17

OAAI

Ryunosuke Muro; Suqi Wang; Taku Ito-Kureha; Hung Hiep Huynh; Kouji Kobiyama; Takuya Sugita; Kazuo Okamoto; Kenta Nakano; Tadashi Okamura; Masato Kubo; Ken J. Ishii; Takeshi Nitta; Hiroshi Takayanagi

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STING agonists as next-generation vaccine adjuvants: mechanisms, opportunities, and challenges

Current Opinion in Virology

IF5.1

2026-05-01

OAAI

Burcu Temizoz; Ken J Ishii

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A poorly reactogenic lipid nanoparticle-mRNA vaccine unveils an innate immune pathway for adverse reactions

npj Vaccines

IF6.5

2026-04-16

OAAI

Tomohiro Takano; Keigo Kumagai; Hitoshi Iuchi; Kazutaka Terahara; Aya Mizuike; Eita Sasaki; Yu Adachi; Ryutaro Kotaki; Saya Moriyama; Shinichiro Ota; Mizuki Fujisawa; Tomoharu Mizukami; Kyoko Saito; Masanori Isogawa; Kohei Soga; Haruyo Nakajima-Adachi; Satoshi Hachimura; Kouji Kobiyama; Ken J. Ishii; Michiaki Hamada; Masayoshi Fukasawa; Masaharu Shinkai; Takayuki Matsumura; Yoshimasa Takahashi

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IL-1 delineates squalene-based adjuvant efficacy and reactogenicity in a cell-type-specific manner

npj Vaccines

IF6.5

2026-03-30

OAAI

Yuya Yoshioka; Anri Nishinaka-Yoshioka; Kouji Kobiyama; Tomoya Hayashi; Yujiro Kidani; Yosuke Yanagida; Junpei Kasahara; Kenichiro Tsujii; Yoshiji Asaoka; Norikazu Kuroda; Akira Kugimiya; Hiroaki Osawa; Akimasa Yoshimura; Motoyasu Onishi; Takayuki Nakagawa; Satoru Ishida; Shinya Omoto; Morio Nagira; Cevayir Coban; Ken J. Ishii

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cGAS-IFN-I responses by extracting nuclear DNA from dying cells via nucleocytosis

Nature Communications

IF15.7

2026-02-18

OAAI

Hideo Negishi; Yusuke Wada; Yoshitaka Shirasaki; Tomoya Hayashi; Yuji Kubota; Tomio Iwasaki; Mina Kurosawa; Tatsuma Ban; Daisuke Muto; Yusuke Suenaga; Taichi Kojima; Yuzuki Matsuda; Sean Lord Irish; Kosuke Dodo; Toru Suzuki; Mai Yamagishi; Burcu Temizoz; Atsushi Yoshimori; Chisato Kanai; Yoji Nagasaki; Masaki Ohmuraya; Tomohiko Tamura; Atsushi Iwama; Toshifumi Inada; Etsushi Kuroda; Kouji Kobiyama; Noriko Toyama-Sorimachi; Mutsuhiro Takekawa; Cevayir Coban; Ken J. Ishii

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Identification of Histone Deacetylase Inhibitor Targeting Type I Interferon and B Cell Abnormalities in Systemic Lupus Erythematosus

Arthritis & Rheumatology

IF10.9

2026-02-01

OAAI

Hirayama, Takehiro; Konaka, Hachiro; Kato, Yasuhiro; Shibahara, Takayuki; Nishizawa, Chisato; Tsujimoto, Kohei; Park, Jeonghoon; Itotagawa, Eri; Jo, Tatsunori; Nishide, Masayuki; Nishida, Sumiyuki; Shima, Yoshihito; Narazaki, Masashi; Aoki, Wataru; Ishii, Ken J.; Takamatsu, Hyota; Kumanogoh, Atsushi

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Resident alveolar macrophages are highly susceptible to the induction of RIPK1/RIPK3-mediated necroptosis which promote efficient pulmonary immune response

