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Alex W. Hewitt

Garvan Institute of Medical Research

88H-index
733Paper Count
3.2WCitation Count
Published Papers 290
Publication Date
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The impact of sex on the immune system explored at the single-cell level
errThe American Journal of Human Genetics
IF0
err2026-05-07
err0
errOAAI
errSeyhan Yazar; Jose Alquicira-Hernandez; Kristof Wing; Anne Senabouth; Stacey Andersen; Kirsten A. Fairfax; Alex W. Hewitt; Joseph E. Powell; Sara Ballouz
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Single-cell analysis of the human immune system reveals sex-specific dynamics of immunosenescence
errNature Aging
IF19.4
err2026-04-10
err0
PREAI
errMaria Sopena-Rios; Aida Ripoll-Cladellas; Fatemeh Omidi; Sara Ballouz; Jose Alquicira-Hernandez; Roy Oelen; Alex W. Hewitt; Lude Franke; Monique G. P. van der Wijst; Joseph E. Powell; Marta Melé
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Opportunistic genomic screening of healthy controls in an Australian biobank
errEuropean Journal of Human Genetics
IF4.6
err2026-04-01
err0
errOAAI
errMitchell, Lucas A.; Young, Mary-Anne; Ohnesorg, Thomas; Hobbs, Matthew; Copty, Joseph; Brown, Jaye S.; Hewitt, Alex W.; Powell, Joseph E.; Macathur, Daniel G.; Willis, Amanda M.
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A large-scale genome-wide association meta-analysis for nevus count provides direct insights into the genetics of melanoma
errNature Communications
IF15.7
err2026-03-10
err0
errOAAI
errG. J. M. Shanika R. Jayasinghe; Gu Zhu; Nirmala Pandeya; Catherine M. Olsen; Nicholas G. Martin; Penelope A. Lind; Sarah E. Medland; Scott D. Gordon; Santiago Diaz-Torres; Gareth Lingham; Samantha S. Y. Lee; Tamar Nijsten; Manfred Kayser; Luba M. Pardo; Grant W. Montgomery; Nicholas K. Hayward; Jane M. Palmer; David J. Hunter; Jiali Han; Alex W. Hewitt; Mario Falchi; D. Timothy Bishop; Kevin M. Brown; Veronique Bataille; David A. Mackey; Mark M. Iles; David C. Whiteman; David L. Duffy; Stuart MacGregor; Matthew H. Law
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errSave
Benchmarking Generative AI Protein Models Reveals Differences Between Structural and Sequence-based Approaches
errGenomics, Proteomics & Bioinformatics
IF0
err2026-02-15
err0
errOAAI
errAlexander J Barnett; Rajendra KC; Pratikshya Pandey; Pamodha Somasiri; Kirsten A Fairfax; Sandy Hung; Alex W Hewitt; null
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errSave
CRISPR-Cas9 mediated gene therapy in inherited bone marrow failure syndromes
errFrontiers in Hematology
IF0
err2025-12-03
err0
errOAAI
errMunugoda Hewa, Nadeesha J. S.; Kc, Rajendra; Hewitt, Alex W.; Fairfax, Kirsten A.
