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G

Gary S. Firestein

uc san diego

102H-index
454Paper Count
4.7WCitation Count
Published Papers 148
Publication Date
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Association of epigenetic trajectory with development of clinical rheumatoid arthritis in anti-citrullinated protein antibody positive individuals: Targeting Immune Responses for Prevention of Rheumatoid Arthritis (TIP-RA)
errArthritis & Rheumatology
IF10.9
err2026-04-22
err0
PREAI
errE. Barton Prideaux PhD; David L. Boyle BA; Eunice Choi BS; Jane H. Buckner MD; William H. Robinson MD, PhD; V. Michael Holers MD; Kevin D. Deane MD; Gary S. Firestein MD; Wei Wang PhD
errShare
errSave
Optimization of a synoviocyte-targeted biologic for inflammatory arthritis in combination or bispecific administration with TNF inhibitors
errJCI INSIGHT
IF6.1
err2025-11-10
err0
errOAAI
errRamsey, Sterling H.; Zhao, Zixuan; Lee, Megan C.; da Rosa, Thales Hein; Schneider, Ava C.; Bollmann, Miriam; Dada, Nour; Frizzi, Katie E.; Han, May M.; Kim, Jaeyeon; Zoccheddu, Martina; Calcutt, Nigel A.; Firestein, Gary S.; Bryson, James W.; Svensson, Mattias N. D.; Santelli, Eugenio; Stanford, Stephanie M.; Bottini, Nunzio
errShare
errSave
Dysregulated Immune Response to Perturbation from Vaccination in ACPA plus Individuals at Risk for Rheumatoid Arthritis
errJOURNAL OF IMMUNOLOGY
IF3.4
err2025-11-01
err0
PREAI
errVenkatesan, Pravina; Glass, Marla C.; Savage, Adam; Bennett, Christy; Ravisankar, Padmapriyadarshini; Gong, Qiuyu; Krishnan, Upaasana; Gustafson, Claire E.; Speake, Cate; Buckner, Jane H.; Firestein, Gary; Holers, V. Michael; Li, Xiao-jun; Torgerson, Troy R.; Deane, Kevin D.; Gillespie, Mark; He, Ziyuan
errShare
errSave
Epigenetic control of pathogenic CD4 T cell polarization during progression to rheumatoid arthritis
errJOURNAL OF IMMUNOLOGY
IF3.4
err2025-11-01
err0
PREAI
errHe, Ziyuan; Venkatesan, Pravina; Savage, Adam; Glass, Marla C.; Okada, Lauren Y.; Krishnan, Upaasana; Bennett, Christy E.; Tran, Nhung T.; He, Yudong D.; Zaim, Samir Rachid; Ravisankar, Padmapriyadarshini; Garber, Jessica; Genge, Palak C.; Lee, Kevin J.; Phalen, Cole G.; Mettey, Regina R.; Feser, Marie L.; Buckner, Jane H.; Goldrath, Ananda W.; Bumol, Thomas F.; Li, Xiao-jun; Holers, Michael; Skene, Peter J.; Firestein, Gary S.; Deane, Kevin D.; Torgerson, Troy R.; Gillespie, Mark A.
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errSave
The B cell compartment exhibits a pro-inflammatory skewing during progression to Rheumatoid Arthritis
errJOURNAL OF IMMUNOLOGY
IF3.4
err2025-11-01
err0
PREAI
errGlass, Marla; He, Ziyuan; Venkatesan, Pravina; Dornisch, Elisabeth; Okada, Lauren; He, Yudong; Zaim, Samir Rachid; Ravisankar, Padmapriyadarshini; Garber, Jessica; Genge, Palak; Gong, Qiuyu; Graybuck, Lucas T.; Gustafson, Claire E.; Hernandez, Veronica; Heubeck, Alex; Kawelo, Erin; Krishnan, Upaasana; Musgrove, Blessing; Parthasarathy, Vaishnavi; Phalen, Cole; Reading, Julian; Stuckey, Tyanna; Bennett, Christy; Zhang, Fan; Boyle, David; Goldrath, Ananda; Bumol, Thomas F.; Li, Xiao-jun; Holers, Michael; Skene, Peter; Savage, Adam; Firestein, Gary; Deane, Kevin D.; Torgerson, Troy R.; Gillespie, Mark
errShare
errSave
Systemic inflammation and transcriptional reprogramming contribute to progression to active rheumatoid arthritis in ACPA plus individuals
errJOURNAL OF IMMUNOLOGY
IF3.4
err2025-11-01
err0
PREAI
errGillespie, Mark A.; He, Ziyuan; Venkatesan, Pravina; Glass, Marla; Feser, Marie; Lazaro, Leander; Okada, Lauren; Tran, Nhung; He, Yudong; Zaim, Samir Rachid; Bennett, Christy; Ravisankar, Priya; Demoruelle, M. Kristen; Gong, Qiuyu; Graybuck, Lucas T.; Gustafson, Claire E.; Krishnan, Upaasana; Kuhn, Kristi A.; Reading, Julian; Zhang, Fan; Boyle, David; Goldrath, Ananda W.; Bumol, Thomas F.; Li, Xiao-jun; Holers, V. Michael; Skene, Peter; Savage, Adam; Firestein, Gary; Deane, Kevin; Torgerson, Troy R.
