Not logged inPeripheral Administration of Selective Glycine Transporter-2 Inhibitor, Oleoyl-D-Lysine, Reverses Chronic Neuropathic Pain but Not Acute or Inflammatory Pain in Male Mice
Wilson, Bruce S.; Peiser-Oliver, Julian; Gillis, Alexander; Evans, Sally; Alamein, Claudia; Mostyn, Shannon N.; Shimmon, Susan; Rawling, Tristan; Christie, MacDonald J.; Vandenberg, Robert J.; Mohammadi, Sarasa A. .png)
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SaveShare Save Share Save Share Save Share Save Low intrinsic efficacy for G protein activation can explain the improved side effect profiles of new opioid agonistsGillis, Alexander; Gondin, Arisbel B.; Kliewer, Andrea; Sanchez, Julie; Lim, Herman D.; Alamein, Claudia; Manandhar, Preeti; Santiago, Marina; Fritzwanker, Sebastian; Schmidel, Frank; Katte, Timothy A.; Reekie, Tristan; Grimsey, Natasha L.; Kassiou, Michael; Kellam, Barrie; Krasel, Cornelius; Halls, Michelle L.; Connor, Mark; Lane, J. Robert; Schulz, Stefan; Christie, Macdonald J.; Canals, Meritxell Share Save Share Save A tetrapeptide class of biased analgesics from an Australian fungus targets the μ-opioid receptorDekan, Zoltan; Sianati, Setareh; Yousuf, Arsalan; Sutcliffe, Katy J.; