Paul A.M. Michels - Publications, H-index & Citations

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Paul A.M. Michels

School of Biological Sciences

70H-index

376Paper Count

2.1WCitation Count

Published Papers 82

Publication Date

MicroRNAs during Echinococcus spp. infection: a comprehensive systematic review and implications for diagnosis and therapy

Parasites & Vectors

IF3.5

2026-07-23

OAAI

Maura Rojas-Pirela; Diego Andrade-Alviárez; Verónica Rojas; Christian Castillo; Alejandro Prieto-Rojas; Vanessa Rueda-Cala; Cristina Carbonell; Daniel Salete-Granado; Candy Pérez; María A. Pérez-Nieto; Paul A. M. Michels; Wilfredo Quiñones; Miguel Marcos; Ulrike Kemmerling

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Characterization of GH18 chitinase in Leishmania braziliensis: expression, structural insights, and implications for vaccine and therapeutic development

Biological Research

IF4.6

2026-04-16

OAAI

Maura Rojas-Pirela; Marirene Chacón-Arnaude; Cristóbal Lárez-Velásquez; María Verónica Rojas; Constanza Cardenas; Ana J. Cáceres; Luis-Antonio Corchete; Diego Andrade-Alviárez; Luis A. Prieto-Rojas; Daniel Salete-Granado; María Á. Pérez-Nieto; Wilfredo Quiñones; Paul A. M. Michels; Miguel Marcos

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Dysregulated Expression of Canonical and Non-Canonical Glycolytic Enzyme Isoforms in Peripheral Blood from Subjects with Alcohol Use Disorder and from Individuals with Acute Alcohol Consumption

Antioxidants 2025, Vol. 14, Page 1143

IF6.6

2025-09-22

OAAI

Maura Rojas-Pirela; Daniel Salete-Granado; Diego Andrade-Alviárez; Alejandro Prieto-Rojas; Cristina Rodríguez; María-Lourdes Aguilar-Sánchez; David Puertas-Miranda; María-Ángeles Pérez-Nieto; Vanessa Rueda-Cala; Candy Pérez; Wilfredo Quiñones; Paul A. M. Michels; Ángeles Almeida; Miguel Marcos

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Metabolomics study of 3-O-p-(Z/E)-coumaroyltormentic acid-treated Trypanosoma brucei brucei

INTERNATIONAL JOURNAL FOR PARASITOLOGY-DRUGS AND DRUG RESISTANCE

IF3.4

2025-06-10

OAAI

Lúcia Mamede; Fanta Fall; Madeline Vast; Kristelle Hughes; Giorgia Martelli; Francesco Caligiore; Bernadette Govaerts; Paul A.M. Michels; Michel Frédérich; Joëlle Quetin-Leclercq

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The glycosomal ATP-dependent phosphofructokinase of Trypanosoma brucei operates also in the gluconeogenic direction

PLOS BIOLOGY

IF7.2

2025-05-16

OAAI

Plazolles, Nicolas; Kulyk, Hanna; Cahoreau, Edern; Biran, Marc; Wargnies, Marion; Pineda, Erika; El Kadri, Mohammad; Rimoldi, Aline; Herve, Perrine; Asencio, Corinne; Riviere, Loic; Michels, Paul A. M.; Inaoka, Daniel; Tetaud, Emmanuel; Portais, Jean-Charles; Bringaud, Frederic

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Insights into biofilm-mediated mechanisms driving last-resort antibiotic resistance in clinical ESKAPE pathogens

Critical Reviews in Microbiology

IF5.1

2025-03-17

PREAI

Christina Shook Cheng Chong; Yin Yin Lau; Paul A. M. Michels; Crystale Siew Ying Lim

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First comprehensive untargeted metabolomics study of suramin-treated Trypanosoma brucei: an integrated data analysis workflow from multifactor data modelling to functional analysis

METABOLOMICS

IF3.3

2024-02-23

PREAI

Fall, Fanta; Mamede, Lucia; Vast, Madeline; De Tullio, Pascal; Hayette, Marie-Pierre; Michels, Paul A. M.; Frederich, Michel; Govaerts, Bernadette; Quetin-Leclercq, Joelle

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How much (ATP) does it cost to build a trypanosome? A theoretical study on the quantity of ATP needed to maintain and duplicate a bloodstream-form Trypanosoma brucei cell (vol 19, e1011522, 2023)

PLOS PATHOGENS

IF4.9

2023-08-30

OAAI

Nascimento, Janaina F.; Souza, Rodolpho O. O.; Alencar, Mayke B.; Marsiccobetre, Sabrina; Murillo, Ana M.; Damasceno, Flavia S.; Girard, Richard B. M. M.; Marchese, Leticia; Luevano-Martinez, Luis A.; Achjian, Renan W.; Haanstra, Jurgen R.; Michels, Paul A. M.; Silber, Ariel M.

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How much (ATP) does it cost to build a trypanosome? A theoretical study on the quantity of ATP needed to maintain and duplicate a bloodstream-form Trypanosoma brucei cell

PLOS PATHOGENS

IF4.9

2023-07-27

OAAI

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Evolution: 'Millefoglie' origin of mitochondrial cristae

CURRENT BIOLOGY

IF7.5

2023-03-01

OAAI

Michels, Paul A. M.; Ginger, Michael L.

