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William G. Kaelin

Harvard Medical School

138H-index
491Paper Count
6.8WCitation Count
Published Papers 133
Publication Date
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Publisher Correction: argeting of HIF2-driven cachexia in kidney cancer
errNature Medicine
IF50
err2026-01-28
err0
errOAAI
errMuhannad Abu-Remaileh; Laura A. Stransky; Nikita Bhalerao; Nitin H. Shirole; Qinqin Jiang; Eddy Saad; Marc Machaalani; Sean M. Vigeant; Hilina Woldemichael; Charles Xu; Jing Lu; Hairong Wei; Zhihong Liu; William Sun; Kei Enomoto; Toni K. Choueiri; Jason R. Pitarresi; Steven A. Carr; Namrata D. Udeshi; William G. Kaelin
errShare
errSave
Targeting of HIF2-driven cachexia in kidney cancer
errNature Medicine
IF50
err2025-11-28
err0
errOAAI
errMuhannad Abu-Remaileh; Laura A. Stransky; Nikita Bhalerao; Nitin H. Shirole; Qinqin Jiang; Eddy Saad; Marc Machaalani; Sean M. Vigeant; Hilina Woldemichael; Charles Xu; Jing Lu; Hairong Wei; Zhihong Liu; William Sun; Kei Enomoto; Toni K. Choueiri; Jason R. Pitarresi; Steven A. Carr; Namrata D. Udeshi; William G. Kaelin
errShare
errSave
The SLC1A1/EAAT3 dicarboxylic amino acid transporter is an epigenetically dysregulated nutrient carrier that sustains oncogenic metabolic programs
errNature Communications
IF15.7
err2025-11-14
err0
errOAAI
errTreg Grubb; Pooneh Koochaki; Sayed Matar; Fatme Ghandour; Marc Machaalani; Eddy Saad; Cerise Tang; Eduard Reznik; Jesminara Khatun; Carleigh Salem; Noah Dubasik; David A. Orlando; Matthew G. Guenther; Gyanu Parajuli; Raghvendra M. Srivastava; Steven R. Martinez; Jesse A. Coker; Ritesh R. Kotecha; A. Ari Hakimi; John M. Asara; Timothy A. Chan; Sakari Vanharanta; Shaun R. Stauffer; William G. Kaelin; Sabina Signoretti; Toni K. Choueiri; Abhishek A. Chakraborty
errShare
errSave
LEVERAGING GENOMIC ALTERATIONS IN GLIOBLASTOMA MULTIFORME
errNEURO-ONCOLOGY
IF13.4
err2025-11-01
err0
errOAAI
errBerger, Tamar; Mcgowan, Nora; Shirole, Nitin; Abu-Remaileh, Muhannad; Ligon, Keith; Cusick, Margaret; Beroukhim, Rameen; Kaelin, William
errShare
errSave
Preclinical and clinical assessment of chemoradiation after mutant IDH inhibitor treatment in IDH-mutant glioma
errNEURO-ONCOLOGY
IF13.4
err2025-11-01
err0
errOAAI
errShi, Diana; Calvo-Fernandez, Ester; Puliyappadamba, Vinesh; Lanman, Tyler; Cruickshank, Aiden; Prost, Diego; Xiao, Yi; Neumann, Ethan; Gudipelly, Sriram; Clark, Louise; Kaphle, Pranita; Shipman, Tracey; Levitt, Michael; Lin, Mathew; Tsai, Alexander; Lee, Joyce; Simons, Donald; Tyagi, Ethika; Rahman, Rifaquat; De Nguyen, Quang-; Wen, Patrick; Haas-Kogan, Daphne; Yates, Kathleen; Manguso, Robert; Bardeesy, Nabeel; Bernstein, Bradley; Wu, Jingyi; Abdullah, Kalil; Jain, Payal; Tron, Adriana; Touat, Mehdi; Castro, L. Nicolas Gonzalez; Suva, Mario; Kaelin, William; Mcbrayer, Samuel
errShare
errSave
The SLC1A1/EAAT3 dicarboxylic amino acid transporter is an epigenetically dysregulated nutrient carrier that sustains oncogenic metabolic programs
errONCOLOGIST
IF4.2
