Emmanuel J. H. J. Wiertz - Publications, H-index & Citations

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Emmanuel J. H. J. Wiertz

Utrecht University

58H-index

184Paper Count

1.2WCitation Count

Published Papers 93

Publication Date

A class II MHC-targeted vaccine elicits immunity against SARS-CoV-2 and its variants

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2021-10-15

OAAI

Pishesha, Novalia; Harmand, Thibault J.; Rothlauf, Paul W.; Praest, Patrique; Alexander, Ryan K.; van den Doel, Renate; Liebeskind, Mariel J.; Vakaki, Maria A.; McCaul, Nicholas; Wijne, Charlotte; Verhaar, Elisha; Pinney, William, III; Heston, Hailey; Bloyet, Louis-Marie; Pontelli, Marjorie Cornejo; Ilagan, Ma Xenia G.; Lebbink, Robert Jan; Buchser, William J.; Wiertz, Emmanuel J. H. J.; Whelan, Sean P. J.; Ploegh, Hidde L.

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The UFM1 Pathway Impacts HCMV US2-Mediated Degradation of HLA Class I

MOLECULES

IF4.6

2021-01-08

OAAI

Schuren, A. B. C.; Boer, I. G. J.; Bouma, E. M.; van de Weijer, M. L.; Costa, A. I.; Hubel, P.; Pichlmair, A.; Lebbink, R. J.; Wiertz, E. J. H. J.

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Quality Control of ER Membrane Proteins by the RNF185/Membralin Ubiquitin Ligase Complex

MOLECULAR CELL

IF16.6

2020-09-01

OAAI

van de Weijer, Michael L.; Krshnan, Logesvaran; Liberatori, Sabrina; Guerrero, Elena Navarro; Robson-Tull, Jacob; Hahn, Lilli; Lebbink, Robert Jan; Wiertz, Emmanuel J. H. J.; Fischer, Roman; Ebner, Daniel; Carvalho, Pedro

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A Broad-Spectrum Antiviral Peptide Blocks Infection of Viruses by Binding to Phosphatidylserine in the Viral Envelope

CELLS

IF5.2

2020-08-29

OAAI

Luteijn, Rutger D.; Praest, Patrique; Thiele, Frank; Sadasivam, Saravanan Manikam; Singethan, Katrin; Drijfhout, Jan W.; Bach, Christian; de Boer, Steffen Matthijn; Lebbink, Robert J.; Tao, Sha; Helfer, Markus; Bach, Nina C.; Protzer, Ulrike; Costa, Ana I.; Killian, J. Antoinette; Drexler, Ingo; Wiertz, Emmanuel J. H. J.

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Splenic Red Pulp Macrophages Cross-Prime Early Effector CTL That Provide Rapid Defense against Viral Infections

JOURNAL OF IMMUNOLOGY

IF3.4

2020-01-01

OAAI

Enders, Marika; Franken, Lars; Philipp, Marie-Sophie; Kessler, Nina; Baumgart, Ann-Kathrin; Eichler, Melanie; Wiertz, Emmanuel J. H.; Garbi, Natalio; Kurts, Christian

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Fluorescent TAP as a Platform for Virus-Induced Degradation of the Antigenic Peptide Transporter

CELLS

IF5.2

2019-12-07

OAAI

Wachalska, Magda; Graul, Malgorzata; Praest, Patrique; Luteijn, Rutger D.; Babnis, Aleksandra W.; Wiertz, Emmanuel J. H. J.; Bienkowska-Szewczyk, Krystyna; Lipinska, Andrea D.

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New insights into the structure of the MHC class I peptide-loading complex and mechanisms of TAP inhibition by viral immune evasion proteins

MOLECULAR IMMUNOLOGY

IF3

2019-09-01

OAAI

Praest, Patrique; Liaci, A. Manuel; Forster, Friedrich; Wiertz, Emmanuel J. H. J.

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A Genome-Wide Haploid Genetic Screen Identifies Heparan Sulfate-Associated Genes and the Macropinocytosis Modulator TMED10 as Factors Supporting Vaccinia Virus Infection

JOURNAL OF VIROLOGY

IF3.8

2019-07-01

OAAI

Luteijn, Rutger D.; van Diemen, Ferdy; Blomen, Vincent A.; Boer, Ingrid G. J.; Sadasivam, Saravanan Manikam; van Kuppevelt, Toin H.; Drexler, Ingo; Brummelkamp, Thijn R.; Lebbink, Robert Jan; Wiertz, Emmanuel J.

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Transmembrane regions of bovine herpesvirus 1-encoded UL49.5 and glycoprotein M regulate complex maturation and ER-Golgi trafficking

JOURNAL OF GENERAL VIROLOGY

IF4.3

2019-03-01

OAAI

Graul, Malgorzata; Kisielnicka, Edyta; Rychlowski, Michal; Verweij, Marieke C.; Tobler, Kurt; Ackermann, Mathias; Wiertz, Emmanuel J. H. J.; Bienkowska-Szewczyk, Krystyna; Lipinska, Andrea D.

