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David M. Holtzman

department of neurology

204H-index
1.0KPaper Count
16.7WCitation Count
Published Papers 427
Publication Date
Network connectivity and amyloid-β align with tau in atypical Alzheimer disease subtypes
err2026-08-14
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errOAAI
errPeter R Millar; Stephanie Doering; Babatunde Adeyemo; Saurabh Jindal; Nicole S McKay; Jeremy F Strain; Julie K Wisch; Gordon Zhaoqi An; Pete Canfield; Shaney Flores; Nicholas V Metcalf; June Roman; Carlos Cruchaga; Jason J Hassenstab; David M Holtzman; John C Morris; Brian A Gordon; Beau M Ances; Tammie LS Benzinger
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Recent advances in Alzheimer’s disease: From molecular mechanisms to therapeutic strategies
errCell
IF42.5
err2026-07-09
err0
errOAAI
errMichelle D. Rudman; Jason D. Ulrich; David M. Holtzman
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Neuroproteasomes regulate endogenous tau paired helical filament formation in an APOE genotype- and age-dependent manner
err2026-05-29
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PREAI
errVictoria Paradise; Kalin D. Konrad-Vicario; Chi Nguyen; Nyle A. Sharif; Xiao Wang; Rijuta D. Mukim; Malavika Sabu; Bianca T. Corjuc; Joanna Bafia; Jack Fu; Gabriella C. Maldonado; Michael Strickland; Sarah L. Grauman; Helen Figueroa; Bradley T. Hyman; David M. Holtzman; Tal Nuriel; Kapil V. Ramachandran
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Low overlap of plasma and CSF protein quantitative trait loci affects protein discovery for neurological disease
err2026-04-29
err0
PREAI
errDaniel Western; Chengran Yang; Jigyasha Timsina; Menghan Liu; Ciyang Wang; Meghan C. Campbell; Paul Kotzbauer; Joel S. Perlmutter; Suzanne E. Schindler; John C. Morris; David M. Holtzman; Ignacio Alvarez; Pau Pastor; Tony Wyss-Coray; Marta Marquié; Amanda Cano; Yun Ju Sung; Itziar de Rojas; Agustín Ruiz; John Budde; Maria Victoria Fernandez; Rawan Tarawneh; Laura Ibanez; Carlos Cruchaga
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GPND-AI NULISA: A 15-Protein AI classifier for diagnosis and co-pathology profiling across neurodegenerative diseases
err2026-04-28
err0
errOAAI
errYing Xu; Marisa N Denkinger; Menghan Liu; Katherine Gong; Yike Chen; Daniel Western; Jigyasha Timsina; Yuchen Cheng; Yunchang Xie; Rui Mu; John Budde; Thomas G. Beach; Geidy E. Serrano; Eric M. Reiman; Alpana Singh; Isabel Alfradique-Dunham; Tammie L. S. Benzinger; Suzanne E. Schindler; John C. Morris; David M. Holtzman; Joel S. Perlumtter; B Joy Snider; Meghan C. Campbell; Paul T. Kotzbauer; Nicholas J. Ashton; Carlos Cruchaga
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GWAS meta-analysis of cerebrospinal fluid Alzheimer’s biomarkers reveals loci regulating lipids, brain volume and autophagy
err2026-04-21
err0
errOAAI
errJigyasha Timsina; Chenyang Jiang; Daniel L. McCartney; Feifei Tao; Maria Carolina Dalmasso; Jenna Najar; Federica Anastasi; Olena Ohlei; Raquel Puerta Fuentes; Chenyu Yang; Joseph Bradley; Daniel Western; Muhammad Ali; Ciyang Wang; Chengran Yang; Ying Wu; Menghan Liu; John Budde; Julie Williams; Rebecca Mahoney; Atahualpa Castillo Morales; Timothy J. Hohman; Logan Dumitrescu; Ting-Chen Wang; Niccolo’ Tesi; Silke Kern; Margda Waern; Ingmar Skoog; Argonde van Harten; Yolande A. L. Pijnenburg; Wiesje M. van der Flier; Pascual Sánchez-Juan; Eloy Rodriguez-Rodriguez; Luca Kleineidam; Oliver Peters; Anja Schneider; Fahri Küçükali; Céline Bellenguez; Benjamin Grenier-Boley; Sami Heikkinen; Itziar de Rojas; Dan Rujescu; Norbert Scherbaum; Lucrezia Hausner; Emrah Düzel; Timo