Not logged inProtective role for kidney TREM2high macrophages in obesity- and diabetes-induced kidney injury
Subramanian, Ayshwarya; Vernon, Katherine A.; Zhou, Yiming; Marshall, Jamie L.; Alimova, Maria; Arevalo, Carlos; Zhang, Fan; Slyper, Michal; Waldman, Julia; Montesinos, Monica S.; Dionne, Danielle; Nguyen, Lan T.; Cuoco, Michael S.; Dubinsky, Dan; Purnell, Jason; Keller, Keith; Sturner, Samuel H.; Grinkevich, Elizabeth; Ghoshal, Ayan; Kotek, Amanda; Trivioli, Giorgio; Richoz, Nathan; Humphrey, Mary B.; Darby, Isabella G.; Miller, Sarah J.; Xu, Yingping; Weins, Astrid; Chloe-Villani, Alexandra; Chang, Steven L.; Kretzler, Matthias; Rosenblatt-Rosen, Orit; Shaw, Jillian L.; Zimmerman, Kurt A.; Clatworthy, Menna R.; Regev, Aviv; Greka, Anna .png)
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SaveThe effect of background noise and its removal on the analysis of single-cell expression dataJanssen, Philipp; Kliesmete, Zane; Vieth, Beate; Adiconis, Xian; Simmons, Sean; Marshall, Jamie; McCabe, Cristin; Heyn, Holger; Levin, Joshua Z.; Enard, Wolfgang; Hellmann, Ines Share Save FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicityWieder, Nicolas; Fried, Juliana Coraor; Kim, Choah; Sidhom, Eriene-Heidi; Brown, Matthew R.; Marshall, Jamie L.; Arevalo, Carlos; Dvela-Levitt, Moran; Kost-Alimova, Maria; Sieber, Jonas; Gabriel, Katlyn R.; Pacheco, Julian; Clish, Clary; Abbasi, Hamdah Shafqat; Singh, Shantanu; Rutter, Justine C.; Therrien, Martine; Yoon, Haejin; Lai, Zon Weng; Baublis, Aaron; Subramanian, Renuka; Devkota, Ranjan; Small, Jonnell; Sreekanth, Vedagopuram; Han, Myeonghoon; Lim, Donghyun; Carpenter, Anne E.; Flannick, Jason; Finucane, Hilary; Haigis, Marcia C.; Claussnitzer, Melina; Sheu, Eric; Stevens, Beth; Wagner, Bridget K.; Choudhary, Amit; Shaw, Jillian L.; Pablo, Juan Lorenzo; Greka, Anna Share Save Genomic autopsy to identify underlying causes of pregnancy loss and perinatal deathByrne, Alicia B.; Arts, Peer; Ha, Thuong T.; Kassahn, Karin S.; Pais, Lynn S.; O'Donnell-Luria, Anne; Babic, Milena; Frank, Mahalia S. B.; Feng, Jinghua; Wang, Paul; Lawrence, David M.; Eshraghi, Leila; Arriola, Luis; Toubia, John; Nguyen, Hung; McGillivray, George; Pinner, Jason; McKenzie, Fiona; Morrow, Rebecca; Lipsett, Jill; Manton, Nick; Khong, T. Yee; Moore, Lynette; Liebelt, Jan E.; Schreiber, Andreas W.; King-Smith, Sarah L.; Hardy, Tristan S. E.; Jackson, Matilda R.; Barnett, Christopher P.; Scott, Hamish S.; Aguet, Francois; Arachchi, Harindra M.; Austin-Tse, Christina A.; Babb, Larry; Baxter, Samantha M.; Brand, Harrison; Byrne, Alicia B.; Chang, Jaime; Chao, Katherine R.; Collins, Ryan L.; Cummings, Beryl; Delano, Kayla; DiTroia, Stephanie