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Annika Spottke

University Hospital Bonn and German Center for Neurodegenerative Diseases

51H-index
382Paper Count
1.0WCitation Count
Published Papers 104
Publication Date
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CSF biomarkers of neuroinflammation are associated with regional atrophy
errJournal of Neurology
IF4.6
err2025-12-24
err0
errOAAI
errSerap Özlü; Martin Dyrba; Alice Grazia; Frederic Brosseron; Katharina Buerger; Peter Dechent; Emrah Düzel; Michael Ewers; Klaus Fliessbach; Wenzel Glanz; Niels Hansen; Julian Hellmann-Regen; Stefan Hetzer; Daniel Janowitz; Ingo Kilimann; Marie Kronmüller; Christoph Laske; Falk Lüsebrink; David Mengel; Robert Perneczky; Oliver Peters; Josef Priller; Alfredo Ramirez; Boris-Stephan Rauchmann; Ayda Rostamzadeh; Anja Schneider; Sebastian Sodenkamp; Annika Spottke; Eike Jakob Spruth; Matthis Synofzik; Jens Wiltfang; Michael T Heneka; Frank Jessen; Stefan Teipel
errShare
errSave
An unsupervised XAI framework for dementia detection with context enrichment
errScientific Reports
IF3.9
err2025-11-12
err0
errOAAI
errDevesh Singh; Yusuf Brima; Fedor Levin; Martin Becker; Bjarne Hiller; Andreas Hermann; Irene Villar-Munoz; Lukas Beichert; Alexander Bernhardt; Katharina Buerger; Michaela Butryn; Peter Dechent; Emrah Düzel; Michael Ewers; Klaus Fliessbach; Silka D. Freiesleben; Wenzel Glanz; Stefan Hetzer; Daniel Janowitz; Doreen Görß; Ingo Kilimann; Okka Kimmich; Christoph Laske; Johannes Levin; Andrea Lohse; Falk Luesebrink; Matthias Munk; Robert Perneczky; Oliver Peters; Lukas Preis; Josef Priller; Johannes Prudlo; Diana Prychynenko; Boris S. Rauchmann; Ayda Rostamzadeh; Nina Roy-Kluth; Klaus Scheffler; Anja Schneider; Louise Droste zu Senden; Björn H. Schott; Annika Spottke; Matthis Synofzik; Jens Wiltfang; Frank Jessen; Marc-André Weber; Stefan J. Teipel; Martin Dyrba
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errSave
Brain Atrophy Does Not Predict Clinical Progression in Progressive Supranuclear Palsy
errMovement Disorders
IF7.6
err2025-08-30
err0
errOAAI
errAndrea Quattrone MD, PhD; Nicolai Franzmeier PhD; Hans-Jürgen Huppertz MD; Nicholas Seneca PhD; Gabor C. Petzold MD; Annika Spottke MD; Johannes Levin MD; Johannes Prudlo MD; Emrah Düzel MD, PhD; the PASSPORT Study Group, the AL-108-231 Investigators, the Arise Investigators, the Tauros MRI Investigators, the DESCRIBE-PSP group; Günter U. Höglinger MD
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Risk factors for dementia and cognitive impairment within 5 years after stroke: a prospective multicentre cohort study
errlancet regional health europe
IF0
err2025-08-19
err0
PREAI
errJule Filler; Marios K. Georgakis; Daniel Janowitz; Marco Duering; Rong Fang; Anna Dewenter; Felix J. Bode; Sebastian Stoesser; Christine Kindler; Peter Hermann; Christian H. Nolte; Thomas G. Liman; Lucia Kerti; Kathleen Bernkopf; Benno Ikenberg; Wenzel Glanz; Michael Wagner; Annika Spottke; Karin Waegemann; Michael Goertler; Silke Wunderlich; Matthias Endres; Inga Zerr; Gabor C. Petzold; Martin Dichgans
errShare
errSave
SMAS: Structural MRI-based AD Score using Bayesian supervised VAE
errComputers in Biology and Medicine
IF6.3
err2025-08-15
err0
errOAAI
