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SaveShare Save Orexin 2 receptor-selective agonist danavorexton (TAK-925) promotes wakefulness in non-human primates and healthy individuals
Evans, Rebecca; Kimura, Haruhide; Nakashima, Masato; Ishikawa, Takashi; Yukitake, Hiroshi; Suzuki, Motohisa; Hazel, James; Faessel, Helene; Wu, Jingtao; Hang, Yaming; Alexander, Robert; Rosen, Laura; Hartman, Deborah S. S.; Ratti, Emiliangelo Share Save The miR-124-AMPAR pathway connects polygenic risks with behavioral changes shared between schizophrenia and bipolar disorderNamkung, Ho; Yukitake, Hiroshi; Fukudome, Daisuke; Lee, Brian J.; Tian, Mengnan; Ursini, Gianluca; Saito, Atsushi; Lam, Shravika; Kannan, Suvarnambiga; Srivastava, Rupali; Niwa, Minae; Sharma, Kamal; Zandi, Peter; Jaaro-Peled, Hanna; Ishizuka, Koko; Chatterjee, Nilanjan; Huganir, Richard L.; Sawa, Akira Share Save Orexin 2 receptor-selective agonist danavorexton improves narcolepsy phenotype in a mouse model and in human patientsEvans, Rebecca; Kimura, Haruhide; Alexander, Robert; Davies, Ceri H.; Faessel, Helene; Hartman, Deborah S.; Ishikawa, Takashi; Ratti, Emiliangelo; Shimizu, Kohei; Suzuki, Motohisa; Tanaka, Shinichiro; Yukitake, Hiroshi; Dauvilliers, Yves; Mignot, Emmanuel Share Save Discovery of TAK-925 as a Potent, Selective, and Brain-Penetrant Orexin 2 Receptor AgonistFujimoto, Tatsuhiko; Rikimaru, Kentaro; Fukuda, Koichiro; Sugimoto, Hiromichi; Masuda, Kei; Ohyabu, Norio; Banno, Yoshihiro; Tokunaga, Norihito; Kawamoto, Tetsuji; Tomata, Yoshihide; Kumagai, Yasumi; Iida, Motoo; Nagano, Yoichi; Yoneyama-Hirozane, Mariko; Shimizu, Yuji; Sasa, Katsunori; Ishikawa, Takashi; Yukitake, Hiroshi; Ito, Mitsuhiro; Aoyama, Kazunobu; Matsumoto, Takahiro Share Save From population to neuron: exploring common mediators for metabolic problems and mental illnessesTakayanagi, Yoichiro; Ishizuka, Koko; Laursen, Thomas M.; Yukitake, Hiroshi; Yang, Kun; Cascella, Nicola G.; Ueda, Shuhei; Sumitomo, Akiko; Narita, Zui; Horiuchi, Yasue; Niwa, Minae; Taguchi, Akiko; White, Morris F.; Eaton, William W.; Mortensen, Preben B.; Sakurai, Takeshi; Sawa, Akira Share Save TAK-925, an orexin 2 receptor-selective agonist, shows robust wake-promoting effects in miceYukitake, Hiroshi; Fujimoto, Tatsuhiko; Ishikawa, Takashi; Suzuki, Atsushi; Shimizu, Yuji; Rikimaru, Kentaro; Ito, Mitsuhiro; Suzuki, Motohisa; Kimura, Haruhide Share Save Ulk2 controls cortical excitatory-inhibitory balance via autophagic regulation of p62 and GABAA receptor trafficking in pyramidal neuronsSumitomo, Akiko; Yukitake, Hiroshi; Hirai, Kazuko; Horike, Kouta; Ueta, Keisho; Chung, Youjin; Warabi, Eiji; Yanagawa, Toru; Kitaoka, Shiho; Furuyashiki, Tomoyuki; Narumiya, Shuh; Hirano, Tomoo; Niwa, Minae; Sibille, Etienne; Hikida, Takatoshi; Sakurai, Takeshi; Ishizuka, Koko; Sawa, Akira; Tomoda, Toshifumi Share Save AN OREXIN 2 RECEPTOR-SELECTIVE AGONIST, TAK-925, SHOWS ROBUST WAKE-PROMOTING EFFECTS IN MICE AND NON-HUMAN PRIMATESYukitake, H.; Ishikawa, T.; Suzuki, A.; Shimizu, Y.; Nakashima, M.; Fujimoto, T.; Rikimaru, K.; Ito, M.; Suzuki, M.; Kimura, H. Share Save Share Save BTZO-2, an antioxidant response element-activator, provides protection against lethal endotoxic shock in miceYukitake, Hiroshi; Kimura, Haruhide; Tajima, Yasukazu; Sato, Yoshimi; Suzuki, Hirobumi; Kajino, Masahiro; Tanida, Seiichi; Takizawa, Masayuki Share Save Share Save Share Save 
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