P.; England, Eleina; Evangelista, Emily; Everett, Selin; Francioli, Laurent C.; Fu, Jack; Ganesh, Vijay S.; Garimella, Kiran, V; Gauthier, Laura D.; Goodrich, Julia K.; Gudmundsson, Sanna; Hall, Stacey J.; Huang, Yongqing; Jahl, Steve; Laricchia, Kristen M.; Larkin, Kathryn E.; Lek, Monkol; Lemire, Gabrielle; Lipson, Rachel B.; Lovgren, Alysia Kern; MacArthur, Daniel G.; Mangilog, Brian E.; Mano, Stacy; Marshall, Jamie L.; Mullen, Thomas E.; Nguyen, Kevin K.; O'Heir, Emily; O'Leary, Melanie C.; Osei-Owusu, Ikeoluwa A.; Pais, Lynn S.; Chavez, Jorge Perez de Acha; Pierce-Hoffman, Emma; Rehm, Heidi L.; Serrano, Milan; Singer-Berk, Moriel; Snow, Hana; Solomonson, Matthew; Son, Rachel G.; Sveden, Abigail; Talkowski, Michael; Tiao, Grace; Udler, Miriam S.; Valivullah, Zaheer; Valkanas, Elise; VanNoy, Grace E.; Wang, Qingbo S.; Watts, Nicholas A.; Weisburd, Ben; Williamson, Clara E.; Wilson, Michael W.; Witzgall, Lauren; Wojcik, Monica H.; Wong, Isaac; Wood, Jordan C.; Zhang, Shifa; Abeysuriya, Disna; Ades, Lesley C.; Amor, David J.; Arbuckle, Susan; Bakshi, Madhura; Barnete, Christopher P.; Berry, Bligh; Boughtwood, Tiffany; Bournazos, Adam; Bray, Alessandra; Chan, Fiona; Chan, Yuen; Chung, Clara; Clark, Jonathan; Collett, Jackie; Colley, Alison; Collins, Felicity; Cooper, Sandra; Corbett, Mark A.; Dahlstrom, Jane E.; Dargaville, Peter; Davies, Janene; Davis, Tenielle; Dearman, Jarrad; Dissanayake, Jayanthi; Dobbins, Julia; Doyle, Helen; Dubowsky, Andrew; Edwards, Matt; Ewans, Lisa J.; Fadia, Mitali; Fennell, Andrew; Finlay, Ken; French, Andrew; Friend, Kathryn; Gardner, Alison E.; Gecz, Jozef; Graf, Nicole; Haan, Eric A.; Hollingsworth, Georgina; Horton, Ari E.; Howting, Denise; Hunter, Matthew F.; Jevon, Gareth; Kamien, Benjamin; Kennedy, Debra; Khong, T. Yee; Krivanek, Michael; Kroes, Thessa; Krzesinski, Emma, I; Kwan, Edward; Lau, Stephanie; LeBlanc, Shannon; Liebelt, Jan; Lindsey-Temple, Suzanna; Lipsett, Jill; Loo, Christine K. C.; Low, Julia; Mallawaarachchi, Amali; Manton, Nick; Matsika, Admire; Mattiske, Tessa; McGaughran, Julie; McGillivray, George; McGregor, Lesley; McKenzie, Fiona; Mittal, Namita; Moghimi, Ali; Moore, Lynette; Albayrak, Hatice Mutlu; Ng, Jessica; Nicholl, Jillian; Pachter, Nicholas; Papadimitriou, John; Parker, Renae; Parsons, Sarah; Patel, Chirag; Pawlowski, Rhonda; Perez-Jurado, Luis A.; Pinner, Jason R.; Politis, Katerina; Poulton, Cathryn; Power, Theresa; Quinn, Michael; Rajagopalan, Sulekha; Regan, Matthew; Rodgers, Jonathan; Rorke, Steuart; Sachdev, Rani; Sallevelt, Suzanne; Sandaradura, Sarah