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D

Dwight V. Nissley

frederick national laboratory for cancer research

29H-index
168Paper Count
5.0KCitation Count
Published Papers 72
Publication Date
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Free Energy and Flexibility Analysis of Autoinhibited Human BRAF
errJournal of Chemical Information and Modeling
IF5.3
err2026-04-21
err0
errOAAI
errJeremy O. B. Tempkin; Fikret Aydin; Sebnem Essiz; Yue Yang; Timothy S. Carpenter; David E. Durrant; Deborah K. Morrison; Helgi I. Ingólfsson; Frederick H. Streitz; Dwight V. Nissely; Felice C. Lightstone; Xiaohua Zhang
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Disulfide tethering reveals cryptic pockets in oncogenic KRAS
errCommunications Chemistry
IF6.2
err2026-03-30
err0
errOAAI
errTrent E. Balius; Marcin Dyba; Vandana Kumari; John-Paul Denson; Ming Yi; Alok K. Sharma; Priyanka Prakash; Emily Alberico; Simon Messing; Vanessa Wall; Albert H. Chan; Dhirendra K. Simanshu; Dwight V. Nissley; Frank McCormick; Dominic Esposito; Anna E. Maciag; David M. Turner
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Structure of SHOC2-KRAS-PP1C complex reveals RAS isoform-specific determinants and insights into targeting complex assembly by RAS inhibitors
errNature Communications
IF15.7
err2026-01-10
err0
errOAAI
errDaniel A. Bonsor; Lorenzo I. Finci; Jacob R. Potter; Lucy C. Young; Vanessa E. Wall; Ruby Goldstein de Salazar; Katie R. Geis; Tyler Stephens; Joseph Finney; Dwight V. Nissley; Frank McCormick; Dhirendra K. Simanshu
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Integrating Ultra-Coarse-Grained Protein Models into Accessible Workflows for Multiscale Molecular Dynamics
errACS Omega
IF4.3
err2025-10-22
err0
errOAAI
errBryce Tu Chi; Stephanie Fulcar; Jonathan Ipe; Olivia Schleifer; Rohan Subramanian; Claire Vlases; Naim Matasci; Konstantia Georgouli; Loïc Pottier; Tim Hsu; Timothy S. Carpenter; Dwight V. Nissley; Felice C. Lightstone; Frederick H. Streitz; Helgi I. Ingólfsson; Fikret Aydin
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Structural basis for LZTR1 recognition of RAS GTPases for degradation
errScience
IF45.8
err2025-09-11
err0
PREAI
errSrisathiyanarayanan Dharmaiah; Daniel A. Bonsor; Stephanie P. Mo; Alvaro Fernandez-Cabrera; Albert H. Chan; Simon Messing; Matthew Drew; Martha Vega; Dwight V. Nissley; Dominic Esposito; Pau Castel; Dhirendra K. Simanshu
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Dynamics and lipid membrane coupling of the RAS-RAF complex revealed via multiscale simulations
errBiophysical Journal
IF3.1
err2025-08-22
err0
errOAAI
errTimothy S. Carpenter; Fikret Aydin; Chris Neale; Que N. Van; Xiaohua Zhang; Harsh Bhatia; Jason W. Sidabras; Peter H. Frank; Konstantia Georgouli; Jeremy O.B. Tempkin; Violeta Burns Casamayor; Gulcin Gulten; Rebika Shrestha; Debanjan Goswami; Francesco Di Natale; Joseph R. Chavez; Adam Moody; Joseph Y. Moon; Tomas Oppelstrup; James N. Glosli; Gautham Dharuman; Sergio Wong; Shusen Liu; Nicolas W. Hengartner; Cesar A. López; Kien Nguyen; Christopher B. Stanley; Liam G. Stanton; Lara Patel; Tyler Reddy; Thomas J. Turbyville; Brian Van Essen; Peer-Timo Bremer; Felice C. Lightstone; Andrew G. Stephen; Sandrasegaram Gnanakaran; Frank McCormick; Dwight V. Nissley; Frederick H. Streitz; Helgi I. Ingólfsson
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Biophysical and structural analysis of KRAS switch-II pocket inhibitors reveals allele-specific binding constraints
errJournal of Biological Chemistry
IF3.9
err2025-07-01
err0
errOAAI
errPatrick Alexander; Albert H. Chan; Dana Rabara; Monalisa Swain; Erik K. Larsen; Marcin Dyba; Oleg Chertov; Mariam Ashraf; Allison Champagne; Ken Lin; Anna Maciag; William K. Gillette; Dwight V. Nissley; Frank McCormick; Dhirendra K. Simanshu; Andrew G. Stephen
