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Structure-based discovery of first inhibitors targeting the helicase activity of human PIF1 Wever, Mark J. A.; Scommegna, Francesca R.; Egea-Rodriguez, Sara; Dehghani-Tafti, Saba; Brandao-Neto, Jose; Poisson, Jean-Francois; Helfrich, Iris; Antson, Alfred A.; Rodeschini, Vincent; Bax, Ben; Roche, Didier; Sanders, Cyril M. Share Save
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Tyrosine 121 moves revealing a ligandable pocket that couples catalysis to ATP-binding in serine racemase Koulouris, Chloe R.; Gardiner, Sian E.; Harris, Tessa K.; Elvers, Karen T.; Roe, S. Mark; Gillespie, Jason A.; Ward, Simon E.; Grubisha, Olivera; Nicholls, Robert A.; Atack, John R.; Bax, Benjamin D. Share Save
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A new class of antibacterials, the imidazopyrazinones, reveal structural transitions involved in DNA gyrase poisoning and mechanisms of resistance (vol 46, pg 4114, 2018) Germe, Thomas; Voros, Judit; Jeannot, Frederic; Taillier, Thomas; Stavenger, Robert A.; Bacque, Eric; Maxwell, Anthony; Bax, Benjamin D. Share Save
A new class of antibacterials, the imidazopyrazinones, reveal structural transitions involved in DNA gyrase poisoning and mechanisms of resistance Germe, Thomas; Voros, Judit; Jeannot, Frederic; Taillier, Thomas; Stavenger, Robert A.; Bacque, Eric; Maxwell, Anthony; Bax, Benjamin D. Share Save
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From PIM1 to PI3Kδ via GSK3β: Target Hopping through the Kinome Henley, Zoe A.; Bax, Benjamin D.; Inglesby, Laura M.; Champigny, Aurelie; Gaines, Simon; Faulder, Paul; Le, Joelle; Thomas, Daniel A.; Washio, Yoshiaki; Baldwin, Ian R. Share Save
Thiophene antibacterials that allosterically stabilize DNA-cleavage complexes with DNA gyrase Chan, Pan F.; Germe, Thomas; Bax, Benjamin D.; Huang, Jianzhong; Thalji, Reema K.; Bacque, Eric; Checchia, Anna; Chen, Dongzhao; Cui, Haifeng; Ding, Xiao; Ingraham, Karen; McCloskey, Lynn; Raha, Kaushik; Srikannathasan, Velupillai; Maxwell, Anthony; Stavenger, Robert A. Share Save
Structural basis of DNA gyrase inhibition by antibacterial QPT-1, anticancer drug etoposide and moxifloxacin Chan, Pan F.; Srikannathasan, Velupillai; Huang, Jianzhong; Cui, Haifeng; Fosberry, Andrew P.; Gu, Minghua; Hann, Michael M.; Hibbs, Martin; Homes, Paul; Ingraham, Karen; Pizzollo, Jason; Shen, Carol; Shillings, Anthony J.; Spitzfaden, Claus E.; Tanner, Robert; Theobald, Andrew J.; Stavenger, Robert A.; Bax, Benjamin D.; Gwynn, Michael N. Share Save
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Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation Lewis, Huw D.; Liddle, John; Coote, Jim E.; Atkinson, Stephen J.; Barker, Michael D.; Bax, Benjamin D.; Bicker, Kevin L.; Bingham, Ryan P.; Campbell, Matthew; Chen, Yu Hua; Chung, Chun-Wa; Craggs, Peter D.; Davis, Rob P.; Eberhard, Dirk; Joberty, Gerard; Lind, Kenneth E.; Locke, Kelly; Maller, Claire; Martinod, Kimberly; Patten, Chris; Polyakova, Oxana; Rise, Cecil E.; Ruediger, Martin; Sheppard, Robert J.; Slade, Daniel J.; Thomas, Pamela; Thorpe, Jim; Yao, Gang; Drewes, Gerard; Wagner, Denisa D.; Thompson, Paul R.; Prinjha, Rab K.; Wilson, David M. Share Save
Protein Arginine Deiminase 2 Binds Calcium in an Ordered Fashion: Implications for Inhibitor Design Slade, Daniel J.; Fang, Pengfei; Dreyton, Christina J.; Zhang, Ying; Fuhrmann, Jakob; Rempel, Don; Bax, Benjamin D.; Coonrod, Scott A.; Lewis, Huw D.; Guo, Min; Gross, Michael L.; Thompson, Paul R. Share Save
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Crystallizing Membrane Proteins in the Lipidic Mesophase. Experience with Human Prostaglandin E2 Synthase 1 and an Evolving Strategy Li, Dianfan; Howe, Nicole; Dukkipati, Abhiram; Shah, Syed T. A.; Bax, Benjamin D.; Edge, Colin; Bridges, Angela; Hardwicke, Phil; Singh, Onkar M. P.; Giblin, Ged; Pautsch, Alexander; Pfau, Roland; Schnapp, Gisela; Wang, Meitian; Olieric, Vincent; Caffrey, Martin Share Save
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