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D

Darrell J. Irvine

Scripps Research Institute

101H-index
594Paper Count
3.7WCitation Count
Published Papers 251
Publication Date
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Vaccination elicits HIV broadly neutralizing antibodies in primates
errNature
IF48.5
err2026-06-30
err0
PREAI
errJon M. Steichen; Patrick J. Madden; Claudia T. Flynn; Swastik Phulera; Monolina Shil; Oleksandr Kalyuzhniy; Alessia Liguori; Carolyne Kifude; Leigh M. Sewall; Christopher A. Cottrell; Krystal M. Ma; Sabyasachi Baboo; Jolene K. Diedrich; Katherine McKenney; Allan C. deCamp; Diane G. Carnathan; Ivy Phung; Parham Ramezani-Rad; Ester Marina-Zárate; Brian Freeman; Zhenfei Xie; Jeong Hyun Lee; Troy Sincomb; Nicole Phelps; Danny Lu; Diana Goodwin; Ryan Tingle; Yumiko Adachi; Nushin Alavi; Jenny Tran; Andy S. Tran; Alyne Nascimento; Catherine Sovie; Daniel L. V. Bader; Hannah Voic; Xiaoya Zhou; Grace Pixton; Agnes Walsh; Mariane B. Melo; Torben Schiffner; Facundo D. Batista; Dennis R. Burton; Darrell J. Irvine; James C. Paulson; John R. Yates; Gabriel Ozorowski; Andrew B. Ward; Guido Silvestri; Shane Crotty; William R. Schief
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Enhanced B cell priming induces broadly neutralizing HIV-1 apex antibodies
errNature
IF48.5
err2026-06-30
err0
PREAI
errLorie Marchitto; Kshitij Wagh; Ryan S. Roark; Severin Coleon; Hui Li; Ashwin N. Skelly; Michael P. Hogarty; Rumi Habib; Wenge Ding; Kasirajan Ayyanathan; Weimin Liu; Zizhang Sheng; Yicheng Guo; Joena Bal; Lena M. Smith; Laura L. Sutherland; Younghoon Park; Andrew J. Connell; Frederic Bibollet-Ruche; Emily Lewis; Samantha J. Plante; Macy J. Akeley; Jinery Lora; Chengyan Zhao; John W. Carey; Christian L. Martella; Yingying Li; Mary S. Campion; Melinda G. Lituchy; Rebecca A. Osbaldeston; Colette G. Gordon; Amie Albertus; Justin Su; Chiaki Noguchi; Ying K. Tam; Christopher Barbosa; Bo Liang; Khaled Amereh; Xuduo Li; Agnes A. Walsh; Darrell J. Irvine; Raiees Andrabi; Robert J. Edwards; Edward F. Kreider; Drew Weissman; Lawrence Shapiro; Peter D. Kwong; Bette T. Korber; Barton F. Haynes; Kevin O. Saunders; Beatrice H. Hahn; George M. Shaw
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Rapid boosting increases germinal center responses to sequential vaccines
errNature Immunology
IF27.6
err2026-06-23
err0
PREAI
errSonya Haupt; Christopher A. Cottrell; Xiaoya Zhou; Jeong Hyun Lee; Alessia Liguori; Nushin Alavi; Danny Lu; Nicole Phelps; Diana Goodwin; Elana Ben-Akiva; Agnes A. Walsh; Darrell J. Irvine; William R. Schief; Shane Crotty
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errSave
Engineering drug-responsive replication machinery for precise control of self-amplifying RNA
errNature Biomedical Engineering
IF26.6
err2026-06-23
err0
errOAAI
errParisa Yousefpour; Justin R. Gregory; Kristen Si; Jan Lonzaric; Yingzhong Li; Junmin Wang; Kashif Qureshi; Amir Ledbetter; Mariane B. Melo; Alexander Hostetler; Ashley A. Lemnios; Jonathan Dye; Linette Rodriguez; Tanaka K. Remba; Rachel Yeung; Melissa Güereca; Yuebao Zhang; Shengwei Wu; Yizhou Dong; Ron Weiss; Darrell J. Irvine
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errSave
Induction of broadly neutralizing HIV antibodies by a two-step mechanism informs vaccine design
errScience
IF45.8
err2026-05-07
err0
PREAI
errAshwin N. Skelly; Harry B. Gristick; Hui Li; Edem Gavor; Andrew J. Connell; Edward F. Kreider; Lorie Marchitto; Michael P. Hogarty; Maddy L. Newby; Joel D. Allen; Weimin Liu; Anthony P. West; Kasirajan Ayyanathan; Mary S. Campion; Kaitlyn Winters; Colette G. Gordon; Rebecca A. Osbaldeston; Macy J. Akeley; Emily Lewis; Yingying Li; Ajay Singh; Kendra Cruickshank; Younghoon Park; Chengyan Zhao; Xuduo Li; Khaled Amereh; Elizabeth Van Itallie; John W. Carey; Amie Albertus; Andrew T. DeLaitsch; Jennifer R. Keeffe; Melinda G. Lituchy; Agnes A. Walsh; Daniel J. Morris; Rumi Habib; Frederic Bibollet-Ruche; Nitesh Mishra; Gabriel Avillion; Nicholas S. Koranda; Samantha J. Plante; Christian L. Martella; Jinery Lora; Eric J. D. Wang; Mark G. Lewis; Malcolm A. Martin; Michel C. Nussenzweig; Michael S. Seaman; Darrell J. Irvine; Kevin J. Wiehe; Barton F. Haynes; Kshitij Wagh; Bette Korber; Raiees Andrabi; Max Crispin; Drew Weissman; Pamela J. Bjorkman; Beatrice H. Hahn; George M. Shaw
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errSave
Vaccine elicitation of HIV broadly neutralizing antibodies from genome-edited B cells in non-human primates and derived lymphoid organoids
errGene Therapy
IF4.5
err2026-04-10
err0
errOAAI
errMary Tenuta; Morgan Bravo; Alex Olson; Celia L. Saney; Jason Weinfurter; Elana Ben-Akiva; Disha Bhange; Christopher A. Cottrell; Logan Vosler; Kimberly Weisgrau; Dennis R. Burton; Darrell J. Irvine; William R. Schief; Eva Rakasz; Chester J. Joyner; James E. Voss
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errSave
Leveraging tissue-resident memory T cells for non-invasive immune monitoring via microneedle skin patches
errNature Biomedical Engineering
IF26.6
err2026-03-02
err0
errOAAI
errSasan Jalili; Ryan R. Hosn; Wei-Che Ko; Khashayar Afshari; Ashok Kumar Dhinakaran; Namit Chaudhary; Laura Maiorino; Nazgol-Sadat Haddadi; Anusha Nathan; Matthew A. Getz; Gaurav D. Gaiha; Mehdi Rashighi; John E. Harris; Paula T. Hammond; Darrell J. Irvine
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errSave
Author Correction: Ivermectin converts cold tumors hot and synergizes with immune checkpoint blockade for treatment of breast cancer
errnpj Breast Cancer
IF7.6
err2026-02-27
err0
errOAAI
errDobrin Draganov; Zhen Han; Aamir Rana; Nitasha Bennett; Darrell J. Irvine; Peter P. Lee
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errSave
Rapidly acquired HIV-1 neutralization breadth in a rhesus V2 apex knockin mouse model after a single bolus immunization
errScience Immunology
IF16.3
err2026-02-13
err0
PREAI
errAmrit Raj Ghosh; Rumi Habib; Nitesh Mishra; Ryan S. Roark; Madhav Akauliya; Ali A. Albowaidey; Joel D. Allen; Khaled Amereh; Gabriel Avillion; Maria Bottermann; Bo Liang; Namit Chaudhary; Sean Callaghan; Jonathan Dye; Xuduo Li; Jordan R. Ellis-Pugh; Rohan Roy Chowdhury; Nicole E. James; Xiaotie Liu; Laura Maiorino; Paula M. Villavicencio; Rebecca Nedellec; Prabhgun Oberoi; Kirsten J. Sowers; Younghoon Park; Thavaleak Prum; Linette Rodriguez; Maria Ssozi; Jonathan L. Torres; Agnes A. Walsh; John E. Warner; Stephanie R. Weldon; Liling Xu; Kevin Wiehe; Max Crispin; Andrew B. Ward; Usha Nair; Beatrice H. Hahn; Dennis R. Burton; Lawrence Shapiro; Peter D. Kwong; Darrell J. Irvine; Raiees Andrabi; George M. Shaw; Facundo D. Batista
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errSave
DNA origami vaccines program antigen-focused germinal centers
errScience
IF45.8
err2026-02-05
err0
PREAI
errAnna Romanov; Grant A. Knappe; Larance Ronsard; Christopher A. Cottrell; Yiming J. Zhang; Heikyung Suh; Lauren Duhamel; Marjan Omer; Asheley P. Chapman; Katie Spivakovsky; Patrick Skog; Claudia T. Flynn; Jeong Hyun Lee; Oleksandr Kalyuzhniy; Alessia Liguori; Molly F. Parsons; Vanessa R. Lewis; Josue Canales; Boris Reizis; Ryan D. Tingle; Torben Schiffner; William R. Schief; Daniel Lingwood; Mark Bathe; Darrell J. Irvine
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errSave
Rapid elicitation of neutralizing Asn332-glycan-independent antibodies to the V3-glycan epitope of HIV-1 Env in nonhuman primates
errNature Immunology
IF27.6
err2026-02-03
err0
errOAAI
errIgnacio Relano-Rodriguez; Jianqiu Du; Zi Jie Lin; Margaret Kerwin; Marta Tarquis-Medina; Eduardo Urbano; Jiayan Cui; Meagan Watkins; Christy L. Lavine; Peng Zhao; Rumi Habib; Colby Agostino; Sukanya Ghosh; Joyce Park; Caroline Boroughs; Agnes A. Walsh; Mariane B. Melo; Niharika Shukla; George M. Shaw; Beatrice H. Hahn; Darrell J. Irvine; Lance Wells; David B. Weiner; Michael S. Seaman; Daniel W. Kulp; Ronald S. Veazey; Jesper Pallesen; Amelia Escolano
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errSave
mRNA delivery of circumsporozoite protein epitope-based malaria vaccines induces protection in a mouse model
errnpj Vaccines
IF6.5
err2025-11-18
err0
errOAAI
errNelson R. Wu; Nathan Beutler; Xiaozhen Hu; Patrick D. Skog; Alessia Liguori; Yevel Flores-Garcia; Laura Maiorino; Sierra Terada; Danny Lu; Yen-Chung Lai; Justin Ndihokubwayo; Torben Schiffner; Christopher A. Cottrell; Saman Eskandarzadeh; Nushin Alavi; Michael Kubitz; Nicole Phelps; Ryan Tingle; Sam Hodges; John E. Youhanna; Sonya Amirzehni; Darrell J. Irvine; Sunny Himansu; Fidel Zavala; Thomas F. Rogers; Dennis R. Burton; William R. Schief
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errSave
Highly functional and prolonged germinal center T follicular helper cell responses are associated with enhanced neutralizing antibody development
errImmunity
IF26.3
err2025-11-07
err0
PREAI
errEster Marina-Zárate; Henry J. Sutton; Paul G. Lopez; Tasha K. Altheide; Michael Bick; Iszac Burton; Elana Ben-Akiva; Katarzyna Kaczmarek Michaels; Kesha Hyacinth; Brandon S. Healy; Deuk Lim; Lars Hangartner; Dennis R. Burton; Diane G. Carnathan; Guido Silvestri; William R. Schief; Darrell J. Irvine; Shane Crotty
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errSave
IL-12-releasing nanoparticles for effective immunotherapy of metastatic ovarian cancer
errNature Materials
IF38.5
err2025-10-31
err0
errOAAI
errIvan S. Pires; Gil Covarrubias; Victoria F. Gomerdinger; Coralie Backlund; Eduardo Nombera Bueno; Margaret M. Billingsley; Mae Pryor; Apoorv Shanker; Ezra Gordon; Shengwei Wu; Andrew J. Pickering; Mariane B. Melo; Heikyung Suh; Darrell J. Irvine; Paula T. Hammond
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errSave
Simultaneous induction of multiple classes of broadly neutralizing antibody precursors by combination germline-targeting immunization in nonhuman primates
errScience Immunology
IF16.3
err2025-10-17
err0
PREAI
errHenry J. Sutton; Krystal M. Ma; Jon M. Steichen; Torben Schiffner; Tasha K. Altheide; Alessia Liguori; Danny Lu; Michael Kubitz; Erik Georgeson; Nicole Phelps; Ryan Tingle; Nushin B. Alavi; Elana Ben-Akiva; Xiaoya Zhou; Carolyne Kifude; Claudia T. Flynn; Eva Rakasz; Darrell J. Irvine; William R. Schief; Shane Crotty