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RNA accessibility impacts potency of Tough Decoy microRNA inhibitors

RNA BIOLOGY

IF3.4

2018-11-07

OAAI

Hooykaas, Marjolein J. G.; Soppe, Jasper A.; De Buhr, Hendrik M.; Kruse, Elisabeth; Wiertz, Emmanuel J. H. J.; Lebbink, Robert J.

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The influence of TAP1 and TAP2 gene polymorphisms on TAP function and its inhibition by viral immune evasion proteins

MOLECULAR IMMUNOLOGY

IF3

2018-09-01

OAAI

Praest, P.; Luteijn, R. D.; Brak-Boer, I. G. J.; Lanfermeijer, J.; Hoelen, H.; Ijgosse, L.; Costa, A. I.; Gorham, R. D., Jr.; Lebbink, R. J.; Wiertz, E. J. H. J.

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Mutagenic repair of double-stranded DNA breaks in vaccinia virus genomes requires cellular DNA ligase IV activity in the cytosol

JOURNAL OF GENERAL VIROLOGY

IF4.3

2018-06-01

OAAI

Luteijn, Rutger David; Drexler, Ingo; Smith, Geoffrey L.; Lebbink, Robert Jan; Wiertz, Emmanuel J. H. J.

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Endocytosed soluble cowpox virus protein CPXV012 inhibits antigen cross-presentation in human monocyte-derived dendritic cells

IMMUNOLOGY AND CELL BIOLOGY

IF3

2018-02-01

OAAI

Spel, Lotte; Luteijn, Rutger D.; Drijfhout, Jan W.; Nierkens, Stefan; Boes, Marianne; Wiertz, Emmanuel J. H.

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Multiple E2 ubiquitin-conjugating enzymes regulate human cytomegalovirus US2-mediated immunoreceptor downregulation

JOURNAL OF CELL SCIENCE

IF3.6

2017-09-01

OAAI

van de Weijer, Michael L.; Schuren, Anouk B. C.; van den Boomen, Dick J. H.; Mulder, Arend; Claas, Frans H. J.; Lehner, Paul J.; Lebbink, Robert Jan; Wiertz, Emmanuel J. H. J.

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combinational CRISPR/Cas9 gene-editing approach can halt HIV replication and prevent viral escape

SCIENTIFIC REPORTS

IF3.9

2017-02-08

121

OAAI

Lebbink, Robert Jan; de Jong, Dorien C. M.; Wolters, Femke; Kruse, Elisabeth M.; van Ham, Petra M.; Wiertz, Emmanuel J. H. J.; Nijhuis, Monique

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The E3 Ubiquitin Ligase TMEM129 Is a Tri-Spanning Transmembrane Protein

VIRUSES-BASEL

IF3.5

2016-11-15

OAAI

van de Weijer, Michael L.; van Muijlwijk, Guus H.; Visser, Linda J.; Costa, Ana I.; Wiertz, Emmanuel J. H. J.; Lebbink, Robert Jan

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Comprehensive profiling of functional Epstein-Barr virus miRNA expression in human cell lines

BMC GENOMICS

IF3.7

2016-08-17

OAAI

Hooykaas, Marjolein J. G.; Kruse, Elisabeth; Wiertz, Emmanuel J. H. J.; Lebbink, Robert Jan

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CRISPR/Cas9-Mediated Genome Editing of Herpesviruses Limits Productive and Latent Infections

PLOS PATHOGENS

IF4.9

2016-06-30

219

OAAI

van Diemen, Ferdy R.; Kruse, Elisabeth M.; Hooykaas, Marjolein J. G.; Bruggeling, Carlijn E.; Schurch, Anita C.; van Ham, Petra M.; Imhof, Saskia M.; Nijhuis, Monique; Wiertz, Emmanuel J. H. J.; Lebbink, Robert Jan

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Recent advances in viral evasion of the MHC Class I processing pathway

CURRENT OPINION IN IMMUNOLOGY

IF5.8

2016-06-01

PREAI

Schuren, Anouk B. C.; Costa, Ana I.; Wiertz, Emmanuel J. H. J.

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The Epstein-Barr Virus Glycoprotein gp150 Forms an Immune-Evasive Glycan Shield at the Surface of Infected Cells

PLOS PATHOGENS

IF4.9

2016-04-14

OAAI

Gram, Anna M.; Oosenbrug, Timo; Lindenbergh, Marthe F. S.; Bull, Christian; Comvalius, Anouskha; Dickson, Kathryn J. I.; Wiegant, Joop; Vrolijk, Hans; Lebbink, Robert Jan; Wolterbeek, Ron; Adema, Gosse J.; Griffioen, Marieke; Heemskerk, Mirjam H. M.; Tscharke, David C.; Hutt-Fletcher, Lindsey M.; Wiertz, Emmanuel J. H. J.; Hoeben, Rob C.; Ressing, Maaike E.

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Research Directions