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M

Meredith Calvert

denali therapeutics inc.

25H-index
80Paper Count
2.6KCitation Count
Published Papers 28
Publication Date
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Author Correction: Fc-engineered large molecules targeting blood-brain barrier transferrin receptor and CD98hc have distinct central nervous system and peripheral biodistribution
errNature Communications
IF15.7
err2026-04-15
err0
errOAAI
errNathalie Khoury; Michelle E. Pizzo; Claire B. Discenza; David Joy; David Tatarakis; Mihail Ivilinov Todorov; Moritz Negwer; Connie Ha; Gabrielly L. De Melo; Lily Sarrafha; Matthew J. Simon; Darren Chan; Roni Chau; Kylie S. Chew; Johann Chow; Allisa Clemens; Yaneth Robles-Colmenares; Jason C. Dugas; Joseph Duque; Doris Kaltenecker; Holly Kane; Amy Leung; Edwin Lozano; Arash Moshkforoush; Elysia Roche; Thomas Sandmann; Mabel Tong; Kaitlin Xa; Yinhan Zhou; Joseph W. Lewcock; Ali Ertürk; Robert G. Thorne; Meredith E. K. Calvert; Y. Joy Yu Zuchero
errShare
errSave
Loss of PILRA promotes microglial immunometabolism to reduce amyloid pathology in cell and mouse models of Alzheimer's disease
errSCIENCE TRANSLATIONAL MEDICINE
IF14.6
err2025-12-03
err0
PREAI
errWeerakkody, Tanya N.; Sabelstrom, Hanna; Andrews, Shan V.; Chadarevian, Jean Paul; Chin, Marcus Y.; Tatarakis, David; Propson, Nicholas E.; Kim, Do Jin; Theolis, Richard; Parico, Gian Carlo G.; Misker, Hiwot; Kung, Jennifer E.; Bandyopadhyay, Abira; Robles Colmenares, Yaneth; Jackson, Taggra-Nicole; Qerqez, Ahlam N.; Balasundar, Srijana; Davis, Sonnet S.; Ha, Connie; Ghosh, Rajarshi; Ravi, Ritesh; Rana, Anil; Germain, Kyla; Tao, Arnold; Xiong, Ken; Braun, Dylan; Raju, Karthik; Huang, Kang-Chieh; Zhan, Lihong; Guo, Jing L.; Safari Yazd, Hoda; Sarrafha, Lily; Capocchi, Joia Kai; Hasselmann, Jonathan; Chadarevian, Alina L.; Tu, Christina; Mansour, Kimiya; Eskandari-Sedighi, Ghazaleh; Tesi, Niccolo; Van Der Lee, Sven; Hulsman, Marc; Oshegov, Georgii; Pijnenburg, Yolande; Calvert, Meredith; Holstege, Henne; Suh, Jung H.; Di Paolo, Gilbert; Davtyan, Hayk; Lewcock, Joseph W.; Blurton-Jones, Mathew; Monroe, Kathryn M.
