Not logged inFunctional and Structural Characterization of Treatment-Emergent Nirmatrelvir Resistance Mutations at Low Frequencies in the Main Protease (Mpro) Reveals a Unique Evolutionary Route for SARS-CoV-2 to Gain Resistance
Deschenes, Natalie M.; Perez-Vargas, Jimena; Zhong, Zoe; Thomas, Merrilee; Kenward, Calem; Mosimann, Wesley A.; Worrall, Liam J.; Waglechner, Nicholas; Li, Angel XinLiu; Maguire, Finlay; Aftanas, Patryk; Smith, Jason R.; Lim, Jared; Young, Robert N.; Cherkasov, Artem; Farooqi, Lubna; Moinuddin, Adnan; Siddiqi, Lina; Malik, Imaan; Lefebvre, Maxime; Paetzel, Mark; Strynadka, Natalie C. J.; Jean, Francois; McGeer, Allison; Kozak, Robert A. .png)
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SaveShare Save Identification of an Optimized Receptor-Binding Domain Subunit Vaccine against SARS-CoV-2Yu, Hong; Worrall, Liam J.; Berger, Thorsten; Petric, Martin; Lin, Bryan H.; Vuckovic, Marija; Robb, Craig S.; Le, Quan; Kenward, Calem; Dai, Chuanbin; Wakeham, Andrew; Liu, Shaofeng; Snow, Bryan; Tobin, Chantal; Budylowski, Patrick; Guvenc, Furkan; You-Ten, Annick; Haight, Jillian; Silvester, Jennifer; Singh, Rashim Pal; Ahn, Sang Kyun; Sultana, Azmiri; Poon, Betty; Lam, Jessica; Christie-Holmes, Natasha; Ostrowski, Mario; Gray-Owen, Scott D.; Kubli, Shawn; Mak, Tak; Strynadka, Natalie C. J.; Brunham, Robert C. Share Save A novel class of broad-spectrum active-site-directed 3C-like protease inhibitors with nanomolar antiviral activity against highly immune-evasive SARS-CoV-2 Omicron subvariantsPerez-Vargas, Jimena; Worrall, Liam J.; Olmstead, Andrea D.; Ton, Anh-Tien; Lee, Jaeyong; Villanueva, Ivan; Thompson, Connor A. H.; Dudek, Svenja; Ennis, Siobhan; Smith, Jason R.; Shapira, Tirosh; De Guzman, Joshua; Gang, Shutong; Ban, Fuqiang; Vuckovic, Marija; Bielecki, Michael; Kovacic, Suzana; Kenward, Calem; Hong, Christopher Yee; Gordon, Danielle G.; Levett, Paul N.; Krajden, Mel; Leduc, Richard; Boudreault, Pierre-Luc; Niikura, Masahiro; Paetzel, Mark; Young, Robert N.; Cherkasov, Artem; Strynadka, Natalie C. J.; Jean, Francois Share Save Share Save X-ray crystallographic characterization of the SARS-CoV-2 main protease polyprotein cleavage sites essential for viral processing and maturationLee, Jaeyong; Kenward, Calem; Worrall, Liam J.; Vuckovic, Marija; Gentile, Francesco; Ton, Anh-Tien; Ng, Myles; Cherkasov, Artem; Strynadka, Natalie C. J.; Paetzel, Mark Share Save SPOR Proteins Are Required for Functionality of Class A Penicillin-Binding Proteins in Escherichia coliPazos, Manuel; Peters, Katharina; Boes, Adrien; Safaei, Yalda; Kenward, Calem; Caveney, Nathanael A.; Laguri, Cedric; Breukink, Eefjan; Strynadka, Natalie C. J.; Simorre, Jean-Pierre; Terrak, Mohammed; Vollmer, Waldemar Share Save Share Save Share Save Share Save Share Save 
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