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J

John A. McIntosh

Merck & Co., Inc.

31H-index
52Paper Count
3.6KCitation Count
Published Papers 29
Publication Date
Biocatalytic cascades enable manufacture of the macrocyclic peptide enlicitide
errScience
IF45.8
err2026-05-07
err0
PREAI
errArtis Klapars; Anna Fryszkowska; Stephanie Galanie; Omer Ad; Ellen Y. Aguilera; Nnamdi Akporji; Chihui An; Stephanus Axnanda; Tewoderos M. Ayele; Richard S. Ayikpoe; Rodell C. Barrientos; Matthew R. Bauerle; Marc R. Becker; Kevin M. Belyk; Lisa Bereznitski; Jackson K. B. Cahn; Karla Camacho Soto; Louis-Charles Campeau; Kevin R. Campos; Anagha Chandra; Hsieh Yao Darryl Chang; Mengbin Chen; Zhiwei Chen; Wai Ling Cheung-Lee; Cheol K. Chung; Stephanie W. Chun; Sarah S. Co; Ryan D. Cohen; Stephen M. Dalby; Guilherme Dal Poggetto; Truc Do; Spencer D. Dreher; Riki J. Drout; Noah P. Dunham; Yi Fan; Ryan M. Flessner; Jacob H. Forstater; Scott P. France; Janaka C. Gamekkanda; Donald R. Gauthier; Agnieszka A. Gil; Jacob W. Greenwood; Noel Ha; Holst M. Halsey; Xinxin Han; Michael Hartmann; Clara Hartmanshenn; Yu He; Edgar Hernandez; Kaori Hiraga; Hsing-I Ho; Cynthia M. Hong; Alan Hruza; Hang Hu; Kari Hullen; Alan M. Hyde; Tetsuji Itoh; Chey M. Jones; Woo-Ok Jung; Kanan Kanuga; James Levi Knippel; Joshua N. Kolev; Jongrock Kong; Birgit Kosjek; Sara Koynov; Michael H. Kress; Bharath Krishnamurthi; Jeffrey T. Kuethe; Thomas T. Kwok; Alfred Y. Lee; Joshua Lee; Qiuhan Li; Shasha Li; Jing Liao; Wenjun Liu; Gurpreet Longia; Emma Madrigal; Peter E. Maligres; Kevin M. Maloney; Erin L. McCarthy; John A. McIntosh; Samaneh Mesbahi-Vasey; Margaret Miller; Mansi Modi; Jeffrey C. Moore; Debopreeti Mukherjee; Grant S. Murphy; Jennifer Victoriano Obligacion; Weilan Pan; Julia Parzecki; Anisha Patel; Teng Peng; Byron K. Peters; Tiffany Piou; Carlos A. Pons Siepermann; Christopher K. Prier; Akasha K. Purohit; Yangzhong Qin; Erik L. Regalado; Mikhail Reibarkh; Nelo R. Rivera; Sandra A. Robaire; Lee Robison; Syamantak Roy; Rebecca T. Ruck; Katie A. Rykaczewski; Christopher H. Schuster; Erica L. Schwalm; Andrew N. Singh; Eric Sirota; Alexandra C. Sun; Weijuan Tang; David A. Thaisrivongs; Nimisha Thakur; Weidong Tong; Van Truong; Ryan Tsoi; Qiang Tu; Ben W. H. Turnbull; Ophelia Ukaegbu; David A. Vargas; Juan E. Velasquez; Deeptak Verma; Heather Wang; Tao Wang; Xiao Wang; Ying Wang; Zhixun Wang; Matthew S. Winston; Chunyu Wu; Brian M. Wyvratt; Kai-Jiong Xiao; Yingju Xu; Jia-Xuan Yan; Hao Yang; Victoria Zhang; Yongqian Zhang; Michelle Zheng; Wendy Zhong
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A Convergent; One-Step Biocatalytic Cascade for the Synthesis of Structurally Diverse Noncanonical Amino Acids
err2026-02-11
err0
PREAI
errJohn A. McIntosh; Susan Zultanski; Jackson Cahn; Zhongxue Dai; Luan Zhengjiao; Fan Haiyang; Mengmeng Bian; Deeptak Verma; Chey M. Jones; Michael Hartmann; Nguyet A. Nguyen; Stephanie Galanie; Harrison M. Snodgrass
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Profiling of Diverse Pyridoxal-5′-Phosphate Dependent Enzymes Reveals Promiscuous Aldolase Activity with (2-Azaaryl)methanamines
err2025-07-09
err0
PREAI
errKendrick L. Smith; Madeline A. Arbuckle; Alexander T. Kim; Chun-Yi Tsai; John A. McIntosh; Deeptak Verma; Eunjae Shim; Alison R. H. Narayan
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Decarboxylation in Natural Products Biosynthesis
errJACS AU
IF8.7
err2024-07-25
err0
errOAAI
errNguyen, Nguyet A.; Forstater, Jacob H.; McIntosh, John A.