Cell Death & Disease

IF9.6

2025-12-22

OAAI

Takumi Adachi; Kazufumi Matsushita; Koubun Yasuda; Masakiyo Nakahira; Mai Imasaka; Michihiko Sugimoto; Zhuohao Yang; Kouji Kobiyama; Tomoya Hayashi; Ken J. Ishii; Yasuo Yoshioka; Masaki Ohmuraya; Yoshitaka Shirasaki; Etsushi Kuroda

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NOX2-Dependent Phagocyte Signaling Mediates Silica-Induced Murine Lung Injury via Macrophage-Neutrophil Interactions

Inflammation

IF5

2025-12-17

OAAI

Masahiro Kusaka; Koji Sakamoto; Yoshiki Ikeyama; Yuki Kondo; Tomoya Hayashi; Akira Ando; Yuta Mori; Tomonori Sato; Miyoko Matsushima; Atsushi Suzuki; Saeka Fujita; Yukihiro Shiraki; Tsutomu Kawabe; Atsushi Enomoto; Ken J. Ishii; Naozumi Hashimoto; Makoto Ishii

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Discovery of DS79540454 via fragment-based drug discovery strategy: New scaffolds of hypoxia-inducible factor prolyl hydroxylase inhibitor

Bioorganic & Medicinal Chemistry Letters

IF2.2

2025-11-19

PREAI

Takeshi Fukuda; Tatsuya Nishi; Takashi Ishiyama; Ryoko Kitazawa; Ken Ishii; Shinichi Takahashi; Yuki Kawabata; Kyoji Yamaguchi; Daichi Baba; Shuichiro Ito; Naoki Tanaka

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Antagonistic stem cell fates under stress govern decisions between hair greying and melanoma

Nature Cell Biology

IF19.1

2025-10-06

PREAI

Yasuaki Mohri; Jialiang Nie; Hironobu Morinaga; Tomoki Kato; Takahiro Aoto; Takashi Yamanashi; Daisuke Nanba; Hiroyuki Matsumura; Sakura Kirino; Kouji Kobiyama; Ken J. Ishii; Masahiro Hayashi; Tamio Suzuki; Takeshi Namiki; Jun Seita; Emi K. Nishimura

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The chitosan nanoparticle-based adjuvant CH-100 orchestrates multifaceted innate immune activation via STING-dependent and -independent pathways

International Immunology

IF3.2

2025-10-01

PREAI

Nagai, Eri; Ori, Daisuke; Kano, Norisuke; Ikegawa, Moe; Kobiyama, Kouji; Ishii, Ken J.; Kawasaki, Takumi; Kawai, Taro

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Vaccine adjuvants as stand-alone immunoprophylaxis in strategies for 100-day rapid responses to future pandemics

International Immunology

IF3.2

2025-09-01

OAAI

Kavian, Niloufar; Kobiyama, Kouji; Ishii, Ken J.; Coban, Cevayir

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An adjuvant database for preclinical evaluation of vaccines and immunotherapeutics

Cell Chemical Biology

IF7.2

2025-08-11

OAAI

Yayoi Natsume-Kitatani; Kouji Kobiyama; Yoshinobu Igarashi; Taiki Aoshi; Noriyuki Nakatsu; Lokesh P. Tripathi; Junichi Ito; Johan Nyström-Persson; Yuji Kosugi; Rodolfo S. Allendes Osorio; Chioko Nagao; Burcu Temizoz; Etsushi Kuroda; Daron M. Standley; Hiroshi Kiyono; Kenji Nakanishi; Satoshi Uematsu; Isao Hamaguchi; Yasuhiro Yasutomi; Jun Kunisawa; Sho Yamasaki; Cevayir Coban; Hiroshi Yamada; Kenji Mizuguchi; Ken J. Ishii

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OTUD3 prevents ulcerative colitis by inhibiting microbiota-mediated STING activation

