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Tom G. Caniels

leiden university

26H-index
52Paper Count
4.1KCitation Count
Published Papers 23
Publication Date
Hyperinflammation by Human Macrophages Induced by SARS-CoV-2 Anti-Spike IgG Is Dependent on Glucose and Fatty Acid Metabolism
err2025-12-01
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errOAAI
errGeyer, Chiara E.; Almeida, Luis; Mes, Lynn; Otto, Frank; Mak, W. Ashwin; Heieis, Graham A.; Veth, Jennifer; de Taeye, Steven W.; Caniels, Tom G.; Bijl, Tom P. L.; van Gils, Marit J.; de Winther, Menno; Van den Bossche, Jan; Chen, Hung-Jen; Houtkooper, Riekelt H.; Everts, Bart; den Dunnen, Jeroen
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Precise targeting of HIV broadly neutralizing antibody precursors in humans
errScience
IF45.8
err2025-05-15
err0
PREAI
errTom G. Caniels; Madhu Prabhakaran; Gabriel Ozorowski; Kellie J. MacPhee; Weiwei Wu; Karlijn van der Straten; Sashank Agrawal; Ronald Derking; Emma I. M. M. Reiss; Katrina Millard; Martina Turroja; Aimee Desrosiers; Jeffrey Bethony; Elissa Malkin; Marinus H. Liesdek; Annelou van der Veen; Michelle Klouwens; Jonne L. Snitselaar; Joey H. Bouhuijs; Rhianna Bronson; Jalen Jean-Baptiste; Suprabhath Gajjala; Zahra Rikhtegaran Tehrani; Alison Benner; Mukundhan Ramaswami; Michael O. Duff; Yung-Wen Liu; Alicia H. Sato; Ju Yeong Kim; Isabel J. L. Baken; Catarina Mendes Silva; Tom P. L. Bijl; Jacqueline van Rijswijk; Judith A. Burger; Albert Cupo; Anila Yasmeen; Swastik Phulera; Wen-Hsin Lee; Kipchoge N. Randall; Shiyu Zhang; Martin M. Corcoran; Isabel Regadas; Alex C. Sullivan; David M. Brown; Jennifer A. Bohl; Kelli M. Greene; Hongmei Gao; Nicole L. Yates; Sheetal Sawant; Jan M. Prins; Neeltje A. Kootstra; Stephen M. Kaminsky; Burc Barin; Farhad Rahaman; Margaret Meller; Vince Philiponis; Dagna S. Laufer; Angela Lombardo; Lindsey Mwoga; Solmaz Shotorbani; Drienna Holman; Richard A. Koup; Per Johan Klasse; Gunilla B. Karlsson Hedestam; Georgia D. Tomaras; Marit J. van Gils; David C. Montefiori; Adrian B. McDermott; Ollivier Hyrien; John P. Moore; Ian A. Wilson; Andrew B. Ward; David J. Diemert; Godelieve J. de Bree; Sarah F. Andrews; Marina Caskey; Rogier W. Sanders
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Plant-produced SARS-CoV-2 antibody engineered towards enhanced potency and in vivo efficacy
err2024-11-19
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errOAAI
errde Taeye, Steven W.; Faye, Loic; Morel, Bertrand; Schriek, Angela I.; Umotoy, Jeffrey C.; Yuan, Meng; Kuzmina, Natalia A.; Turner, Hannah L.; Zhu, Xueyong; Gruenwald-Gruber, Clemens; Poniman, Meliawati; Burger, Judith A.; Caniels, Tom G.; Fitchette, Anne-Catherine; Desgagnes, Rejean; Stordeur, Virginie; Mirande, Lucie; Beauverger, Guillaume; de Bree, Godelieve; Ozorowski, Gabriel; Ward, Andrew B.; Wilson, Ian A.; Bukreyev, Alexander; Sanders, Rogier W.; Vezina, Louis-Philippe; Beaumont, Tim; van Gils, Marit J.; Gomord, Veronique