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Engineering Hydroxylase Activity, Selectivity, and Stability for a Scalable Concise Synthesis of a Key Intermediate to Belzutifan
err2024-02-19
err19
PREAI
errCheung-Lee, Wai Ling; Kolev, Joshua N.; Mcintosh, John A.; Gil, Agnieszka A.; Pan, Weilan; Xiao, Li; Velasquez, Juan E.; Gangam, Rekha; Winston, Matthew S.; Li, Shasha; Abe, Kotoe; Alwedi, Embarek; Dance, Zachary E. X.; Fan, Haiyang; Hiraga, Kaori; Kim, Jungchul; Kosjek, Birgit; Le, Diane N.; Marzijarani, Nastaran Salehi; Mattern, Keith; Mcmullen, Jonathan P.; Narsimhan, Karthik; Vikram, Ajit; Wang, Wei; Yan, Jia-Xuan; Yang, Rong-Sheng; Zhang, Victoria; Zhong, Wendy; Dirocco, Daniel A.; Morris, William J.; Murphy, Grant S.; Maloney, Kevin M.
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pH-Switchable Phase-Transfer Agents for Host Cell Protein Rejection in the Cascaded Biocatalytic Synthesis of an Active Pharmaceutical Ingredient
err2022-12-22
err3
PREAI
errWinston, Matthew S.; Poirier, Marc; Liu, Zhijian; Peng, Feng; Humphrey, Guy R.; McIntosh, John A.; Reibarkh, Mikhail; Wang, Fengqiang; Guetschow, Erik D.; Castro, Steve; Hoyt, Erik; Lamberto, David J.; Sirk, Kevin
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Diverse Catalytic Reactions for the Stereoselective Synthesis ofCyclic Dinucleotide MK-1454
err2022-03-25
err30
PREAI
errBenkovics, Tamas; Peng, Feng; Phillips, Eric M.; An, Chihui; Bade, Rachel S.; Chung, Cheol K.; Dance, Zachary E. X.; Fier, Patrick S.; Forstater, Jacob H.; Liu, Zhijian; Liu, Zhuqing; Maligres, Peter E.; Marshall, Nicholas M.; Marzijarani, Nastaran Salehi; McIntosh, John A.; Miller, Steven P.; Moore, Jeffrey C.; Neel, Andrew J.; Obligacion, Jennifer, V; Pan, Weilan; Pirnot, Michael T.; Poirier, Marc; Reibarkh, Mikhail; Sherry, Benjamin D.; Song, Zhiguo Jake; Tan, Lushi; Turnbull, Ben W. H.; Verma, Deeptak; Waldman, Jacob H.; Wang, Lu; Wang, Tao; Winston, Matthew S.; Xu, Feng
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Quantitation and speciation of residual protein within active pharmaceutical ingredients using image analysis with SDS-PAGE
err2022-01-01
err8
PREAI
errSmith, Joseph P.; Ralbovsky, Nicole M.; Lauro, Mackenzie L.; Hoyt, Erik; Guetschow, Erik D.; Wang, Fengqiang; McIntosh, John A.; Liu, Zhijian; Mangion, Ian; Variankaval, Narayan; Bu, Xiaodong
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Engineered Ribosyl-1-Kinase Enables Concise Synthesis of Molnupiravir, an Antiviral for COVID-19
err2021-10-29
err109
errOAAI
errMcIntosh, John A.; Benkovics, Tamas; Silverman, Steven M.; Huffman, Mark A.; Kong, Jongrock; Maligres, Peter E.; Itoh, Tetsuji; Yang, Hao; Verma, Deeptak; Pan, Weilan; Ho, Hsing-, I; Vroom, Jonathan; Knight, Anders M.; Hurtak, Jessica A.; Klapars, Artis; Fryszkowska, Anna; Morris, William J.; Strotman, Neil A.; Murphy, Grant S.; Maloney, Kevin M.; Fier, Patrick S.
