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G

Gregory L. Challis

monash university

58H-index
216Paper Count
2.0WCitation Count
Published Papers 103
Publication Date
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A bacterial metabolite rewires fungal metabolism, triggering the hyphae-to-yeast transition
errCurrent Biology
IF7.5
err2026-08-19
err0
errOAAI
errManasa Bharathwaj; Vinzenz Hofferek; Angavai Swaminathan; Rachael Turner; Françios A.B. Olivier; Maalavikha Prabhakaran; Yu Zhang; Malcolm J. McConville; Gregory L. Challis; Traude H. Beilharz; Ana Traven
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errSave
Molecular basis for depsipeptide HDAC inhibitor combinatorial biosynthesis
errNature Communications
IF15.7
err2026-07-01
err0
errOAAI
errMunro Passmore; Xinyun Jian; Xinyi Zhao; Emmanuel L. C. de los Santos; Douglas M. Roberts; Józef R. Lewandowski; Matthew Jenner; Lona M. Alkhalaf; Gregory L. Challis
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Substrate Scope and Catalytic Mechanism of α; β-Epoxyketone Synthase EpnF Illuminated by In Situ Esterase-Mediated Deprotection
errACS Catalysis
IF13.1
err2026-06-25
err0
errOAAI
errCallum J. Bullock; Marlene L. Rothe; Joshua W. Cartwright; Munro Passmore; Alex J. Mullins; Fabrizio Alberti; Józef R. Lewandowski; Lona M. Alkhalaf; Gregory L. Challis
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PARAS: High-Accuracy Machine Learning of Substrate Specificities in Nonribosomal Peptide Synthetases
errJACS Au
IF8.7
err2026-04-10
err0
errOAAI
errBarbara R. Terlouw; Chuan Huang; David Meijer; José D. D. Cediel-Becerra; Ruolin He; Marlene L. Rothe; Matthew Jenner; Shanshan Zhou; Yu Zhang; Christopher D. Fage; Yuta Tsunematsu; Gilles P. van Wezel; Serina L. Robinson; Fabrizio Alberti; Lona M. Alkhalaf; Marc G. Chevrette; Gregory L. Challis; Marnix H. Medema
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Total Synthesis of iso-Gladiolin Methyl Ester (Lagriene Methyl Ester) via Catalytic Asymmetric C–C Coupling of Alcohols
errJournal of the American Chemical Society
IF15.6
err2026-02-18
err0
PREAI
errKatherine L. Verboom; Yoon Cho; James A. Duncan; Yu Zhang; Lona M. Alkhalaf; Gregory L. Challis; Michael J. Krische
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errSave
Trifunctional flavoenzyme-catalyzed asymmetric 4-alkyl-butenolide assembly in avenolide biosynthesis
errNature Communications
IF15.7
err2026-02-07
err0
errOAAI
errWenrui Li; Jinlian Zhao; Weibo Zeng; Ruifei Zhang; Lei Yan; Yuting Fan; Jiaxin Liu; Wenzhao Wang; Gregory L. Challis; Shanshan Zhou
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errSave
Discovery of Late Intermediates in Methylenomycin Biosynthesis Active against Drug-Resistant Gram-Positive Bacterial Pathogens
errJournal of the American Chemical Society
IF15.6
err2025-10-27
err0
errOAAI
errChristophe Corre; Gideon A. Idowu; Lijiang Song; Melanie E. Whitehead; Lona M. Alkhalaf; Gregory L. Challis
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errSave
Phosphine-Mediated (3 + 2) Cycloaddition of Electron-Poor Terminal Alkynes: A Concise Route to Premethylenomycin C Lactone
errThe Journal of Organic Chemistry
IF0
err2025-07-29
err0
PREAI
errAlexander I. Wright; Chenxi Zhang; Jing Cao; Yuji Nakano; Lucia Sánchez-Jiménez; Julia DeBono; Sankeert Kapatkar; Gregory L. Challis; David W. Lupton
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errSave
Teicoplanin Nonribosomal Peptide Synthetase Is Unable to Incorporate Alpha-Ketoacid Building Blocks
errBIOCHEMISTRY
IF3
err2025-04-11
err0
PREAI
errRatnayake, Minuri S.; Jian, Xinyun; Tailhades, Julien; Challis, Gregory L.; Hansen, Mathias H.; Lewandowski, Jozef R.; Cryle, Max J.
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Mode of Action and Mechanisms of Resistance to the Unusual Polyglycosylated Thiopeptide Antibiotic Persiathiacin A
errACS INFECTIOUS DISEASES
IF3.8
err2024-12-09
err0
PREAI
errWoodgate, Jason; Sumang, Felaine A.; Salliss, Mary E.; Belousoff, Matthew; Ward, Alan C.; Challis, Gregory L.; Zenkin, Nikolay; Errington, Jeff; Dashti, Yousef
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errSave
Molecular Basis for Short-Chain Thioester Hydrolysis by Acyl Hydrolases in trans-Acyltransferase Polyketide Synthases
errJACS AU
IF8.7
err2024-11-18
err1
errOAAI
