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W

Wen-Hsin Lee

Scripps Research Institute

17H-index
75Paper Count
1.0KCitation Count
Published Papers 33
Publication Date
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Germline-targeting HIV immunogen induces cross-neutralizing antibodies in outbred macaques
errImmunity
IF26.3
err2026-04-14
err0
errOAAI
errNitesh Mishra; Bo Liang; Ryan S. Roark; Amrit Raj Ghosh; Sean Callaghan; Wen-Hsin Lee; Xuduo Li; Anh L. Vo; Gabriel Avillion; Rohan Roy Chowdhury; Rumi Habib; Frederic Bibollet-Ruche; Gabriella Giese; Prabhgun Oberoi; Khaled Amereh; Anjali Somanathan; Yuxin Zhu; Yuexiu Zhang; Muzaffer Kassab; Lifei Tjio
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errSave
Virus glycoprotein nanodisc platform for vaccine analytics
errNature Communications
IF15.7
err2026-02-10
err0
errOAAI
errKimmo Rantalainen; Alessia Liguori; Gabriel Ozorowski; Claudia Flynn; Jon M. Steichen; Olivia M. Swanson; Patrick J. Madden; Sabyasachi Baboo; Swastik Phulera; Anant Gharpure; Danny Lu; Oleksandr Kalyuzhniy; Patrick Skog; Sierra Terada; Monolina Shil; Jolene K. Diedrich; Erik Georgeson; Ryan Tingle; Saman Eskandarzadeh; Wen-Hsin Lee; Nushin Alavi; Diana Goodwin; Michael Kubitz; Sonya Amirzehni; Sunny Himansu; Devin Sok; Jeong Hyun Lee; John R. Yates; James C. Paulson; Shane Crotty; Torben Schiffner; Andrew B. Ward; William R. Schief
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errSave
Accelerated cGMP production of near-native HIV-1 Env trimers following electroporation transfection and immunogenicity analysis
errnpj Vaccines
IF6.5
err2025-08-20
err0
errOAAI
errShridhar Bale; Elena Gustchina; Javier Guenaga; Victor Ayala; Wen-Hsin Lee; Gabriel Ozorowski; Stephen Whitney; Richard Wilson; Sabyasachi Baboo; Jolene K. Diedrich; Esmeralda D. Doyle; Lauren Hudacik; Elana Ben-Akiva; Kristen A. Rodrigues; Darrell J. Irvine; John R. Yates; James C. Paulson; Andrew B. Ward; Timothy Fouts; Richard T. Wyatt
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errSave
Vaccination with mRNA-encoded membrane-anchored HIV envelope trimers elicited tier 2 neutralizing antibodies in a phase 1 clinical trial
errScience Translational Medicine
IF14.6
err2025-07-30
err0
PREAI
errK. Rachael Parks; Zoe Moodie; Mary A. Allen; Catherine Yen; Briana D. Furch; Kellie J. MacPhee; Gabriel Ozorowski; Jack Heptinstall; William O. Hahn; Zihan Zheng; Huiyin Lu; Shannon Grant; Elize Domin; Michael O. Duff; Aaron Seese; Constanza Marini-Macouzet; Lamar Ballweber-Fleming; Wen-Hsin Lee; Christopher A. Cottrell; Alessia Liguori; Erik Georgeson; Nushin Alavi; Michael Kubitz; Nicole Phelps; Kelly E. Seaton; Kristen W. Cohen; Maija A. Anderson; Kajari Mondal; Dagna S. Laufer; James G. Kublin; Andrew B. Ward; Ollivier Hyrien; Stephen C. De Rosa; Sunny Himansu; Brett Leav; Caroline Reuter; Georgia D. Tomaras; David Montefiori; Stephen R. Walsh; Ian Frank; Magdalena E. Sobieszczyk; Paul A. Goepfert; Kathryn E. Stephenson; Lindsey R. Baden; Hong Van Tieu; Michael C. Keefer; Jesse Clark; Sharon A. Riddler; William R. Schief; M. Juliana McElrath
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errSave
Vaccination with an mRNA-encoded membrane-bound HIV envelope trimer induces neutralizing antibodies in animal models