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Investigational eIF2B activator DNL343 modulates the integrated stress response in preclinical models of TDP-43 pathology and individuals with ALS in a randomized clinical trial
errNature Communications
IF15.7
err2025-08-18
err0
errOAAI
errBrittany N. Flores; Seungyoon B. Yu; Isaac V. Cohen; Melania H. Fanok; Wei Luan; Romeo D. Maciuca; Linus D. Sun; Richard M. Tsai; Maurits Vissers; Lars Smits; Tommy M. Bunte; Anna Bakardjiev; Srijana Balasundar; Meredith E. K. Calvert; Marcus Y. Chin; Sarah K. Dobbins; William E. Dowdle; Meng Fang; Jules A. A. C. Heuberger; Connie L. Ha; Fen Huang; Takashi Miyamoto; Maksim Osipov; Lidia Madrid San Martin; Katie Saund; David Tatarakis; Anthony Q. Vu; Chenling Xiong; Gene W. Yeo; Geert Jan Groeneveld; Leonard H. van den Berg; Shyeilla Dhuria; Anthony A. Estrada; Danna Jennings; Thomas Sandmann; Carole Ho; Kimberly Scearce-Levie; Ernie Yulyaningsih; Adam K. Walker; Gilbert Di Paolo; Lesley A. Kane; Matthew D. Troyer; Joseph W. Lewcock
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errSave
Transferrin receptor-mediated transport at the blood-brain barrier is elevated during early development and maintained across aging and in an Alzheimer’s mouse model
errJournal of Cerebral Blood Flow & Metabolism
IF4.5
err2025-08-16
err0
errOAAI
errVanessa O Torres; Michelle E Pizzo; Darren Chan; Jason C Dugas; David Huynh; David Joy; Eric K Liang; Lily Sarrafha; Isabel Becerra; Roni Chau; Kylie S Chew; Johann Chow; Claire B Discenza; Timothy K Earr; Laura Furaso; Nathalie Khoury; Kendra J Lechtenberg; Amy W Leung; Hoang N Nguyen; Emmanuel S Ojo; Elysia Roche; Matthew J Simon; Hilda Solanoy; Mabel Tong; Raymond K Tong; Kirk Henne; Joseph W Lewcock; Ryan J Watts; Meredith E Calvert; Robert G Thorne; Y Joy Yu Zuchero
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errSave
Transferrin receptor–targeted anti-amyloid antibody enhances brain delivery and mitigates ARIA
errScience
IF45.8
err2025-08-07
err0
PREAI
errMichelle E. Pizzo; Edward D. Plowey; Nathalie Khoury; Wanda Kwan; Jordan Abettan; Sarah L. DeVos; Claire B. Discenza; Timothy Earr; David Joy; Ming Lye-Barthel; Elysia Roche; Darren Chan; Jason C. Dugas; Kapil Gadkar; Stefan Hamann; René Meisner; Jennifer Sebalusky; Ana Claudia Silva Amaral; Isabel Becerra; Roni Chau; Johann Chow; Allisa J. Clemens; Mark S. Dennis; Joseph Duque; Laura Fusaro; Jennifer A. Getz; Mihalis S. Kariolis; Do Jin Kim; Kendra J. Lechtenberg; Amy Wing-Sze Leung; Arash Moshkforoush; Hoang N. Nguyen; Emmanuel S. Ojo; Elliot R. Thomsen; Vanessa O. Torres; Pascal E. Sanchez; Lu Shan; Adam P. Silverman; Zachary K. Sweeney; Hilda Solanoy; Raymond Tong; Meredith E. Calvert; Ryan J. Watts; Robert G. Thorne; Paul H. Weinreb; Dominic M. Walsh; Joseph W. Lewcock; Thierry Bussiere; Y. Joy Yu Zuchero
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Dual targeting of transferrin receptor and CD98hc enhances brain exposure of large molecules
errCell Reports
IF6.9
err2025-07-22
err0
PREAI