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Deep Dive into Machine Learning Models for Protein Engineering
err2020-04-06
err151
errOAAI
errXu, Yuting; Verma, Deeptak; Sheridan, Robert P.; Liaw, Andy; Ma, Junshui; Marshall, Nicholas M.; McIntosh, John; Sherer, Edward C.; Svetnik, Vladimir; Johnston, Jennifer M.
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Molecular basis for the broad substrate selectivity of a peptide prenyltransferase
err2016-11-21
err50
errOAAI
errHao, Yue; Pierce, Elizabeth; Roe, Daniel; Morita, Maho; McIntosh, John A.; Agarwal, Vinayak; Cheatham, Thomas E., III; Schmidt, Eric W.; Nair, Satish K.
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Highly Stereoselective Biocatalytic Synthesis of Key Cyclopropane Intermediate to Ticagrelor
err2016-10-19
err69
errOAAI
errHernandez, Kari E.; Renata, Hans; Lewis, Russell D.; Kan, S. B. Jennifer; Zhang, Chen; Forte, Jared; Rozzell, David; McIntosh, John A.; Arnold, Frances H.
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Metabolic model for diversity-generating biosynthesis
err2016-02-01
err58
errOAAI
errTianero, Ma. Diarey; Pierce, Elizabeth; Raghuraman, Shrinivasan; Sardar, Debosmita; McIntosh, John A.; Heemstra, John R.; Schonrock, Zachary; Covington, Brett C.; Maschek, J. Alan; Cox, James E.; Bachmann, Brian O.; Olivera, Baldomero M.; Ruffner, Duane E.; Schmidt, Eric W.
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Structural Adaptability Facilitates Histidine Heme Ligation in a Cytochrome P450
err2015-09-23
err36
errOAAI
errMcIntosh, John A.; Heel, Thomas; Buller, Andrew R.; Chio, Linda; Arnold, Frances H.
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Enantioselective Enzyme-Catalyzed Aziridination Enabled by Active-Site Evolution of a Cytochrome P450
err2015-04-22
err151
errOAAI
errFarwell, Christopher C.; Zhang, Ruijie K.; McIntosh, John A.; Hyster, Todd K.; Arnold, Frances H.
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Enzyme-Controlled Nitrogen-Atom Transfer Enables Regiodivergent C-H Amination
err2014-10-24
err156
errOAAI
errHyster, Todd K.; Farwell, Christopher C.; Buller, Andrew R.; McIntosh, John A.; Arnold, Frances H.
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Enantioselective lmidation of Sulfides via Enzyme-Catalyzed Intermolecular Nitrogen-Atom Transfer
err2014-06-05
err113
errOAAI
errFarwell, Christopher C.; McIntosh, John A.; Hyster, Todd K.; Wang, Z. Jane; Arnold, Frances H.
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Expanding P450 catalytic reaction space through evolution and engineering
err2014-04-01
err141
errOAAI
errMclntosh, John A.; Farwell, Christopher C.; Arnold, Frances H.
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Recognition Sequences and Substrate Evolution in Cyanobactin Biosynthesis
err2014-03-26
err82
errOAAI
errSardar, Debosmita; Pierce, Elizabeth; McIntosh, John A.; Schmidt, Eric W.
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