errScience Translational Medicine
IF14.6
err2025-07-30
err0
errOAAI
errParham Ramezani-Rad; Christopher A. Cottrell; Ester Marina-Zárate; Alessia Liguori; Elise Landais; Jonathan L. Torres; Amber Myers; Jeong Hyun Lee; Sabyasachi Baboo; Claudia Flynn; Katherine McKenney; Eugenia Salcedo; Xiaoya Zhou; Oleksandr Kalyuzhniy; Erik Georgeson; Nicole Phelps; Danny Lu; Saman Eskandarzadeh; Sergey Menis; Michael Kubitz; Bettina Groschel; Nushin Alavi; Abigail M. Jackson; Wen-Hsin Lee; Andy S. Tran; Elana Ben-Akiva; Katarzyna Kaczmarek Michaels; Jolene K. Diedrich; Chiamaka A. Enemuo; Vanessa Lewis; Arpan Pradhan; Sudhir Pai Kasturi; Torben Schiffner; Jon M. Steichen; Diane G. Carnathan; Sunny Himansu; John R. Yates; James C. Paulson; Gabriel Ozorowski; Darrell J. Irvine; Guido Silvestri; Devin Sok; Andrew B. Ward; Shane Crotty; William R. Schief
errShare
errSave
Precise targeting of HIV broadly neutralizing antibody precursors in humans
errScience
IF45.8
err2025-05-15
err0
PREAI
errTom G. Caniels; Madhu Prabhakaran; Gabriel Ozorowski; Kellie J. MacPhee; Weiwei Wu; Karlijn van der Straten; Sashank Agrawal; Ronald Derking; Emma I. M. M. Reiss; Katrina Millard; Martina Turroja; Aimee Desrosiers; Jeffrey Bethony; Elissa Malkin; Marinus H. Liesdek; Annelou van der Veen; Michelle Klouwens; Jonne L. Snitselaar; Joey H. Bouhuijs; Rhianna Bronson; Jalen Jean-Baptiste; Suprabhath Gajjala; Zahra Rikhtegaran Tehrani; Alison Benner; Mukundhan Ramaswami; Michael O. Duff; Yung-Wen Liu; Alicia H. Sato; Ju Yeong Kim; Isabel J. L. Baken; Catarina Mendes Silva; Tom P. L. Bijl; Jacqueline van Rijswijk; Judith A. Burger; Albert Cupo; Anila Yasmeen; Swastik Phulera; Wen-Hsin Lee; Kipchoge N. Randall; Shiyu Zhang; Martin M. Corcoran; Isabel Regadas; Alex C. Sullivan; David M. Brown; Jennifer A. Bohl; Kelli M. Greene; Hongmei Gao; Nicole L. Yates; Sheetal Sawant; Jan M. Prins; Neeltje A. Kootstra; Stephen M. Kaminsky; Burc Barin; Farhad Rahaman; Margaret Meller; Vince Philiponis; Dagna S. Laufer; Angela Lombardo; Lindsey Mwoga; Solmaz Shotorbani; Drienna Holman; Richard A. Koup; Per Johan Klasse; Gunilla B. Karlsson Hedestam; Georgia D. Tomaras; Marit J. van Gils; David C. Montefiori; Adrian B. McDermott; Ollivier Hyrien; John P. Moore; Ian A. Wilson; Andrew B. Ward; David J. Diemert; Godelieve J. de Bree; Sarah F. Andrews; Marina Caskey; Rogier W. Sanders
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errSave
Vaccination of nonhuman primates elicits a broadly neutralizing antibody lineage targeting a quaternary epitope on the HIV-1 Env trimer
errImmunity
IF26.3
err2025-05-07
err0
PREAI
errFabian-Alexander Schleich; Shridhar Bale; Javier Guenaga; Gabriel Ozorowski; Monika Àdori; Xiaohe Lin; Xaquin Castro Dopico; Richard Wilson; Mark Chernyshev; Alma Teresia Cotgreave; Marco Mandolesi; Jocelyn Cluff; Esmeralda D. Doyle; Leigh M. Sewall; Wen-Hsin Lee; Shiyu Zhang; Sijy O’Dell; Brandon S. Healy; Deuk Lim; Vanessa R. Lewis; Elana Ben-Akiva; Darrell J. Irvine; Nicole A. Doria-Rose; Martin Corcoran; Diane Carnathan; Guido Silvestri; Ian A. Wilson; Andrew B. Ward; Gunilla B. Karlsson Hedestam; Richard T. Wyatt
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errSave
Molecular parameters governing antibody FcgR signaling and effector functions in the context of HIV envelope
errCELL REPORTS
IF6.9
err2025-04-01
err0
errOAAI
errBick, Michael, V; Puig, Eduard; Beauparlant, David; Nedellec, Rebecca; Burton, Iszac; Ardaghi, Keihvan; Zalunardo, Thea R.; Bastidas, Raiza; Li, Xuduo; Guenaga, Javier; Lee, Wen-Hsin; Wyatt, Richard; Zhu, Wenwen; Crispin, Max; Ozorowski, Gabriel; Ward, Andrew B.; Burton, Dennis R.; Hangartner, Lars
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errSave
Mosaic and mixed HIV-1 glycoprotein nanoparticles elicit antibody responses to broadly neutralizing epitopes
errPLOS PATHOGENS
IF4.9
err2024-10-03
err0
errOAAI
errBrinkkemper, Mitch; Kerster, Gius; Brouwer, Philip J. M.; Tran, Andy S.; Torres, Jonathan L.; Ettema, Roos A.; Nijhuis, Haye; Allen, Joel D.; Zhu, Wenwen; Gao, Hongmei; Lee, Wen-Hsin; Bijl, Tom P. L.; Snitselaar, Jonne L.; Burger, Judith A.; Bontjer, Ilja; Olijhoek, Wouter; Ravichandran, Rashmi; van Breemen, Marielle J.; Del Moral-Sanchez, Ivan; Derking, Ronald; Sliepen, Kwinten; Ozorowski, Gabriel; Crispin, Max; Montefiori, David C.; Claireaux, Mathieu; Ward, Andrew B.; van Gils, Marit J.; King, Neil P.; Sanders, Rogier W.
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errSave
Immunization of cows with HIV envelope trimers generates broadly neutralizing antibodies to the V2-apex from the ultralong CDRH3 repertoire
errPLOS PATHOGENS
IF4.9
err2024-09-09
err0
errOAAI
errAltman, Pilar X.; Ozorowski, Gabriel; Stanfield, Robyn L.; Haakenson, Jeremy; Appel, Michael; Parren, Mara; Lee, Wen-Hsin; Sang, Huldah; Woehl, Jordan; Saye-Francisco, Karen; Sewall, Leigh M.; Joyce, Collin; Song, Ge; Porter, Katelyn; Landais, Elise; Andrabi, Raiees; Wilson, Ian A.; Ward, Andrew B.; Mwangi, Waithaka; Smider, Vaughn V.; Burton, Dennis R.; Sok, Devin
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errSave
Use of 3M-052-AF with Alum adjuvant in HIV trimer vaccine induces human autologous neutralizing antibodies
errJOURNAL OF EXPERIMENTAL MEDICINE
IF10.6
err2024-09-05
err1
PREAI
errHahn, William O.; Parks, K. Rachael; Shen, Mingchao; Ozorowski, Gabriel; Janes, Holly; Ballweber-Fleming, Lamar; Davis, Amanda S. Woodward; Duplessis, Chris; Tomai, Mark; Dey, Antu K.; Sagawa, Zachary K.; De Rosa, Stephen C.; Seese, Aaron; Siddaramaiah, Latha Kallur; Stamatatos, Leonidas; Lee, Wen-Hsin; Sewall, Leigh M.; Karlinsey, Dalton; Turner, Hannah L.; Rubin, Vanessa; Furth, Sarah; MacPhee, Kellie; Duff, Michael; Corey, Lawrence; Keefer, Michael C.; Edupuganti, Srilatha; Frank, Ian; Maenza, Janine; Baden, Lindsey R.; Hyrien, Ollivier; Sanders, Rogier W.; Moore, John P.; Ward, Andrew B.; Tomaras, Georgia D.; Montefiori, David C.; Rouphael, Nadine; McElrath, M. Juliana
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errSave
Defining bottlenecks and opportunities for Lassa virus neutralization by structural profiling of vaccine-induced polyclonal antibody responses
errCELL REPORTS
IF6.9
err2024-09-01
err1
errOAAI
errBrouwer, Philip J. M.; Perrett, Hailee R.; Beaumont, Tim; Nijhuis, Haye; Kruijer, Sabine; Burger, Judith A.; Bontjer, Ilja; Lee, Wen-Hsin; Ferguson, James A.; Schauflinger, Martin; Muller-Krauter, Helena; Sanders, Rogier W.; Strecker, Thomas; van Gils, Marit J.; Ward, Andrew B.
