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A TRAILR2/CDH3 bispecific antibody demonstrates selective apoptosis and tumor regression in CDH3-positive pancreatic cancer Jung, Peter; Glaser, Stefan P.; Han, Jing; Popa, Alexandra; Pisarsky, Laura; Feng, Ningping; Geyer, Antonia; Haderk, Franziska; Alpar, Donat; Bristow, Christopher; Schmittner, Susanne; Traexler, Paula-Elena; Mahendra, Mikhila; Poehn, Birgit; Gandhi, Poojabahen; Fiorelli, Roberto; Awate, Sanket; Budano, Nicole; Martin, Florian; Albrecht, Christoph; Drobits-Handl, Barbara; Anand, Sathanandam S.; Kasturirangan, Srinath; Trapani, Francesca; Schweifer, Norbert; Marszalek, Joseph R.; Tontsch-Grunt, Ulrike; Pearson, Mark; Heffernan, Timothy P.; Kraut, Norbert; Vellano, Christopher P.; Garcia-Martinez, Juan Manuel Share Save
A TRAILR2/CDH3 bispecific antibody demonstrates selective apoptosis and tumor regression in CDH3-positive pancreatic cancer Jung, P.; Glaser, S. P.; Han, J.; Popa, A.; Pisarsky, L.; Feng, N.; Geyer, A.; Haderk, F.; Alpar, D.; Bristow, C.; Drobits-Handl, B.; Kasturirangan, S.; Trapani, F.; Marszalek, J. R.; Tontsch-Grunt, U.; Pearson, M.; Heffernan, T. P.; Kraut, N.; Vellano, C. P.; Garcia-Martinez, J. M. Share Save
KRASmulti inhibitor BI 3706674 shows efficacy in KRAS-driven preclinical models of cancer that supports clinical testing in patients with tumors harboring KRASG12V mutations and KRAS wild-type amplifications Tedeschi, A.; Peng, D. H.; Schischlik-Siegl, F.; Schaaf, O.; Gerlach, D.; Rocchetti, F.; Popow, J.; Broeker, J.; Wunberg, T.; Boghossian, A. S.; Rees, M. G.; Ronan, M. M.; Roth, J. A.; Williams, M.; Vellano, C.; Marszalek, J. R.; Heffernan, T. P.; Pearson, M.; Kraut, N.; Dorothea, R. Share Save
Co-targeting SOS1 enhances the antitumor effects of KRASG12C inhibitors by addressing intrinsic and acquired resistance Thatikonda, Venu; Lyu, Hengyu; Jurado, Sabine; Kostyrko, Kaja; Bristow, Christopher A.; Albrecht, Christoph; Alpar, Donat; Arnhof, Heribert; Bergner, Oliver; Bosch, Karin; Feng, Ningping; Gao, Sisi; Gerlach, Daniel; Gmachl, Michael; Hinkel, Melanie; Lieb, Simone; Jeschko, Astrid; Machado, Annette A.; Madensky, Thomas; Marszalek, Ethan D.; Mahendra, Mikhila; Melo-Zainzinger, Gabriella; Molkentine, Jessica M.; Jaeger, Philipp A.; Peng, David H.; Schenk, Robyn L.; Sorokin, Alexey; Strauss, Sandra; Trapani, Francesca; Kopetz, Scott; Vellano, Christopher P.; Petronczki, Mark; Kraut, Norbert; Heffernan, Timothy P.; Marszalek, Joseph R.; Pearson, Mark; Waizenegger, Irene C.; Hofmann, Marco H. Share Save
Unraveling ETC complex I function in ferroptosis reveals a potential ferroptosis-inducing therapeutic strategy for LKB1-deficient cancers Mao, Chao; Lei, Guang; Horbath, Amber; Wang, Min; Lu, Zhengze; Yan, Yuelong; Liu, Xiaoguang; Kondiparthi, Lavanya; Chen, Xiong; Cheng, Jun; Li, Qidong; Xu, Zhihao; Zhuang, Li; Fang, Bingliang; Marszalek, Joseph R.; V. Poyurovsky, Masha; Olszewski, Kellen; Gan, Boyi Share Save
KRASmulti inhibitor BI 3706674 shows efficacy in KRAS-driven preclinical models of cancer that supports clinical testing in patients with tumors harbouring KRASG12V mutations and KRAS wild-type amplifications Tedeschi, Antonio; Peng, David H.; Schischlik, Fiorella; Herdeis, Lorenz; Schaaf, Otmar; Santoro, Valeria; Gerlach, Daniel; Savarese, Fabio; Lipp, Jesse; Haslinger, Christian; Rocchetti, Francesca; Popow, Johannes; Huber, Heinrich J.; Wilding, Birgit; Treu, Matthias; Fuchs, Julian; Broeker, Joachim; Wunber, Tobias; Gmachl, Michael; Rumpel, Klaus; Rees, Matthew; Ron, Melissa; Roth, Jennifer; Williams, Mariah; Deckard, Charles; Ramamoorthy, Vandhana; Daniele, Joseph R.; Ajani, Jaffer A.; Meric-Bernstam, Funda; Kopetz, Scott; Kim, Michael; Gibbons, Don L.; Vellano, Christopher P.; Marszalek, Joseph R.; Heffernan, Timothy P.; McConnell, Darryl; Pearson, Mark; Kraut, Norbert; Rudolph, Dorothea Share Save