errA. Nemali; J. Bernal; R. Yakupov; Singh D.; M. Dyrba; E.I. Incesoy; S. Mukherjee; O. Peters; E. Ersözlü; J. Hellmann-Regen; L. Preis; J. Priller; E. Spruth; S. Altenstein; A. Lohse; A. Schneider; K. Fliessbach; O. Kimmich; J. Wiltfang; N. Hansen; B. Schott; A. Rostamzadeh; W. Glanz; M. Butryn; K. Buerger; D. Janowitz; M. Ewers; R. Perneczky; B. Rauchmann; S. Teipel; I. Kilimann; D. Goerss; C. Laske; S. Sodenkamp; A. Spottke; M. Coenjaerts; F. Brosseron; F. Lüsebrink; P. Dechent; K. Scheffler; S. Hetzer; L. Kleineidam; M. Stark; F. Jessen; E. Duzel; G. Ziegler
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errSave
Circulating cytokine levels and 5-year vascular recurrence after stroke: A multicenter prospective cohort study
errEuropean Stroke Journal
IF4.5
err2025-08-11
err0
errOAAI
errLanyue Zhang; Mohamad Ali Antabi; Jana Mattar; Omar El Bounkari; Rong Fang; Karin Waegemann; Felix J Bode; Sebastian Stösser; Peter Hermann; Thomas G Liman; Christian H Nolte; Benno Ikenberg; Kathleen Bernkopf; Wenzel Glanz; Daniel Janowitz; Annika Spottke; Michael Wolfgang Görtler; Silke Wunderlich; Inga Zerr; Gabor C Petzold; Matthias Endres; Jürgen Bernhagen; Martin Dichgans; Marios K Georgakis
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Progression to Parkinson's dementia is not modulated by genetic risk variants for Alzheimer's or Parkinson's disease
errJournal of Parkinson’s Disease
IF0
err2025-07-30
err0
errOAAI
errKayenat Parveen; J Alexander Ross; Hendrik van der Wurp; Monika Balzer-Geldsetzer; Daniela Berg; Günther Deuschl; Thomas Gasser; Rüdiger Hilker-Roggendorf; Elke Kalbe; Inga Liepelt-Scarfone; Brit Mollenhauer; Oliver Riedel; Sandra Röske; Jörg B Schulz; Annika Spottke; Alexander Storch; Claudia Trenkwalder; Jan Kassubek; Karsten Witt; Richard Dodel; Ullrich Wüllner; Alfredo Ramirez; Maria Carolina Dalmasso
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errSave
Associations between digital speech features of automated cognitive tasks and trajectories of brain atrophy and cognitive decline in early Alzheimer's disease
errJournal of Alzheimer’s Disease
IF3.1
err2025-07-20
err0
PREAI
errQingyue Li; Stefanie Koehler; Alexandra Koenig; Martin Dyrba; Elisa Mallik; Nicklas Linz; Josef Priller; Eike Spruth; Slawek Altenstein; Jens Wiltfang; Inga Zerr; Claudia Bartels; Franziska Maier; Ayda Rostamzadeh; Emrah Duezel; Wenzel Glanz; Enise I Incesoy; Michaela Butryn; Christoph Laske; Sebastian Sodenkamp; Matthias HJ Munk; Bjoern Falkenburger; Antje Osterrath; Ingo Kilimann; Melina Stark; Luca Kleineidam; Michael T Heneka; Annika Spottke; Michael Wagner; Frank Jessen; Gabor C Petzold; Fedor Levin; Stefan Teipel
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errSave
Speech-based digital cognitive assessments for detection of mild cognitive impairment: Validation against paper-based neurocognitive assessment scores
errJournal of Alzheimer’s Disease
IF3.1
err2025-05-25
err0
PREAI
errZampeta-Sofia Alexopoulou; Stefanie Köhler; Elisa Mallick; Johannes Tröger; Nicklas Linz; Eike Spruth; Klaus Fliessbach; Claudia Bartels; Ayda Rostamzadeh; Wenzel Glanz; Enise I Incesoy; Michaela Butryn; Ingo Kilimann; Sebastian Sodenkamp; Matthias HJ Munk; Antje Osterrath; Anna Esser; Sandra Roeske; Ingo Frommann; Melina Stark; Luca Kleineidam; Annika Spottke; Josef Priller; Anja Schneider; Jens Wiltfang; Frank Jessen; Emrah Düzel; Bjoern Falkenburger; Michael Wagner; Christoph Laske; Valeria Manera; Stefan Teipel; Alexandra König