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Germline-targeting HIV vaccination induces neutralizing antibodies to the CD4 binding site
err2024-08-30
err1
PREAI
errCaniels, Tom G.; Medina-Ramirez, Max; Zhang, Shiyu; Kratochvil, Sven; Xian, Yuejiao; Koo, Ja-Hyun; Derking, Ronald; Samsel, Jakob; van Schooten, Jelle; Pecetta, Simone; Lamperti, Edward; Yuan, Meng; Carrasco, Maria Rios; del Moral Sanchez, Ivan; Allen, Joel D.; Bouhuijs, Joey H.; Yasmeen, Anila; Ketas, Thomas J.; Snitselaar, Jonne L.; Bijl, Tom P. L.; Martin, Isabel Cuella; Torres, Jonathan L.; Cupo, Albert; Shirreff, Lisa; Rogers, Kenneth; Mason, Rosemarie D.; Roederer, Mario; Greene, Kelli M.; Gao, Hongmei; Silva, Catarina Mendes; Baken, Isabel J. L.; Tian, Ming; Alt, Frederick W.; Pulendran, Bali; Seaman, Michael S.; Crispin, Max; van Gils, Marit J.; Montefiori, David C.; McDermott, Adrian B.; Villinger, Francois J.; Koup, Richard A.; Moore, John P.; Klasse, Per Johan; Ozorowski, Gabriel; Batista, Facundo D.; Wilson, Ian A.; Ward, Andrew B.; Sanders, Rogier W.
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Identification of new drugs to counteract anti-spike IgG- induced hyperinflammation in severe COVID-19
err2023-09-12
err4
errOAAI
errGeyer, Chiara E.; Chen, Hung-Jen; Bye, Alexander P.; Manz, Xue; Guerra, Denise; Caniels, Tom G.; Bijl, Tom P. L.; Griffith, Guillermo R.; Hoepel, Willianne; de Taeye, Steven W.; Veth, Jennifer; Vlaar, Alexander P. J.; Vidarsson, Gestur; Bogaard, Harm Jan; Aman, Jurjan; Gibbins, Jonathan M.; van Gils, Marit J.; de Winther, Menno P. J.; den Dunnen, Jeroen
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SARS-CoV-2 Spike N-Terminal Domain Engages 9-O-Acetylated?2-8-Linked Sialic Acids
err2023-04-27
err16
errOAAI
errTomris, Ilhan; Unione, Luca; Nguyen, Linh; Zaree, Pouya; Bouwman, Kim M.; Liu, Lin; Li, Zeshi; Fok, Jelle A.; Carrasco, Maria Rios; van der Woude, Roosmarijn; Kimpel, Anne L. M.; Linthorst, Mirte W.; Kilavuzoglu, Sinan E.; Verpalen, Enrico C. J. M.; Caniels, Tom G.; Sanders, Rogier W.; Heesters, Balthasar A. .; Pieters, Roland J.; Jimenez-Barbero, Jesu's; Klassen, John S.; Boons, Geert-Jan; de Vries, Robert P.
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Germline-targeting HIV-1 Env vaccination induces VRC01-class antibodies with rare insertions
err2023-04-01
err15
errOAAI
errCaniels, Tom G.; Medina-Ramirez, Max; Zhang, Jinsong; Sarkar, Anita; Kumar, Sonu; LaBranche, Alex; Derking, Ronald; Allen, Joel D.; Snitselaar, Jonne L.; Capella-Pujol, Joan; Sanchez, Ivan del Moral; Yasmeen, Anila; Diaz, Marilyn; Aldon, Yoann; Bijl, Tom P. L.; Venkatayogi, Sravani; Beem, Joshua S. Martin; Newman, Amanda; Jiang, Chuancang; Lee, Wen-Hsin; Pater, Maarten; Burger, Judith A.; Breemen, Marielle J. van; Taeye, Steven W. de; Rantalainen, Kimmo; LaBranche, Celia; Saunders, Kevin O.; Montefiori, David; Ozorowski, Gabriel; Ward, Andrew B.; Crispin, Max; Moore, John P.; Klasse, Per Johan; Haynes, Barton F.; Wilson, Ian A.; Wiehe, Kevin; Verkoczy, Laurent; Sanders, Rogier W.