KRASmulti inhibitor BI 3706674, an orally bioavailable, direct inhibitor of diverse oncogenic KRAS variants drives tumor regression in KRASG12V-driven preclinical models Peng, David Hwa; Tedeschi, Antonio; Herdeis, Lorenz; Schaaf, Otmar; Savarese, Fabio; Rocchetti, Francesca; Popow, Johannes; Huber, Heinrich J.; Wilding, Birgit; Treu, Matthias; Fuchs, Julian; Broeker, Joachim; Wunberg, Tobias; Schischlik, Firoella; Lipp, Jesse; Williams, Mariah; Chandler, Vaness; Deckard, Charles E.; Ramamoorthy, Vandhana; Daniele, Joseph R.; Kopetz, Scott; Kim, Michael; Gibbons, Don L.; Vellano, Christopher P.; Marszalek, Joseph R.; Heffernan, TImothy P.; McConnell, Darryl; Pearson, Mark; Kraut, Norbert; Rudolph, Dorothea Share Save
Chromosome 3 copy number loss alone drives tumor evolution to aggressive disease in uveal melanoma Srinivasan, Sanjana; Rose, Johnathon; Minelli, Rosalba; Terranova, Christopher; Shah, Parth; Daniele, Joseph R.; Peoples, Michael; He, Meng; Liu, Chiu-Yi; Gay, Jason; Soeung, Melinda; Soni, Sanjay; Wang, Fangyang; Bristow, Christopher; Wani, Khalida; Perelli, Luigi; Loza, Dmitry; Feng, Ningping; Tarabichi, Maxime; Van Loo, Peter; Futreal, Andrew; Woodman, Scott; Lazar, Alexander; Vellano, Christopher P.; Marszalek, Joseph; Draetta, Giulio F.; Heffernan, Timothy; Carugo, Alessandro; Genovese, Giannicola; Giuliani, Virginia Share Save
SOS1 inhibition in combination with HER2 inhibition in models of HER2driven cancer Schenk, Robyn L.; Kostyrko, Kaja; Popow, Johannes; Gewinner, Christina; Baum, Anke; Albrecht, Christoph; Hinkel, Melanie; Jacob, Robin; Madensky, Tom; Ruzicka, Regina; Strauss, Eva; Lyu, Hengyu; Lopez, Anastasia M.; Feng, Ningping; Vellano, Christopher P.; Marszalek, Joseph R.; Heffernan, Timothy P.; Pearson, Mark; Hofmann, Marco H. Share Save
Development of advanced preclinical modeling for a comprehensive characterization of cardiac angiosarcoma biology Minelli, Rosalba; Perelli, Luigi; Bivona, Benjamin J.; Srinivasan, Sanjana; Catania, Desiree; Amador, Bianca E.; Robinson, Frederick S.; Rose, Johnathon L.; Terranova, Christopher T.; Martinez, Alejandro Hernandez; Deckard, Charles E.; Le, Courtney N.; Hsu, Kuo-Shun; Peoples, Michael; Subramaniam, Aparna; Beird, Hannah C.; Feng, Ningping; Daniele, Joseph R.; Vellano, Christopher; Marszalek, Joseph; Ravi, Vinod; Lazar, Alexander J.; Futreal, Andrew; Heffernan, Timothy P.; Genovese, Giannicola; Giuliani, Virginia Share Save
ASCL2+tumor cells modulate the response of colorectal cancer to MAPK targeting therapy Villarreal, Oscar E.; Lee, Hey Min; Ha Tran; Machado, Annette; Alshenaifi, Jumanah; Wong, Chi Wut; Coker, Olu; Minelli, Rosalba; Peoples, Michael; Martinez, Alejandro Hernandez; Fowlkes, Natalie; Kanikarla, Preeti; Lin, Kangyu; Bristow, Christopher; Viale, Andrea; Marszalek, Joseph R.; Shen, John Paul; Kopetz, Scott Share Save
BI KRASmulti, a first-in-class, orally bioavailable and direct inhibitor of diverse oncogenic KRAS variants drives tumor regression in KRAS G12V-driven preclinical models Peng, David H.; Tedeschi, Antonio; Herdeis, Lorenz; Savarese, Fabio; Rocchetti, Francesca; Johannes, Popow; Huber, Heinrich J.; Melillo, Nicola; Dickinson, Jake; Mistry, Hitesh B.; Wilding, Birgit; Treu, Matthias; Fuchs, Julian; Broker, Joachim; Wunberg, Tobias; Schischlik, Fiorella; Lipp, Jesse; Ramamoorthy, Vandhana; Daniele, Joseph R.; Kopetz, Scott; Kim, Michael; Gibbons, Don L.; Vellano, Christopher P.; Marszalek, Joseph R.; Heffernan, Timothy P.; McConnell, Darryl; Pearson, Mark; Kraut, Norbert; Rudolph, Dorothea Share Save