errShare
errSave
Process evaluation and lessons learned from the formation of a multi-sector partnership: the Healing Experiences of Adversity among Latinos (HEALthy4You)
errFRONTIERS IN HEALTH SERVICES
IF2.7
err2025-10-17
err0
errOAAI
errViglione, Clare; Westermann, Amy; Godino, Job; Rhee, Kyung E.; Melendrez, Blanca; Tu, Xin M.; Boyle, David L.; Hogarth, Michael; Aarons, Gregory A.; Crespo, Noe C.; Gidwani, Pradeep; Holguin, Margarita; Juarez, Cynthia; Merino-Gonzalez, Deysi B.; Osorio, Liliana; Ramirez, Herminia; Smith, Micaela; Terrana, Alec; Firestein, Gary S.; Hekler, Eric
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errSave
Progression to rheumatoid arthritis in at-risk individuals is defined by systemic inflammation and by T and B cell dysregulation
errScience Translational Medicine
IF14.6
err2025-09-24
err0
PREAI
errZiyuan He; Marla C. Glass; Pravina Venkatesan; Marie L. Feser; Leander Lazaro; Lauren Y. Okada; Nhung T. T. Tran; Yudong D. He; Samir Rachid Zaim; Christy E. Bennett; Padmapriyadarshini Ravisankar; Elisabeth M. Dornisch; Alexandra C. Ferrannini; Najeeb A. Arishi; Ashley G. Asamoah; Saman Barzideh; Lynne A. Becker; Elizabeth A. Bemis; Jane H. Buckner; Christopher E. Collora; Megan A. L. Criley; M. Kristen Demoruelle; Chelsie L. Fleischer; Jessica Garber; Palak C. Genge; Qiuyu Gong; Lucas T. Graybuck; Claire E. Gustafson; Brian C. Hattel; Veronica Hernandez; Alexander T. Heubeck; Erin K. Kawelo; Upaasana Krishnan; Emma L. Kuan; Kristine A. Kuhn; Christian M. LaFrance; Kevin J. Lee; Ruoxin Li; Cara Lord; Regina R. Mettey; Laura Moss; Blessing Musgrove; Katherine HY Nguyen; Andrea Ochoa; Vaishnavi Parthasarathy; Mark-Phillip Pebworth; Chong Pedrick; Tao Peng; Cole G. Phalen; Julian Reading; Charles R. Roll; Jennifer A. Seifert; Marguerite D. Siedschlag; Cate Speake; Christopher C. Striebich; Tyanna J. Stuckey; Elliott G. Swanson; Hideto Takada; Tylor Thai; Zachary J. Thomson; Nguyen Trieu; Vlad Tsaltskan; Wei Wang; Morgan D. A. Weiss; Amy Westermann; Fan Zhang; David L. Boyle; Ananda W. Goldrath; Thomas F. Bumol; Xiao-jun Li; V. Michael Holers; Peter J. Skene; Adam K. Savage; Gary S. Firestein; Kevin D. Deane; Troy R. Torgerson; Mark A. Gillespie
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errSave
Regulation of fibroblast-like synoviocyte function by cadherin 6 in rheumatoid arthritis
errArthritis Research & Therapy
IF4.6
err2025-08-30
err0
errOAAI
errCamilla R. L. Machado; Eunice Choi; Narayanan B. Perumal; Robert J. Benschop; Gregory R. Dressler; Wei Wang; David L. Boyle; Gary S. Firestein
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errSave
Modulation of the PTPRS proteoglycan switch by antibodies binding to the membrane-proximal fibronectin-type III domain
errJournal of Biological Chemistry
IF3.9
err2025-07-10
err0
errOAAI
errThales Hein Da Rosa; Sterling H. Ramsey; Judy J. Lee; Natalia Y. Kozlova; Zixuan Zhao; Jaeyeon Kim; Ava C. Schneider; Sheng Li; Madhusudhanarao Katiki; Gary S. Firestein; Ramachandran Murali; Eugenio Santelli; Stephanie M. Stanford; Nunzio Bottini
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errSave
Distinct mucosal endotypes as initiators and drivers of rheumatoid arthritis
errNATURE REVIEWS RHEUMATOLOGY
IF32.7
err2024-09-09
err0
PREAI
errHolers, V. Michael; Demoruelle, Kristen M.; Buckner, Jane H.; James, Eddie A.; Firestein, Gary S.; Robinson, William H.; Steere, Allen C.; Zhang, Fan; Norris, Jill M.; Kuhn, Kristine A.; Deane, Kevin D.
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errSave
Dysregulated NUB1 and Neddylation Enhances Rheumatoid Arthritis Fibroblast-Like Synoviocyte Inflammatory Responses
