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S

Stephen J. Haggarty

massachusetts general hospital

73H-index
277Paper Count
3.3WCitation Count
Published Papers 118
Publication Date
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MAPT splicing modulators reduce 4R tau and rescue tauopathy phenotypes in human neurons and in a mouse model
errScience Translational Medicine
IF14.6
err2026-08-19
err0
PREAI
errM. Catarina Silva; Hannah Lindmeier; Paolo Pigini; Jennifer Laughlin; Yong Yu; Christie Morrill; Michael A. Arnold; Scott J. Barraza; Khalil Saadipour; Monal Dieterich; Angela Minnella; Lin-Ing Wang; Wencheng Li; Kausiki Datta; Nanjing Zhang; Jana Narasimhan; Christopher R. Trotta; Matthew G. Woll; Ellen M. Welch; Kellie Benzow; Kul Karanjeet; Steven Lotz; Taylor Bertucci; Sally Temple; Stephen J. Haggarty; Michael Koob; Jeffrey Trimmer; Marla Weetall; Elisabetta Morini
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errSave
Correction: Discovery and optimization of tau targeted protein degraders enabled by patient induced pluripotent stem cells-derived neuronal models of tauopathy
errFrontiers in Cellular Neuroscience
IF4
err2026-04-07
err0
errOAAI
errMC M. Catarina Silva; GN Ghata Nandi; KA Katherine A. Donovan; QC Quan Cai; BC Bethany C. Berry; RP Radoslaw P. Nowak; ES Eric S. Fischer; NS Nathanael S. Gray †; FM Fleur M. Ferguson †; SJ Stephen J. Haggarty
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A repeat expansion in GOLGA8A is a major risk factor for atypical frontotemporal lobar degeneration with ubiquitin-positive inclusions
errNature Genetics
IF29
err2026-03-12
err0
errOAAI
errWouter De Coster; Marleen Van den Broeck; Matt Baker; Nikhil B. Ghayal; Sarah Wynants; Anthony Batzler; Cyril Pottier; Sara Alidadiani; Fahri Küçükali; Gregory D. Jenkins; Rafaela Policarpo; Marka van Blitterswijk; Mariely DeJesus-Hernandez; Alexandra I. Soto-Beasley; Júlia Faura; Elise Coopman; Saskia Hutten; Merel O. Mol; David Wallon; Anne Sieben; Elizabeth C. Finger; Melissa E. Murray; Shelley L. Forrest; Maria C. Tartaglia; Claire Troakes; Jeroen G. J. van Rooij; Aivi T. Nguyen; R. Ross Reichard; Natalie L. Woodman; Alissa L. Nana; Sandra Weintraub; Tamar Gefen; Bart De Vil; Istvan Bodi; Oscar L. Lopez; Susana Boluda; Serge Belliard; Florence Lebert; Florent Marguet; Qinwen Mao; Marsel M. Mesulam; Adam L. Boxer; Mathieu Vandenbulcke; EunRan Suh; Jolien Schaeverbeke; Jean-Charles Lambert; Sonja W. Scholz; Clifton L. Dalgard; Bryan J. Traynor; Raphael J. Gibbs; Gerard D. Schellenberg; Dorothee Dormann; Geert Joris; Tim De Pooter; Peter De Rijk; Svenn D’Hert; Jasper Van Dongen; Julie van der Zee; Mojca Strazisar; Marla Gearing; Thomas Kukar; Margaret Flanagan; Sebastiaan Engelborghs; Bernardino Ghetti; Kathy L. Newell; Andrew King; Sigrun Roeber; Howard J. Rosen; Salvatore Spina; Patrick Cras; Nilüfer Ertekin-Taner; Zbigniew K. Wszolek; Ryan J. Uitti; William P. Cheshire; Wolfgang Singer; Jochen Herms; Keith A. Josephs; Jennifer L. Whitwell; Ronald C. Petersen; Florence Pasquier; Gaël Nicolas; Rudolph Castellani; Jonathan Glass; Bruce L. Miller; Gabor G. Kovacs; Robert A. Rissman; Annie Hiniker; Vincent Deramecourt; Lee-Cyn Ang; Jin Lee-Way; Vivianna M. Van Deerlin; Brittany N. Dugger; Dietmar R. Thal; Lea