Grimmer; Jens Wiltfang; Rik Vandenberghe; Sebastiaan Engelborghs; Stefanie Heilmann-Heimbach; Matthias Schmid; Thomas Tegos; Nikolaos Scarmeas; Oriol Dols-Icardo; Fermin Moreno; Jordi Pérez-Tur; María J. Bullido; Raquel Sánchez-Valle; Victoria Álvarez; Pablo García-González; Pablo Mir; Luis M. Real; Gerard Piñol-Ripoll; Jose María García-Alberca; Harro Seelaar; Inez Ramakers; Janne Papma; Marc Hulsman; Christoph Laske; Stefan Teipel; Josef Priller; Robert Perneczky; Katharina Buerger; Markus M. Nöthen; Piotr Lewczuk; Johannes Kornhuber; Harald Hampel; Ina Giegling; Oliver Goldhardt; Janine Diehl-Schmid; Victor Andrade; Michael MT. Heneka; Lutz Frölich; Jonathan Vogelgsang; Caroline Graff; Hakan Thonberg; Abbe Ullgren; Goran Papenberg; Jean-François Deleuze; Carole Dufouil; Michael Wagner; Frank Jessen; Henne Holstege; Cornelia van Duijn; Thibaud Lebouvier; Olivier Hannon; Ville Leinonen; Hilkka Soininen; Sanna-Kaisa Herukka; Vilmantas Giedraitis; Malin Löwenmark; Lena Kilander; Patricia Genius; Blanca Rodríguez; Emma S. Luckett; Arcadi Navarro; Amanda Cano; Marta Marquié; Kaj Blennow; Henrik Zetterberg; Alberto Lleo; Mercè Boada; Agustin Ruiz; Virginia Man-Yee Lee; Vivianna M. Van Deerlin; Yuetiva Deming; Sterling C. Johnson; Corinne D. Engelman; Pau Pastor; Ignacio Alvarez; Elaine R. Peskind; Amanda J. Heslegrave; Andrew J. Saykin; Kwangsik Nho; Suzanne E. Schindler; John C. Morris; David M. Holtzman; Eric McDade; Alan E. Renton; Alison Goate; Laura Ibanez; Matthias Riemenschneider; Marilyn S. Albert; Simon M. Laws; Tenielle Porter; Eleanor K. O’Brien; Leslie M. Shaw; Betty M. Tijms; Martin Ingelsson; Pieter Jelle Visser; Mikko Hiltunen; Kristel Sleegers; Craig W. Ritchie; Rebecca Sims; Michael Belloy; Jean-Charles Lambert; Natalia Vilor-Tejedor; Maria Victoria Fernández; Qingqin S. Li; Michael W. Nagle; Riccardo E. Marioni; Alfredo Ramirez; Lars Bertram; Sven J. van der Lee; Carlos Cruchaga
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Targeting amyloid-β pathology by chimeric antigen receptor astrocyte (CAR-A) therapy
errScience
IF45.8
err2026-03-05
err0
PREAI
errYun Chen; Yizhou Liu; Khai Nguyen; Junjie Wu; Sihui Song; Kent Lin; Patrick F. Rodrigues; Siling Du; Charles Zhou; Kyle Xiong; Megan Bosch; Peter Bor-Chian Lin; Darya Khantakova; Shitong Wu; May Wu; Carla Yuede; David M. Holtzman; Marco Colonna
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Predicting onset of symptomatic Alzheimerʼs disease with plasma p-tau217 clocks
err2026-02-19
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errOAAI
errKellen K. Petersen; Marta Milà-Alomà; Yan Li; Lianlian Du; Chengjie Xiong; Duygu Tosun; Benjamin Saef; Ziad S. Saad; Lei Du-Cuny; Janaky Coomaraswamy; Yulia Mordashova; Carrie E. Rubel; Emily A. Meyers; Leslie M. Shaw; Jeffrey L. Dage; Nicholas J. Ashton; Henrik Zetterberg; Kyle Ferber; Gallen Triana-Baltzer; Michael Baratta; Erin G. Rosenbaugh; Carlos Cruchaga; Eric McDade; David M. Holtzman; John C. Morris; J. Martin Sabandal; Randall J. Bateman; Anthony W. Bannon; William Z. Potter; Suzanne E. Schindler
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Lipidome and Proteome of Astrocyte and Microglia ApoE Lipoprotein Reveal Differences Based on Cell Type and ApoE Isoform
err2026-02-13
err0
errOAAI
errMichael R. Strickland; Zhen Wang; Lesley R. Golden; Hu Wang; Ping Lu; Yingxue Ren; G.Travis Tabor; Na Zhao; Jason D. Ulrich; Xianlin Han; Junmin Peng; David M. Holtzman
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Context matters: Conflicting roles of interferon-γ signaling in CNS diseases
err2026-01-21
err0
errOAAI
errNulman, Jonathan; Ulrich, Jason D.; Holtzman, David M.
