Eyram Kpenu - Publications, H-index & Citations

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Eyram Kpenu

biochemistry

4H-index

16Paper Count

48Citation Count

Published Papers 7

Publication Date

Targeting APE1 endonuclease activity impairs metastasis and enhances genotoxic therapy response in pancreatic cancer

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

IF12.8

2026-04-02

OAAI

Eyram K. Kpenu; Mahmut Mijit; Silpa Gampala; Sheng Liu; Jun Wan; Randall S. Wireman; Jacqueline Peil; Dana K. Mitchell; Sanya Haiaty; Rajesh Sardar; Akanksha Sharma; Millie M. Georgiadis; Melissa L. Fishel; Mark R. Kelley

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A Phase I study targeting the APE1/ref-1 redox signaling protein with APX3330: First clinical agent targeting APE1/ref-1 in Cancer

The Oncologist

IF0

2025-12-19

OAAI

Mark R Kelley; Jun Wan; Sheng Liu; Eyram Kpenu; Randall Wireman; Amber L Mosley; Hao Liu; Nehal J Lakhani; Saﬁ Shahda; Bert O’Neil; Mateusz Opyrchal; Richard A Messmann

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Ref-1 redox activity modulates canonical Wnt signaling in endothelial cells

REDOX BIOLOGY

IF11.9

2025-06-01

OAAI

Hartman, Gabriella D.; Sishtla, Kamakshi; Kpenu, Eyram K.; Mijit, Mahmut; Muniyandi, Anbukkarasi; Jo, Ha-Neul; Junge, Harald J.; Shaw, Aaron; Bischof, Daniela; Liu, Sheng; Wan, Jun; Kelley, Mark R.

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Ref-1 redox activity regulates retinal neovascularization by modulating transcriptional activation of HIF-1α

FASEB JOURNAL

IF4.2

2025-02-04

OAAI

Hartman, Gabriella D.; Muniyandi, Anbukkarasi; Sishtla, Kamakshi; Kpenu, Eyram K.; Miller, William P.; Kaplan, Bryan A.; Kim, Leo A.; Liu, Sheng; Wan, Jun; Qi, Xiaoping; Boulton, Michael E.; Kelley, Mark R.; Corson, Timothy W.

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Ref-1 redox activity modulates canonical Wnt signaling in endothelial cells

FREE RADICAL BIOLOGY AND MEDICINE

IF8.2

2024-11-01

PREAI

Hartman, Gabriella; Kpenu, Eyram; Maihemuti, Mijiti; Jo, Ha-Neul; Junge, Harald; Kelley, Mark; Corson, Timothy

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Challenging PDAC adaptability: Uncovering therapeutic vulnerabilities in APE1 DNA repair mechanisms

CANCER RESEARCH

IF16.6

2024-09-15

PREAI

Kpenu, Eyram K.; Wireman, Randall; Mijiti, Mahmut; Gampala, Silpa; Fishel, Melissa L.; Kelley, Mark R.

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Activation of the integrated stress response (ISR) pathways in response to Ref-1 inhibition in human pancreatic cancer and its tumor microenvironment

FRONTIERS IN MEDICINE

IF3

2023-04-27

OAAI

Mijit, Mahmut; Boner, Megan; Cordova, Ricardo A.; Gampala, Silpa; Kpenu, Eyram; Klunk, Angela J.; Zhang, Chi; Kelley, MarK R.; Staschke, Kirk A.; Fishel, Melissa L.

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Research Directions