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BBO-10203 inhibits tumor growth without inducing hyperglycemia by blocking RAS-PI3Kα interaction
errScience
IF45.8
err2025-06-12
err0
PREAI
errDhirendra K. Simanshu; Rui Xu; James P. Stice; Daniel J. Czyzyk; Siyu Feng; John-Paul Denson; Erin Riegler; Yue Yang; Cathy Zhang; Sofia Donovan; Brian P. Smith; Maria Abreu-Blanco; Ming Chen; Cindy Feng; Lijuan Fu; Dana Rabara; Lucy C. Young; Marcin Dyba; Wupeng Yan; Ken Lin; Samar Ghorbanpoorvalukolaie; Erik K. Larsen; Wafa Malik; Allison Champagne; Katie Parker; Jin Hyun Ju; Stevan Jeknic; Dominic Esposito; David M. Turner; Felice C. Lightstone; Bin Wang; Paul M. Wehn; Keshi Wang; Andrew G. Stephen; Anna E. Maciag; Aaron N. Hata; Kerstin W. Sinkevicius; Dwight V. Nissley; Eli M. Wallace; Frank McCormick; Pedro J. Beltran
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Blocking C-terminal processing of KRAS4b via a direct covalent attack on the CaaX-box cysteine
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2025-05-09
err0
errOAAI
errMaciag, Anna E.; Yang, Yue; Sharma, Alok K.; Turner, David M.; Dehart, Caroline J.; Abdelkarim, Hazem; Fan, Lixin; Smith, Brian P.; Kumari, Vandana; Dyba, Marcin; Rigby, Megan; Badillo, Jean A. Castillo; Adams, Lauren; Fornelli, Luca; Fox, Stephen; Brafman, Alla; Turbyville, Thomas; Gillette, William; Messing, Simon; Agamasu, Constance; Wolfe, Andrew L.; Gysin, Stephan; Chan, Albert H.; Simanshu, Dhirendra K.; Esposito, Dominic; Chertov, Oleg; Stephen, Andrew G.; Arkin, Michelle; Renslo, Adam; Kelleher, Neil L.; Gaponenko, Vadim; Lightstone, Felice C.; Nissley, Dwight, V; McCormick, Frank
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Enhanced Exploration of Protein Conformational Space through Integration of Ultra-Coarse-Grained Models to Multiscale Workflows
errJOURNAL OF PHYSICAL CHEMISTRY B
IF2.9
err2025-05-08
err0
errOAAI
errAydin, Fikret; Georgouli, Konstantia; Pottier, Loic; Oppelstrup, Tomas; Carpenter, Timothy S.; Tempkin, Jeremy O. B.; Bremer, Peer-Timo; Nissley, Dwight V.; Streitz, Frederick H.; Lightstone, Felice C.; Ingolfsson, Helgi I.
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Structural insights into isoform-specific RAS-PI3Kα interactions and the role of RAS in PI3Kα activation
errNATURE COMMUNICATIONS
IF15.7
err2025-01-09
err0
errOAAI
errCzyzyk, Daniel; Yan, Wupeng; Messing, Simon; Gillette, William; Tsuji, Takashi; Yamaguchi, Mitsuhiro; Furuzono, Shinji; Turner, David M.; Esposito, Dominic; Nissley, Dwight V.; Mccormick, Frank; Simanshu, Dhirendra K.
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The prominent pervasive oncogenic role and tissue specific permissiveness of RAS gene mutations
errSCIENTIFIC REPORTS
IF3.9
err2024-10-26
err0
errOAAI
errYi, Ming; Soppet, Daniel; Mccormick, Frank; Nissley, Dwight V.
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Generating Protein Structures for Pathway Discovery Using Deep Learning
errJOURNAL OF CHEMICAL THEORY AND COMPUTATION
IF5.5
err2024-10-10
err0
errOAAI
errGeorgouli, Konstantia; Stephany, Robert R.; Tempkin, Jeremy O. B.; Santiago, Claudio; Aydin, Fikret; Heimann, Mark A.; Pottier, Loic; Zhang, Xiaohua; Carpenter, Timothy S.; Hsu, Tim; Nissley, Dwight V.; Streitz, Frederick H.; Lightstone, Felice C.; Ingolfsson, Helgi I.; Bremer, Peer-Timo
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BBO-10203, an orally bioavailable small molecule that disrupts the RAS-PI3Kα interaction leading to pAKT and tumor growth inhibition in models of breast, lung and colorectal cancer
errEUROPEAN JOURNAL OF CANCER
IF7.1
err2024-10-01
err0
PREAI
errSimanshu, D.; Xu, R.; Stice, J.; Czyzyk, D.; Feng, S.; Yang, Y.; Denson, J. P.; Riegler, E.; Zhang, C.; Fu, L.; Lin, K.; Lightstone, F. C.; Wang, K.; Stephen, A. G.; Maciag, A. E.; Sinkevicius, K.; Nissley, D. V.; Wallace, E. M.; McCormick, F.; Beltran, P.