Science Immunology

IF16.3

2025-07-18

PREAI

Bo Li; Taiki Sakaguchi; Haruka Tani; Takayoshi Ito; Mari Murakami; Ryu Okumura; Masao Kobayashi; Daisuke Okuzaki; Daisuke Motooka; Hiroki Ikeuchi; Takayuki Ogino; Tsunekazu Mizushima; Seiichi Hirota; Yuriko Otake-Kasamoto; Toshihiro Kishikawa; Shota Nakamura; Kouji Kobiyama; Ken J. Ishii; Takao Hashiguchi; Taro Kawai; Etsushi Kuroda; Shinichiro Shinzaki; Wataru Ise; Tomohiro Kurosaki; Akira Kikuchi; Yoshihiko Tomofuji; Yukinori Okada; Kiyoshi Takeda; Hisako Kayama

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Immunological analysis of LC16m8 vaccine: preclinical and early clinical insights into mpox

EBIOMEDICINE

IF10.8

2025-05-01

PREAI

Kobiyama, Kouji; Utsumi, Daichi; Kaku, Yu; Sasaki, Eita; Yasui, Fumihiko; Okamura, Tomotaka; Onodera, Taishi; Tobuse, Asuka Joy; Sakkour, Areej; Amiry, Ahmad Faisal; Hayashi, Tomoya; Temizoz, Burcu; Liu, Kaiwen; Negishi, Hideo; Toyama-Sorimachi, Noriko; Kohara, Michinori; Sawasaki, Tatsuya; Takagi, Junichi; Sato, Kei; Takahashi, Yoshimasa; Yasutomi, Yasuhiro; Ishii, Ken J.

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Immunogenicity, safety, and tolerability of a β-glucan-CpG-adjuvanted respiratory syncytial virus vaccine in Japanese healthy participants aged 60 to 80 years: A phase 2, randomized, double-blind, dose-finding study

HUMAN VACCINES & IMMUNOTHERAPEUTICS

IF3.5

2025-04-21

OAAI

Tetsuo Nakayama; Makoto Iwanami; Sachiko Sakakibara; Ryuta Mukasa; Aisaku Ota; Kei Furihata; Yuko Honda; Ken J. Ishii

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miR-147-3p in pathogenic CD4 T cells controls chemokine receptor expression for the development of experimental autoimmune diseases

JOURNAL OF AUTOIMMUNITY

IF7

2024-12-01

OAAI

Iijima, Norifumi; Yamaguchi, Masaya; Hayashi, Tomoya; Rui, Yuxiang; Ohira, Yuta; Miyamoto, Yoichi; Niino, Masaaki; Okuno, Tatsusada; Suzuki, Osamu; Oka, Masahiro; Ishii, Ken J.

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A stress sensor, IRE1a, is required for bacterial-exotoxin-induced interleukin-1b production in tissue-resident macrophages

CELL REPORTS

IF6.9

2024-04-01

OAAI

Sasaki, Izumi; Fukuda-Ohta, Yuri; Nakai, Chihiro; Wakaki-Nishiyama, Naoko; Okamoto, Chizuyo; Okuzaki, Daisuke; Morita, Shuhei; Kaji, Shiori; Furuta, Yuki; Hemmi, Hiroaki; Kato, Takashi; Yamamoto, Asumi; Tosuji, Emi; Saitoh, Shin-Ichiroh; Tanaka, Takashi; Hoshino, Katsuaki; Fukuda, Shinji; Miyake, Kensuke; Kuroda, Etsushi; Ishii, Ken J.; Iwawaki, Takao; Furukawa, Koichi; Kaisho, Tsuneyasu

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5,6-dimethylxanthenone-4-acetic acid (DMXAA), a partial STING agonist, competes for human STING activation

FRONTIERS IN IMMUNOLOGY

IF5.9

2024-03-12

OAAI

Temizoz, Burcu; Shibahara, Takayuki; Hioki, Kou; Hayashi, Tomoya; Kobiyama, Kouji; Lee, Michelle Sue Jann; Surucu, Naz; Sag, Erdal; Kumanogoh, Atsushi; Yamamoto, Masahiro; Gursel, Mayda; Ozen, Seza; Kuroda, Etsushi; Coban, Cevayir; Ishii, Ken J.

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Research Directions