err2025-10-01
err0
errOAAI
errGrubb, Treg; Koochaki, Pooneh; Matar, Sayed; Ghandour, Fatme; Machaalani, Marc; Saad, Eddy; Tang, Cerise; Reznik, Eduard; Khatun, Jesminara; Salem, Carleigh; Dubasik, Noah; Orlando, David A.; Guenther, Matthew G.; Parajuli, Gyanu; Srivastava, Raghvendra M.; Martinez, Steven R.; Coker, Jesse; Kotecha, Ritesh; Hakimi, A. Ari; Asara, John; Chan, Timothy; Vanharanta, Sakari; Stauffer, Shaun; Kaelin, William G.; Signoretti, Sabina; Choueri, Toni; Chakraborty, Abhishek
errShare
errSave
A GENETIC MOUSE MODEL OF IDH-MUTANT GLIOMA RESPONDS TO MUTANT IDH INHIBITION AND REVEALS ENHANCED EFFICACY OF SALVAGE CHEMORADIATION AFTER VORASIDENIB
errNEURO-ONCOLOGY
IF13.4
err2025-10-01
err0
errOAAI
errShi, D. D.; Calvo-Fernandez, E.; Puliyappadamba, V. T.; Xiao, Y.; Neumann, E.; Gudipelly, S.; Clark, L.; Kaphle, P.; Levitt, M. M.; Lin, M.; Tsai, A. C.; Lee, J. H.; Simmons, D.; Tyagi, E.; Abdullah, K.; Nguyen, Q.; Jain, P.; Tron, A.; Suva, M. L.; Kaelin, W. G.; McBrayer, S. K.
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errSave
Killing the Science Golden Goose
errThe American Journal of Medicine
IF0
err2025-04-15
err0
PREAI
errWilliam G. Kaelin
errShare
errSave
HIF regulates multiple translated endogenous retroviruses: Implications for cancer immunotherapy
errCELL
IF42.5
err2025-02-01
err0
errOAAI
errJiang, Qinqin; Braun, David A.; Clauser, Karl R.; Ramesh, Vijyendra; Shirole, Nitin H.; Duke-Cohan, Joseph E.; Nabilsi, Nancy; Kramer, Nicholas J.; Forman, Cleo; Lippincott, Isabelle E.; Klaeger, Susan; Phulphagar, Kshiti M.; Chea, Vipheaviny; Kim, Nawoo; Vanasse, Allison P.; Saad, Eddy; Parsons, Teagan; Carr-Reynolds, Melissa; Carulli, Isabel; Pinjusic, Katarina; Jiang, Yijia; Li, Rong; Syamala, Sudeepa; Rachimi, Suzanna; Verzani, Eva K.; Stevens, Jonathan D.; Lane, William J.; Camp, Sabrina Y.; Meli, Kevin; Pappalardi, Melissa B.; Herbert, Zachary T.; Qiu, Xintao; Cejas, Paloma; Long, Henry W.; Shukla, Sachet A.; Allen, Eliezer M. Van; Choueiri, Toni K.; Churchman, L. Stirling; Abelin, Jennifer G.; Gurer, Cagan; Macbeath, Gavin; Childs, Richard W.; Carr, Steven A.; Keskin, Derin B.; Wu, Catherine J.; Kaelin Jr, William G.
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errSave
Toward a CRISPR- based mouse model of Vhl- deficient clear cell kidney cancer: Initial experience and lessons learned
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2024-10-04
err0
errOAAI
errStransky, Laura A.; Gao, Wenhua; Schmidt, Laura S.; Bi, Kevin; Ricketts, Christopher J.; Ramesh, Vijyendra; James, Amy; Difilippantonio, Simone; Ileva, Lilia; Kalen, Joseph D.; Karim, Baktiar; Jeon, Albert; Morgan, Tamara; Warner, Andrew C.; Turan, Sevilay; Unite, Joanne; Tran, Bao; Choudhari, Sulbha; Zhao, Yongmei; Linn, Douglas E.; Yun, Changhong; Dhandapani, Sripriya; Parab, Vaishali; Pinheiro, Elaine M.; Morris, Nicole; He, Lixia; Vigeant, Sean M.; Pignon, Jean- Christophe; Ivins, Maura Sticco --; Signoretti, Sabina; Allen, Eliezer M. Van; Linehan, W. Marston; Kaelin, William G.