errRobert C. Wells; Padma Akkapeddi; Darren Chan; David Joy; Arash Moshkforoush; Roni Chau; Johann Chow; Gerald Maxwell Cherf; Ellen Y.T. Chien; Allisa Clemens; Michelle E. Pizzo; Ahlam N. Qerqez; Tiffany Tran; Isabel Becerra; Jason C. Dugas; Joseph Duque; Timothy K. Earr; David Huynh; Do Jin Kim; Amy Wing-Sze Leung; Eric Liang; Hoang N. Nguyen; Yaneth Robles-Colmenares; Holly Kane; Elysia Roche; Patricia Sacayon; Kaitlin Xa; Hilda Solanoy; Mark S. Dennis; Joseph W. Lewcock; Ryan J. Watts; Mihalis S. Kariolis; Robert G. Thorne; Christopher M. Koth; Meredith E.K. Calvert; Y. Joy Yu Zuchero; Kylie S. Chew
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ETV:SGSH, a brain-penetrant enzyme transport vehicle for SGSH, improves lysosomal and microglial morphology, degeneration and cognitive behavior in MPS IIIA mice
errMOLECULAR GENETICS AND METABOLISM
IF3.5
err2024-02-01
err0
PREAI
errMasoud, Shababa T.; Nguyen, Hoang; Discenza, Claire; Joy, David; Simms, Jeffrey; Lo, Iris; Chun, You Young; Holtzman, Julia; Tsogtbaatar, Khishig; Leung, Amy Wing-Sze; Becerra, Isabel; Thomsen, Elliot; Gill, Audrey; Rajendra, Yashas; Seay, Alexander; Jafarnejad, Mohammad; Bakardjiev, Anna; Calvert, Meredith E. K.; Mahon, Cathal S.; Thorne, Robert; Chessler, Steven; Henne, Kirk; Sanchez, Pascal; Arguello, Annie
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SARM1 is responsible for calpain-dependent dendrite degeneration in mouse hippocampal neurons
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err2024-02-01
err3
errOAAI
errMiyamoto, Takashi; Kim, Chaeyoung; Chow, Johann; Dugas, Jason C.; Degroot, Jack; Bagdasarian, Alex L.; Thottumkara, Arun P.; Larhammar, Martin; Calvert, Meredith E. K.; Fox, Brian M.; Lewcock, Joseph W.; Kane, Lesley A.
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Rab12 is a regulator of LRRK2 and its activation by damaged lysosomes
errELIFE
IF0
err2023-10-24
err8
errOAAI
errWang, Xiang; Bondar, Vitaliy V.; Davis, Oliver B.; Maloney, Michael T.; Agam, Maayan; Chin, Marcus Y.; Ho, Audrey Cheuk-Nga; Ghosh, Rajarshi; Leto, Dara E.; Joy, David; Calvert, Meredith E. K.; Lewcock, Joseph W.; Di Paolo, Gilbert; Thorne, Robert G.; Sweeney, Zachary K.; Henry, Anastasia G.
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CD98hc is a target for brain delivery of biotherapeutics (vol 14, 5053, 2023)
errNATURE COMMUNICATIONS
IF15.7
err2023-09-07
err0
errOAAI
errChew, Kylie S.; Wells, Robert C.; Moshkforoush, Arash; Chan, Darren; Lechtenberg, Kendra J.; Tran, Hai L.; Chow, Johann; Kim, Do Jin; Robles-Colmenares, Yaneth; Srivastava, Devendra B.; Tong, Raymond K.; Tong, Mabel; Xa, Kaitlin; Yang, Alexander; Zhou, Yinhan; Akkapeddi, Padma; Annamalai, Lakshman; Bajc, Kaja; Blanchette, Marie; Cherf, Gerald Maxwell; Earr, Timothy K.; Gill, Audrey; Huynh, David; Joy, David; Knight, Kristen N.; Lac, Diana; Leung, Amy Wing-Sze; Lexa, Katrina W.; Liau, Nicholas P. D.; Becerra, Isabel; Malfavon, Mario; Mcinnes, Joseph; Nguyen, Hoang N.; Lozano, Edwin I.; Pizzo, Michelle E.; Roche, Elysia; Sacayon, Patricia; Calvert, Meredith E. K.; Daneman, Richard; Dennis, Mark S.; Duque, Joseph; Gadkar, Kapil; Lewcock, Joseph W.; Mahon, Cathal S.; Meisner, Rene; Solanoy, Hilda; Thorne, Robert G.; Watts, Ryan J.; Zuchero, Y. Joy Yu; Kariolis, Mihalis S.
