David C. Briggs - Publications, H-index & Citations

Back

David C. Briggs

francis crick institute

23H-index

89Paper Count

1.5KCitation Count

Published Papers 26

Publication Date

Unlocking the secrets of SARS-CoV-2 nsp3 by combining experiments with AlphaFold2 domain prediction

Life Science Alliance

IF2.9

2026-02-20

PREAI

Edich, Maximilian; Gao, Yunyun; Briggs, David C.; Thorn, Andrea

Save

Xylosyltransferase engineering to manipulate proteoglycans in mammalian cells

Nature Chemical Biology

IF13.7

2026-01-20

OAAI

Zhen Li; Himanshi Chawla; Lucia Di Vagno; Aisling Ní Cheallaigh; Meg Critcher; Douglas Sammon; Edgar Gonzalez-Rodriguez; David C. Briggs; Nara Chung; Vincent Chang; Keira E. Mahoney; Anna Cioce; Ganka Bineva-Todd; Pei-Ying Wang; Yi-Chang Liu; Lloyd D. Murphy; Yen-Hsi Chen; Yoshiki Narimatsu; Rebecca L. Miller; Lianne I. Willems; Stacy A. Malaker; Mia L. Huang; Gavin J. Miller; Erhard Hohenester; Benjamin Schumann

Save

Penetrant PKCβ mutation in ATLL displays a mixed gain-of-function

BIOCHEMICAL JOURNAL

IF4.3

2025-11-01

OAAI

Brown, Sophie J. L.; Briggs, David C.; Costello, Patrick; Yaguchi, Hiroko; Bangham, Charles R. M.; Parker, Peter J.; McDonald, Neil Q.

Save

Optimized PAR-2 RING dimerization mediates cooperative and selective membrane binding for robust cell polarity

EMBO JOURNAL

IF8.3

2024-06-21

OAAI

Bland, Tom; Hirani, Nisha; Briggs, David C.; Rossetto, Riccardo; Ng, KangBo; Taylor, Ian A.; McDonald, Neil Q.; Zwicker, David; Goehring, Nathan W.

Save

Architecture and regulation of a GDNF-GFRα1 synaptic adhesion assembly

NATURE COMMUNICATIONS

IF15.7

2023-11-20

OAAI

Houghton, F. M.; Adams, S. E.; Rios, A. S.; Masino, L.; Purkiss, A. G.; Briggs, D. C.; Ledda, F.; Mcdonald, N. Q.

Save

Molecular mechanism of decision-making in glycosaminoglycan biosynthesis

NATURE COMMUNICATIONS

IF15.7

2023-10-13

OAAI

Sammon, Douglas; Krueger, Anja; Busse-Wicher, Marta; Morgan, Rhodri Marc; Haslam, Stuart M.; Schumann, Benjamin; Briggs, David C.; Hohenester, Erhard

Save

V3: an enigmatic isoform of the proteoglycan versican

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

IF4.7

2023-08-01

PREAI

Wight, Thomas N.; Day, Anthony J.; Kang, Inkyung; Harten, Ingrid A.; Kaber, Gernot; Briggs, David C.; Braun, Kathleen R.; Lemire, Joan M.; Kinsella, Michael G.; Hinek, Aleksander; Merrilees, Mervyn J.

Save

Structure of PLA2R reveals presentation of the dominant membranous nephropathy epitope and an immunogenic patch

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2022-07-11

OAAI

Fresquet, Maryline; Lockhart-Cairns, Michael P.; Rhoden, Samuel J.; Jowitt, Thomas A.; Briggs, David C.; Baldock, Clair; Brenchley, Paul E.; Lennon, Rachel

Save

Discovery of N-Trisubstituted Pyrimidine Derivatives as Type I RET and RET Gatekeeper Mutant Inhibitors with a Novel Kinase Binding Pose

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2022-01-27

OAAI

Zhang, Lingtian; Moccia, Marialuisa; Briggs, David C.; Bharate, Jaideep B.; Lakkaniga, Naga Rajiv; Knowles, Phillip; Yan, Wei; Tran, Phuc; Kharbanda, Anupreet; Wang, Xiuqi; Leung, Yuet-Kin; Frett, Brendan; Santoro, Massimo; McDonald, Neil Q.; Carlomagno, Francesca; Li, Hong-yu

Save

The impact of AlphaFold2 on experimental structure solution

FARADAY DISCUSSIONS

IF3.1

2022-01-01

OAAI

Edich, Maximilian; Briggs, David C.; Kippes, Oliver; Gao, Yunyun; Thorn, Andrea

Save

Metabolic precision labeling enables selective probing of O-linked N-acetylgalactosamine glycosylation