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Understanding repertoire sequencing data through a multiscale computational model of the germinal center
err2023-03-16
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errGarcia-Valiente, Rodrigo; Merino Tejero, Elena; Stratigopoulou, Maria; Balashova, Daria; Jongejan, Aldo; Lashgari, Danial; Pelissier, Aurelien; Caniels, Tom G.; Claireaux, Mathieu A. F.; Musters, Anne; van Gils, Marit J.; Martinez, Maria Rodriguez; de Vries, Niek; Meyer-Hermann, Michael; Guikema, Jeroen E. J.; Hoefsloot, Huub; van Kampen, Antoine H. C.
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Discriminating cross-reactivity in polyclonal IgG1 responses against SARS-CoV-2 variants of concern
err2022-10-15
err9
errOAAI
errvan Rijswijck, Danique M. H.; Bondt, Albert; Hoek, Max; van der Straten, Karlijn; Caniels, Tom G.; Poniman, Meliawati; Eggink, Dirk; Reusken, Chantal; de Bree, Godelieve J.; Sanders, Rogier W.; van Gils, Marit J.; Heck, Albert J. R.
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Antigenic cartography using sera from sequence-confirmed SARS-CoV-2 variants of concern infections reveals antigenic divergence of Omicron
errIMMUNITY
IF26.3
err2022-09-01
err56
errOAAI
errvan der Straten, Karlijn; Guerra, Denise; Gils, Marit J. van; Bontjer, Ilja; Caniels, Tom G.; Willigen, Hugo D. G. van; Wynberg, Elke; Poniman, Meliawati; Burger, Judith A.; Bouhuijs, Joey H.; van Rijswijk, Jacqueline; Olijhoek, Wouter; Liesdek, Marinus H.; Lavell, A. H. Ayesha; Appelman, Brent; Sikkens, Jonne J.; Bomers, Marije K.; Han, Alvin X.; Nichols, Brooke E.; Prins, Maria; Vennema, Harry; Reusken, Chantal; Jong, Marije Menno D. de; Bree, Godelieve J. de; Russell, Colin A.; Eggink, Dirk; Sanders, Rogier W.
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A public antibody class recognizes an S2 epitope exposed on open conformations of SARS-CoV-2 spike
err2022-08-04
err34
errOAAI
errClaireaux, Mathieu; Caniels, Tom G.; de Gast, Marlon; Han, Julianna; Guerra, Denise; Kerster, Gius; van Schaik, Barbera D. C.; Jongejan, Aldo; Schriek, Angela, I; Grobben, Marloes; Brouwer, Philip J. M.; van der Straten, Karlijn; Aldon, Yoann; Capella-Pujol, Joan; Snitselaar, Jonne L.; Olijhoek, Wouter; Aartse, Aafke; Brinkkemper, Mitch; Bontjer, Ilja; Burger, Judith A.; Poniman, Meliawati; Bijl, Tom P. L.; Torres, Jonathan L.; Copps, Jeffrey; Martin, Isabel Cuella; de Taeye, Steven W.; de Bree, Godelieve J.; Ward, Andrew B.; Sliepen, Kwinten; van Kampen, Antoine H. C.; Moerland, Perry D.; Sanders, Rogier W.; van Gils, Marit J.
