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SaveAlteration of microglial metabolism and inflammatory profile contributes to neurotoxicity in a hiPSC-derived microglia model of frontotemporal dementia 3
Haukedal, Henriette; Lorenzen, Signe Syshoj; Westi, Emil Winther; Corsi, Giulia I.; Gadekar, Veerendra P.; McQuade, Amanda; Davtyan, Hayk; Doncheva, Nadezhda T.; Schmid, Benjamin; Chandrasekaran, Abinaya; Seemann, Stefan E.; Cirera, Susanna; Blurton-Jones, Mathew; Meyer, Morten; Gorodkin, Jan; Aldana, Blanca I.; Freude, Kristine Share Save Share Save The transcriptomic landscape of neurons carrying PSEN1 mutations reveals changes in extracellular matrix components and non-coding gene expressionCorsi, Giulia I.; Gadekar, Veerendra P.; Haukedal, Henriette; Doncheva, Nadezhda T.; Anthon, Christian; Ambardar, Sheetal; Palakodeti, Dasaradhi; Hyttel, Poul; Freude, Kristine; Seemann, Stefan E.; Gorodkin, Jan Share Save Golgi fragmentation - One of the earliest organelle phenotypes in Alzheimer's disease neuronsHaukedal, Henriette; Corsi, Giulia I.; Gadekar, Veerendra P.; Doncheva, Nadezhda T.; Kedia, Shekhar; de Haan, Noortje; Chandrasekaran, Abinaya; Jensen, Pia; Schionning, Pernille; Vallin, Sarah; Marlet, Frederik Ravnkilde; Poon, Anna; Pires, Carlota; Agha, Fawzi Khoder; Wandall, Hans H.; Cirera, Susanna; Simonsen, Anja Hviid; Nielsen, Troels Tolstrup; Nielsen, Jorgen Erik; Hyttel, Poul; Muddashetty, Ravi; Aldana, Blanca I.; Gorodkin, Jan; Nair, Deepak; Meyer, Morten; Larsen, Martin Rossel; Freude, Kristine Share Save Massively targeted evaluation of therapeutic CRISPR off-targets in cellsPan, Xiaoguang; Qu, Kunli; Yuan, Hao; Xiang, Xi; Anthon, Christian; Pashkova, Liubov; Liang, Xue; Han, Peng; Corsi, Giulia, I; Xu, Fengping; Liu, Ping; Zhong, Jiayan; Zhou, Yan; Ma, Tao; Jiang, Hui; Liu, Junnian; Wang, Jian; Jessen, Niels; Bolund, Lars; Yang, Huanming; Xu, Xun; Church, George M.; Gorodkin, Jan; Lin, Lin; Luo, Yonglun Share Save Share Save Share Save Astrocytic reactivity triggered by defective autophagy and metabolic failure causes neurotoxicity in frontotemporal dementia type 3Chandrasekaran, Abinaya; Dittlau, Katarina Stoklund; Corsi, Giulia, I; Haukedal, Henriette; Doncheva, Nadezhda T.; Ramakrishna, Sarayu; Ambardar, Sheetal; Salcedo, Claudia; Schmidt, Sissel, I; Zhang, Yu; Cirera, Susanna; Pihl, Maria; Schmid, Benjamin; Nielsen, Troels Tolstrup; Nielsen, Jorgen E.; Kolko, Miriam; Kobolak, Julianna; Dinnyes, Andras; Hyttel, Poul; Palakodeti, Dasaradhi; Gorodkin, Jan; Muddashetty, Ravi S.; Meyer, Morten; Aldana, Blanca, I; Freude, Kristine K. Share Save Enhancing CRISPR-Cas9 gRNA efficiency prediction by data integration and deep learningXiang, Xi; Corsi, Giulia, I; Anthon, Christian; Qu, Kunli; Pan, Xiaoguang; Liang, Xue; Han, Peng; Dong, Zhanying; Liu, Lijun; Zhong, Jiayan; Ma, Tao; Wang, Jinbao; Zhang, Xiuqing; Jiang, Hui; Xu, Fengping; Liu, Xin; Xu, Xun; Wang, Jian; Yang, Huanming; Bolund, Lars; Church, George M.; Lin, Lin; Gorodkin, Jan; Luo, Yonglun Share Save Share Save 
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