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SaveShare Save Isoform-selective TGF-β3 inhibition for systemic sclerosisSun, Tianhe; Heiden, Jason A. Vander; Gao, Xia; Yin, Jianping; Uttarwar, Salil; Liang, Wei -Ching; Jia, Guiquan; Yadav, Rajbharan; Huang, Zhiyu; Mitra, Mayurranjan; Halpern, Wendy; Bender, Hannah S.; Brightbill, Hans D.; Wu, Yan; Lupardus, Patrick; Ramalingam, Thirumalai; Arron, Joseph R. Share Save Dual antibody inhibition of KLK5 and KLK7 for Netherton syndrome and atopic dermatitisChavarria-Smith, Joseph; Chiu, Cecilia P. 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Share Save Massive antibody discovery used to probe structure-function relationships of the essential outer membrane protein LptDStorek, Kelly M.; Chan, Joyce; Vij, Rajesh; Chiang, Nancy; Lin, Zhonghua; Bevers, Jack, III; Koth, Christopher M.; Vernes, Jean-Michel; Meng, Y. Gloria; Yin, JianPing; Wallweber, Heidi; Dalmas, Olivier; Shriver, Stephanie; Tam, Christine; Schneider, Kellen; Seshasayee, Dhaya; Nakamura, Gerald; Smith, Peter A.; Payandeh, Jian; Koerber, James T.; Comps-Agrae, Laetitia; Rutherford, Steven T. Share Save ERK mutations and amplification confer resistance to ERK-inhibitor therapyJaiswal, Bijay S.; Durinck, Steffen; Stawiski, Eric W.; Yin, Jianping; Wang, Weiru; Lin, Eva; Moffat, John; Martin, Scott E.; Modrusan, Zora; Seshagiri, Somasekar Share Save Selective Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12) with Activity in a Model of Alzheimer's DiseasePatel, Snahel; Meilandt, William J.; Erickson, Rebecca I.; Chen, Jinhua; Deshmukh, Gauri; Estrada, Anthony A.; Fuji, Reina N.; Gibbons, Paul; Gustafson, Amy; Harris, Seth F.; Imperio, Jose; Liu, Wendy; Liu, Xingrong; Liu, Yichin; Lyssikatos, Joseph P.; Ma, Changyou; Yin, Jianping; Lewcock, Joseph W.; Siu, Michael Share Save Activation mechanism of oncogenic C-helix shifting mutations in BRAF, EGFR, and HER2Foster, Scott; Whalen, Dan; Ozen, Aysegul; Wongchenko, Matt; Yin, JianPing; Yen, Ivana; Schaefer, Gabriele; Mayfield, John; Chmielecki, Juliann; Stephens, Phil; Albacker, Lee; Yan, Yibing; Song, Kyung; Hatzivassiliou, Georgia; Eigenbrot, Charles; Yu, Christine; Shaw, Andrey; Manning, Gerard; Skelton, Nicholas; Hymowitz, Sarah; Malek, Shiva Share Save Discovery of (S)-1-(1-(4-Chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one (GDC-0994), an Extracellular Signal-Regulated Kinase 1/2 (ERK1/2) Inhibitor in Early Clinical DevelopmentBlake, James F.; Burkard, Michael; Chan, Jocelyn; Chen, Huifen; Chou, Kang-Jye; Diaz, Dolores; Dudley, Danette A.; Gaudino, John J.; Gould, Stephen E.; Grina, Jonas; Hunsaker, Thomas; Liu, Lichuan; Martinson, Matthew; Moreno, David; Mueller, Lars; Orr, Christine; Pacheco, Patricia; Qin, Ann; Rasor, Kevin; Ren, Li; Robarse, Kirk; Shahidi-Latham, Sheerin; Stults, Jeffrey; Sullivan, Francis; Wang, Weiru; Yin, Jianping; Zhou, Aihe; Belvin, Marcia; Merchant, Mark; Moffat, John; Schwarz, Jacob B. Share Save Scaffold-Hopping and Structure-Based Discovery of Potent, Selective, And Brain Penetrant N-(1H-Pyrazol-3-yl)pyridin-2-amine Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12)Patel, Snahel; Harris, Seth F.; Gibbons, Paul; Deshmukh, Gauri; Gustafson, Amy; Kellar, Terry; Lin, Han; Liu, Xingrong; Liu, Yanzhou; Liu, Yichin; Ma, Changyou; Scearce-Levie, Kimberly; Ghosh, Arundhati Sengupta; Shin, Young G.; Solanoy, Hilda; Wang, Jian; Wang, Bei; Yin, Jianping; Siu, Michael; Lewcock, Joseph W. Share Save Discovery of Highly Potent, Selective, and Efficacious Small Molecule Inhibitors of ERK1/2Ren, Li; Grina, Jonas; Moreno, David; Blake, James F.; Gaudino, John J.; Garrey, Rustam; Metcalf, Andrew T.; Burkard, Michael; Martinson, Matthew; Rasor, Kevin; Chen, Huifen; Dean, Brian; Gould, Stephen E.; Pacheco, Patricia; Shahidi-Latham, Sheerin; Yin, Jianping; West, Kristina; Wang, Weiru; Moffat, John G.; Schwarz, Jacob B. Share Save Share Save Phosphorylation-dependent activity of the deubiquitinase DUBAHuang, Oscar W.; Ma, Xiaolei; Yin, JianPing; Flinders, Jeremy; Maurer, Till; Kayagaki, Nobuhiko; Phung, Qui; Bosanac, Ivan; Arnott, David; Dixit, Vishva M.; Hymowitz, Sarah G.; Starovasnik, Melissa A.; Cochran, Andrea G. Share Save Structural and Functional Analysis of a C3b-specific Antibody That Selectively Inhibits the Alternative Pathway of ComplementKatschke, Kenneth J., Jr.; Stawicki, Scott; Yin, Jianping; Steffek, Micah; Xi, Hongkang; Sturgeon, Lizette; Hass, Philip E.; Loyet, Kelly M.; DeForge, Laura; Wu, Yan; Campagne, Menno van Lookeren; Wiesmann, Christian Share Save Lymphotoxin-α β heterotrimers are shed from the surface of activated human lymphocytes and circulate in human serumYoung, Judy; Nguyen, Allen; Yu, Xin; Chiang, Eugene; Corpuz, Racquel; Yin, JianPing; Kung, Catherine; Vandien, Richard; Yansura, Dan; DeForge, Laura; Wong, Wai Lee; Grogan, Jane Share Save 
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