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2020-09-28

OAAI

Debets, Marjoke F.; Tastan, Omur Y.; Wisnovsky, Simon P.; Malaker, Stacy A.; Angelis, Nikolaos; Moeckl, Leonhard K. R.; Choi, Junwon; Flynn, Helen; Wagner, Lauren J. S.; Bineva-Todd, Ganka; Antonopoulos, Aristotelis; Cioce, Anna; Browne, William M.; Li, Zhen; Briggs, David C.; Douglas, Holly L.; Hess, Gaelen T.; Agbay, Anthony J.; Roustan, Chloe; Kjaer, Svend; Haslam, Stuart M.; Snijders, Ambrosius P.; Bassik, Michael C.; Moerner, W. E.; Li, Vivian S. W.; Bertozzi, Carolyn R.; Schumann, Benjamin

Save

Bioisosteric Discovery of NPA101.3, a Second-Generation RET/VEGFR2 Inhibitor Optimized for Single-Agent Polypharmacology

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2020-04-16

OAAI

Moccia, Marialuisa; Frett, Brendan; Zhang, Lingtian; Lakkaniga, Naga Rajiv; Briggs, David C.; Chauhan, Rakhee; Brescia, Annalisa; Federico, Giorgia; Yan, Wei; Santoro, Massimo; McDonald, Neil Q.; Li, Hong-yu; Carlomagno, Francesca

Save

Inter-?-inhibitor heavy chain-1 has an integrin-like 3D structure mediating immune regulatory activities and matrix stabilization during ovulation

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2020-04-01

OAAI

Briggs, David C.; Langford-Smith, Alexander W. W.; Birchenough, Holly L.; Jowitt, Thomas A.; Kielty, Cay M.; Enghild, Jan J.; Baldock, Clair; Milner, Caroline M.; Day, Anthony J.

Save

Cryo-EM structures of the XPF-ERCC1 endonuclease reveal how DNA-junction engagement disrupts an auto-inhibited conformation

NATURE COMMUNICATIONS

IF15.7

2020-02-28

OAAI

Jones, Morgan; Beuron, Fabienne; Borg, Aaron; Nans, Andrea; Earl, Christopher P.; Briggs, David C.; Snijders, Ambrosius P.; Bowles, Maureen; Morris, Edward P.; Linch, Mark; McDonald, Neil Q.

Save

Homodimerization of the Lymph Vessel Endothelial Receptor LYVE-1 through a Redox-labile Disulfide Is Critical for Hyaluronan Binding in Lymphatic Endothelium

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2016-11-01

OAAI

Banerji, Suneale; Lawrance, William; Metcalfe, Clive; Briggs, David C.; Yamauchi, Akira; Dushek, Omer; van der Merwe, P. Anton; Day, Anthony J.; Jackson, David G.

Save

Structural basis of laminin binding to the LARGE glycans on dystroglycan

NATURE CHEMICAL BIOLOGY

IF13.7

2016-08-15

OAAI

Briggs, David C.; Yoshida-Moriguchi, Takako; Zheng, Tianqing; Venzke, David; Anderson, Mary E.; Strazzulli, Andrea; Moracci, Marco; Yu, Liping; Hohenester, Erhard; Campbell, Kevin P.

Save

Metal Ion-dependent Heavy Chain Transfer Activity of TSG-6 Mediates Assembly of the Cumulus-Oocyte Matrix

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2015-11-01

OAAI

Briggs, David C.; Birchenough, Holly L.; Ali, Tariq; Rugg, Marilyn S.; Waltho, Jon P.; Ievoli, Elena; Jowitt, Thomas A.; Enghild, Jan J.; Richter, Ralf P.; Salustri, Antonietta; Milner, Caroline M.; Day, Anthony J.

Save

Incorporation of Pentraxin 3 into Hyaluronan Matrices Is Tightly Regulated and Promotes Matrix Cross-linking

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2014-10-01

OAAI

Baranova, Natalia S.; Inforzato, Antonio; Briggs, David C.; Tilakaratna, Viranga; Enghild, Jan J.; Thakar, Dhruv; Milner, Caroline M.; Day, Anthony J.; Richter, Ralf P.

Save

A Refined Model for the TSG-6 Link Module in Complex with Hyaluronan USE OF DEFINED OLIGOSACCHARIDES TO PROBE STRUCTURE AND FUNCTION

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2014-02-01

OAAI

Higman, Victoria A.; Briggs, David C.; Mahoney, David J.; Blundell, Charles D.; Sattelle, Benedict M.; Dyer, Douglas P.; Green, Dixy E.; DeAngelis, Paul L.; Almond, Andrew; Milner, Caroline M.; Day, Anthony J.

Save

Inter-α-inhibitor Impairs TSG-6-induced Hyaluronan Cross-linking

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2013-10-01

OAAI

Baranova, Natalia S.; Foulcer, Simon J.; Briggs, David C.; Tilakaratna, Viranga; Enghild, Jan J.; Milner, Caroline M.; Day, Anthony J.; Richter, Ralf P.

Save

Research Directions