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errSave
mRNA lipid nanoparticles expressing cell-surface cleavage independent HIV Env trimers elicit autologous tier-2 neutralizing antibodies
errFRONTIERS IN IMMUNOLOGY
IF5.9
err2024-07-25
err1
errOAAI
errGuenaga, Javier; Alirezaei, Mehrdad; Feng, Yu; Alameh, Mohamad-Gabriel; Lee, Wen-Hsin; Baboo, Sabyasachi; Cluff, Jocelyn; Wilson, Richard; Bale, Shridhar; Ozorowski, Gabriel; Lin, Paulo; Tam, Ying; Diedrich, Jolene K.; Yates III, John R.; Paulson, James C.; Ward, Andrew B.; Weissman, Drew; Wyatt, Richard T.
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errSave
Structure-guided mutagenesis of OSCAs reveals differential activation to mechanical stimuli
errELIFE
IF0
err2024-04-09
err2
errOAAI
errJojoa-Cruz, Sebastian; Dubin, Adrienne E.; Lee, Wen-Hsin; Ward, Andrew B.
errShare
errSave
Triple tandem trimer immunogens for HIV-1 and influenza nucleic acid-based vaccines
errNPJ VACCINES
IF6.5
err2024-04-06
err1
errOAAI
errdel Moral-Sanchez, Ivan; Wee, Edmund G.; Xian, Yuejiao; Lee, Wen-Hsin; Allen, Joel D.; de la Pena, Alba Torrents; Rocha, Rebeca Froes; Ferguson, James; Leon, Andre N.; Koekkoek, Sylvie; Schermer, Edith E.; Burger, Judith A.; Kumar, Sanjeev; Zwolsman, Robby; Brinkkemper, Mitch; Aartse, Aafke; Eggink, Dirk; Han, Julianna; Yuan, Meng; Crispin, Max; Ozorowski, Gabriel; Ward, Andrew B.; Wilson, Ian A.; Hanke, Tomas; Sliepen, Kwinten; Sanders, Rogier W.