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errSave
CD98hc is a target for brain delivery of biotherapeutics
errNATURE COMMUNICATIONS
IF15.7
err2023-08-19
err17
errOAAI
errChew, Kylie S.; Wells, Robert C.; Moshkforoush, Arash; Chan, Darren; Lechtenberg, Kendra J.; Tran, Hai L.; Chow, Johann; Kim, Do Jin; Robles-Colmenares, Yaneth; Srivastava, Devendra B.; Tong, Raymond K.; Tong, Mabel; Xa, Kaitlin; Yang, Alexander; Zhou, Yinhan; Akkapeddi, Padma; Annamalai, Lakshman; Bajc, Kaja; Blanchette, Marie; Cherf, Gerald Maxwell; Earr, Timothy K.; Gill, Audrey; Huynh, David; Joy, David; Knight, Kristen N.; Lac, Diana; Leung, Amy Wing-Sze; Lexa, Katrina W.; Liau, Nicholas P. D.; Becerra, Isabel; Malfavon, Mario; McInnes, Joseph; Nguyen, Hoang N.; Lozano, Edwin I.; Pizzo, Michelle E.; Roche, Elysia; Sacayon, Patricia; Calvert, Meredith E. K.; Daneman, Richard; Dennis, Mark S.; Duque, Joseph; Gadkar, Kapil; Lewcock, Joseph W.; Mahon, Cathal S.; Meisner, Rene; Solanoy, Hilda; Thorne, Robert G.; Watts, Ryan J.; Zuchero, Y. Joy Yu; Kariolis, Mihalis S.
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errSave
Phosphorylation by casein kinase 2 regulates Nap1 localization and function
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-27
err67
errOAAI
errCalvert, Meredith E. K.; Keck, Kristin M.; Ptak, Celeste; Shabanowitz, Jeffrey; Hunt, Donald F.; Pemberton, Lucy F.
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errSave
Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microglia
errMOLECULAR NEURODEGENERATION
IF17.5
err2022-06-11
err46
errOAAI
errXia, Dan; Lianoglou, Steve; Sandmann, Thomas; Calvert, Meredith; Suh, Jung H.; Thomsen, Elliot; Dugas, Jason; Pizzo, Michelle E.; DeVos, Sarah L.; Earr, Timothy K.; Lin, Chia-Ching; Davis, Sonnet; Ha, Connie; Leung, Amy Wing-Sze; Hoang Nguyen; Chau, Roni; Yulyaningsih, Ernie; Lopez, Isabel; Solanoy, Hilda; Masoud, Shababa T.; Liang, Chun-chi; Lin, Karin; Astarita, Giuseppe; Khoury, Nathalie; Zuchero, Joy Yu; Thorne, Robert G.; Shen, Kevin; Miller, Stephanie; Palop, Jorge J.; Garceau, Dylan; Sasner, Michael; Whitesell, Jennifer D.; Harris, Julie A.; Hummel, Selina; Gnorich, Johannes; Wind, Karin; Kunze, Lea; Zatcepin, Artem; Brendel, Matthias; Willem, Michael; Haass, Christian; Barnett, Daniel; Zimmer, Till S.; Orr, Anna G.; Scearce-Levie, Kimberly; Lewcock, Joseph W.; Di Paolo, Gilbert; Sanchez, Pascal E.
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errSave
Molecular architecture determines brain delivery of a transferrin receptor-targeted lysosomal enzyme
errJOURNAL OF EXPERIMENTAL MEDICINE
IF10.6
err2022-02-28
err33
errOAAI
errArguello, Annie; Mahon, Cathal S.; Calvert, Meredith E. K.; Chan, Darren; Dugas, Jason C.; Pizzo, Michelle E.; Thomsen, Elliot R.; Chau, Roni; Damo, Lorna A.; Duque, Joseph; Fang, Meng; Giese, Tina; Kim, Do Jin; Liang, Nicholas; Nguyen, Hoang N.; Solanoy, Hilda; Tsogtbaatar, Buyankhishig; Ullman, Julie C.; Wang, Junhua; Dennis, Mark S.; Diaz, Dolores; Gunasekaran, Kannan; Henne, Kirk R.; Lewcock, Joseph W.; Sanchez, Pascal E.; Troyer, Matthew D.; Harris, Jeffrey M.; Scearce-Levie, Kimberly; Shan, Lu; Watts, Ryan J.; Thorne, Robert G.; Henry, Anastasia G.; Kariolis, Mihalis S.
