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Development of new increased potency Ref-1/APE1 targeted inhibitors that show promise for clinical applications against solid tumors Gampala, Silpa; Moon, Hye-Ran; Wireman, Randall; Peil, Jacqueline; Kiran, Sonia; Masters, Andi; Bach, Christine; Smith-Kinnamen, Whitney; Doud, Emma; Rai, Ratan; Mosley, Amber L.; Georgiadis, Millie M.; Han, Bumsoo; Zhang, Chi; Hamdouchi, Chafiq; Wikel, James; Kelley, Mark R.; Fishel, Melissa L. Share Save
Oral APX3330 Reduces the DRSS Worsening after 24-weeks of Daily Treatment-Efficacy and Safety Results of the ZETA-1 Phase 2 Trial in Diabetic Retinopathy Gonzalez, Victor H.; Brigell, Mitchell G.; Su, Daniel; Patel, Ronil; Withers, Barbara; Kelley, Mark; Haddad, Louis; Sooch, Mina; Pepose, Jay S.; Kaiser, Peter K.; Boyer, David S. Share Save
APE1/Ref-1 Interacts with NPM1 within Nucleoli and Plays a Role in the rRNA Quality Control Process Vascotto, Carlo; Fantini, Damiano; Romanello, Milena; Cesaratto, Laura; Deganuto, Marta; Leonardi, Antonio; Radicella, J. Pablo; Kelley, Mark R.; D'Ambrosio, Chiara; Scaloni, Andrea; Quadrifoglio, Franco; Tell, Gianluca Share Save
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Exploring transcriptional regulators Ref-1 and STAT3 as therapeutic targets in malignant peripheral nerve sheath tumours (vol 124, pg 1566, 2021) Gampala, Silpa; Shah, Fenil; Zhang, Chi; Rhodes, Steven D.; Babb, Olivia; Grimard, Michelle; Wireman, Randall S.; Rad, Ellie; Calver, Brian; Bai, Ren-Yuan; Staedtke, Verena; Hulsey, Emily L.; Saadatzadeh, M. Reza; Pollok, Karen E.; Tong, Yan; Smith, Abbi E.; Clapp, D. Wade; Tee, Andrew R.; Kelley, Mark R.; Fishel, Melissa L. Share Save
Ref-1 redox activity alters cancer cell metabolism in pancreatic cancer: exploiting this novel finding as a potential target Gampala, Silpa; Shah, Fenil; Lu, Xiaoyu; Moon, Hye-Ran; Babb, Olivia; Ganesh, Nikkitha Umesh; Sandusky, George; Hulsey, Emily; Armstrong, Lee; Mosely, Amber L.; Han, Bumsoo; Ivan, Mircea; Yeh, Jing-Ruey Joanna; Kelley, Mark R.; Zhang, Chi; Fishel, Melissa L. Share Save
Exploring transcriptional regulators Ref-1 and STAT3 as therapeutic targets in malignant peripheral nerve sheath tumours Gampala, Silpa; Shah, Fenil; Zhang, Chi; Rhodes, Steven D.; Babb, Olivia; Grimard, Michelle; Wireman, Randall S.; Rad, Ellie; Calver, Brian; Bai, Ren-Yuan; Staedtke, Verena; Hulsey, Emily L.; Saadatzadeh, M. Reza; Pollok, Karen E.; Tong, Yan; Smith, Abbi E.; Clapp, D. Wade; Tee, Andrew R.; Kelley, Mark R.; Fishel, Melissa L. Share Save
Ref-1 redox function identified as mitochondrial metabolic regulator in pancreatic cancer cells but not in CAFs Gampala, Silpa; Shah, Fenil; Lu, Xiaoyu; Moon, Hye-Ran; Sandusky, George E.; Hulsey, Emily; Mosley, Amber L.; Han, Bamsoo; Zhang, Chi; Kelley, Mark R.; Fishel, Melissa L. Share Save
Signaling through Ref-1 and STAT3 in soft tissue sarcoma (MPNST) and the effects of perturbing this pathway on tumor cell survival and gene expression Shah, Fenil; Babb, Olivia; Zhang, Chi; Gampala, Silpa; Zhang, Emily; Rhodes, Steven D.; Tee, Andrew R.; Calver, Brian; Rad, Ellie; Staedtke, Verena; Pollok, Karen E.; Clapp, D. Wade; Kelley, Mark R.; Fishel, Melissa L. Share Save
A phase I study targeting the APE1/Ref-1 DNA repair-redox signaling protein with the APX3330 inhibitor Kelley, Mark R.; Shahda, Safi; Lakhani, Nehal J.; O'Neil, Bert; Chu, Lincy; Anderson, Amanda K.; Wan, Jun; Mosley, Amber L.; Liu, Hao; Messmann, Richard A. Share Save
Antitumor Activity and Mechanistic Characterization of APE1/Ref-1 Inhibitors in Bladder Cancer Fishel, Melissa; Xia, Hanyu; McGeown, Jack; McIlwain, David W.; Elbanna, May Faek Mohamed; Craft, Ariel A.; Kaimakliotis, Hristos Z.; Sandusky, George; Zhang, Chi; Pili, Roberto; Kelley, Mark R.; Jerde, Travis J. Share Save
Inhibition of APE1-endonuclease activity affects cell metabolism in colon cancer cells via a p53-dependent pathway Codrich, Marta; Comelli, Marina; Malfatti, Matilde Clarissa; Mio, Catia; Ayyildiz, Dilara; Zhang, Chi; Kelley, Mark R.; Terrosu, Giovanni; Pucillo, Carlo Em; Tell, Gianluca Share Save
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Discovery of Macrocyclic Inhibitors of Apurinic/Apyrimidinic Endonuclease 1 Trilles, Richard; Beglov, Dmitri; Chen, Qiujia; He, Hongzhen; Wireman, Randall; Reed, April; Chennamadhavuni, Spandan; Panek, James S.; Brown, Lauren E.; Vajda, Sandor; Porco, John A., Jr.; Kelley, Mark R.; Georgiadis, Millie M. Share Save
Inhibition of Inflammatory Signaling in Tet2 Mutant Preleukemic Cells Mitigates Stress-Induced Abnormalities and Clonal Hematopoiesis Cai, Zhigang; Kotzin, Jonathan J.; Ramdas, Baskar; Chen, Sisi; Nelanuthala, Sai; Palam, Lakshmi Reddy; Pandey, Ruchi; Mali, Raghuveer Singh; Liu, Yan; Kelley, Mark R.; Sandusky, George; Mohseni, Morvarid; Williams, Adam; Henao-Mejia, Jorge; Kapur, Reuben Share Save
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