errFage, Christopher D.; Passmore, Munro; Tatman, Ben P.; Smith, Helen G.; Jian, Xinyun; Dissanayake, Upeksha C.; Foran, Mia E.; Cisneros, G. Andres; Challis, Gregory L.; Lewandowski, Jozef R.; Jenner, Matthew
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Gladiolin produced by pathogenic Burkholderia synergizes with amphotericin B through membrane lipid rearrangements
errMBIO
IF4.7
err2024-11-13
err0
errOAAI
errSimm, Claudia; Lee, Tzong-Hsien; Weerasinghe, Harshini; Walsh, Dean; Nakou, Ioanna T.; Shankar, Madhu; Tse, Wai Chung; Zhang, Yu; Inman, Rebecca; Mulder, Roger J.; Harrison, Freya; Aguilar, Marie-Isabel; Challis, Gregory L.; Traven, Ana
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errSave
Discovery and Biosynthesis of Persiathiacins: Unusual Polyglycosylated Thiopeptides Active Against Multidrug Resistant Tuberculosis
errACS INFECTIOUS DISEASES
IF3.8
err2024-08-27
err1
errOAAI
errDashti, Yousef; Mohammadipanah, Fatemeh; Zhang, Yu; Cerqueira Diaz, Pietra M.; Vocat, Anthony; Zabala, Daniel; Fage, Christopher D.; Romero-Canelon, Isolda; Bunk, Boyke; Sproer, Cathrin; Alkhalaf, Lona M.; Overmann, Joerg; Cole, Stewart T.; Challis, Gregory L.
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errSave
Discovery and Biosynthesis of Streptolateritic Acids A-D: Acyclic Pentacarboxylic Acids from Streptomyces sp. FXJ1.172 with Promising Activity against Potato Common Scab
errJOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
IF6.2
err2024-06-20
err0
PREAI
errWang, Kairui; Liu, Ning; Liu, Minghao; Zhao, Pan; Zhong, Naiqin; Challis, Gregory L.; Huang, Ying
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errSave
Native ESI-MS and Collision-Induced Unfolding (CIU) of the Complex between Bacterial Elongation Factor-Tu and the Antibiotic Enacyloxin IIa
errJOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
IF2.7
err2024-06-03
err0
errOAAI
errBaines, Cameron; Sargeant, Jacob; Fage, Christopher D.; Pugh, Hannah; Alkhalaf, Lona M.; Challis, Gregory L.; Oldham, Neil J.
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errSave
Antibiotic Skeletal Diversification via Differential Enoylreductase Recruitment and Module Iteration in trans-Acyltransferase Polyketide Synthases
errJOURNAL OF THE AMERICAN CHEMICAL SOCIETY
IF15.6
err2024-02-23
err2
errOAAI
errJian, Xinyun; Pang, Fang; Hobson, Christian; Jenner, Matthew; Alkhalaf, Lona M.; Challis, Gregory L.
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Metagenomic domain substitution for the high-throughput modification of nonribosomal peptides
errNATURE CHEMICAL BIOLOGY
IF13.7
err2023-11-23
err9
errOAAI
errMessenger, Sarah R.; Mcguinniety, Edward M. R.; Stevenson, Luke J.; Owen, Jeremy G.; Challis, Gregory L.; Ackerley, David F.; Calcott, Mark J.
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Parallelized gene cluster editing illuminates mechanisms of epoxyketone proteasome inhibitor biosynthesis
errNUCLEIC ACIDS RESEARCH
IF13.1
err2023-01-31
err5
errOAAI
errHuang, Chuan; Zabala, Daniel; de los Santos, Emmanuel L. C.; Song, Lijiang; Corre, Christophe; Alkhalaf, Lona M.; Challis, Gregory L.
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Diene incorporation by a dehydratase domain variant in modular polyketide synthases
errNATURE CHEMICAL BIOLOGY
IF13.7
err2022-09-15
err2
errOAAI
errHobson, Christian; Jenner, Matthew; Jian, Xinyun; Griffiths, Daniel; Roberts, Douglas M.; Rey-Carrizo, Matias; Challis, Gregory L.
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errSave
Cloning and expression of Burkholderia polyyne biosynthetic gene clusters in Paraburkholderia hosts provides a strategy for biopesticide development
errMICROBIAL BIOTECHNOLOGY
IF5.2
err2022-07-13
err10
errOAAI
errPetrova, Yoana D.; Zhao, Jinlian; Webster, Gordon; Mullins, Alex J.; Williams, Katherine; Alswat, Amal S.; Challis, Gregory L.; Bailey, Andy M.; Mahenthiralingam, Eshwar
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Research Directions

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Co-authors
Cooperation Journals
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H-index: 177 · Papers: 1.1K
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R. Paul Ross
H-index: 154 · Papers: 1.1K
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Christopher T. Walsh
H-index: 144 · Papers: 852
G
Gordon Dougan
H-index: 144 · Papers: 952
J
Jon Clardy
H-index: 137 · Papers: 1.4K
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