BI KRASmulti, a first-in-class, orally bioavailable and direct inhibitor of diverse oncogenic KRAS variants drives tumor regression in preclinical models and validates wild-type amplified KRAS as a therapeutic target Tedeschi, Antonio; Herdeis, Lorenz; Santoro, Valeria; Savarese, Fabio; Wilding, Birgit; Treu, Matthias; Fuchs, Julian; Broker, Joachim; Wunberg, Tobias; Gmachl, Michael; Klaus, Rumpel; Schischlik, Fiorella; Lipp, Jesse; Peng, David H.; Williams, Mariah; Deckard, Charles; Ramamoorthy, Vandhana; Daniele, Joseph R.; Ajani, Jaffer A.; Meric-Bernstam, Funda; Vellano, Christopher R.; Marszalek, Joseph R.; Heffernan, Timothy P.; McConnell, Darryl; Pearson, Mark; Kraut, Norbert; Rudolph, Dorothea Share Save
TAS2940 inhibits intracranial tumor growth and prolongs survival in HER2-aberrant and EGFR-amplified patient-derived xenograft models Han, Jing; Mahendra, Mikhila; Gandhi, Poojabahen; Daniele, Joseph R.; Carrillo, Caroline C.; Bivona, Benjamin J.; Feng, Ningping; Heymach, John V.; Meric-Bernstam, Funda; Oguchi, Kei; Mizuarai, Shinji; Heffernan, Timothy P.; Vellano, Christopher P.; Marszalek, Joseph R. Share Save
Deploying spatial transcriptomics to inform intratumoral heterogeneity in late-stage uveal melanoma leveraging advanced preclinical modeling and clinical samples Srinivasan, Sanjana; Rose, Johnathon; Daniele, Joseph R.; Peoples, Michael; He, Meng; Minelli, Rosalba; Liu, Chiu-Yi; Gay, Jason; Soeung, Melinda; Wani, Khalida; Perelli, Luigi; Loza, Dmitriy; Feng, Ningping; Vellano, Christopher P.; Marszalek, Joseph; Draetta, Giulio F.; Futreal, P. Andrew; Woodman, Scott E.; Lazar, Alexander J.; Heffernan, Timothy; Carugo, Alessandro; Genovese, Giannicola; Giuliani, Virginia Share Save
Complex I inhibitor of oxidative phosphorylation in advanced solid tumors and acute myeloid leukemia: phase I trials Yap, Timothy A.; Daver, Naval; Mahendra, Mikhila; Zhang, Jixiang; Kamiya-Matsuoka, Carlos; Meric-Bernstam, Funda; Kantarjian, Hagop M.; Ravandi, Farhad; Collins, Meghan E.; Di Francesco, Maria Emilia; Dumbrava, Ecaterina E.; Fu, Siqing; Gao, Sisi; Gay, Jason P.; Gera, Sonal; Han, Jing; Hong, David S.; Jabbour, Elias J.; Ju, Zhenlin; Karp, Daniel D.; Lodi, Alessia; Molina, Jennifer R.; Baran, Natalia; Naing, Aung; Ohanian, Maro; Pant, Shubham; Pemmaraju, Naveen; Bose, Prithviraj; Piha-Paul, Sarina A.; Rodon, Jordi; Salguero, Carolina; Sasaki, Koji; Singh, Anand K.; Subbiah, Vivek; Tsimberidou, Apostolia M.; Xu, Quanyun A.; Yilmaz, Musa; Zhang, Qi; Li, Yuan; Bristow, Christopher A.; Bhattacharjee, Meenakshi B.; Tiziani, Stefano; Heffernan, Timothy P.; Vellano, Christopher P.; Jones, Philip; Heijnen, Cobi J.; Kavelaars, Annemieke; Marszalek, Joseph R.; Konopleva, Marina Share Save
Subtype and Site Specific-Induced Metabolic Vulnerabilities in Prostate Cancer Mossa, Federica; Robesti, Daniele; Sumankalai, Ramachandran; Corey, Eva; Titus, Mark; Kang, Yuqi; Zhang, Jianhua; Briganti, Alberto; Montorsi, Francesco; Vellano, Christopher P.; Marszalek, Joseph R.; Frigo, Daniel E.; Logothetis, Christopher J.; Gujral, Taranjit S.; Dondossola, Eleonora Share Save
Simultaneous targeting of glycolysis and oxidative phosphorylation as a therapeutic strategy to treat diffuse large B-cell lymphoma Noble, Richard A.; Thomas, Huw; Zhao, Yan; Herendi, Lili; Howarth, Rachel; Dragoni, Ilaria; Keun, Hector C.; Vellano, Christopher P.; Marszalek, Joseph R.; Wedge, Stephen R. Share Save
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