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Structural basis for TIR domain-mediated innate immune signaling by Toll- like receptor adaptors TRIF and TRAM Manik, Mohammad K.; Pan, Mengqi; Xiao, Le; Gu, Weixi; Kim, Hyoyoung; Pospich, Sabrina; Hedger, Andrew; Vajjhala, Parimala R.; Lee, Morris Y. L.; Qian, Xiaoqi; Landsberg, Michael J.; Ve, Thomas; Nanson, Jeffrey D.; Raunser, Stefan; Stacey, Katryn J.; Wu, Hao; Kobe, Bostjan Share Save
Structural characterization of macro domain-containing Thoeris antiphage defense systems Shi, Yun; Masic, Veronika; Mosaiab, Tamim; Rajaratman, Premraj; Hartley-Tassell, Lauren; Sorbello, Mitchell; Goulart, Cassia C.; Vasquez, Eduardo; Mishra, Biswa P.; Holt, Stephanie; Gu, Weixi; Kobe, Bostjan; Ve, Thomas Share Save
Tetramerization is essential for the enzymatic function of the Pseudomonas aeruginosa virulence factor UDP-glucose pyrophosphorylase Dirr, Larissa; Cleeves, Sven; Ramon Roth, Isabel; Li, Linghui; Fiebig, Timm; Ve, Thomas; Haeussler, Susanne; Braun, Armin; von Itzstein, Mark; Fuehring, Jana I. Share Save
o-Vanillin binds covalently to MAL/TIRAP Lys-210 but independently inhibits TLR2 Rahaman, Md. Habibur; Thygesen, Sara J.; Maxwell, Michael J.; Kim, Hyoyoung; Mudai, Prerna; Nanson, Jeffrey D.; Jia, Xinying; Vajjhala, Parimala R.; Hedger, Andrew; Vetter, Irina; Haselhorst, Thomas; Robertson, Avril A. B.; Dymock, Brian; Ve, Thomas; Mobli, Mehdi; Stacey, Katryn J.; Kobe, Bostjan Share Save
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Plant and prokaryotic TIR domains generate distinct cyclic ADPR NADase products Bayless, Adam M.; Chen, Sisi; Ogden, Sam C.; Xu, Xiaoyan; Sidda, John D.; Manik, Mohammad K.; Li, Sulin; Kobe, Bostjan; Ve, Thomas; Song, Lijiang; Grant, Murray; Wan, Li; Nishimura, Marc T. Share Save
Megahertz pulse trains enable multi-hit serial femtosecond crystallography experiments at X-ray free electron lasers Holmes, Susannah; Kirkwood, Henry J.; Bean, Richard; Giewekemeyer, Klaus; Martin, Andrew, V; Hadian-Jazi, Marjan; Wiedorn, Max O.; Oberthuer, Dominik; Marman, Hugh; Adriano, Luigi; Al-Qudami, Nasser; Bajt, Sasa; Barak, Imrich; Bari, Sadia; Bielecki, Johan; Brockhauser, Sandor; Coleman, Mathew A.; Cruz-Mazo, Francisco; Danilevski, Cyril; Doerner, Katerina; Ganan-Calvo, Alfonso M.; Graceffa, Rita; Fanghor, Hans; Heymann, Michael; Frank, Matthias; Kaukher, Alexander; Kim, Yoonhee; Kobe, Bostjan; Knoska, Juraj; Laurus, Torsten; Letrun, Romain; Maia, Luis; Messerschmidt, Marc; Metz, Markus; Michelat, Thomas; Mills, Grant; Molodtsov, Serguei; Monteiro, Diana C. F.; Morgan, Andrew J.; Muennich, Astrid; Murillo, Gisel E. Pena; Previtali, Gianpietro; Round, Adam; Sato, Tokushi; Schubert, Robin; Schulz, Joachim; Shelby, Megan; Seuring, Carolin; Sellberg, Jonas A.; Sikorski, Marcin; Silenzi, Alessandro; Stern, Stephan; Sztuk-Dambietz, Jola; Szuba, Janusz; Trebbin, Martin; Vagovic, Patrick; Ve, Thomas; Weinhausen, Britta; Wrona, Krzysztof; Xavier, Paul Lourdu; Xu, Chen; Yefanov, Oleksandr; Nugent, Keith A.; Chapman, Henry N.; Mancuso, Adrian P.; Barty, Anton; Abbey, Brian; Darmanin, Connie Share Save