A.; Shamassi, Maryam; Shamon, Roshan; Sherburn, Isabella; Slee, Ennie; Solinas, Annalisa; Sugo, Ella; Thompson, Elizabeth; Tripathy, Sagarika; Vasudevan, Anand; Vazquez, Melisa; Verma, Kunal; Viki, Mthulisi; Wallis, Mathew; Webber, Dani L.; Weber, Martin; Whale, Karen; Wilson, Meredith; Worgan, Lisa; Yu, Sui Share Save Share Save Compressed sensing for highly efficient imaging transcriptomicsCleary, Brian; Simonton, Brooke; Bezney, Jon; Murray, Evan; Alam, Shahul; Sinha, Anubhav; Habibi, Ehsan; Marshall, Jamie; Lander, Eric S.; Chen, Fei; Regev, Aviv Share Save Targeting a Braf/Mapk pathway rescues podocyte lipid peroxidation in CoQ-deficiency kidney diseaseSidhom, Eriene-Heidi; Kim, Choah; Kost-Alimova, Maria; Ting, May Theng; Keller, Keith; Avila-Pacheco, Julian; Watts, Andrew J. B.; Vernon, Katherine A.; Marshall, Jamie L.; Reyes-Bricio, Estefania; Racette, Matthew; Wieder, Nicolas; Kleiner, Giulio; Grinkevich, Elizabeth J.; Chen, Fei; Weins, Astrid; Clish, Clary B.; Shaw, Jillian L.; Quinzii, Catarina M.; Greka, Anna Share Save WGS and RNA Studies Diagnose Noncoding DMD Variants in Males With High Creatine KinaseWaddell, Leigh B.; Bryen, Samantha J.; Cummings, Beryl B.; Bournazos, Adam; Evesson, Frances J.; Joshi, Himanshu; Marshall, Jamie L.; Tukiainen, Taru; Valkanas, Elise; Weisburd, Ben; Sadedin, Simon; Davis, Mark R.; Faiz, Fathimath; Gooding, Rebecca; Sandaradura, Sarah A.; O'Grady, Gina L.; Tchan, Michel C.; Mowat, David R.; Oates, Emily C.; Farrar, Michelle A.; Sampaio, Hugo; Ma, Alan; Neas, Katherine; Wang, Min-Xia; Charlton, Amanda; Chan, Charles; Kenwright, Diane N.; Graf, Nicole; Arbuckle, Susan; Clarke, Nigel F.; MacArthur, Daniel G.; Jones, Kristi J.; Lek, Monkol; Cooper, Sandra T. Share Save The effect of LRRK2 loss-of-function variants in humans (vol 26, pg 869, 2020)Whiffin, Nicola; Armean, Irina M.; Kleinman, Aaron; Marshall, Jamie L.; Minikel, Eric V.; Goodrich, Julia K.; Quaife, Nicholas M.; Cole, Joanne B.; Wang, Qingbo; Karczewski, Konrad J.; Cummings, Beryl B.; Francioli, Laurent; Laricchia, Kristen; Guan, Anna; Alipanahi, Babak; Morrison, Peter; Baptista, Marco A. S.; Merchant, Kalpana M.; Armean, Irina M.; Armean, Irina M.; Banks, Eric; Bergelson, Louis; Cibulskis, Kristian; Collins, Ryan L.; Connolly, Kristen M.; Covarrubias, Miguel; Cummings, Beryl; Daly, Mark J.; Donnelly, Stacey; Farjoun, Yossi; Ferriera, Steven; Gabriel, Stacey; Gauthier, Laura D.; Gentry, Jeff; Gupta, Namrata; Jeandet, Thibault; Kaplan, Diane; Laricchia, Kristen M.; Llanwarne, Christopher; Munshi, Ruchi; Neale, Benjamin M.; Novod, Sam; O'Donnell-Luria, Anne H.; Petrillo, Nikelle; Poterba, Timothy; Roazen, David; Ruano-Rubio, Valentin; Saltzman, Andrea; Samocha, Kaitlin