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Variable peptide processing of a Conus (Asprella) neocostatus α-conotoxin generates bioactive toxiforms that are potent against distinct nicotinic acetylcholine receptor subtypes Ramones, Cydee Marie V.; Taguchi, Ryoichi S.; Gamba, Ella Mae E.; Isagan, Abe Ernest Johann E.; Watkins, Maren; Chicote, Meljune O.; Velarde, Michael C.; Villaraza, Aaron Joseph L.; Yu, Eizadora T.; Olivera, Baldomero M.; Concepcion, Gisela P.; Lluisma, Arturo O. Share Save
Conotoxin kM-RIIIJ reveals interplay between Kv1-channels and persistent sodium currents in proprioceptive DRG neurons Raghuraman, Shrinivasan; Carter, Jackson; Walter, Markel; Karthikeyan, Manju; Chase, Kevin; Giglio, Matias L.; Giacobassi, Mario; Teichert, Russell W.; Terlau, Heinrich; Olivera, Baldomero M. Share Save
χ-Conotoxins are an Evolutionary Innovation of Mollusk-Hunting Cone Snails as a Counter-Adaptation to Prey Defense Espino, Samuel; Watkins, Maren; Probst, Rodolfo; Koch, Thomas Lund; Chase, Kevin; Imperial, Julita; Robinson, Samuel D.; Florez Salcedo, Paula; Taylor, Dylan; Gajewiak, Joanna; Yandell, Mark; Safavi-Hemami, Helena; Olivera, Baldomero M. Share Save
The conotoxin Contulakin-G reverses hypersensitivity observed in rodent models of cancer-induced bone pain without inducing tolerance or motor disturbance Martin, Laurent F.; Almuslim, Moyad; Ismail, Khaled A.; Ibrahim, Mohab M.; Moutal, Aubin; Cheng, Kevin; Stratton, Harrison J.; Price, Theodore J.; Vanderah, Todd W.; Olivera, Baldomero M.; Khanna, Rajesh; Patwardhan, Amol Share Save
Fish-hunting cone snail disrupts prey's glucose homeostasis with weaponized mimetics of somatostatin and insulin Yeung, Ho Yan; Ramiro, Iris Bea L.; Andersen, Daniel B.; Koch, Thomas Lund; Hamilton, Alexander; Bjorn-Yoshimoto, Walden E.; Espino, Samuel; Vakhrushev, Sergey Y.; Pedersen, Kasper B.; de Haan, Noortje; Ederveen, Agnes L. Hipgrave; Olivera, Baldomero M.; Knudsen, Jakob G.; Brauner-Osborne, Hans; Schjoldager, Katrine T.; Holst, Jens Juul; Safavi-Hemami, Helena Share Save
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Using Constellation Pharmacology to Characterize a Novel α-Conotoxin from Conus ateralbus Neves, Jorge L. B.; Urcino, Cristoval; Chase, Kevin; Dowell, Cheryl; Hone, Arik J.; Morgenstern, David; Chua, Victor M.; Ramiro, Iris Bea L.; Imperial, Julita S.; Leavitt, Lee S.; Phan, Jasmine; Fisher, Fernando A.; Watkins, Maren; Raghuraman, Shrinivasan; Tun, Jortan O.; Ueberheide, Beatrix M.; McIntosh, J. Michael; Vasconcelos, Vitor; Olivera, Baldomero M.; Gajewiak, Joanna Share Save
Analogs of α-conotoxin PnIC selectively inhibit α7β2-over α7-only subtype nicotinic acetylcholine receptors via a novel allosteric mechanism George, Andrew A.; John, Sabin J.; Lucero, Linda M.; Eaton, J. Brek; Jaiswal, Ekta; Christensen, Sean B.; Gajewiak, Joanna; Watkins, Maren; Cao, Yiwei; Olivera, Baldomero M.; Im, Wonpil; Mcintosh, J. Michael; Whiteaker, Paul Share Save
Identification of sodium channel toxins from marine cone snails of the subgenera Textilia and Afonsoconus Mcmahon, Kirsten L.; O'Brien, Henrik; Schroeder, Christina I.; Deuis, Jennifer R.; Venkatachalam, Dhananjeyan; Huang, Di; Green, Brad R.; Bandyopadhyay, Pradip K.; Li, Qing; Yandell, Mark; Safavi-Hemami, Helena; Olivera, Baldomero M.; Vetter, Irina; Robinson, Samuel D. Share Save
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CYP1B1-derived epoxides modulate the TRPA1 channel in chronic pain Sun, Lili; Zhang, Jie; Niu, Changshan; Deering-Rice, Cassandra E.; Hughen, Ronald W.; Lamb, John G.; Rose, Katherine; Chase, Kevin M.; Almestica-Roberts, Marysol; Walter, Markel; Schmidt, Eric W.; Light, Alan R.; Olivera, Baldomero M.; Reilly, Christopher A. Share Save
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Somatostatin venom analogs evolved by fish-hunting cone snails: From prey capture behavior to identifying drug leads Ramiro, Iris Bea L.; Bjorn-Yoshimoto, Walden E.; Imperial, Julita S.; Gajewiak, Joanna; Salcedo, Paula Florez; Watkins, Maren; Taylor, Dylan; Resager, William; Ueberheide, Beatrix; Brauner-Osborne, Hans; Whitby, Frank G.; Hill, Christopher P.; Martin, Laurent F.; Patwardhan, Amol; Concepcion, Gisela P.; Olivera, Baldomero M.; Safavi-Hemami, Helena Share Save
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Conotoxin contulakin-G engages a neurotensin receptor 2/R-type calcium channel (Cav2.3) pathway to mediate spinal antinociception Martin, Laurent; Ibrahim, Mohab; Gomez, Kimberly; Yu, Jie; Cai, Song; Chew, Lindsey A.; Bellampalli, Shreya S.; Moutal, Aubin; Largent-Milnes, Tally; Porreca, Frank; Khanna, Rajesh; Olivera, Baldomero M.; Patwardhan, Amol Share Save
The Tunicate Metabolite 2-(3,5-Diiodo-4-methoxyphenyl)ethan-1-amine Targets Ion Channels of Vertebrate Sensory Neurons Paguigan, Noemi D.; Yan, Yannan; Karthikeyan, Manju; Chase, Kevin; Carter, Jackson; Leavitt, Lee S.; Lim, Albebson L.; Lin, Zhenjian; Memon, Tosifa; Christensen, Sean; Bentzen, Bo H.; Schmitt, Nicole; Reilly, Christopher A.; Teichert, Russell W.; Raghuraman, Shrinivasan; Olivera, Baldomero M.; Schmidt, Eric W. Share Save
Nicotinic Acetylcholine Receptor Partial Antagonist Polyamides from Tunicates and Their Predatory Sea Slugs Paguigan, Noemi D.; Tun, Jortan O.; Leavitt, Lee S.; Lin, Zhenjian; Chase, Kevin; Dowell, Cheryl; Deering-Rice, Cassandra E.; Lim, Albebson L.; Karthikeyan, Manju; Hughen, Ronald W.; Zhang, Jie; Peterson, Randall T.; Reilly, Christopher A.; Light, Alan R.; Raghuraman, Shrinivasan; McIntosh, J. Michael; Olivera, Baldomero M.; Schmidt, Eric W. Share Save
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