Ucl fimbriae regulation and glycan receptor specificity contribute to gut colonisation by extra-intestinal pathogenic Escherichia coli Hancock, Steven J.; Lo, Alvin W.; Ve, Thomas; Day, Christopher J.; Tan, Lendl; Mendez, Alejandra A.; Minh-Duy Phan; Nguyen Thi Khanh Nhu; Peters, Kate M.; Richards, Amanda C.; Fleming, Brittany A.; Chang, Chyden; Ngu, Dalton H. Y.; Forde, Brian M.; Haselhorst, Thomas; Goh, Kelvin G. K.; Beatson, Scott A.; Jennings, Michael P.; Mulvey, Matthew A.; Kobe, Bostjan; Schembri, Mark A. Share Save
Structural and biochemical characterization of Acinetobacter baumannii ZnuA Alquethamy, Saleh; Ganio, Katherine; Luo, Zhenyao; Hossain, Sheikh I.; Hayes, Andrew J.; Ve, Thomas; Davies, Mark R.; Deplazes, Evelyne; Kobe, Bostjan; McDevitt, Christopher A. Share Save
Structural basis of SARM1 activation, substrate recognition, and inhibition by small molecules Shi, Yun; Kerry, Philip S.; Nanson, Jeffrey D.; Bosanac, Todd; Sasaki, Yo; Krauss, Raul; Saikot, Forhad K.; Adams, Sarah E.; Mosaiab, Tamim; Masic, Veronika; Mao, Xianrong; Rose, Faith; Vasquez, Eduardo; Furrer, Marieke; Cunnea, Katie; Brearley, Andrew; Gu, Weixi; Luo, Zhenyao; Brillault, Lou; Landsberg, Michael J.; DiAntonio, Aaron; Kobe, Bostjan; Milbrandt, Jeffrey; Hughes, Robert O.; Ve, Thomas Share Save
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Neurotoxin-mediated potent activation of the axon degeneration regulator SARM1 Loreto, Andrea; Angeletti, Carlo; Gu, Weixi; Osborne, Andrew; Nieuwenhuis, Bart; Gilley, Jonathan; Merlini, Elisa; Arthur-Farraj, Peter; Amici, Adolfo; Luo, Zhenyao; Hartley-Tassell, Lauren; Ve, Thomas; Desrochers, Laura M.; Wang, Qi; Kobe, Bostjan; Orsomando, Giuseppe; Coleman, Michael P. Share Save
MyD88 TIR domain higher-order assembly interactions revealed by microcrystal electron diffraction and serial femtosecond crystallography Clabbers, Max T. B.; Holmes, Susannah; Muusse, Timothy W.; Vajjhala, Parimala R.; Thygesen, Sara J.; Malde, Alpeshkumar K.; Hunter, Dominic J. B.; Croll, Tristan, I; Flueckiger, Leonie; Nanson, Jeffrey D.; Rahaman, Md Habibur; Aquila, Andrew; Hunter, Mark S.; Liang, Mengning; Yoon, Chun Hong; Zhao, Jingjing; Zatsepin, Nadia A.; Abbey, Brian; Sierecki, Emma; Gambin, Yann; Stacey, Katryn J.; Darmanin, Connie; Kobe, Bostjan; Xu, Hongyi; Ve, Thomas Share Save
SARM1 is a metabolic sensor activated by an increased NMN/NAD+ ratio to trigger axon degeneration Figley, Matthew D.; Gu, Weixi; Nanson, Jeffrey D.; Shi, Yun; Sasaki, Yo; Cunnea, Katie; Malde, Alpeshkumar K.; Jia, Xinying; Luo, Zhenyao; Saikot, Forhad K.; Mosaiab, Tamim; Masic, Veronika; Holt, Stephanie; Hartley-Tassell, Lauren; McGuinness, Helen Y.; Manik, Mohammad K.; Bosanac, Todd; Landsberg, Michael J.; Kerry, Philip S.; Mobli, Mehdi; Hughes, Robert O.; Milbrandt, Jeffrey; Kobe, Bostjan; DiAntonio, Aaron; Ve, Thomas Share Save
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