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errSave
Fully automated MRI-based analysis of the locus coeruleus in aging and Alzheimer's disease dementia using ELSI-Net
errALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING
IF4.4
err2025-05-12
err0
errOAAI
errDuennwald, M; Krohn, F; Sciarra, A; Sarkar, M; Schneider, A; Fliessbach, K; Kimmich, O; Jessen, F; Rostamzadeh, A; Glanz, W; Incesoy, EI; Teipel, S; Kilimann, I; Goerss, D; Spottke, A; Brustkern, J; Heneka, MT; Brosseron, F; Lüsebrink, F; Haemmerer, D; Düzel, E; Tönnies, K; Oeltze-Jafra, S; Betts, MJ
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errSave
A computational ontology framework for the synthesis of multi-level pathology reports from brain MRI scans
errJOURNAL OF ALZHEIMERS DISEASE
IF3.1
err2025-04-01
err0
PREAI
errSingh, Devesh; Grazia, Alice; Reiz, Achim; Hermann, Andreas; Altenstein, Slawek; Beichert, Lukas; Bernhardt, Alexander; Buerger, Katharina; Butryn, Michaela; Dechent, Peter; Duezel, Emrah; Ewers, Michael; Fliessbach, Klaus; Freiesleben, Silka D.; Glanz, Wenzel; Hetzer, Stefan; Janowitz, Daniel; Kilimann, Ingo; Kimmich, Okka; Laske, Christoph; Levin, Johannes; Lohse, Andrea; Luesebrink, Falk; Munk, Matthias; Perneczky, Robert; Peters, Oliver; Preis, Lukas; Priller, Josef; Prudlo, Johannes; Rauchmann, Boris S.; Rostamzadeh, Ayda; Roy-Kluth, Nina; Scheffler, Klaus; Schneider, Anja; Schneider, Luisa S.; Schott, Bjoern H.; Spottke, Annika; Spruth, Eike J.; Synofzik, Matthis; Wiltfang, Jens; Jessen, Frank; Teipel, Stefan J.; Dyrba, Martin
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errSave
Linking higher amyloid beta 1-38 (Aβ(1-38)) levels to reduced Alzheimer's disease progression risk
errALZHEIMERS & DEMENTIA
IF11.1
err2025-01-27
err0
errOAAI
errSchneider, LS; Freiesleben, SD; van Breukelen, G; Wang, X; Brosseron, F; Heneka, MT; Teipel, S; Kleineidam, L; Stark, M; Roy-Kluth, N; Wagner, M; Spottke, A; Schmid, M; Roeske, S; Laske, C; Munk, MH; Perneczky, R; Rauchmann, BS; Buerger, K; Janowitz, D; Duezel, E; Glanz, W; Jessen, F; Rostamzadeh, A; Wiltfang, J; Bartels, C; Kilimann, I; Schneider, A; Fliessbach, K; Priller, J; Spruth, EJ; Hellmann-Regen, J; Peters, O
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errSave
Environmental enrichment is associated with favorable memory-related functional brain activity patterns in older adults
errFRONTIERS IN AGING NEUROSCIENCE
IF4.5
err2024-12-24
err0
errOAAI
errHass, Simon; Liebscher, Maxie; Richter, Anni; Fliessbach, Klaus; Laske, Christoph; Sodenkamp, Sebastian; Peters, Oliver; Hellmann-Regen, Julian; Ersoezlue, Ersin; Priller, Josef; Spruth, Eike Jakob; Altenstein, Slawek; Roeske, Sandra; Schneider, Anja; Schuetze, Hartmut; Spottke, Annika; Esser, Anna; Teipel, Stefan; Kilimann, Ingo; Wiltfang, Jens; Rostamzadeh, Ayda; Glanz, Wenzel; Incesoy, Enise I.; Luesebrink, Falk; Dechent, Peter; Hetzer, Stefan; Scheffler, Klaus; Wagner, Michael; Jessen, Frank; Duezel, Emrah; Gloeckner, Franka; Schott, Bjoern Hendrik; Wirth, Miranka; Klimecki, Olga; DELCODE Study Grp
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errSave
Locus coeruleus signal intensity and emotion regulation in agitation in Alzheimer's disease
errBRAIN COMMUNICATIONS