T. Grinberg; Carlos Cruchaga; Thomas Arzberger; David G. Munoz; Julia Keith; Lorne Zinman; Ekaterina Rogaeva; Edward B. Lee; Stephen J. Haggarty; Olaf Ansorge; Masud Husain; Glenda M. Halliday; Safa Al-Sarraj; Owen A. Ross; Kristel Sleegers; Rik Vandenberghe; Bradley F. Boeve; Neill R. Graff-Radford; Julia Kofler; Charles L. White; Tammaryn Lashley; Manuela Neumann; Joanna M. Biernacka; William W. Seeley; Harro Seelaar; John C. van Swieten; Jonathan D. Rohrer; Dennis W. Dickson; Ian R. A. Mackenzie; Rosa Rademakers
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errSave
Deciphering distinct genetic risk factors for FTLD-TDP pathological subtypes via whole-genome sequencing
errNATURE COMMUNICATIONS
IF15.7
err2025-04-25
err0
errOAAI
errPottier, Cyril; Kuecuekali, Fahri; Baker, Matt; Batzler, Anthony; Jenkins, Gregory D.; van Blitterswijk, Marka; Vicente, Cristina T.; De Coster, Wouter; Wynants, Sarah; van de Walle, Pieter; Ross, Owen A.; Murray, Melissa E.; Faura, Julia; Haggarty, Stephen J.; van Rooij, Jeroen GJ.; Mol, Merel O.; Hsiung, Ging-Yuek R.; Graff, Caroline; Oeijerstedt, Linn; Neumann, Manuela; Asmann, Yan; Mcdonnell, Shannon K.; Baheti, Saurabh; Josephs, Keith A.; Whitwell, Jennifer L.; Bieniek, Kevin F.; Forsberg, Leah; Heuer, Hilary; Lago, Argentina Lario; Geier, Ethan G.; Yokoyama, Jennifer S.; Oddi, Alexis P.; Flanagan, Margaret; Mao, Qinwen; Hodges, John R.; Kwok, John B.; Domoto-Reilly, Kimiko; Synofzik, Matthis; Wilke, Carlo; Onyike, Chiadi; Dickerson, Bradford C.; Evers, Bret M.; Dugger, Brittany N.; Munoz, David G.; Keith, Julia; Zinman, Lorne; Rogaeva, Ekaterina; Suh, Eunran; Gefen, Tamar; Geula, Changiz; Weintraub, Sandra; Diehl-Schmid, Janine; Farlow, Martin R.; Edbauer, Dieter; Woodruff, Bryan K.; Caselli, Richard J.; Donker Kaat, Laura L.; Huey, Edward D.; Reiman, Eric M.; Mead, Simon; King, Andrew; Roeber, Sigrun; Nana, Alissa L.; Ertekin-Taner, Nilufer; Knopman, David S.; Petersen, Ronald C.; Petrucelli, Leonard; Uitti, Ryan J.; Wszolek, Zbigniew K.; Ramos, Eliana Marisa; Grinberg, Lea T.; Tempini, Maria Luisa Gorno; Rosen, Howard J.; Spina, Salvatore; Piguet, Olivier; Grossman, Murray; Trojanowski, John Q.; Keene, C. Dirk; Jin, Lee-Way; Prudlo, Johannes; Geschwind, Daniel H.; Rissman, Robert A.; Cruchaga, Carlos; Ghetti, Bernardino; Halliday, Glenda M.; Beach, Thomas G.; Serrano, Geidy E.; Arzberger, Thomas; Herms, Jochen; Boxer, Adam L.; Honig, Lawrence S.; Vonsattel, Jean P.; Lopez, Oscar L.; Kofler, Julia; White, Charles L.; Gearing, Marla; Glass, Jonathan; Rohrer, Jonathan D.; Irwin, David J.; Lee, Edward B.; Van Deerlin, Vivianna; Castellani, Rudolph; Mesulam, Marsel M.; Tartaglia, Maria C.; Finger, Elizabeth C.; Troakes, Claire; Al-Sarraj, Safa; Dalgard, Clifton L.; Miller, Bruce L.; Seelaar, Harro; Graff-Radford, Neill R.; Boeve, Bradley F.; Mackenzie, Ian RA.; van Swieten, John C.; Seeley, William W.; Sleegers, Kristel; Dickson, Dennis W.; Biernacka, Joanna M.; Rademakers, Rosa
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errSave
Targeted protein degradation with bifunctional molecules as a novel therapeutic modality for Alzheimer's disease & beyond
errNEUROTHERAPEUTICS
IF6.9
err2024-12-01
err3
PREAI
errSandhof, C. Alexander; Murray, Heide F. B.; Silva, M. Catarina; Haggarty, Stephen J.
