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J

Jennifer A. Roth

the eli and edythe l. broad institute

31H-index
397Paper Count
5.4KCitation Count
Published Papers 65
Publication Date
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Histone H4 lysine 20 tri-methylation safeguards breast cancer lineage fidelity and unfolded protein response
errNature Communications
IF15.7
err2026-08-22
err0
errOAAI
errZheqi Li; Amatullah Tawawalla; Pierre Foidart; Marco Seehawer; Jun Nishida; Ernesto Rojas Jimenez; Triet M. Bui; Xiao-Yun Huang; Matthew G. Rees; Melissa M. Ronan; Jennifer A. Roth; Laura E. Stevens; Miguel Munoz Gomez; Rong Li; Henry W. Long; Kornelia Polyak
errShare
errSave
Proximity-Induced Rewiring of Oncogenic Kinase Triggers Apoptosis
errACS Central Science
IF10.4
err2026-04-09
err0
errOAAI
errManuel L. Merz; Veronika M. Shoba; Rajaiah Pergu; Zachary C. Severance; Dhanushka N. P. Munkanatta Godage; Arghya Deb; Hui Si Kwok; Prashant Singh; Sameek Singh; Jonathan B. Allen; Wenzhi Tian; Pallavi M. Gosavi; Santosh K. Chaudhary; Viktoriya Anokhina; Ellen L. Weisberg; N. Connor Payne; Yao He; Rohil Dhaliwal; Reilly Osadchey; Mrinal Shekhar; Ralph Mazitschek; Matthew G. Rees; Jennifer A. Roth; Qiang Cui; James D. Griffin; Brian B. Liau; Amit Choudhary
errShare
errSave
Synthesis and Biological Evaluation of Colibactin Derivatives
errACS CHEMICAL BIOLOGY
IF3.8
err2025-12-01
err0
PREAI
errAiran, Yougant; Fedorova, Olga; Heer, Collin; Rees, Matthew G.; Ronan, Melissa M.; Roth, Jennifer A.; Bindra, Ranjit S.; Herzon, Seth B.
errShare
errSave
Discovery of a Potent and Selective TEAD Degrader with Durable Degradation Activity
errAdvanced Science
IF14.1
err2025-10-05
err0
errOAAI
errLinhui Cao; Jing Yang; Yuhang Liu; Xiaotong Chen; Yufang Shi; Yunshuo Zhao; Yong Zhang; Jian Chen; Bowen Li; Wuqiang Wen; Lu Chen; Bo Peng; Lu Huang; Yanli Sun; Lixin Zhou; Matthew G Rees; Melissa M Ronan; Jennifer A Roth; Zhixiang Guo; Jing Xing; Guangya Zhu; Yazhou Wang; Baishan Jiang; Jing Lu; Kehao Zhao; Wenchao Lu
errShare
errSave
Targeting histone H2B acetylated enhanceosomes via p300/CBP degradation in prostate cancer
errNature Genetics
IF29
err2025-10-03
err0
errOAAI
errJie Luo; Zhixiang Chen; Yuanyuan Qiao; Jean Ching-Yi Tien; Eleanor Young; Rahul Mannan; Somnath Mahapatra; Rupam Bhattacharyya; Lanbo Xiao; Tongchen He; Sanjana Eyunni; Yuping Zhang; Yang Zheng; Fengyun Su; Xuhong Cao; Rui Wang; Yunhui Cheng; Rithvik Seri; James George; Miriam Shahine; Stephanie J. Miner; Matthew G. Rees; Melissa M. Ronan; Jennifer A. Roth; Ulka Vaishampayan; Mi Wang; Shaomeng Wang; Abhijit Parolia; Arul M. Chinnaiyan
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errSave
CF10 Displayed Improved Activity Relative to 5-FU in a Mouse CRLM Model Under Conditions of Physiological Folate
errCancers 2025, Vol. 17, Page 2739
IF4.4
err2025-08-23
err0
PREAI
errCharles Chidi Okechukwu; Xue Ma; Wencheng Li; Ralph D’Agostino, Jr.; Matthew G. Rees; Melissa M. Ronan; Jennifer A. Roth; William H. Gmeiner
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errSave
A neomorphic protein interface catalyzes covalent inhibition of RASG12D aspartic acid in tumors