IF4.5
err2024-12-17
err0
errOAAI
errLiu, Kathy Y.; Betts, Matthew J.; Haemmerer, Dorothea; Duezel, Emrah; Mather, Mara; Roiser, Jonathan P.; Schneider, Anja; Spottke, Annika; Rostamzadeh, Ayda; Schott, Bjoern H.; Rauchmann, Boris-Stephan; Laske, Christoph; Janowitz, Daniel; Spruth, Eike J.; Ersoezlue, Ersin; Luesebrink, Falk; Jessen, Frank; Frommann, Ingo; Kilimann, Ingo; Wiltfang, Jens; Brustkern, Johanna; Priller, Josef; Hellman-Regen, Julian; Buerger, Katharina; Fliessbach, Klaus; Scheffler, Klaus; Kleineidam, Luca; Stark, Melina; Ewers, Michael; Wagner, Michael; Peters, Oliver; Dechent, Peter; Perneczky, Robert; Sodenkamp, Sebastian; Hetzer, Stefan; Teipel, Stefan; Glanz, Wenzel; Howard, Robert
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errSave
Artificial intelligence-based rapid brain volumetry substantially improves differential diagnosis in dementia
errALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING
IF4.4
err2024-12-11
err0
errOAAI
errRudolph, Jan; Rueckel, Johannes; Doepfert, Joerg; Ling, Wen Xin; Opalka, Jens; Brem, Christian; Hesse, Nina; Ingenerf, Maria; Koliogiannis, Vanessa; Solyanik, Olga; Hoppe, Boj F.; Zimmermann, Hanna; Flatz, Wilhelm; Forbrig, Robert; Patzig, Maximilian; Rauchmann, Boris-Stephan; Perneczky, Robert; Peters, Oliver; Priller, Josef; Schneider, Anja; Fliessbach, Klaus; Hermann, Andreas; Wiltfang, Jens; Jessen, Frank; Duezel, Emrah; Buerger, Katharina; Teipel, Stefan; Laske, Christoph; Synofzik, Matthis; Spottke, Annika; Ewers, Michael; Dechent, Peter; Haynes, John-Dylan; Levin, Johannes; Liebig, Thomas; Ricke, Jens; Ingrisch, Michael; Stoecklein, Sophia
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errSave
Blood-based quantification of Aβ oligomers indicates impaired clearance from brain in ApoE ε4 positive subjects
errCOMMUNICATIONS MEDICINE
IF6.3
err2024-12-10
err1
errOAAI
errBloemeke, Lara; Rehn, Fabian; Pils, Marlene; Kraemer-Schulien, Victoria; Cousin, Anneliese; Kutzsche, Janine; Bujnicki, Tuyen; Freiesleben, Silka D.; Schneider, Luisa-Sophie; Preis, Lukas; Priller, Josef; Spruth, Eike J.; Altenstein, Slawek; Schneider, Anja; Fliessbach, Klaus; Wiltfang, Jens; Hansen, Niels; Rostamzadeh, Ayda; Duezel, Emrah; Glanz, Wenzel; Incesoy, Enise I.; Buerger, Katharina; Janowitz, Daniel; Ewers, Michael; Perneczky, Robert; Rauchmann, Boris-Stephan; Teipel, Stefan; Kilimann, Ingo; Laske, Christoph; Munk, Matthias H.; Spottke, Annika; Roy, Nina; Heneka, Michael T.; Brosseron, Frederic; Wagner, Michael; Roeske, Sandra; Ramirez, Alfredo; Schmid, Matthias; Jessen, Frank; Bannach, Oliver; Peters, Oliver; Willbold, Dieter
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errSave
Perivascular space enlargement accelerates in ageing and Alzheimer's disease pathology: evidence from a three-year longitudinal multicentre study
errALZHEIMERS RESEARCH & THERAPY
IF7.6
err2024-10-31
err1
errOAAI
