Not logged inGain of chromosome 17 is an early genetic abnormality in neuroblastoma with PPM1D emerging as a strong candidate oncogene driving tumor progression
Milosevic, Jelena; Fransson, Susanne; Svensson, Johanna; Otte, Jorg; Olsen, Thale K.; Sveinbjornsson, Baldur; Hertwig, Falk; Bartenhagen, Christoph; Abel, Frida; Reinsbach, Susanne E.; Djos, Anna; Javanmardi, Niloufar; Shi, Yao; Hehir-Kwa, Jane Y.; Mensenkamp, Arjen; Tytgat, Godelieve AM.; Holmberg, Johan; Molenaar, Jan J.; Jongmans, Marjolijn; Fischer, Matthias; Baryawno, Ninib; Gisselsson, David; Martinsson, Tommy; Kogner, Per; Johnsen, John Inge .png)
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SaveTargeted inhibition of WIP1 and histone H3K27 demethylase activity synergistically suppresses neuroblastoma growthTreis, Diana; Lundberg, Kristina Ihrmark; Bell, Nicola; Polychronopoulos, Panagiotis Alkinoos; Tuemmler, Conny; Akerlund, Emma; Aliverti, Stefania; Lilienthal, Ingrid; Pepich, Adena; Seashore-Ludlow, Brinton; Sakaguchi, Kazuyasu; Kogner, Per; Johnsen, John Inge; Wickstroem, Malin Share Save METTL3/MYCN cooperation drives neural crest differentiation and provides therapeutic vulnerability in neuroblastomaThombare, Ketan; Vaid, Roshan; Pucci, Perla; Lundberg, Kristina Ihrmark; Ayyalusamy, Ritish; Baig, Mohammad Hassan; Mendez, Akram; Burgos-Panadero, Rebeca; Hoeppner, Stefanie; Bartenhagen, Christoph; Sjovall, Daniel; Rehan, Aqsa Ali; Nale, Sagar Dattatraya; Djos, Anna; Martinsson, Tommy; Jaako, Pekka; Dong, Jae-June; Kogner, Per; Johnsen, John Inge; Fischer, Matthias; Turner, Suzanne D.; Mondal, Tanmoy Share Save The ROCK-1/2 inhibitor RKI-1447 blocks N-MYC, promotes cell death, and emerges as a synergistic partner for BET inhibitors in neuroblastomaPepich, Adena; Tummler, Conny; Abu Ajamieh, Sara; Treis, Diana; Boje, Ammelie Svea; Vellema, Quinty; Tsea, Ioanna; Akerlund, Emma; Seashore-Ludlow, Brinton; Fard, Shahrzad Shirazi; Kogner, Per; Johnsen, John Inge; Wickstrom, Malin Share Save Development of an orthotopic medulloblastoma zebrafish model for rapid drug testingvan Bree, Niek; Oppelt, Ann-Sophie; Lindstroem, Susanne; Zhou, Leilei; Boutin, Lola; Coyle, Beth; Swartling, Fredrik J.; Johnsen, John Inge; Braeutigam, Lars; Wilhelm, Margareta Share Save Genomic tumor evolution dictates human medulloblastoma progressionRuchiy, Yana; Tsea, Ioanna; Preka, Efthalia; Verhoeven, Bronte Manouk; Olsen, Thale Kristin; Mei, Shenglin; Sinha, Indranil; Blomgren, Klas; Carlson, Lena-Maria; Dyberg, Cecilia; Johnsen, John Inge; Baryawno, Ninib Share Save Share Save Joint single-cell genetic and transcriptomic analysis reveal pre-malignant SCP-like subclones in human neuroblastomaOlsen, Thale K.; Otte, Jorg; Mei, Shenglin; Embaie, Bethel Tesfai; Kameneva, Polina; Cheng, Huaitao; Gao, Teng; Zachariadis, Vasilios; Tsea, Ioanna; Bjorklund, Asa; Kryukov, Emil; Hou, Ziyi; Johansson, Anna; Sundstrom, Erik; Martinsson, Tommy; Fransson, Susanne; Stenman, Jakob; Fard, Shahrzad Shirazi; Johnsen, John Inge; Kogner, Per; Adameyko, Igor; Enge, Martin; Kharchenko, Peter V.; Baryawno, Ninib Share Save Single-cell analyses of metastatic bone marrow in human neuroblastoma reveals microenvironmental remodeling and metastaticMei, Shenglin; Alchahin, Adele M.; Embaie, Bethel Tesfai; Gavriliuc, Ioana Maria; Verhoeven, Bronte Manouk; Zhao, Ting; Li, Xiangyun; Jeffries, Nathan Elias; Pepich, Adena; Sarkar, Hirak; Olsen, Thale Kristin; Wickstrom, Malin; Stenman, Jakob; Reina-Bedoya, Oscar; Kharchenko, Peter V.; Saylor, Philip J.; Johnsen, John Inge; Sykes, David B.; Kogner, Per; Baryawno, Ninib