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Trypanosoma brucei: Metabolomics for analysis of cellular metabolism and drug discovery

METABOLOMICS

IF3.3

2022-03-19

OAAI

Fall, Fanta; Mamede, Lucia; Schioppa, Laura; Ledoux, Allison; De Tullio, Pascal; Michels, Paul; Frederich, Michel; Quetin-Leclercq, Joelle

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Fast acting allosteric phosphofructokinase inhibitors block trypanosome glycolysis and cure acute African trypanosomiasis in mice

NATURE COMMUNICATIONS

IF15.7

2021-02-16

OAAI

McNae, Iain W.; Kinkead, James; Malik, Divya; Yen, Li-Hsuan; Walker, Martin K.; Swain, Chris; Webster, Scott P.; Gray, Nick; Fernandes, Peter M.; Myburgh, Elmarie; Blackburn, Elizabeth A.; Ritchie, Ryan; Austin, Carol; Wear, Martin A.; Highton, Adrian J.; Keats, Andrew J.; Vong, Antonio; Dornan, Jacqueline; Mottram, Jeremy C.; Michels, Paul A. M.; Pettit, Simon; Walkinshaw, Malcolm D.

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Biochemical and transcript level differences between the three human phosphofructokinases show optimisation of each isoform for specific metabolic niches

BIOCHEMICAL JOURNAL

IF4.3

2020-11-27

OAAI

Fernandes, Peter M.; Kinkead, James; McNae, Iain; Michels, Paul A. M.; Walkinshaw, Malcolm D.

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Kinetic and structural studies of Trypanosoma and Leishmania phosphofructokinases show evolutionary divergence and identify AMP as a switch regulating glycolysis versus gluconeogenesis

FEBS JOURNAL

IF4.2

2020-01-08

OAAI

Fernandes, Peter M.; Kinkead, James; McNae, Iain W.; Vasquez-Valdivieso, Monserrat; Wear, Martin A.; Michels, Paul A. M.; Walkinshaw, Malcolm D.

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Drug Target Selection for Trypanosoma cruzi Metabolism by Metabolic Control Analysis and Kinetic Modeling

CURRENT MEDICINAL CHEMISTRY

IF3.5

2019-12-13

PREAI

Saavedra, Emma; Gonzalez-Chavez, Zabdi; Moreno-Sanchez, Rafael; Michels, Paul A. M.

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Discovery of trypanocidal coumarins with dual inhibition of both the glycerol kinase and alternative oxidase of Trypanosoma brucei brucei

FASEB JOURNAL

IF4.2

2019-09-16

OAAI

Balogun, Emmanuel Oluwadare; Inaoka, Daniel Ken; Shiba, Tomoo; Tsuge, Chiaki; May, Benjamin; Sato, Tomohiro; Kido, Yasutoshi; Nara, Takeshi; Aoki, Takashi; Honma, Teruki; Tanaka, Akiko; Inoue, Masayuki; Matsuoka, Shigeru; Michels, Paul A. M.; Watanabe, Yoh-Ichi; Moore, Anthony L.; Harada, Shigeharu; Kita, Kiyoshi

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Gamma-glutamylcysteine synthetase and tryparedoxin 1 exert high control on the antioxidant system in Trypanosoma cruzi contributing to drug resistance and infectivity

REDOX BIOLOGY

IF11.9

2019-09-01

OAAI

Gonzalez-Chavez, Zabdi; Vazquez, Citlali; Mejia-Tlachi, Marlen; Marquez-Duenas, Claudia; Manning-Cela, Rebeca; Encalada, Rusely; Rodriguez-Enriquez, Sara; Michels, Paul A. M.; Moreno-Sanchez, Rafael; Saavedra, Emma

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The kinetic characteristics of human and trypanosomatid phosphofructokinases for the reverse reaction

BIOCHEMICAL JOURNAL

IF4.3

2019-01-18

OAAI

Fernandes, Peter M.; Kinkead, James; McNae, Iain W.; Bringaud, Frederic; Michels, Paul A. M.; Walkinshaw, Malcolm D.

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Redox regulation of pyruvate kinase M2 by cysteine oxidation and S-nitrosation

BIOCHEMICAL JOURNAL

IF4.3

2018-10-31

OAAI

Mitchell, Alice Rose; Yuan, Meng; Morgan, Hugh P.; McNae, Iain W.; Blackburn, Elizabeth A.; Le Bihan, Thierry; Homem, Rafael A.; Yu, Manda; Loake, Gary J.; Michels, Paul A.; Wear, Martin A.; Walkinshaw, Malcolm D.

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An allostatic mechanism for M2 pyruvate kinase as an amino-acid sensor

BIOCHEMICAL JOURNAL

IF4.3

2018-05-31

OAAI

Yuan, Meng; McNae, Iain W.; Chen, Yiyuan; Blackburn, Elizabeth A.; Wear, Martin A.; Michels, Paul A. M.; Fothergill-Gilmore, Linda A.; Hupp, Ted; Walkinshaw, Malcolm D.

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Research Directions