errScience
IF45.8
err2025-07-24
err0
PREAI
errCaroline Weller; G. Leslie Burnett; Lingyan Jiang; Sujata Chakraborty; Dongyu Zhang; Nicole A. Vita; Julien Dilly; Eejung Kim; Benjamin Maldonato; Kyle Seamon; Diane F. Eilerts; Anthony Milin; Abby Marquez; Jessica Spradlin; Ciara Helland; Andrea Gould; Tamar Bar Ziv; Phuong Dinh; Shelby L. Steele; Zhican Wang; Yunming Mu; Seema Chugh; Hanrong Feng; Conner Hennessey; Junning Wang; Jennifer Roth; Matthew Rees; Melissa Ronan; Brian M. Wolpin; William C. Hahn; Matthew Holderfield; Zhengping Wang; Elena S. Koltun; Mallika Singh; Adrian L. Gill; Jacqueline A. M. Smith; Andrew J. Aguirre; Jingjing Jiang; John E. Knox; David Wildes
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errSave
Tegavivint triggers TECR-dependent nonapoptotic cancer cell death
errNATURE CHEMICAL BIOLOGY
IF13.7
err2025-05-26
err0
PREAI
errLeak, Logan; Wang, Ziwei; Joseph, Alby J.; Johnson, Brianna; Chan, Alyssa A.; Decosto, Cassandra M.; Magtanong, Leslie; Ko, Pin-Joe; Lee, Weaverly Colleen; Ritho, Joan; Manukian, Sophia; Millner, Alec; Chitkara, Shweta; Salinas, Jennifer J.; Skouta, Rachid; Rees, Matthew G.; Ronan, Melissa M.; Roth, Jennifer A.; Myers, Chad L.; Moffat, Jason; Boone, Charles; Bensinger, Steven J.; Nathanson, David A.; Atilla-Gokcumen, G. Ekin; Moding, Everett J.
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errSave
Article Targeted degradation of CDK9 potently disrupts the network
errCELL CHEMICAL BIOLOGY
IF7.2
err2025-04-01
err0
errOAAI
errToure, Mohammed A.; Motoyama, Keisuke; Xiang, Yichen; Urgiles, Julie; Kabinger, Florian; Koglin, Ann-Sophie; Iyer, Ramya S.; Gagnon, Kaitlyn; Kumar, Amruth; Ojeda, Samuel; Harrison, Drew A.; Rees, Matthew G.; Roth, Jennifer A.; Ott, Christopher J.; Schiavoni, Richard; Whittaker, Charles A.; Levine, Stuart S.; White, Forest M.; Calo, Eliezer; Richters, Andre; Koehler, Angela N.
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errSave
KRASmulti inhibitor BI 3706674 shows efficacy in KRAS-driven preclinical models of cancer that supports clinical testing in patients with tumors harboring KRASG12V mutations and KRAS wild-type amplifications
errEUROPEAN JOURNAL OF CANCER
IF7.1
err2024-10-01
err0
PREAI
errTedeschi, A.; Peng, D. H.; Schischlik-Siegl, F.; Schaaf, O.; Gerlach, D.; Rocchetti, F.; Popow, J.; Broeker, J.; Wunberg, T.; Boghossian, A. S.; Rees, M. G.; Ronan, M. M.; Roth, J. A.; Williams, M.; Vellano, C.; Marszalek, J. R.; Heffernan, T. P.; Pearson, M.; Kraut, N.; Dorothea, R.
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errSave
BRD-810 is a highly selective MCL1 inhibitor with optimized in vivo clearance and robust efficacy in solid and hematological tumor models
errNATURE CANCER
IF28.5
err2024-08-23
err3
errOAAI
errRauh, Ulrike; Wei, Guo; Serrano-Wu, Michael; Kosmidis, Georgios; Kaulfuss, Stefan; Siegel, Franziska; Thede, Kai; Mcfarland, James; Lemke, Christopher T.; Werbeck, Nicolas; Nowak-Reppel, Katrin; Pilari, Sabine; Menz, Stephan; Ocker, Matthias; Zhang, Weiqun; Davis, Kyle; Poncet-Montange, Guillaume; Roth, Jennifer; Daniels, Douglas; Kaushik, Virendar K.; Hubbard, Brian; Ziegelbauer, Karl; Golub, Todd R.