E.; Schleicher, Molly; Seed, Cotton; Solomonson, Matthew; Soto, Jose; Tiao, Grace; Tibbetts, Kathleen; Tolonen, Charlotte; Vittal, Christopher; Wade, Gordon; Wang, Arcturus; Watts, Nicholas A.; Weisburd, Ben; Aguilar-Salinas, Carlos A.; Aguilar-Salinas, Carlos A.; Ahmad, Tariq; Albert, Christine M.; Ardissino, Diego; Atzmon, Gil; Barnard, John; Beaugerie, Laurent; Benjamin, Emelia J.; Boehnke, Michael; Bonnycastle, Lori L.; Bottinger, Erwin P.; Bowden, Donald W.; Bown, Matthew J.; Chambers, John C.; Chan, Juliana C.; Chasman, Daniel; Cho, Judy; Chung, Mina K.; Cohen, Bruce; Correa, Adolfo; Dabelea, Dana; Darbar, Dawood; Duggirala, Ravindranath; Dupuis, Josee; Ellinor, Patrick T.; Elosua, Roberto; Erdmann, Jeanette; Farkkila, Martti; Florez, Jose; Franke, Andre; Getz, Gad; Glaser, Benjamin; Glatt, Stephen J.; Goldstein, David; Gonzalez, Clicerio; Groop, Leif; Haiman, Christopher; Hanis, Craig; Harms, Matthew; Hiltunen, Mikko; Holi, Matti M.; Hultman, Christina M.; Kallela, Mikko; Kaprio, Jaakko; Kathiresan, Sekar; Kim, Bong-Jo; Kim, Young Jin; Kirov, George; Kooner, Jaspal; Koskinen, Seppo; Krumholz, Harlan M.; Kugathasan, Subra; Kwak, Soo Heon; Laakso, Markku; Lehtimaki, Terho; Loos, Ruth J. F.; Lubitz, Steven A.; Ma, Ronald C. W.; MacArthur, Daniel G.; Marrugat, Jaume; Mattila, Kari M.; McCarroll, Steven; McCarthy, Mark I.; McGovern, Dermot; McPherson, Ruth; Meigs, James B.; Melander, Olle; Metspalu, Andres; Nilsson, Peter M.; O'Donovan, Michael C.; Ongur, Dost; Orozco, Lorena; Owen, Michael J.; Palmer, Colin N. A.; Palotie, Aarno; Park, Kyong Soo; Pato, Carlos; Pulver, Ann E.; Rahman, Nazneen; Remes, Anne M.; Riou, John D.; Ripatti, Samuli; Roden, Dan M.; Saleheen, Danish; Salomaa, Veikko; Samani, Nilesh J.; Scharf, Jeremiah; Schunkert, Heribert; Shoemaker, Moore B.; Sklar, Pamela; Soininen, Hilkka; Sokol, Harry; Spector, Tim; Sullivan, Patrick F.; Suvisaari, Jaana; Tai, E. Shyong; Teo, Yik Ying; Tiinamaija, Tuomi; Tsuang, Ming; Turner, Dan; Tusie-Luna, Teresa; Vartiainen, Erkki; Vawter, Marquis P.; Ware, James S.; Watkins, Hugh; Weersma, Rinse K.; Wessman, Maija; Wilson, James G.; Xavier, Ramnik J.; Ware, James S.; Havulinna, Aki S.; Iliadou, Bozenna; Lee, Jung-Jin; Nadkarni, Girish N.; Whiteman, Cole; Agee, Michelle; Agee, Michelle; Auton, Adam; Bell, Robert K.; Bryc, Katarzyna; Elson, Sarah L.; Fontanillas, Pierre; Furlotte, Nicholas A.; Hicks, Barry; Hinds, David A.; Huber, Karen E.; Jewett, Ethan M.; Jiang, Yunxuan; Lin, Keng-Han; Litterman, Nadia K.; McIntyre, Matthew H.; McManus, Kimberly F.; Mountain, Joanna L.; Noblin, Elizabeth S.; Northover, Carrie A. M.; Pitts, Steven J.; Poznik, G. David; Sathirapongsasuti, J. Fah; Shelton, Janie