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Author Correction: Neuroprotective role of Sirt1 in mammalian models of Huntington’s disease through activation of multiple Sirt1 targets
err2025-11-26
err0
PREAI
errMali Jiang; Jiawei Wang; Jinrong Fu; Lin Du; Hyunkyung Jeong; Tim West; Lan Xiang; Qi Peng; Zhipeng Hou; Huan Cai; Tamara Seredenina; Nicolas Arbez; Shanshan Zhu; Katherine Sommers; Jennifer Qian; Jiangyang Zhang; Susumu Mori; X William Yang; Kellie L K Tamashiro; Susan Aja; Timothy H Moran; Ruth Luthi-Carter; Bronwen Martin; Stuart Maudsley; Mark P Mattson; Robert H Cichewicz; Christopher A Ross; David M Holtzman; Dimitri Krainc; Wenzhen Duan
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High-sensitivity plasma proteomics reveals disease-specific signatures and predictive biomarkers of Alzheimer’s disease phenotypes in a large mixed-dementia cohort
err2025-11-19
err0
errOAAI
errKatherine Gong; Jigyasha Timsina; Muhammad Ali; Yike Chen; Menghan Liu; Ciyang Wang; Cyril Pottier; Geoffrey K. Feld; Gyujin Heo; Tammie L. S. Benzinger; Cyrus A. Raji; Beau Ances; Brian A. Gordon; Julie K. Wisch; Suzanne E. Schindler; John C. Morris; David M. Holtzman; Laura Ibanez; Carlos Cruchaga
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Lymphoid gene expression supports neuroprotective microglia function
errNature
IF48.5
err2025-11-05
err0
errOAAI
errPinar Ayata; Jessica M. Crowley; Matthew F. Challman; Vinaya Sahasrabuddhe; Maud Gratuze; Sebastian Werneburg; Diogo Ribeiro; Emma C. Hays; Violeta Durán-Laforet; Travis E. Faust; Philip Hwang; Francisco Mendes Lopes; Chrysa Nikopoulou; Sarah Buchholz; Robert E. Murphy; Taoyu Mei; Anna A. Pimenova; Carmen Romero-Molina; Francesca Garretti; Tulsi A. Patel; Claudia De Sanctis; Angie V. Ramirez Jimenez; Megan Crow; Felix D. Weiss; Jason D. Ulrich; Edoardo Marcora; John W. Murray; Felix Meissner; Andreas Beyer; Dan Hasson; John F. Crary; Dorothy P. Schafer; David M. Holtzman; Alison M. Goate; Alexander Tarakhovsky; Anne Schaefer
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The effect of APOE isoforms on the immune response and tau-mediate neurodegeneration
err2025-11-01
err0
PREAI
errBor-Chian Lin, Peter; Hu, Hao; Zeng, Carisa; Sharma, Prabal; Li, Yongyi; Jiang, Hong; Artyomov, Maxim N.; Ulrich, Jason D.; Holtzman, David M.
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ApoE is Secreted as a Lipid Nanoparticle by Mammalian Cells: Implications for Alzheimer’s Disease Pathogenesis
err2025-10-24
err0
PREAI
errRicardo Hernandez Arriaza; Dylan Reil; Nina Fatuzzo; Mengying Fu; Yuqin Dai; David Fernandez Martinez; Hong Jiang; David M. Holtzman; Michael D. Greicius; Chaitan Khosla
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Maternal inheritance suppresses CAA and amyloid plaques in 5xFAD (Tg7031)/APOE4 mice
errNeuron
IF15
err2025-09-17
err0
PREAI
errFareeha Saadi; Ilia V. Katritch; Samira Parhizkar; Brisa Lugo; Yoonho Cho; Jason D. Ulrich; David M. Holtzman
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Systematic analysis of cellular cross-talk reveals a role for SEMA6D-TREM2 regulating microglial function in Alzheimer’s disease
err2025-07-30
err0
PREAI
errRicardo D’Oliveira Albanus; Gina M. Finan; Logan Brase; Nicholas Sweeney; Tae Yeon Kim; Shuo Chen; Yeonsu Ryoo; Joseph Park; Qi Guo; Abhirami Kannan; Mariana Acquarone; Shih-Feng You; Brenna C. Novotny; Emily M. Mace; Patricia M. Ribeiro Pereira; John C. Morris; David M. Holtzman; Eric McDade; Martin Farlow; Jasmeer P. Chhatwal; Bruno A. Benitez; Laura Piccio; Richard J. Perrin; Greg T. Sutherland; Qin Ma; Celeste M. Karch; Doo Yeon Kim; Rudolph E. Tanzi; Hongjun Fu; Oscar Harari; Tae-Wan Kim
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Lemborexant ameliorates tau-mediated sleep loss and neurodegeneration in males in a mouse model of tauopathy
err2025-05-27
err0
PREAI
errParhizkar, Samira; Bao, Xin; Chen, Wei; Rensing, Nicholas; Chen, Yun; Kipnis, Michal; Song, Sihui; Gent, Grace; Tycksen, Eric; Manis, Melissa; Lee, Choonghee; Serrano, Javier Remolina; Bosch, Megan E.; Franke, Emily; Yuede, Carla M.; Landsness, Eric C.; Wong, Michael; Holtzman, David M.
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Lecanemab Treatment in a Specialty Memory Clinic
err2025-05-12
err0
PREAI
errPaczynski, Madeline; Hofmann, Anna; Posey, Zachary; Gregersen, Maren; Rudman, Michelle; Ellington, Dawn; Aldinger, Melissa; Musiek, Erik S.; Holtzman, David M.; Bateman, Randall J.; Long, Justin M.; Ghoshal, Nupur; Carr, David B.; Dow, Alan; Namazie-Kummer, Sheyda; Jana, Nayid; Xiong, Chengjie; Morris, John C.; Benzinger, Tammie L. S.; Schindler, Suzanne E.; Snider, B. Joy
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