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errSave
Large-scale drug screening in iPSC-derived motor neurons from sporadic ALS patients identifies a potential combinatorial therapy
errNature Neuroscience
IF20
err2025-11-24
err0
errOAAI
errChristopher R. Bye; Elizabeth Qian; Katherine Lim; Maciej Daniszewski; Fleur C. Garton; Bảo C. Trần-Lê; Helena H. Liang; Tian Lin; John G. Lock; Duncan E. Crombie; Steven Morgan; Yi Hu; Samantha K. Barton; Lucy M. Palmer; Elvan Djouma; Saritha Kodikara; Kim-Anh Lê Cao; Thanuja Dharmadasa; Anjali K. Henders; Laura A. Ziser; Matthew C. Kiernan; Kevin Talbot; Merrilee Needham; Susan Fletcher; Paul Talman; Susan Mathers; Naomi R. Wray; Alex W. Hewitt; Alice Pebay; Bradley J. Turner
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errSave
Automated quantification of Ki-67 expression in breast cancer from H&E-stained slides using a transformer-based regression model
errBreast Cancer Research
IF5.6
err2025-11-19
err0
errOAAI
errAbadh K. Chaurasia; Patrick W. Toohey; Matthew T. Bennett; Helen C. Harris; Alex W. Hewitt
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errSave
Generalizable features of pegRNA design for prime editing of inherited retinal diseases
errOphthalmic Genetics
IF1
err2025-11-01
err0
PREAI
errPatterson, Freya M.; Tran, Minh Thuan Nguyen; Guinan, Thomas; Khalid, Mohd Khairul Nizam Mohd; Kc, Rajendra; Fairfax, Kirsten A.; Liu, Guei-Sheung; Cook, Anthony L.; Hung, Sandy S.; Hewitt, Alex W.
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A multitrait polygenic risk score for open-angle glaucoma stratifies risk of pigmentary glaucoma in pigment dispersion syndrome.
errOphthalmology Glaucoma
IF3.2
err2025-10-21
err0
PREAI
errAntonia Kolovos; Ayub Qassim; Henry Marshall; Thi Thi Nguyen; Joshua Schmidt; Mark M. Hassall; Victoria Tang; Giorgina Maxwell; John Landers; Richard Mills; Stewart Lake; Stuart Graham; Angela Schulz; Anna Galanopoulos; Robert J. Casson; Ivan Goldberg; Michael Coote; Stephen Best; Jed Lusthaus; Paul R. Healey; Leslie Burnett; Marc Töteberg-Harms; Erin A. Boese; Andrew E. Pouw; Puya Gharahkhani; Todd Scheetz; Alex W. Hewitt; Stuart MacGregor; Owen M. Siggs; Emmanuelle Souzeau; John H. Fingert; Jamie E. Craig
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errSave
Genomic structural equation Modeling analysis of glaucoma Endophenotypes: investigating genetic architecture and non-intraocular pressure mechanisms
errHUMAN MOLECULAR GENETICS
IF3.2
err2025-10-01
err0
PREAI
errMarzban, Maryam; Diaz-Torres, Santiago; Thorp, Jackson; Ong, Jue Sheng; Khawaja, Anthony P.; Hammond, Christopher J.; Hysi, Pirro G.; Pasquale, Louis R.; Kraft, Peter; Kang, Jae H.; Hewitt, Alex W.; Mackey, David A.; Craig, Jamie E.; Wiggs, Janey L.; MacGregor, Stuart; Gharahkhani, Puya
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errSave
Association of polygenic scores for glaucoma with measures of retinal ganglion cell integrity in young and older adults
errAmerican Journal of Ophthalmology
IF4.2
err2025-09-26
err0
PREAI
errSamantha Sze-Yee Lee; Santiago Diaz Torres; Gareth Lingham; Seyhan Yazar; Michael Hunter; Jamie E Craig; Alex W Hewitt; Stuart MacGregor; Puya Gharahkhani; David A Mackey
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Multi-resolution vision transformer model for histopathological skin cancer subtype classification using whole slide images
errComputers in Biology and Medicine
IF6.3
err2025-07-09
err0
errOAAI
errAbadh K. Chaurasia; Patrick W. Toohey; Helen C. Harris; Alex W. Hewitt
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errSave
Evaluating Practical Approaches for Including MYOC Variants Alongside Common Variants for Genetics-Based Risk Stratification for Glaucoma
errAMERICAN JOURNAL OF OPHTHALMOLOGY
IF4.2
err2025-06-01
err0
PREAI
errLe, NQ; He, WX; Law, MH; Medland, SE; Mackey, DA; Hewitt, AW; Gharahkhani, P; Macgregor, S
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errSave
Reply
errOphthalmology Science
IF4.6
err2025-04-05
err0
errOAAI
errAbadh K. Chaurasia; Connor J. Greatbatch; Xikun Han; Puya Gharahkhani; David A. Mackey; Stuart MacGregor; Jamie E. Craig; Alex W. Hewitt
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errSave
Functional genomics in age-related macular degeneration: From genetic associations to understanding disease mechanisms
errEXPERIMENTAL EYE RESEARCH
IF2.7
err2025-03-01
err0
PREAI
errRatnapriya, Rinki; Grassman, Felix; Chen, Rui; Hewitt, Alex; Du, Jianhai; Saban, Daniel R.; Klaver, Caroline C. W.; Ash, John; Stambolian, Dwight; Tumminia, Santa J.; Qian, Jiang; Husain, Deeba; Iyengar, Sudha K.; den Hollander, Anneke I.
