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Hartmut Kühn

charité—university medicine berlin

72H-index
418Paper Count
1.7WCitation Count
Published Papers 164
Publication Date
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Structural Improvement of the Allosteric ALOX15 Inhibitor Octyl (N-(5-(1H-Indol-2-yl)-2-methoxyphenyl)sulfamoyl)carbamate
errMolecules
IF4.6
err2026-07-23
err0
errOAAI
errViktor Gavrilyuk; Vladislav Aksenov; Kirill Petrov; Angelina V. Kurchatova; Dmitriy Bortnevskij; Alexander Zhuravlev; Alexey Golovanov; Hartmut Kuhn; Igor Ivanov
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ALLOSTERIC PROPERTIES OF MAMMALIAN ALOX15 ORTHOLOGS
errJournal of Biological Chemistry
IF3.9
err2026-02-05
err0
errOAAI
errJiaxing Yang; Astrid Borchert; Hartmut Kuhn
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Oxidative Stress Mediated by Macrophages Promotes Angiogenesis and Early Development of Endometriosis
errAntioxidants
IF6.6
err2026-01-24
err0
errOAAI
errGene Chi Wai Man; Astrid Borchert; Tao Zhang; Sze Wan Hung; Hartmut Kühn; Chi Chiu Wang
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Exploring allosteric properties of mammalian ALOX15: octyl (N-(4-(benzofuran-2-yl)-2-methoxyphenyl)sulfamoyl)- and octyl (N-(4-(1H-indol-2-yl)-2-methoxyphenyl)sulfamoyl)carbamates as ALOX inhibitors
errRSC Adv.
IF4.6
err2025-09-22
err0
errOAAI
errViktor Gavrilyuk; Alejandro Cruz; Vladislav Aksenov; Danila Nurgaliev; Alexander Zhuravlev; Alexey Golovanov; José M. Lluch; Hartmut Kuhn; Igor Ivanov; Àngels González-Lafont
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Arachidonoyl-carnitine and arachidonoyl-coenzyme A are suitable substrates for mammalian ALOX isoforms.
errJournal of Lipid Research
IF4.1
err2025-07-17
err0
errOAAI
errXin Chen; Sahanawaz Parvez; Hannah F. Wiegand; Liuhui Wu; Sabine Stehling; Astrid Borchert; Junlin Yang; Polamarasetty Aparoy; Hartmut Kuhn
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The reaction specificity of mammalian ALOX15B orthologs does not depend on the evolutionary ranking of the animals
errJOURNAL OF LIPID RESEARCH
IF4.1
err2025-04-01
err0
errOAAI
errGuendem, Eda; Stehling, Sabine; Borchert, Astrid; Kuhn, Hartmut
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Eicosanoid biosynthesizing enzymes in Prototheria
errBIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
IF3.3
err2025-01-01
err0
errOAAI
errKakularam, Kumar R.; Guendem, Eda; Stehling, Sabine; Rothe, Michael; Heydeck, Dagmar; Kuhn, Hartmut
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Oral administration of butylated hydroxytoluene induces neuroprotection in a streptozotocin-induced rat Alzheimer's disease model via inhibition of neuronal ferroptosis
errMOLECULAR MEDICINE
IF6.4
err2024-11-08
err0
errOAAI
errFaraji, Parisa; Parandavar, Elham; Kuhn, Hartmut; Habibi-Rezaei, Mehran; Borchert, Astrid; Zahedi, Elham; Ahmadian, Shahin
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Butylated Hydroxytoluene (BHT) Protects SH-SY5Y Neuroblastoma Cells from Ferroptotic Cell Death: Insights from In Vitro and In Vivo Studies
errANTIOXIDANTS
IF6.6
err2024-02-17
err7
errOAAI
errFaraji, Parisa; Borchert, Astrid; Ahmadian, Shahin; Kuhn, Hartmut
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Impact of ACE I gene insertion/deletion, A-240T polymorphisms and the renin-angiotensin-aldosterone system on COVID-19 disease
errVIROLOGY JOURNAL
IF3.8
err2024-01-10
err5
errOAAI
errZobel, Christian M.; Kuhn, Hartmut; Schreiner, Maximilian; Wenzel, Werner; Wendtland, Jasper; Goekeri, Cengiz; Scheit, Lorenz; Oltmanns, Klaas; Rauschning, Dominic; Grossegesse, Marica; Hofmann, Natalie; Wirtz, Hubert; Spethmann, Sebastian
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Knock-in mice expressing a humanized arachidonic acid 15-lipoxygenase (Alox15) carry a partly dysfunctional erythropoietic system
errCELLULAR & MOLECULAR BIOLOGY LETTERS
IF10.2
err2023-11-29
err3
errOAAI
errReisch, Florian; Heydeck, Dagmar; Schaefer, Marjann; Rothe, Michael; Yang, Jiaxing; Stehling, Sabine; Pueschel, Gerhard P.; Kuhn, Hartmut
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Adipokines in cachexia of patients with lung cancer