F.; Shringarpure, Suyash; Tian, Chao; Tung, Joyce Y.; Vacic, Vladimir; Wang, Xin; Wilson, Catherine H.; Daly, Mark; Esko, Tonu; Hultman, Christina; Loos, Ruth J. F.; Milani, Lili; Palotie, Aarno; Pato, Carlos; Pato, Michele; Saleheen, Danish; Sullivan, Patrick F.; Alfoldi, Jessica; Cannon, Paul; MacArthur, Daniel G. Share Save Share Save HyPR-seq: Single-cell quantification of chosen RNAs via hybridization and sequencing of DNA probesMarshall, Jamie L.; Doughty, Benjamin R.; Subramanian, Vidya; Guckelberger, Philine; Wang, Qingbo; Chen, Linlin M.; Rodriques, Samuel G.; Zhang, Kaite; Fulco, Charles P.; Nasser, Joseph; Grinkevich, Elizabeth J.; Noel, Teia; Mangiameli, Sarah; Bergman, Drew T.; Greka, Anna; Lander, Eric S.; Chen, Fei; Engreitz, Jesse M. Share Save Share Save A High-Content Screen for Mucin-1-Reducing Compounds Identifies Fostamatinib as a Candidate for Rapid Repurposing for Acute Lung InjuryKost-Alimova, Maria; Sidhom, Eriene-Heidi; Satyam, Abhigyan; Chamberlain, Brian T.; Dvela-Levitt, Moran; Melanson, Michelle; Alper, Seth L.; Santos, Jean; Gutierrez, Juan; Subramanian, Ayshwarya; Byrne, Patrick J.; Grinkevich, Elizabeth; Reyes-Bricio, Estefania; Kim, Choah; Clark, Abbe R.; Watts, Andrew J. B.; Thompson, Rebecca; Marshall, Jamie; Pablo, Juan Lorenzo; Coraor, Juliana; Roignot, Julie; Vernon, Katherine A.; Keller, Keith; Campbell, Alissa; Emani, Maheswarareddy; Racette, Matthew; Bazua-Valenti, Silvana; Padovano, Valeria; Weins, Astrid; McAdoo, Stephen P.; Tam, Frederick W. K.; Ronco, Luciene; Wagner, Florence; Tsokos, George C.; Shaw, Jillian L.; Greka, Anna Share Save The effect of LRRK2 loss-of-function variants in humansWhiffin, Nicola; Armean, Irina M.; Kleinman, Aaron; Marshall, Jamie L.; Minikel, Eric V.; Goodrich, Julia K.; Quaife, Nicholas M.; Cole, Joanne B.; Wang, Qingbo; Karczewski, Konrad J.; Cummings, Beryl B.; Francioli, Laurent; Laricchia, Kristen; Guan, Anna; Alipanahi, Babak; Morrison, Peter; Baptista, Marco A. S.; Merchant, Kalpana M.; Ware, James S.; Havulinna, Aki S.; Iliadou, Bozenna; Lee, Jung-Jin; Nadkarni, Girish N.; Whiteman, Cole; Daly, Mark; Esko, Tonu; Hultman, Christina; Loos, Ruth J. F.; Milani, Lili; Palotie, Aarno; Pato, Carlos; Pato, Michele; Saleheen, Danish; Sullivan, Patrick F.; Alfoldi, Jessica; Cannon, Paul; MacArthur, Daniel G. Share Save Efficient, continuous mutagenesis in human cells using a pseudo-random DNA editorChen, Haiqi; Liu, Sophia; Padula, Samuel; Lesman, Daniel; Griswold, Kettner; Lin, Allen; Zhao, Tongtong; Marshall, Jamie L.; Chen, Fei Share Save Single cell census of human kidney organoids shows reproducibility and diminished off-target cells after