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Genome-Wide Association Study to Identify Genetic Variants Associated With Diabetic Maculopathy
errINVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
IF4.7
err2025-03-01
err0
errOAAI
errGurung, Rajya L.; Nangia, Charvi; Cai, Tengda; Fitzgerald, Liesel M.; Mccomish, Bennet J.; Liu, Ebony; Kaidonis, Georgia; Ridge, Bronwyn; Hewitt, Alex W.; Vote, Brendan; Verma, Nitin; Craig, Jamie E.; Palmer, Colin N. A.; Burdon, Kathryn P.; Meng, Weihua
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A generalised vision transformer-based self-supervised model for diagnosing and grading prostate cancer using histological images
errPROSTATE CANCER AND PROSTATIC DISEASES
IF5.8
err2025-03-01
err0
errOAAI
errChaurasia, Abadh K.; Harris, Helen C.; Toohey, Patrick W.; Hewitt, Alex W.
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errSave
A Multitrait Open-Angle Glaucoma Polygenic Risk Score Stratifies Risk of Glaucoma Diagnosis and Severity in Eyes with Pseudoexfoliation
errOphthalmology
IF9.5
err2025-02-24
err0
errOAAI
errAntonia Kolovos; Ayub Qassim; Mark M. Hassall; Henry N. Marshall; Joshua Schmidt; Thi Thi Nguyen; Weixiong He; Sean Mullany; Georgina L. Hollitt; Ella C. Berry; Victoria Tang; Tiger Zhou; Stewart Lake; Richard Mills; John Landers; Robert J. Casson; Anna Galanopoulos; Stuart L. Graham; Angela Schulz; Paul R. Healey; Paul Mitchell; Ivan Goldberg; John Grigg; Jonathan Ruddle; David A. Mackey; Kathryn P. Burdon; Alex W. Hewitt; Mathias Seviiri; Puya Gharahkhani; Emmanuelle Souzeau; Owen M. Siggs; Stuart MacGregor; Jamie E. Craig
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errSave
Genome-wide meta-analysis identifies 22 loci for normal tension glaucoma with significant overlap with high tension glaucoma
errNATURE COMMUNICATIONS
IF15.7
err2024-11-17
err0
errOAAI
errDiaz-Torres, Santiago; He, Weixiong; Yu, Regina; Khawaja, Anthony P.; Hammond, Christopher J.; Hysi, Pirro G.; Pasquale, Louis R.; Wu, Yeda; Kubo, Michiaki; Akiyama, Masato; Aung, Tin; Cheng, Ching-Yu; Khor, Chiea Chuen; Kraft, Peter; Kang, Jae H.; Hewitt, Alex W.; Mackey, David A.; Craig, Jamie E.; Wiggs, Janey L.; Ong, Jue-Sheng; MacGregor, Stuart; Gharahkhani, Puya; Han, Xikun; Hamel, Andrew R.; Young, Terri L.; Lotery, Andrew J.; Jorgenson, Eric; Choquet, Helene; Hauser, Michael; Bailey, Jessica N. Cooke; Nakazawa, Toru; Shiga, Yukihiro; Segre, Ayellet V.
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Research Directions

No research directions
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