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errSave
A combined adjuvant approach primes robust germinal center responses and humoral immunity in non-human primates
errNATURE COMMUNICATIONS
IF15.7
err2023-11-04
err4
errOAAI
errPhung, Ivy; Rodrigues, Kristen A.; Marina-Zarate, Ester; Maiorino, Laura; Pahar, Bapi; Lee, Wen-Hsin; Melo, Mariane; Kaur, Amitinder; Allers, Carolina; Fahlberg, Marissa; Grasperge, Brooke F.; Dufour, Jason P.; Schiro, Faith; Aye, Pyone P.; Lopez, Paul G.; Torres, Jonathan L.; Ozorowski, Gabriel; Eskandarzadeh, Saman; Kubitz, Michael; Georgeson, Erik; Groschel, Bettina; Nedellec, Rebecca; Bick, Michael; Kaczmarek Michaels, Katarzyna; Gao, Hongmei; Shen, Xiaoying; Carnathan, Diane G.; Silvestri, Guido; Montefiori, David C.; Ward, Andrew B.; Hangartner, Lars; Veazey, Ronald S.; Burton, Dennis R.; Schief, William R.; Irvine, Darrell J.; Crotty, Shane
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errSave
Affinity-matured homotypic interactions induce spectrum of PfCSP structures that influence protection from malaria infection
errNATURE COMMUNICATIONS
IF15.7
err2023-07-28
err6
errOAAI
errMartin, Gregory M.; Torres, Jonathan L.; Pholcharee, Tossapol; Oyen, David; Flores-Garcia, Yevel; Gibson, Grace; Moskovitz, Re'em; Beutler, Nathan; Jung, Diana D. D.; Copps, Jeffrey; Lee, Wen-Hsin; Gonzalez-Paez, Gonzalo; Emerling, Daniel; MacGill, Randall S.; Locke, Emily; King, C. Richter; Zavala, Fidel; Wilson, Ian A.; Ward, Andrew B.
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errSave
Structural basis of epitope selectivity and potent protection from malaria by PfCSP antibody L9
errNATURE COMMUNICATIONS
IF15.7
err2023-05-17
err4
errOAAI
errMartin, Gregory M.; Fernandez-Quintero, Monica L.; Lee, Wen-Hsin; Pholcharee, Tossapol; Eshun-Wilson, Lisa; Liedl, Klaus R.; Pancera, Marie; Seder, Robert A.; Wilson, Ian A.; Ward, Andrew B.
errShare
errSave
Germline-targeting HIV-1 Env vaccination induces VRC01-class antibodies with rare insertions
errCELL REPORTS MEDICINE
IF10.6
err2023-04-01
err15
errOAAI
errCaniels, Tom G.; Medina-Ramirez, Max; Zhang, Jinsong; Sarkar, Anita; Kumar, Sonu; LaBranche, Alex; Derking, Ronald; Allen, Joel D.; Snitselaar, Jonne L.; Capella-Pujol, Joan; Sanchez, Ivan del Moral; Yasmeen, Anila; Diaz, Marilyn; Aldon, Yoann; Bijl, Tom P. L.; Venkatayogi, Sravani; Beem, Joshua S. Martin; Newman, Amanda; Jiang, Chuancang; Lee, Wen-Hsin; Pater, Maarten; Burger, Judith A.; Breemen, Marielle J. van; Taeye, Steven W. de; Rantalainen, Kimmo; LaBranche, Celia; Saunders, Kevin O.; Montefiori, David; Ozorowski, Gabriel; Ward, Andrew B.; Crispin, Max; Moore, John P.; Klasse, Per Johan; Haynes, Barton F.; Wilson, Ian A.; Wiehe, Kevin; Verkoczy, Laurent; Sanders, Rogier W.
errShare
errSave
Induction of cross-neutralizing antibodies by a permuted hepatitis C virus glycoprotein nanoparticle vaccine candidate
errNATURE COMMUNICATIONS
IF15.7
err2022-11-25
err25
errOAAI
errSliepen, Kwinten; Radi, Laura; Capella-Pujol, Joan; Watanabe, Yasunori; Zon, Ian; Chumbe, Ana; Lee, Wen-Hsin; de Gast, Marlon; Koopsen, Jelle; Koekkoek, Sylvie; Del Moral-Sanchez, Ivan; Brouwer, Philip J. M.; Ravichandran, Rashmi; Ozorowski, Gabriel; King, Neil P.; Ward, Andrew B.; van Gils, Marit J.; Crispin, Max; Schinkel, Janke; Sanders, Rogier W.
errShare
errSave

Research Directions

No research directions
Co-authors
Cooperation Journals
J
John R. Yates
H-index: 188 · Papers: 1.5K
I
Ian A. Wilson
H-index: 179 · Papers: 1.7K
A
Alessandro Sette
H-index: 174 · Papers: 1.4K
D
Dennis R. Burton
H-index: 172 · Papers: 800
L
Lawrence Corey
H-index: 162 · Papers: 1.2K
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