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errSave
Benzoxazole-derivatives enhance progranulin expression and reverse the aberrant lysosomal proteome caused by GRN haploinsufficiency
errNATURE COMMUNICATIONS
IF15.7
err2024-07-20
err0
errOAAI
errTesla, Rachel; Guhl, Charlotte; Werthmann, Gordon C.; Dixon, Danielle; Cenik, Basar; Addepalli, Yesu; Liang, Jue; Fass, Daniel M.; Rosenthal, Zachary; Haggarty, Stephen J.; Williams, Noelle S.; Posner, Bruce A.; Ready, Joseph M.; Herz, Joachim
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Dissecting OGT's TPR domain to identify determinants of cellular function
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2024-05-20
err3
PREAI
errPotter, Sarah C.; Gibbs, Bettine E.; Hammel, Forrest A.; Joiner, Cassandra M.; Paulo, Joao A.; Janetzko, John; Levine, Zebulon G.; Fei, George Q.; Haggarty, Stephen J.; Walker, Suzanne
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errSave
Epigenetic modulation through BET bromodomain inhibitors as a novel therapeutic strategy for progranulin-deficient frontotemporal dementia
errSCIENTIFIC REPORTS
IF3.9
err2024-04-20
err3
errOAAI
errRosenthal, Zachary C.; Fass, Daniel M.; Payne, N. Connor; She, Angela; Patnaik, Debasis; Hennig, Krista M.; Tesla, Rachel; Werthmann, Gordon C.; Guhl, Charlotte; Reis, Surya A.; Wang, Xiaoyu; Chen, Yueting; Placzek, Michael; Williams, Noelle S.; Hooker, Jacob; Herz, Joachim; Mazitschek, Ralph; Haggarty, Stephen J.
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errSave
Small molecule regulators of microRNAs identified by high-throughput screen coupled with high-throughput sequencing
errNATURE COMMUNICATIONS
IF15.7
err2023-11-21
err13
errOAAI
errNguyen, Lien D.; Wei, Zhiyun; Silva, M. Catarina; Barberan-Soler, Sergio; Zhang, Jiarui; Rabinovsky, Rosalia; Muratore, Christina R.; Stricker, Jonathan M. S.; Hortman, Colin; Young-Pearse, Tracy L.; Haggarty, Stephen J.; Krichevsky, Anna M.
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errSave
Bipolar disorder-iPSC derived neural progenitor cells exhibit dysregulation of store-operated Ca2+ entry and accelerated differentiation
errMOLECULAR PSYCHIATRY
IF10.1
err2023-07-04
err8
errOAAI
errHewitt, Tristen; Alural, Beguem; Tilak, Manali; Wang, Jennifer; Becke, Natalina; Chartley, Ellis; Perreault, Melissa; Haggarty, Stephen J.; Sheridan, Steven D.; Perlis, Roy H.; Jones, Nina; Mellios, Nikolaos; Lalonde, Jasmin
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errSave
A Cdk5-derived peptide inhibits Cdk5/p25 activity and improves neurodegenerative phenotypes
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2023-04-12
err24
errOAAI
errPao, Ping-Chieh; Seo, Jinsoo; Lee, Audrey; Kritskiy, Oleg; Patnaik, Debasis; Penney, Jay; Raju, Ravikiran M.; Geigenmuller, Ute; Silva, M. Catarina; Lucente, Diane E.; Gusella, James F.; Dickerson, Bradford C.; Loon, Anjanet; Yu, Margaret X.; Bula, Michael; Yu, Melody; Haggarty, Stephen J.; Tsai, Li-Hue
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errSave
Small Molecule Regulators of microRNAs in Human iPSC-derived Neurons Identified by High-Throughput Screen Coupled High-Throughput Sequencing
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err2023-01-01
err0
errOAAI
errNguyen, Lien; Wei, Zhiyun; Silva, M. Catarina; Barberan-Soler, Sergio; Muratore, Christina; Young-Pearse, Tracy; Haggarty, Stephen; Krichevsky, Anna
errShare
errSave
Chemically targeting the redox switch in AP1 transcription factor ΔFOSB
errNUCLEIC ACIDS RESEARCH
IF13.1
err2022-08-30
err3
errOAAI
errKumar, Ashwani; Aglyamova, Galina; Yim, Yun Young; Bailey, Aaron O.; Lynch, Haley M.; Powell, Reid T.; Nguyen, Nghi D.; Rosenthal, Zachary; Zhao, Wen-Ning; Li, Yi; Chen, Jianping; Fan, Shanghua; Lee, Hubert; Russell, William K.; Stephan, Clifford; Robison, Alfred J.; Haggarty, Stephen J.; Nestler, Eric J.; Zhou, Jia; Machius, Mischa; Rudenko, Gabby
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errSave
Brain-specific deletion of GIT1 impairs cognition and alters phosphorylation of synaptic protein networks implicated in schizophrenia susceptibility
errMOLECULAR PSYCHIATRY
IF10.1
err2022-05-03
err4
errOAAI
errFass, Daniel M.; Lewis, Michael C.; Ahmad, Rushdy; Szucs, Matthew J.; Zhang, Qiangge; Fleishman, Morgan; Wang, Dongqing; Kim, Myung Jong; Biag, Jonathan; Carr, Steven A.; Scolnick, Edward M.; Premont, Richard T.; Haggarty, Stephen J.