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errSave
Mechanisms of Resistance to Oncogenic KRAS Inhibition in Pancreatic Cancer
errCANCER DISCOVERY
IF33.3
err2024-07-05
err7
PREAI
errDilly, Julien; Hoffman, Megan T.; Abbassi, Laleh; Li, Ziyue; Paradiso, Francesca; Parent, Brendan D.; Hennessey, Connor J.; Jordan, Alexander C.; Morgado, Micaela; Dasgupta, Shatavisha; Uribe, Giselle A.; Yang, Annan; Kapner, Kevin S.; Hambitzer, Felix P.; Qiang, Li; Feng, Hanrong; Geisberg, Jacob; Wang, Junning; Evans, Kyle E.; Lyu, Hengyu; Schalck, Aislyn; Feng, Ningping; Lopez, Anastasia M.; Bristow, Christopher A.; Kim, Michael P.; Rajapakshe, Kimal I.; Bahrambeigi, Vahid; Roth, Jennifer A.; Garg, Kavita; Guerrero, Paola A.; Stanger, Ben Z.; Cristea, Simona; Lowe, Scott W.; Baslan, Timour; Van Allen, Eliezer M.; Mancias, Joseph D.; Chan, Emily; Anderson, Abraham; Katlinskaya, Yuliya V.; Shalek, Alex K.; Hong, David S.; Pant, Shubham; Hallin, Jill; Anderes, Kenna; Olson, Peter; Heffernan, Timothy P.; Chugh, Seema; Christensen, James G.; Maitra, Anirban; Wolpin, Brian M.; Raghavan, Srivatsan; Nowak, Jonathan A.; Winter, Peter S.; Dougan, Stephanie K.; Aguirre, Andrew J.
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errSave
Mechanism of Action of KL-50, a Candidate Imidazotetrazine for the Treatment of Drug-Resistant Brain Cancers
errJOURNAL OF THE AMERICAN CHEMICAL SOCIETY
IF15.6
err2024-05-30
err1
PREAI
errHuseman, Eric D.; Lo, Anna; Fedorova, Olga; Elia, James L.; Gueble, Susan E.; Lin, Kingson; Sundaram, Ranjini K.; Oh, Joonseok; Liu, Jinchan; Menges, Fabian; Rees, Matthew G.; Ronan, Melissa M.; Roth, Jennifer A.; Batista, Victor S.; Crawford, Jason M.; Pyle, Anna M.; Bindra, Ranjit S.; Herzon, Seth B.
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errSave
Genetic dependencies associated with transcription factor activities in human cancer cell lines
errCELL REPORTS
IF6.9
err2024-05-01
err0
errOAAI
errThatikonda, Venu; Supper, Verena; Wachter, Johannes; Kaya, Onur; Kombara, Anju; Bilgilier, Ceren; Ravichandran, Madhwesh C.; Lipp, Jesse J.; Sharma, Rahul; Badertscher, Lukas; Boghossian, Andrew S.; Rees, Matthew G.; Ronan, Melissa M.; Roth, Jennifer A.; Grosche, Sarah; Ller, Ralph A. Neumu euro; Mauri, Barbara Mair Federico; Popa, Alexandra
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errSave
Group 3 medulloblastoma transcriptional networks collapse under domain specific EP300/CBP inhibition
errNATURE COMMUNICATIONS
IF15.7
err2024-04-25
err1
errOAAI
errShendy, Noha A. M.; Bikowitz, Melissa; Sigua, Logan H.; Zhang, Yang; Mercier, Audrey; Khashana, Yousef; Nance, Stephanie; Liu, Qi; Delahunty, Ian M.; Robinson, Sarah; Goel, Vanshita; Rees, Matthew G.; Ronan, Melissa A.; Wang, Tingjian; Kocak, Mustafa; Roth, Jennifer A.; Wang, Yingzhe; Freeman, Burgess B.; Orr, Brent A.; Abraham, Brian J.; Roussel, Martine F.; Schonbrunn, Ernst; Qi, Jun; Durbin, Adam D.