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Mitochondrial fission is a critical modulator of mutant APP-induced neural toxicity
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err2021-01-01
err16
errOAAI
errShields, Lauren Y.; Li, Huihui; Nguyen, Kevin; Kim, Hwajin; Doric, Zak; Garcia, Joseph H.; Gill, T. Michael; Haddad, Dominik; Vossel, Keith; Calvert, Meredith; Nakamura, Ken
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errSave
A molecular mechanism for probabilistic bet hedging and its role in viral latency
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2020-07-06
err15
errOAAI
errChaturvedi, Sonali; Klein, Jonathan; Vardi, Noam; Bolovan-Fritts, Cynthia; Wolf, Marie; Du, Kelvin; Mlera, Luwanika; Calvert, Meredith; Moorman, Nathaniel J.; Goodrum, Felicia; Huang, Bo; Weinberger, Leor S.
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errSave
Brain delivery of therapeutic proteins using an Fc fragment blood-brain barrier transport vehicle in mice and monkeys
errSCIENCE TRANSLATIONAL MEDICINE
IF14.6
err2020-05-27
err208
PREAI
errKariolis, Mihalis S.; Wells, Robert C.; Getz, Jennifer A.; Kwan, Wanda; Mahon, Cathal S.; Tong, Raymond; Kim, Jin; Srivastava, Ankita; Bedard, Catherine; Henne, Kirk R.; Giese, Tina; Assimon, Victoria A.; Chen, Xiaocheng; Zhang, Yin; Solanoy, Hilda; Jenkins, Katherine; Sanchez, Pascal E.; Kane, Lesley; Miyamoto, Takashi; Chew, Kylie S.; Pizzo, Michelle E.; Liang, Nicholas; Calvert, Meredith E. K.; DeVos, Sarah L.; Baskaran, Sulochanadevi; Hall, Sejal; Sweeney, Zachary K.; Thorne, Robert G.; Watts, Ryan J.; Dennis, Mark S.; Silverman, Adam P.; Zuchero, Y. Joy Yu
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A single H/ACA small nucleolar RNA mediates tumor suppression downstream of oncogenic RAS
errELIFE
IF0
err2019-09-03
err101
errOAAI
errMcMahon, Mary; Contreras, Adrian; Holm, Mikael; Uechi, Tamayo; Forester, Craig M.; Pang, Xiaming; Jackson, Cody; Calvert, Meredith E.; Chen, Bin; Quigley, David A.; Luk, John M.; Kelley, R. Kate; Gordan, John D.; Gill, Ryan M.; Blanchard, Scott C.; Ruggero, Davide
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errSave
Lightsheet fluorescence microscopy of branching human fetal kidney
errKIDNEY INTERNATIONAL
IF12.6
err2018-02-01
err9
errOAAI
errIsaacson, Dylan; Shen, Joel; McCreedy, Dylan; Calvert, Meredith; McDevitt, Todd; Cunha, Gerald; Baskin, Laurence
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Dichotomous Branching of Human Fetal Lung Demonstrated with Light Sheet Fluorescence Microscopy
errAMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
IF19.4
err2017-12-01
err5
errOAAI
errIsaacson, Dylan; Shen, Joel; McCreedy, Dylan; Calvert, Meredith; Cunha, Gerald; Baskin, Laurence
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errSave

Research Directions

No research directions
Co-authors
Cooperation Journals
C
Christian Haass
H-index: 135 · Papers: 665
D
Donald F. Hunt
H-index: 120 · Papers: 527
J
Jeffrey Shabanowitz
H-index: 112 · Papers: 392
G
Gerald R. Cunha
H-index: 103 · Papers: 475
T
Thomas M. Gill
H-index: 101 · Papers: 643
View more