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A single-shot adenoviral vaccine provides hemagglutinin stalk-mediated protection against heterosubtypic influenza challenge in mice
err2022-05-01
err22
errOAAI
errBliss, Carly M.; Freyn, Alec W.; Caniels, Tom G.; Leyva-Grado, Victor H.; Nachbagauer, Raffael; Sun, Weina; Tan, Gene S.; Gillespie, Virginia L.; McMahon, Meagan; Krammer, Florian; Hill, Adrian V. S.; Palese, Peter; Coughlan, Lynda
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A SARS-CoV-2 Wuhan spike virosome vaccine induces superior neutralization breadth compared to one using the Beta spike
err2022-03-10
err11
errOAAI
errvan der Velden, Yme U.; Grobben, Marloes; Caniels, Tom G.; Burger, Judith A.; Poniman, Meliawati; Oomen, Melissa; Siteur-van Rijnstra, Esther; Tejjani, Khadija; Guerra, Denise; Kempers, Ronald; Stegmann, Toon; van Gils, Marit J.; Sanders, Rogier W.
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A single mRNA vaccine dose in COVID-19 patients boosts neutralizing antibodies against SARS-CoV-2 and variants of concern
err2022-01-01
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errOAAI
errvan Gils, Marit J.; van Willigen, Hugo D. G.; Wynberg, Elke; Han, Alvin X.; van der Straten, Karlijn; Burger, Judith A.; Poniman, Meliawati; Oomen, Melissa; Tejjani, Khadija; Bouhuijs, Joey H.; Verveen, Anouk; Lebbink, Romy; Dijkstra, Maartje; Appelman, Brent; Lavell, A. H. Ayesha; Caniels, Tom G.; Bontjer, Ilja; van Vught, Lonneke A.; Vlaar, Alexander P. J.; Sikkens, Jonne J.; Bomers, Marije K.; Russell, Colin A.; Kootstra, Neeltje A.; Sanders, Rogier W.; Prins, Maria; de Bree, Godelieve J.; de Jong, Menno D.
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A third SARS-CoV-2 spike vaccination improves neutralization of variants-of-concern
err2021-12-03
err15
errOAAI
errBrinkkemper, Mitch; Brouwer, Philip J. M.; Maisonnasse, Pauline; Grobben, Marloes; Caniels, Tom G.; Poniman, Meliawati; Burger, Judith A.; Bontjer, Ilja; Oomen, Melissa; Bouhuijs, Joey H.; van der Linden, Cynthia A.; Villaudy, Julien; van der Velden, Yme U.; Sliepen, Kwinten; van Gils, Marit J.; Le Grand, Roger; Sanders, Rogier W.
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Probing Affinity, Avidity, Anticooperativity, and Competition in Antibody and Receptor Binding to the SARS-CoV-2 Spike by Single Particle Mass Analyses
err2021-11-04
err21
errOAAI
errYin, Victor; Lai, Szu-Hsueh; Caniels, Tom G.; Brouwer, Philip J. M.; Brinkkemper, Mitch; Aldon, Yoann; Liu, Hejun; Yuan, Meng; Wilson, Ian A.; Sanders, Rogier W.; van Gils, Marit J.; Heck, Albert J. R.