errEUROPEAN RESPIRATORY JOURNAL
IF21
err2023-10-27
err1
PREAI
errHofmann, Lukas; Frommelt, Charlotte; Ossenberg, Malte; Oberhuber-Kurth, Jonas; Pappisch, Johanna; Kerkhoff, Teresa; Linder, Nicolas; Busse, Harald; Ebert, Thomas; Toenjes, Anke; Kraemer, Sebastian; Kuhn, Hartmut; Wirtz, Hubert; Frille, Armin
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Different Structures-Similar Effect: Do Substituted 5-(4-Methoxyphenyl)-1H-indoles and 5-(4-Methoxyphenyl)-1H-imidazoles Represent a Common Pharmacophore for Substrate Selective Inhibition of Linoleate Oxygenase Activity of ALOX15?
errMOLECULES
IF4.6
err2023-07-14
err1
errOAAI
errZhuravlev, Alexander; Cruz, Alejandro; Aksenov, Vladislav; Golovanov, Alexey; Lluch, Jose M.; Kuhn, Hartmut; Gonzalez-Lafont, Angels; Ivanov, Igor
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Novel Genetic Risk and Metabolic Signatures of Insulin Signaling and Androgenesis in the Anovulation of Polycystic Ovary Syndrome
errENGINEERING
IF11.6
err2023-04-01
err1
errOAAI
errWu, Xiaoke; Wang, Chi Chiu; Cao, Yijuan; Li, Jian; Li, Zhiqiang; Ma, Hongli; Gao, Jingshu; Chang, Hui; Zhang, Duojia; Cong, Jing; Wang, Yu; Wu, Qi; Han, Xiaoxiao; Chung, Pui Wah Jacqueline; Li, Yiran; Zheng, Xu; Chen, Lingxi; Zeng, Lin; Borchert, Astrid; Kuhn, Hartmut; Chen, Zi-Jiang; Ng, Ernest Hung Yu; Stener-Victorin, Elisabet; Zhang, Heping; Legro, Richard S.; Mol, Ben Willem J.; Shi, Yongyong
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Male guanine-rich RNA sequence binding factor 1 knockout mice (Grsf1-/-) gain less body weight during adolescence and adulthood
errCELL AND BIOSCIENCE
IF6.2
err2022-12-09
err4
errOAAI
errDumoulin, Bernhard; Heydeck, Dagmar; Jaehn, Desiree; Lasse, Moritz; Sofi, Sajad; Ufer, Christoph; Kuhn, Hartmut
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Structural and functional evaluation mammalian and plant lipoxygenases upon association with nanodics as membrane mimetics
errBIOPHYSICAL CHEMISTRY
IF2.2
err2022-09-01
err3
PREAI
errUlusan, Sinem; Sheraj, Ilir; Stehling, Sabine; Ivanov, Igor; Das, Aditi; Kuehn, Hartmut; Banerjee, Sreeparna
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Male Knock-in Mice Expressing an Arachidonic Acid Lipoxygenase 15B (Alox15B) with Humanized Reaction Specificity Are Prematurely Growth Arrested When Aging
errBIOMEDICINES
IF3.9
err2022-06-10
err13
errOAAI
errSchaefer, Marjann; Kakularam, Kumar R.; Reisch, Florian; Rothe, Michael; Stehling, Sabine; Heydeck, Dagmar; Pueschel, Gerhard P.; Kuhn, Hartmut
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N-Substituted 5-(1H-Indol-2-yl)-2-methoxyanilines Are Allosteric Inhibitors of the Linoleate Oxygenase Activity of Selected Mammalian ALOX15 Orthologs: Mechanism of Action
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2022-01-25
err7
errOAAI
errGolovanov, Alexey; Zhuravlev, Alexander; Cruz, Alejandro; Aksenov, Vladislav; Shafiullina, Rania; Kakularam, Kumar R.; Lluch, Jose M.; Kuhn, Hartmut; Gonzalez-Lafont, Angels; Ivanov, Igor
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Paralog- and ortholog-specificity of inhibitors of human and mouse lipoxygenase-isoforms
errBIOMEDICINE & PHARMACOTHERAPY
IF7.5
err2022-01-01
err8
errOAAI
errKakularam, Kumar Reddy; Karst, Felix; Polamarasetty, Aparoy; Ivanov, Igor; Heydeck, Dagmar; Kuhn, Hartmut
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Knock-In Mice Expressing a 15-Lipoxygenating Alox5 Mutant Respond Differently to Experimental Inflammation Than Reported Alox5-/- Mice
errMETABOLITES
IF3.7
err2021-10-12
err13
errOAAI
errMarbach-Breitrueck, Eugenia; Rohwer, Nadine; Infante-Duarte, Carmen; Romero-Suarez, Silvina; Labuz, Dominika; Machelska, Halina; Kutzner, Laura; Schebb, Nils Helge; Rothe, Michael; Reddanna, Pallu; Weylandt, Karsten H.; Wieler, Lothar H.; Heydeck, Dagmar; Kuhn, Hartmut
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Research Directions

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Co-authors
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Alan S. Go
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M
Michael Stümvoll
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