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errSave
Progress in cancer vaccines enabled by nanotechnology
errNature Nanotechnology
IF34.9
err2025-10-17
err0
PREAI
errB. J. Kim; Nouran S. Abdelfattah; Alexander Hostetler; Darrell J. Irvine
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errSave
Immunometabolic defects of CD8+ T cells disrupt gut barrier integrity in people with HIV
errCell
IF42.5
err2025-09-11
err0
errOAAI
errUpasana Das Adhikari; Leah M. Froehle; Alexandra N. Pipkin; Heeva Baharlou; Alice H. Linder; Palak Shah; Amanda Hussey; Qiming Zhang; Sarah Nyquist; Saleh Khwaled; Fangtao Chi; Swagata Goswami; Sabhyata Sedhain; Salina Hussain; Thomas J. Diefenbach; Benjamin J. Read; Byungji Kim; Darrell Irvine; Osaretin Asowata; Mark Ladinsky; Pamela Bjorkman; Fusi Madela; Shakeel Kader; Alex K. Shalek; Musie Ghebremichael; Henrik Kloverpris; Alison E. Ringel; Ömer H. Yilmaz; Douglas S. Kwon
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errSave
Directed evolution-based discovery of ligands for in vivo restimulation of chimeric antigen receptor T cells
errNature Biomedical Engineering
IF26.6
err2025-08-25
err0
errOAAI
errTomasz M. Grzywa; Alexandra Neeser; Ranjani Ramasubramanian; Anna Romanov; Ryan Tannir; Naveen K. Mehta; Benjamin Cossette; Duncan M. Morgan; Beatriz Goncalves; Ina Sukaj; Elisa Bergaggio; Stephan Kadauke; Regina M. Myers; Luca Paruzzo; Guido Ghilardi; Austin Cozzone; Stephen J. Schuster; Noelle Frey; Libin Zhang; Parisa Yousefpour; Wuhbet Abraham; Heikyung Suh; Marco Ruella; Stephan A. Grupp; Roberto Chiarle; K. Dane Wittrup; Leyuan Ma; Darrell J. Irvine
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errSave
HIV broadly neutralizing antibody precursors to the Apex epitope induced in nonhuman primates
errScience Immunology
IF16.3
err2025-08-22
err0
PREAI
errKrystal M. Ma; Henry J. Sutton; Payal P. Pratap; Jon M. Steichen; Diane Carnathan; James Quinn; Oleksandr Kalyuzhniy; Alessia Liguori; Sashank Agrawal; Sabyasachi Baboo; Patrick Madden; Christopher A. Cottrell; Jordan R. Willis; Jeong-Hyun Lee; Elise Landais; Xiaozhen Hu; Parham Ramezani-Rad; Gabriel Ozorowski; Vanessa R. Lewis; Jolene K. Diedrich; Xiaoya Zhou; Tasha K. Altheide; Nicole Phelps; Erik Georgeson; Nushin B. Alavi; Danny Lu; Saman Eskandarzadeh; Michael Kubitz; Yumiko Adachi; Tina-Marie Mullen; Murillo Silva; Mariane B. Melo; Sunny Himansu; Darrell J. Irvine; Dennis R. Burton; John R. Yates; James C. Paulson; Devin Sok; Ian A. Wilson; Guido Silvestri; Andrew B. Ward; Shane Crotty; William R. Schief
errShare
errSave
Immunofocusing on the conserved fusion peptide of HIV envelope glycoprotein in rhesus macaques
errnpj Vaccines
IF6.5
err2025-08-20
err0
errOAAI
errPayal P. Pratap; Christopher A. Cottrell; James Quinn; Diane G. Carnathan; Daniel L. V. Bader; Andy S. Tran; Chiamaka A. Enemuo; Julia T. Ngo; Sara T. Richey; Hongmei Gao; Xiaoying Shen; Kelli M. Greene; Jonathan Hurtado; Katarzyna Kaczmarek Michaels; Elana Ben-Akiva; Ashley Lemnios; Mariane B. Melo; Joel D. Allen; Gabriel Ozorowski; Max Crispin; Bryan Briney; David Montefiori; Guido Silvestri; Darrell J. Irvine; Shane Crotty; Andrew B. Ward
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Research Directions

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