errARTHRITIS & RHEUMATOLOGY
IF10.9
err2024-06-05
err1
errOAAI
errSendo, Sho; Machado, Camilla R. L.; Boyle, David L.; Benschop, Robert J.; Perumal, Narayanan B.; Choi, Eunice; Wang, Wei; Firestein, Gary S.
errShare
errSave
Joint-specific rheumatoid arthritis fibroblast-like synoviocyte regulation identified by integration of chromatin access and transcriptional activity
errJCI INSIGHT
IF6.1
err2024-05-23
err0
errOAAI
errChoi, Eunice; Machado, Camilla R. L.; Okano, Takaichi; Boyle, David; Wang, Wei; Firestein, Gary S.
errShare
errSave
Laser Capture Microscopy RNA Sequencing for Topological Mapping of Synovial Pathology During Rheumatoid Arthritis
errARTHRITIS & RHEUMATOLOGY
IF10.9
err2024-05-21
err0
PREAI
errVan Espen, Benjamin; Prideaux, E. Barton; Wilson, Andrew R.; Machado, Camilla R. L.; Sendo, Sho; Parker, James; Seumois, Gregory; Sacchetti, Cristiano; Belongia, Anna C.; Perumal, Narayanan B.; Vijayanand, Pandurangan; Linnik, Matthew D.; Benschop, Robert J.; Wang, Wei; Bottini, Nunzio; Firestein, Gary S.; Stanford, Stephanie M.
errShare
errSave
Mapping the dynamic genetic regulatory architecture of HLA genes at single-cell resolution
errNATURE GENETICS
IF31.8
err2023-11-30
err5
errOAAI
errKang, Joyce B.; Shen, Amber Z.; Gurajala, Saisriram; Nathan, Aparna; Rumker, Laurie; Aguiar, Vitor R. C.; Valencia, Cristian; Lagattuta, Kaitlyn A.; Zhang, Fan; Jonsson, Anna Helena; Yazar, Seyhan; Alquicira-Hernandez, Jose; Khalili, Hamed; Ananthakrishnan, Ashwin N.; Jagadeesh, Karthik; Dey, Kushal; Albrecht, Jennifer; Apruzzese, William; Banda, Nirmal; Barnas, Jennifer L.; Bathon, Joan M.; Ben-Artzi, Ami; Boyce, Brendan F.; Boyle, David L.; Bridges, S. Louis; Bykerk, Vivian P.; Campbell, Debbie; Ceponis, Arnold; Cordle, Andrew; Deane, Kevin D.; Firestein, Gary S.; James, Judith A.; Weinand, Kathryn; Xavier, Ramnik J.; Rao, Deepak A.; Brenner, Michael B.; Gutierrez-Arcelus, Maria; Luo, Yang; Sakaue, Saori; Raychaudhuri, Soumya
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errSave
Multifaceted immune dysregulation characterizes individuals at-risk for rheumatoid arthritis
errNATURE COMMUNICATIONS
IF15.7
err2023-11-22
err4
errOAAI
errJames, Eddie A.; Holers, V. Michael; Iyer, Radhika; Prideaux, E. Barton; Rao, Navin L.; Rims, Cliff; Muir, Virginia S.; Posso, Sylvia E.; Bloom, Michelle S.; Zia, Amin; Elliott, Serra E.; Adamska, Julia Z.; Ai, Rizi; Brewer, R. Camille; Seifert, Jennifer A.; Moss, Laurakay; Barzideh, Saman; Demoruelle, M. Kristen; Striebich, Christopher C.; Okamoto, Yuko; Sainbayar, Enkhtsogt; Crook, Alexandra A.; Peterson, Ryan A.; Vanderlinden, Lauren A.; Wang, Wei; Boyle, David L.; Robinson, William H.; Buckner, Jane H.; Firestein, Gary S.; Deane, Kevin D.
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errSave
Fibroblast multiplicity in RA: a synovial state of affairs
errNATURE REVIEWS RHEUMATOLOGY
IF32.7
err2023-08-21
err2
PREAI
errMachado, Camilla R. L.; Firestein, Gary S.
errShare
errSave
Association of Antibodies to Citrullinated Protein Antigens (ACPA) With Coronary Artery Calcium and Abdominal Aorta Calcium in a Multi-Ethnic Community-Dwelling Population
errCIRCULATION
IF38.6
err2023-02-28
err0
PREAI
errHughes-Austin, Jan M.; Katz, Ronit; Firestein, Gary; Robinson, William; Criqui, Michael H.; Ix, Joachim H.
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errSave
Rheumatoid Arthritis - Common Origins, Divergent Mechanisms
errNEW ENGLAND JOURNAL OF MEDICINE
IF78.5
err2023-02-09
err228
PREAI
errGravallese, Ellen M.; Firestein, Gary S.
errShare
errSave
Targeting fibroblast-like synoviocytes in rheumatoid arthritis
errCURRENT OPINION IN PHARMACOLOGY
IF4.2
err2022-12-01
err73
errOAAI
errTsaltskan, Vladislav; Firestein, Gary S.
errShare
errSave

Research Directions

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