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errSave
Identifying cancer vulnerabilities associated with changes in chromatin accessibility by simultaneously profiling hundreds of cancer cell lines with ATAC-seq
errCANCER RESEARCH
IF16.6
err2024-04-05
err0
PREAI
errBorck, Patricia; Wienand, Kirsty; Duarte, Fabiana; Qin, Alvin; Zhang, Ruochi; Babu, Juliana; Zhang, Simone; Maffa, Samuel; Horlbeck, Max; Shrestha, Rojesh; Dempster, Joshua; Roth, Jennifer; Campbell, Catarina; Buenrostro, Jason; Vazquez, Francisca
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errSave
KRASmulti inhibitor BI 3706674 shows efficacy in KRAS-driven preclinical models of cancer that supports clinical testing in patients with tumors harbouring KRASG12V mutations and KRAS wild-type amplifications
errCANCER RESEARCH
IF16.6
err2024-03-22
err0
PREAI
errTedeschi, Antonio; Peng, David H.; Schischlik, Fiorella; Herdeis, Lorenz; Schaaf, Otmar; Santoro, Valeria; Gerlach, Daniel; Savarese, Fabio; Lipp, Jesse; Haslinger, Christian; Rocchetti, Francesca; Popow, Johannes; Huber, Heinrich J.; Wilding, Birgit; Treu, Matthias; Fuchs, Julian; Broeker, Joachim; Wunber, Tobias; Gmachl, Michael; Rumpel, Klaus; Rees, Matthew; Ron, Melissa; Roth, Jennifer; Williams, Mariah; Deckard, Charles; Ramamoorthy, Vandhana; Daniele, Joseph R.; Ajani, Jaffer A.; Meric-Bernstam, Funda; Kopetz, Scott; Kim, Michael; Gibbons, Don L.; Vellano, Christopher P.; Marszalek, Joseph R.; Heffernan, Timothy P.; McConnell, Darryl; Pearson, Mark; Kraut, Norbert; Rudolph, Dorothea
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errSave
EWS-FLI1-driven upregulation of UGT3A2 unlocks drug sensitivity pathway in Ewing sarcoma
errCANCER RESEARCH
IF16.6
err2024-03-22
err0
PREAI
errOlaoye, Olasunkanmi; Harrington, Colleen; Ross, Kenneth; Seong, Bo Kyung A.; de Waal, Luk; Qi, Jun; Roth, Jennifer; Stegmaier, Kimberly
errShare
errSave
Novel WRN helicase inhibitors selectively target microsatellite unstable cancer cells
errCANCER RESEARCH
IF16.6
err2024-03-22
err0
PREAI
errPicco, Gabriele; Rao, Yanhua; Al Saedi, Angham; Vieira, Sara F.; Lee, Yang; Shenje, Ray; Bhosle, Shriram; Walker, Samantha; May, Kieron; Herranz-Ors, Carmen; Dicer, Cansu; Gibson, Freddy; Banerjee, Ruby; Werner, Thilo; Cottom, Josh; Peng, Yang; Deng, Nanhua; Landis, Phil; Angel, Thomas; Bush, Jacob; Rees, Matthew G.; Ronan, Melissa M.; Roth, Jennifer A.; Lightfoot, Howard; Zappacosta, Francesca; Pettinger, Jonathan; Barthorpe, Syd; Eberl, Chris; Jones, Brian; Schneck, Jess; Murphy, Dennis; Taygerly, Josh; DeMartino, Mike; Coelho, Matthew; Houseley, Jon; Schwartz, Benjamin; Garnett, Mathew J.
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errSave
Assessing cancer drug combination efficacy across 900+PRISM cell lines in a multiplexed screening assay
errCANCER RESEARCH
IF16.6
err2024-03-22
err0
PREAI
errGeorge, Ashish Bino; Nair, Shiker; Kocak, Mustafa; Nguyen, Ellen; Kalathungal, Alvin; Fazio, Anthony; Ponsi, Cole; Golabi, Aydin; Ronan, Melissa A.; Rees, Matthew G.; Roth, Jennifer A.
errShare
errSave

Research Directions

No research directions
Co-authors
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