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errSave
Induction of DEPP1 by HIF Mediates Multiple Hallmarks of Ischemic Cardiomyopathy
errCIRCULATION
IF38.6
err2024-09-03
err0
errOAAI
errWyant, Gregory A.; Jiang, Qinqin; Singh, Madhu; Qayyum, Shariq; Levrero, Clara; Maron, Bradley A.; Kaelin Jr, William G.
errShare
errSave
Targeting the HIF2-VEGF axis in renal cell carcinoma (vol 26, pg 1519, 2020)
errNATURE MEDICINE
IF50
err2024-08-28
err0
errOAAI
errChoueiri, Toni K.; Kaelin Jr, William G.
errShare
errSave
The INDIGO trial: Precision medicine finally comes to glioma
errNEURO-ONCOLOGY
IF13.4
err2023-10-12
err0
PREAI
errShi, Diana D.; Kaelin, William G.
errShare
errSave
Downregulation of the HIF2a target cyclin D1 underlies the efficacy of the HIF2a inhibitor belzutifan in kidney cancer.
errCANCER RESEARCH
IF16.6
err2023-08-15
err0
PREAI
errShirole, Nitin H.; Kesar, Devishi; Sellers, William R.; Kaelin, William G., Jr.
errShare
errSave
Prolonged hypoxia alleviates prolyl hydroxylation-mediated suppression of RIPK1 to promote necroptosis and inflammation
errNATURE CELL BIOLOGY
IF19.1
err2023-07-03
err16
errOAAI
errZhang, Tao; Xu, Daichao; Liu, Jianping; Wang, Min; Duan, Li-Juan; Liu, Min; Meng, Huyan; Zhuang, Yuan; Wang, Huibing; Wang, Yingnan; Lv, Mingming; Zhang, Zhengyi; Hu, Jia; Shi, Linyu; Guo, Rui; Xie, Xingxing; Liu, Hui; Erickson, Emily; Wang, Yaru; Yu, Wenyu; Dang, Fabin; Guan, Dongxian; Jiang, Cong; Dai, Xiaoming; Inuzuka, Hiroyuki; Yan, Peiqiang; Wang, Jingchao; Babuta, Mrigya; Lian, Gewei; Tu, Zhenbo; Miao, Ji; Szabo, Gyongyi; Fong, Guo-Hua; Karnoub, Antoine E.; Lee, Yu-Ru; Pan, Lifeng; Kaelin, William G.; Yuan, Junying; Wei, Wenyi
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errSave
Diverse effects of mutations in Exon II of the von Hippel-Lindau (VHL) tumor suppressor gene on the interaction of pVHL with the cytosolic chaperonin and pVHL-dependent ubiquitin ligase activity
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-28
err74
errOAAI
errHansen, WJ; Ohh, M; Moslehi, J; Kondo, K; Kaelin, WG; Welch, WJ
errShare
errSave
Regulation of hypoxia-inducible mRNAs by the von Hippel-Lindau tumor suppressor protein requires binding to complexes containing elongins B/C and Cul2
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-28
err376
errOAAI
errLonergan, KM; Iliopoulos, O; Ohh, M; Kamura, T; Conaway, RC; Conaway, JW; Kaelin, WG
errShare
errSave
Cells degrade a novel inhibitor of differentiation with E1A-like properties upon exiting the cell cycle
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-28
err112
errOAAI
errMiyake, S; Sellers, WR; Safran, M; Li, XT; Zhao, WQ; Grossman, SR; Gan, JM; DeCaprio, JA; Adams, PD; Kaelin, WG
errShare
errSave
Viral oncoproteins discriminate between p53 and the p53 homolog p73
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-28
err183
errOAAI
errMarin, MC; Jost, CA; Irwin, MS; DeCaprio, JA; Caput, D; Kaelin, WG
errShare
errSave
PVHL modification by NEDD8 is required for fibronectin matrix assembly and suppression of tumor development
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-27
err186
errOAAI
errStickle, NH; Chung, J; Klco, JM; Hill, RP; Kaelin, WG; Ohh, M
errShare
errSave

Research Directions

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Co-authors
Cooperation Journals
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Eric S. Lander
H-index: 271 · Papers: 897
G
Gad Getz
H-index: 248 · Papers: 1.8K
M
Matthew Meyerson
H-index: 223 · Papers: 1.9K
C
Craig B. Thompson
H-index: 206 · Papers: 767
S
Steven P. Gygi
H-index: 195 · Papers: 1.0K
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