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BBO-10203, a first-in-class, orally bioavailable, selective covalent small molecule that inhibits RAS- driven PI3Kalpha activity without affecting glucose metabolism
errCANCER RESEARCH
IF16.6
err2024-05-02
err1
PREAI
errBeltran, Pedro; Dhirendra, Simanshu; Xu, Rui; Chen, Ming; Czyzyk, Daniel; Donovan, Sofia; Feng, Siyu; Feng, Cindy; Fu, Lijuan; Lightstone, Felice; Lin, Ken; Maciag, Anna; Nissley, Dwight; Riegler, Erin; Sinkevicius, Kerstin; Stephen, Andrew; Stice, James; Turner, David; Wang, Bin; Wang, Keshi; Yang, Yue; Zhang, Cathy; McCormick, Frank; Wallace, Eli
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Membrane lipids drive formation of KRAS4b-RAF1 RBDCRD nanoclusters on the membrane (vol 7, 242 , 2024)
errCOMMUNICATIONS BIOLOGY
IF5.1
err2024-04-11
err0
errOAAI
errShrestha, Rebika; Carpenter, Timothy S.; Van, Que N.; Agamasu, Constance; Tonelli, Marco; Aydin, Fikret; Chen, De; Gulten, Gulcin; Glosli, James N.; Lopez, Cesar A.; Oppelstrup, Tomas; Neale, Chris; Gnanakaran, Sandrasegaram; Gillette, William K.; Ingolfsson, Helgi I.; Lightstone, Felice C.; Stephen, Andrew G.; Streitz, Frederick H.; Nissley, Dwight V.; Turbyville, Thomas J.
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BBO-8520, a first-in-class, direct inhibitor of KRASG12C (ON), locks GTP-bound KRASG12C in the state 1 conformation resulting in rapid and complete blockade of effector binding
errCANCER RESEARCH
IF16.6
err2024-04-05
err2
PREAI
errMaciag, Anna E.; Stice, James; Wang, Bin; Sharma, Alok; Chan, Albert; Lin, Ken; Singh, Devansh; Dyba, Marcin; Yang, Yue; Setoodeh, Saman; Smith, Brian P.; Rabara, Dana; Zhang, Zuhui; Larsen, Erik K.; Esposito, Dom; Denson, John Paul; Ranieri, Michela; Meynardie, Mary; Mehdizadeh, Sadaf; Alexander, Patrick; Blanco, Maria Abreu; Turner, David; Xu, Rui; Lightstone, Felice C.; Wong, Kwok Kin; Simanshu, Dhirendra; Wang, Keshi; Stephen, Andrew G.; Sinkevicius, Kerstin; Nissley, Dwight V.; Wallace, Eli; McCormick, Frank; Beltran, Pedro J.
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A Top-Down Proteomic Assay to Evaluate KRAS4B-Compound Engagement
errANALYTICAL CHEMISTRY
IF6.7
err2024-03-18
err2
errOAAI
errD'Ippolito, Robert A.; Rabara, Dana; Blanco, Maria Abreu; Alberico, Emily; Drew, Matthew R.; Ramakrishnan, Nitya; Sontan, Dara; Widmeyer, Stephanie R. T.; Scheidemantle, Grace M.; Messing, Simon; Turner, David; Arkin, Michelle; Maciag, Anna E.; Stephen, Andrew G.; Esposito, Dominic; Mccormick, Frank; Nissley, Dwight V.; Dehart, Caroline J.
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Structural dynamics of RAF1-HSP90-CDC37 and HSP90 complexes reveal asymmetric client interactions and key structural elements
errCOMMUNICATIONS BIOLOGY
IF5.1
err2024-03-02
err5
errOAAI
errFinci, Lorenzo I.; Chakrabarti, Mayukh; Gulten, Gulcin; Finney, Joseph; Grose, Carissa; Fox, Tara; Yang, Renbin; Nissley, Dwight V.; McCormick, Frank; Esposito, Dominic; Balius, Trent E.; Simanshu, Dhirendra K.
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Membrane lipids drive formation of KRAS4b-RAF1 RBDCRD nanoclusters on the membrane
errCOMMUNICATIONS BIOLOGY
IF5.1
err2024-02-28
err8
errOAAI
errShrestha, Rebika; Carpenter, Timothy S.; Van, Que N.; Agamasu, Constance; Tonelli, Marco; Aydin, Fikret; Chen, De; Gulten, Gulcin; Glosli, James N.; Lopez, Cesar A.; Oppelstrup, Tomas; Neale, Chris; Gnanakaran, Sandrasegaram; Gillette, William K.; Ingolfsson, Helgi I.; Lightstone, Felice C.; Stephen, Andrew G.; Streitz, Frederick H.; Nissley, Dwight V.; Turbyville, Thomas J.
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Research Directions

No research directions
Co-authors
Cooperation Journals
K
Kwok‐Kin Wong
H-index: 140 · Papers: 1.7K
F
Frank McCormick
H-index: 130 · Papers: 787
N
Neil L. Kelleher
H-index: 106 · Papers: 712
C
Chen‐Yu Zhang
H-index: 105 · Papers: 778
J
John W. Mellors
H-index: 102 · Papers: 616
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