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COVA1-18 neutralizing antibody protects against SARS-CoV-2 in three preclinical models
err2021-10-20
err33
errOAAI
errMaisonnasse, Pauline; Aldon, Yoann; Marc, Aurelien; Marlin, Romain; Dereuddre-Bosquet, Nathalie; Kuzmina, Natalia A.; Freyn, Alec W.; Snitselaar, Jonne L.; Goncalves, Antonio; Caniels, Tom G.; Burger, Judith A.; Poniman, Meliawati; Bontjer, Ilja; Chesnais, Virginie; Diry, Segolene; Iershov, Anton; Ronk, Adam J.; Jangra, Sonia; Rathnasinghe, Raveen; Brouwer, Philip J. M.; Bijl, Tom P. L.; van Schooten, Jelle; Brinkkemper, Mitch; Liu, Hejun; Yuan, Meng; Mire, Chad E.; van Breemen, Marielle J.; Contreras, Vanessa; Naninck, Thibaut; Lemaitre, Julien; Kahlaoui, Nidhal; Relouzat, Francis; Chapon, Catherine; Fang, Raphael Ho Tsong; McDanal, Charlene; Osei-Twum, Mary; St-Amant, Natalie; Gagnon, Luc; Montefiori, David C.; Wilson, Ian A.; Ginoux, Eric; de Bree, Godelieve J.; Garcia-Sastre, Adolfo; Schotsaert, Michael; Coughlan, Lynda; Bukreyev, Alexander; van der Werf, Sylvie; Guedj, Jeremie; Sanders, Rogier W.; van Gils, Marit J.; Le Grand, Roger
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Emerging SARS-CoV-2 variants of concern evade humoral immune responses from infection and vaccination
err2021-09-03
err79
errOAAI
errCaniels, Tom G.; Bontjer, Ilja; van der Straten, Karlijn; Poniman, Meliawati; Burger, Judith A.; Appelman, Brent; Lavell, Ayesha H. A.; Oomen, Melissa; Godeke, Gert-Jan; Valle, Coralie; Mogling, Ramona; van Willigen, Hugo D. G.; Wynberg, Elke; Schinkel, Michiel; van Vught, Lonneke A.; Guerra, Denise; Snitselaar, Jonne L.; Chaturbhuj, Devidas N.; Martin, Isabel Cuella; Moore, John P.; de Jong, Menno D.; Reusken, Chantal; Sikkens, Jonne J.; Bomers, Marije K.; de Bree, Godelieve J.; van Gils, Marit J.; Eggink, Dirk; Sanders, Rogier W.
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High titers and low fucosylation of early human anti-SARS-CoV-2 IgG promote inflammation by alveolar macrophages
err2021-06-02
err153
errOAAI
errHoepel, Willianne; Chen, Hung-Jen; Geyer, Chiara E.; Allahverdiyeva, Sona; Manz, Xue D.; de Taeye, Steven W.; Aman, Jurjan; Mes, Lynn; Steenhuis, Maurice; Griffith, Guillermo R.; Bonta, Peter, I; Brouwer, Philip J. M.; Caniels, Tom G.; van der Straten, Karlijn; Golebski, Korneliusz; Jonkers, Rene E.; Larsen, Mads D.; Linty, Federica; Nouta, Jan; van Roomen, Cindy P. A. A.; van Baarle, Frank E. H. P.; van Drunen, Cornelis M.; Wolbink, Gertjan; Vlaar, Alexander P. J.; de Bree, Godelieve J.; Sanders, Rogier W.; Willemsen, Lisa; Neele, Annette E.; van de Beek, Diederik; Rispens, Theo; Wuhrer, Manfred; Bogaard, Harm Jan; van Gils, Marit J.; Vidarsson, Gestur; de Winther, Menno; den Dunnen, Jeroen
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SARS-CoV-2 variants of concern partially escape humoral but not T- cell responses in COVID-19 convalescent donors and vaccinees
err2021-05-28
err432
errOAAI
errGeers, Daryl; Shamier, Marc C.; Bogers, Susanne; den Hartog, Gerco; Gommers, Lennert; Nieuwkoop, Nella N.; Schmitz, Katharina S.; Rijsbergen, Laurine C.; van Osch, Jolieke A. T.; Dijkhuizen, Emma; Smits, Gaby; Comvalius, Anouskha; van Mourik, Djenolan; Caniels, Tom G.; van Gils, Marit J.; Sanders, Rogier W.; Munnink, Bas B. Oude; Molenkamp, Richard; de Jager, Herbert J.; Haagmans, Bart L.; de Swart, Rik L.; Koopmans, Marion P. G.; van Binnendijk, Robert S.; de Vries, Rory D.; GeurtsvanKessel, Corine H.
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