Share Save Single-cell analysis of immune and stroma cell remodeling in clear cell renal cell carcinoma primary tumors and bone metastatic lesionsMei, Shenglin; Alchahin, Adele M.; Tsea, Ioanna; Kfoury, Youmna; Hirz, Taghreed; Jeffries, Nathan Elias; Zhao, Ting; Xu, Yanxin; Zhang, Hanyu; Sarkar, Hirak; Wu, Shulin; Subtelny, Alexander O.; Johnsen, John Inge; Zhang, Yida; Salari, Keyan; Wu, Chin-Lee; Randolph, Mark A.; Scadden, David T.; Dahl, Douglas M.; Shin, John; Kharchenko, Peter V.; Saylor, Philip J.; Sykes, David B.; Baryawno, Ninib Share Save METTL3 drives telomere targeting of TERRA lncRNA through m6A-dependent R-loop formation: a therapeutic target for ALT-positive neuroblastomaVaid, Roshan; Thombare, Ketan; Mendez, Akram; Burgos-Panadero, Rebeca; Djos, Anna; Jachimowicz, Daniel; Lundberg, Kristina Ihrmark; Bartenhagen, Christoph; Kumar, Navinder; Tummler, Conny; Sihlbom, Carina; Fransson, Susanne; Johnsen, John Inge; Kogner, Per; Martinsson, Tommy; Fischer, Matthias; Mondal, Tanmoy Share Save SINGLE-CELL TRANSCRIPTOMIC ANALYSIS REVEALS DISTINCT GENOMIC LANDSCAPES, CELL TRAJECTORIES, AND TUMOUR-MICROENVIRONMENT INTERACTIONS IN FOUR SUBTYPES OF MEDULLOBLASTOMARuchiy, Yana; Tsea, Ioanna; Verhoeven, Bronte Manouk; Sinha, Indranil; Preka, Efthalia; Olsen, Thale Kristin; Mei, Shenglin; Blomgren, Klas; Johnsen, John Inge; Carlson, Lena-Maria; Dyberg, Cecilia; Baryawno, Ninib Share Save Mutant p53 gain of function mediates cancer immune escape that is counteracted by APR-246Zhou, Xiaolei; Santos, Gema Sanz; Zhan, Yue; Oliveira, Mariana M. S.; Rezaei, Shiva; Singh, Madhurendra; Peuget, Sylvain; Westerberg, Lisa S.; Johnsen, John Inge; Selivanova, Galina Share Save DHODH is an independent prognostic marker and potent therapeutic target in neuroblastomaOlsen, Thale Kristin; Dyberg, Cecilia; Embaie, Bethel Tesfai; Alchahin, Adele; Milosevic, Jelena; Ding, Jane; Otte, Jorg; Tummler, Conny; Myrberg, Ida Hed; Westerhout, Ellen M.; Koster, Jan; Versteeg, Rogier; Ding, Han-Fei; Kogner, Per; Johnsen, John Inge; Sykes, David B.; Baryawno, Ninib Share Save The immune cell atlas of human neuroblastomaVerhoeven, Bronte Manouk; Mei, Shenglin; Olsen, Thale Kristin; Gustafsson, Karin; Valind, Anders; Lindstrom, Axel; Gisselsson, David; Fard, Shahrzad Shirazi; Hagerling, Catharina; Kharchenko, Peter, V; Kogner, Per; Johnsen, John Inge; Baryawno, Ninib Share Save Omega-3 fatty acids decrease CRYAB, production of oncogenic prostaglandin E2 and suppress tumor growth in medulloblastomaLjungblad, Linda; Bergqvist, Filip; Tummler, Conny; Madawala, Samanthi; Olsen, Thale Kristin; Andonova, Teodora; Jakobsson, Per-Johan; Johnsen, John Inge; Pickova, Jana; Strandvik, Birgitta; Kogner, Per; Gleissman, Helena; Wickstrom, Malin Share Save GIT1 protects against breast cancer growth through negative regulation of NotchZhang, Songbai; Miyakawa, Ayako; Wickstrom, Malin; Dyberg, Cecilia; Louhivuori, Lauri; Varas-Godoy, Manuel; Kemppainen, Kati; Kanatani, Shigeaki; Kaczynska, Dagmara; Ellstrom, Ivar Dehnisch; Elfman, Lotta; Kronqvist, Pauliina; Repo, Heli; Mikoshiba, Katsuhiko; Sahlgren, Cecilia; Johnsen, John Inge; Uhlen, Per Share Save Share Save Share Save Inhibition of the ubiquitin-proteasome system by an NQO1-activatable compoundGiovannucci, Tatiana A.; Salomons, Florian A.; Haraldsson, Martin; Elfman, Lotta H. M.; Wickstroem, Malin; Young, Patrick; Lundbaeck, Thomas; Eirich, Juergen; Altun, Mikael; Jafari, Rozbeh; Gustavsson, Anna-Lena; Johnsen, John Inge; Dantuma, Nico P. Share Save 
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