errMenze, Inga; Bernal, Jose; Kaya, Pinar; Aki, Cagla; Pfister, Malte; Geisendoerfer, Jonas; Yakupov, Renat; Coello, Roberto Duarte; Valdes-Hernandez, Maria d. C.; Heneka, Michael T.; Brosseron, Frederic; Schmid, Matthias C.; Glanz, Wenzel; Incesoy, Enise I.; Butryn, Michaela; Rostamzadeh, Ayda; Meiberth, Dix; Peters, Oliver; Preis, Lukas; Lammerding, Dominik; Gref, Daria; Priller, Josef; Spruth, Eike J.; Altenstein, Slawek; Lohse, Andrea; Hetzer, Stefan; Schneider, Anja; Fliessbach, Klaus; Kimmich, Okka; Vogt, Ina R.; Wiltfang, Jens; Bartels, Claudia; Schott, Bjoern H.; Hansen, Niels; Dechent, Peter; Buerger, Katharina; Janowitz, Daniel; Perneczky, Robert; Rauchmann, Boris-Stephan; Teipel, Stefan; Kilimann, Ingo; Goerss, Doreen; Laske, Christoph; Munk, Matthias H.; Sanzenbacher, Carolin; Hinderer, Petra; Scheffler, Klaus; Spottke, Annika; Roy-Kluth, Nina; Luesebrink, Falk; Neumann, Katja; Wardlaw, Joanna; Jessen, Frank; Schreiber, Stefanie; Duezel, Emrah; Ziegler, Gabriel
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errSave
Longitudinal evidence for a mutually reinforcing relationship between white matter hyperintensities and cortical thickness in cognitively unimpaired older adults
errALZHEIMERS RESEARCH & THERAPY
IF7.6
err2024-10-28
err0
errOAAI
errBernal, Jose; Menze, Inga; Yakupov, Renat; Peters, Oliver; Hellmann-Regen, Julian; Freiesleben, Silka Dawn; Priller, Josef; Spruth, Eike Jakob; Altenstein, Slawek; Schneider, Anja; Fliessbach, Klaus; Wiltfang, Jens; Schott, Bjoern H.; Jessen, Frank; Rostamzadeh, Ayda; Glanz, Wenzel; Incesoy, Enise I.; Buerger, Katharina; Janowitz, Daniel; Ewers, Michael; Perneczky, Robert; Rauchmann, Boris-Stephan; Teipel, Stefan; Kilimann, Ingo; Laske, Christoph; Sodenkamp, Sebastian; Spottke, Annika; Esser, Anna; Luesebrink, Falk; Dechent, Peter; Hetzer, Stefan; Scheffler, Klaus; Schreiber, Stefanie; Duezel, Emrah; Ziegler, Gabriel
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errSave
Risk factors and clinical significance of post-stroke incident ischemic lesions
errALZHEIMERS & DEMENTIA
IF11.1
err2024-10-17
err0
errOAAI
errFang, Rong; Duering, Marco; Bode, Felix J.; Stoesser, Sebastian; Meissner, Julius N.; Hermann, Peter; Liman, Thomas G.; Nolte, Christian H.; Kerti, Lucia; Ikenberg, Benno; Bernkopf, Kathleen; Glanz, Wenzel; Janowitz, Daniel; Wagner, Michael; Neumann, Katja; Speck, Oliver; Duezel, Emrah; Gesierich, Benno; Dewenter, Anna; Spottke, Annika; Waegemann, Karin; Goertler, Michael; Wunderlich, Silke; Zerr, Inga; Petzold, Gabor C.; Endres, Matthias; Georgakis, Marios K.; Dichgans, Martin
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errSave
Automated remote speech-based testing of individuals with cognitive decline: Bayesian agreement of transcription accuracy
errALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING
IF4.4
err2024-10-06
err0
errOAAI
errKoenig, Alexandra; Koehler, Stefanie; Troeger, Johannes; Duezel, Emrah; Glanz, Wenzel; Butryn, Michaela; Mallick, Elisa; Priller, Josef; Altenstein, Slawek; Spottke, Annika; Kimmich, Okka; Falkenburger, Bjoern; Osterrath, Antje; Wiltfang, Jens; Bartels, Claudia; Kilimann, Ingo; Laske, Christoph; Munk, Matthias H.; Roeske, Sandra; Frommann, Ingo; Hoffmann, Daniel C.; Jessen, Frank; Wagner, Michael; Linz, Nicklas; Teipel, Stefan
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Research Directions

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Co-authors
Cooperation Journals
A
André G. Uitterlinden
H-index: 234 · Papers: 2.0K
J
John C. Morris
H-index: 212 · Papers: 2.4K
B
Bruce M. Psaty
H-index: 207 · Papers: 1.8K
B
Børge G. Nordestgaard
H-index: 192 · Papers: 1.8K
V
Vilmundur Guðnason
H-index: 189 · Papers: 1.4K
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