transplantationSubramanian, Ayshwarya; Sidhom, Eriene-Heidi; Emani, Maheswarareddy; Vernon, Katherine; Sahakian, Nareh; Zhou, Yiming; Kost-Alimova, Maria; Slyper, Michal; Waldman, Julia; Dionne, Danielle; Nguyen, Lan T.; Weins, Astrid; Marshall, Jamie L.; Rosenblatt-Rosen, Orit; Regev, Aviv; Greka, Anna Share Save Identification of a Novel Deep Intronic Mutation in CAPN3 Presenting a Promising Target for Therapeutic Splice ModulationHu, Ying; Mohassel, Payam; Donkervoort, Sandra; Yun, Pomi; Bolduc, Veronique; Ezzo, Daniel; Dastgir, Jahannaz; Marshall, Jamie L.; Lek, Monkol; MacArthur, Daniel G.; Foley, A. Reghan; Bonnemann, Carsten G. Share Save Stabilization of the cardiac sarcolemma by sarcospan rescues DMD-associated cardiomyopathyParvatiyar, Michelle S.; Brownstein, Alexandra J.; Kanashiro-Takeuchi, Rosemeire M.; Collado, Judd R.; Jones, Karissa M. Dieseldorff; Gopal, Jay; Hammond, Katherine G.; Marshall, Jamie L.; Ferrel, Abel; Beedle, Aaron M.; Chamberlain, Jeffrey S.; Pinto, Jose Renato; Crosbie, Rachelle H. Share Save A recurrent COL6A1 pseudoexon insertion causes muscular dystrophy and is effectively targeted by splice-correction therapiesBolduc, Veronique; Foley, A. Reghan; Solomon-Degefa, Herimela; Sarathy, Apurva; Donkervoort, Sandra; Hu, Ying; Chen, Grace S.; Sizov, Katherine; Nalls, Matthew; Zhou, Haiyan; Aguti, Sara; Cummings, Beryl B.; Lek, Monkol; Tukiainen, Taru; Marshall, Jamie L.; Regev, Oded; Marek-Yagel, Dina; Sarkozy, Anna; Butterfield, Russell J.; Jou, Cristina; Jimenez-Mallebrera, Cecilia; Li, Yan; Gartioux, Corine; Mamchaoui, Kamel; Allamand, Valerie; Gualandi, Francesca; Ferlini, Alessandra; Hanssen, Eric; Wilton, Steve D.; Lamande, Shireen R.; MacArthur, Daniel G.; Wagener, Raimund; Muntoni, Francesco; Bonnemann, Carsten G. Share Save Resolving the full spectrum of human genome variation using Linked-ReadsMarks, Patrick; Garcia, Sarah; Barrio, Alvaro Martinez; Belhocine, Kamila; Bernate, Jorge; Bharadwaj, Rajiv; Bjornson, Keith; Catalanotti, Claudia; Delaney, Josh; Fehr, Adrian; Fiddes, Ian T.; Galvin, Brendan; Heaton, Haynes; Herschleb, Jill; Hindson, Christopher; Holt, Esty; Jabara, Cassandra B.; Jett, Susanna; Keivanfar, Nikka; Kyriazopoulou-Panagiotopoulou, Sofia; Lek, Monkol; Lin, Bill; Lowe, Adam; Mahamdallie, Shazia; Maheshwari, Shamoni; Makarewicz, Tony; Marshall, Jamie; Meschi, Francesca; O'Keefe, Christopher J.; Ordonez, Heather; Patel, Pranav; Price, Andrew; Royall, Ariel; Ruark, Elise; Seal, Sheila; Schnall-Levin, Michael; Shah, Preyas; Stafford, David; Williams, Stephen; Wu, Indira; Xu, Andrew Wei; Rahman, Nazneen; MacArthur, Daniel; Church, Deanna M. Share Save 
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