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KRASmulti inhibitor BI 3706674 shows efficacy in KRAS-driven preclinical models of cancer that supports clinical testing in patients with tumors harbouring KRASG12V mutations and KRAS wild-type amplifications Tedeschi, Antonio; Peng, David H.; Schischlik, Fiorella; Herdeis, Lorenz; Schaaf, Otmar; Santoro, Valeria; Gerlach, Daniel; Savarese, Fabio; Lipp, Jesse; Haslinger, Christian; Rocchetti, Francesca; Popow, Johannes; Huber, Heinrich J.; Wilding, Birgit; Treu, Matthias; Fuchs, Julian; Broeker, Joachim; Wunber, Tobias; Gmachl, Michael; Rumpel, Klaus; Rees, Matthew; Ron, Melissa; Roth, Jennifer; Williams, Mariah; Deckard, Charles; Ramamoorthy, Vandhana; Daniele, Joseph R.; Ajani, Jaffer A.; Meric-Bernstam, Funda; Kopetz, Scott; Kim, Michael; Gibbons, Don L.; Vellano, Christopher P.; Marszalek, Joseph R.; Heffernan, Timothy P.; McConnell, Darryl; Pearson, Mark; Kraut, Norbert; Rudolph, Dorothea Share Save
KRASmulti inhibitor BI 3706674, an orally bioavailable, direct inhibitor of diverse oncogenic KRAS variants drives tumor regression in KRASG12V-driven preclinical models Peng, David Hwa; Tedeschi, Antonio; Herdeis, Lorenz; Schaaf, Otmar; Savarese, Fabio; Rocchetti, Francesca; Popow, Johannes; Huber, Heinrich J.; Wilding, Birgit; Treu, Matthias; Fuchs, Julian; Broeker, Joachim; Wunberg, Tobias; Schischlik, Firoella; Lipp, Jesse; Williams, Mariah; Chandler, Vaness; Deckard, Charles E.; Ramamoorthy, Vandhana; Daniele, Joseph R.; Kopetz, Scott; Kim, Michael; Gibbons, Don L.; Vellano, Christopher P.; Marszalek, Joseph R.; Heffernan, TImothy P.; McConnell, Darryl; Pearson, Mark; Kraut, Norbert; Rudolph, Dorothea Share Save
SOS1 inhibition in combination with HER2 inhibition in models of HER2driven cancer Schenk, Robyn L.; Kostyrko, Kaja; Popow, Johannes; Gewinner, Christina; Baum, Anke; Albrecht, Christoph; Hinkel, Melanie; Jacob, Robin; Madensky, Tom; Ruzicka, Regina; Strauss, Eva; Lyu, Hengyu; Lopez, Anastasia M.; Feng, Ningping; Vellano, Christopher P.; Marszalek, Joseph R.; Heffernan, Timothy P.; Pearson, Mark; Hofmann, Marco H. Share Save
Development and characterisation of KRASmulti inhibitors for the treatment of KRAS mutant pancreatic ductal adenocarcinoma Tedeschi, Antonio; Schaaf, Otmar; Gmachl, Michael; Herdeis, Lorenz; Rocchetti, Francesca; Popow, Johannes; Schischlik, Fiorella; Gerlach, Daniel; Lipp, Jesse; Broker, Joachim; Mantoulidis, Andreas; Smethurst, Chris; Kessler, Dirk; Boettcher, Jark; Wunberg, Tobias; Santoro, Valeria; Waterson, Alex; Phan, Jason; Little, Andrew; Abbott, Jason; Sun, Qi; Fesik, Stephen; Mcconnell, Darryl; Pearson, Mark A.; Kraut, Norbert; Rudolph, Dorothea Share Save
Interrogation of cancer gene dependencies reveals paralog interactions of autosome and sex chromosome-encoded genes Koeferle, Anna; Schlattl, Andreas; Hoermann, Alexandra; Thatikonda, Venu; Popa, Alexandra; Spreitzer, Fiona; Ravichandran, Madhwesh C.; Supper, Verena; Oberndorfer, Sarah; Puchner, Teresa; Wieshofer, Corinna; Corcokovic, Maja; Reiser, Christoph; Woehrle, Simon; Popow, Johannes; Pearson, Mark; Martinez, Javier; Weitzer, Stefan; Mair, Barbara; Neumueller, Ralph A. Share Save
Highly Selective PTK2 Proteolysis Targeting Chimeras to Probe Focal Adhesion Kinase Scaffolding Functions Popow, Johannes; Arnhof, Heribert; Bader, Gerd; Berger, Helmut; Ciulli, Alessio; Covini, David; Dank, Christian; Gmaschitz, Teresa; Greb, Peter; Karolyi-Ozguer, Jale; Koegl, Manfred; McConnell, Darryl B.; Pearson, Mark; Rieger, Maria; Rinnenthal, Joerg; Roessler, Vanessa; Schrenk, Andreas; Spina, Markus; Steurer, Steffen; Trainor, Nicole; Traxler, Elisabeth; Wieshofer, Corinna; Zoephel, Andreas; Ettmayer, Peter Share Save
The novel BET bromodomain inhibitor BI 894999 represses super-enhancer-associated transcription and synergizes with CDK9 inhibition in AML Gerlach, Daniel; Tontsch-Grunt, Ulrike; Baum, Anke; Popow, Johannes; Scharn, Dirk; Hofmann, Marco H.; Engelhardt, Harald; Kaya, Onur; Beck, Janina; Schweifer, Norbert; Gerstberger, Thomas; Zuber, Johannes; Savarese, Fabio; Kraut, Norbert Share Save
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The mammalian tRNA ligase complex mediates splicing of XBP1 mRNA and controls antibody secretion in plasma cells Jurkin, Jennifer; Henkel, Theresa; Nielsen, Anne Faerch; Minnich, Martina; Popow, Johannes; Kaufmann, Therese; Heindl, Katrin; Hoffmann, Thomas; Busslinger, Meinrad; Martinez, Javier Share Save
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A transcription factor-based mechanism for mouse heterochromatin formation (vol 19, pg 1023, 2012) Bulut-Karslioglu, Aydan; Perrera, Valentina; Scaranaro, Manuela; de la Rosa-Velazquez, Inti Alberto; van de Nobelen, Suzanne; Shukeir, Nicholas; Popow, Johannes; Gerle, Borbala; Opravil, Susanne; Pagani, Michaela; Meidhof, Simone; Brabletz, Thomas; Manke, Thomas; Lachner, Monika; Jenuwein, Thomas Share Save
A transcription factor-based mechanism for mouse heterochromatin formation Bulut-Karslioglu, Aydan; Perrera, Valentina; Scaranaro, Manuela; de la Rosa-Velazquez, Inti Alberto; van de Nobelen, Suzanne; Shukeir, Nicholas; Popow, Johannes; Gerle, Borbala; Opravil, Susanne; Pagani, Michaela; Meidhof, Simone; Brabletz, Thomas; Manke, Thomas; Lachner, Monika; Jenuwein, Thomas Share Save
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