errShare
errSave
Discovery and Optimization of Tau Targeted Protein Degraders Enabled by Patient Induced Pluripotent Stem Cells-Derived Neuronal Models of Tauopathy
errFRONTIERS IN CELLULAR NEUROSCIENCE
IF4
err2022-03-03
err24
errOAAI
errSilva, M. Catarina; Nandi, Ghata; Donovan, Katherine A.; Cai, Quan; Berry, Bethany C.; Nowak, Radoslaw P.; Fischer, Eric S.; Gray, Nathanael S.; Ferguson, Fleur M.; Haggarty, Stephen J.
errShare
errSave
A bidirectional competitive interaction between circHomer1 and Homer1b within the orbitofrontal cortex regulates reversal learning
errCELL REPORTS
IF6.9
err2022-01-01
err26
errOAAI
errHafez, Alexander K.; Zimmerman, Amber J.; Papageorgiou, Grigorios; Chandrasekaran, Jayapriya; Amoah, Stephen K.; Lin, Rixing; Lozano, Evelyn; Pierotti, Caroline; Dell'Orco, Michela; Hartley, Brigham J.; Alural, Begum; Lalonde, Jasmin; Esposito, John Matthew; Berretta, Sabina; Squassina, Alessio; Chillotti, Caterina; Voloudakis, Georgios; Shao, Zhipin; Fullard, John F.; Brennand, Kristen J.; Turecki, Gustavo; Roussos, Panos; Perlis, Roy H.; Haggarty, Stephen J.; Perrone-Bizzozero, Nora; Brigman, Jonathan L.; Mellios, Nikolaos
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errSave
Design, Synthesis, and Evaluation of Thienodiazepine Derivatives as Positron Emission Tomography Imaging Probes for Bromodomain and Extra-Terminal Domain Family Proteins
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2021-09-22
err21
PREAI
errBai, Ping; Lan, Yu; Patnaik, Debasis; Wang, Hao; Liu, Yan; Chen, Zude; Yuan, Gengyang; Afshar, Sepideh; Striar, Robin; Zagaroli, Julia S.; Tocci, Darcy R.; Langan, Amelia G.; Haggarty, Stephen J.; Wang, Changning
errShare
errSave
High-content image-based analysis and proteomic profiling identifies Tau phosphorylation inhibitors in a human iPSC-derived glutamatergic neuronal model of tauopathy
errSCIENTIFIC REPORTS
IF3.9
err2021-08-23
err12
errOAAI
errCheng, Chialin; Reis, Surya A.; Adams, Emily T.; Fass, Daniel M.; Angus, Steven P.; Stuhlmiller, Timothy J.; Richardson, Jared; Olafson, Hailey; Wang, Eric T.; Patnaik, Debasis; Beauchamp, Roberta L.; Feldman, Danielle A.; Silva, M. Catarina; Sur, Mriganka; Johnson, Gary L.; Ramesh, Vijaya; Miller, Bruce L.; Temple, Sally; Kosik, Kenneth S.; Dickerson, Bradford C.; Haggarty, Stephen J.
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errSave
Exifone Is a Potent HDAC1 Activator with Neuroprotective Activity in Human Neuronal Models of Neurodegeneration
errACS CHEMICAL NEUROSCIENCE
IF3.9
err2021-01-08
err15
errOAAI
errPatnaik, Debasis; Pao, Ping-Chieh; Zhao, Wen-Ning; Silva, M. Catarina; Hylton, Norma K.; Chindavong, Peter S.; Pan, Ling; Tsai, Li-Huei; Haggarty, Stephen J.
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errSave
Identification and Mechanistic Characterization of a Peptide Inhibitor of Glycogen Synthase Kinase (GSK3β) Derived from the Disrupted in Schizophrenia 1 (DISC1) Protein
errACS CHEMICAL NEUROSCIENCE
IF3.9
err2020-11-30
err5
errOAAI
errSaundh, Stephanie L.; Patnaik, Debasis; Gagne, Steve; Bishop, Joshua A.; Lipsit, Sean; Amat, Samat; Pujari, Narsimha; Nambisan, Anand Krishnan; Bigsby, Robert; Murphy, Mary; Tsai, Li-Huei; Haggarty, Stephen J.; Leung, Adelaine Kwun-Wai
errShare
errSave

Research Directions

No research directions
Co-authors
Cooperation Journals
J
John Q. Trojanowski
H-index: 255 · Papers: 1.8K
L
Luigi Ferrucci
H-index: 237 · Papers: 2.6K
E
Eric N. Olson
H-index: 224 · Papers: 979
D
Dennis W. Dickson
H-index: 218 · Papers: 2.3K
R
Rudolf Jaenisch
H-index: 209 · Papers: 802
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