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Functional and Structural Characterization of Treatment-Emergent Nirmatrelvir Resistance Mutations at Low Frequencies in the Main Protease (Mpro) Reveals a Unique Evolutionary Route for SARS-CoV-2 to Gain Resistance Deschenes, Natalie M.; Perez-Vargas, Jimena; Zhong, Zoe; Thomas, Merrilee; Kenward, Calem; Mosimann, Wesley A.; Worrall, Liam J.; Waglechner, Nicholas; Li, Angel XinLiu; Maguire, Finlay; Aftanas, Patryk; Smith, Jason R.; Lim, Jared; Young, Robert N.; Cherkasov, Artem; Farooqi, Lubna; Moinuddin, Adnan; Siddiqi, Lina; Malik, Imaan; Lefebvre, Maxime; Paetzel, Mark; Strynadka, Natalie C. J.; Jean, Francois; McGeer, Allison; Kozak, Robert A. Share Save
Cryo-EM analyses unveil details of mechanism and targocil-II mediated inhibition of S. aureus WTA transporter TarGH Li, Franco K. K.; Peters, Shaun C.; Worrall, Liam J.; Sun, Tianjun; Hu, Jinhong; Vuckovic, Marija; Farha, Maya; Palacios, Armando; Caveney, Nathanael A.; Brown, Eric D.; Strynadka, Natalie C. J. Share Save
Characterization of novel small molecule inhibitors of estrogen receptor-activation function 2 (ER-AF2) Foo, Jane; Gentile, Francesco; Massah, Shabnam; Morin, Helene; Singh, Kriti; Lee, Joseph; Smith, Jason; Ban, Fuqiang; Leblanc, Eric; Young, Robert; Strynadka, Natalie; Lallous, Nada; Cherkasov, Artem Share Save
Cryo-EM characterization of the anydromuropeptide permease AmpG central to bacterial fitness and β-lactam antibiotic resistance Sverak, Helena E.; Yaeger, Luke N.; Worrall, Liam J.; Vacariu, Condurache M.; Glenwright, Amy J.; Vuckovic, Marija; Al Azawi, Zayni-Dean; Lamers, Ryan P.; Marko, Victoria A.; Skorupski, Clarissa; Soni, Arvind S.; Tanner, Martin E.; Burrows, Lori L.; Strynadka, Natalie C. J. Share Save
Cobalt as a Cofactor for α-Galactosaminidase-Catalyzed Cleavage of Blood Group Antigens Tian, Yuqing; Worrall, Liam J.; Sim, Lyann; Liu, Feng; Nasseri, Seyed A.; Rahfeld, Peter; Mu, Wanmeng; Kizhakkedathu, Jayachandran N.; Strynadka, Natalie C. J.; Withers, Stephen G. Share Save
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Identification of an Optimized Receptor-Binding Domain Subunit Vaccine against SARS-CoV-2 Yu, Hong; Worrall, Liam J.; Berger, Thorsten; Petric, Martin; Lin, Bryan H.; Vuckovic, Marija; Robb, Craig S.; Le, Quan; Kenward, Calem; Dai, Chuanbin; Wakeham, Andrew; Liu, Shaofeng; Snow, Bryan; Tobin, Chantal; Budylowski, Patrick; Guvenc, Furkan; You-Ten, Annick; Haight, Jillian; Silvester, Jennifer; Singh, Rashim Pal; Ahn, Sang Kyun; Sultana, Azmiri; Poon, Betty; Lam, Jessica; Christie-Holmes, Natasha; Ostrowski, Mario; Gray-Owen, Scott D.; Kubli, Shawn; Mak, Tak; Strynadka, Natalie C. J.; Brunham, Robert C. Share Save
A novel class of broad-spectrum active-site-directed 3C-like protease inhibitors with nanomolar antiviral activity against highly immune-evasive SARS-CoV-2 Omicron subvariants Perez-Vargas, Jimena; Worrall, Liam J.; Olmstead, Andrea D.; Ton, Anh-Tien; Lee, Jaeyong; Villanueva, Ivan; Thompson, Connor A. H.; Dudek, Svenja; Ennis, Siobhan; Smith, Jason R.; Shapira, Tirosh; De Guzman, Joshua; Gang, Shutong; Ban, Fuqiang; Vuckovic, Marija; Bielecki, Michael; Kovacic, Suzana; Kenward, Calem; Hong, Christopher Yee; Gordon, Danielle G.; Levett, Paul N.; Krajden, Mel; Leduc, Richard; Boudreault, Pierre-Luc; Niikura, Masahiro; Paetzel, Mark; Young, Robert N.; Cherkasov, Artem; Strynadka, Natalie C. J.; Jean, Francois Share Save
Investigation into the Mechanism of Action of the Tuberculosis Drug Candidate SQ109 and Its Metabolites and Analogues in Mycobacteria Malwal, Satish R. R.; Mazurek, Ben; Ko, Jihee; Xie, Pujun; Barnes, Chikako; Varvitsiotis, Christine; Zimmerman, Matthew D. D.; Olatunji, Samir; Lee, Jaeyong; Xie, Min; Sarathy, Jansy; Caffrey, Martin; Strynadka, Natalie C. J.; Dartois, Veronique; Dick, Thomas; Lee, Bom Nae Rin; Russell, David G. G.; Oldfield, Eric Share Save
Vinyl Halide-Modified Unsaturated Cyclitols are Mechanism-Based Glycosidase Inhibitors Danby, Phillip M.; Jeong, Andrew; Sim, Lyann; Sweeney, Ryan P.; Wardman, Jacob F.; Karimi, Ryan; Geissner, Andreas; Worrall, Liam J.; Reid, Jolene. P.; Strynadka, Natalie C. J.; Withers, Stephen G. Share Save
Large-Scale Virtual Screening for the Discovery of SARS-CoV-2 Papain-like Protease (PLpro) Non-covalent Inhibitors Garland, Olivia; Ton, Anh-Tien; Moradi, Shoeib; Smith, Jason R.; Kovacic, Suzana; Ng, Kurtis; Pandey, Mohit; Ban, Fuqiang; Lee, Jaeyong; Vuckovic, Marija; Worrall, Liam J.; Young, Robert N.; Pantophlet, Ralph; Strynadka, Natalie C. J.; Cherkasov, Artem Share Save
An anti-HER2 biparatopic antibody that induces unique HER2 clustering and complement-dependent cytotoxicity Weisser, Nina E.; Sanches, Mario; Escobar-Cabrera, Eric; O'Toole, Jason; Whalen, Elizabeth; Chan, Peter W. Y.; Wickman, Grant; Abraham, Libin; Choi, Kate; Harbourne, Bryant; Samiotakis, Antonios; Rojas, Andrea Hernandez; Volkers, Gesa; Wong, Jodi; Atkinson, Claire E.; Baardsnes, Jason; Worrall, Liam J.; Browman, Duncan; Smith, Emma E.; Baichoo, Priya; Cheng, Chi Wing; Guedia, Joy; Kang, Sohyeong; Mukhopadhyay, Abhishek; Newhook, Lisa; Ohrn, Anders; Raghunatha, Prajwal; Zago-Schmitt, Matteo; Schrag, Joseph D.; Smith, Joel; Zwierzchowski, Patricia; Scurll, Joshua M.; Fung, Vincent; Black, Sonia; Strynadka, Natalie C. J.; Gold, Michael R.; Presta, Leonard G.; Ng, Gordon; Dixit, Surjit Share Save
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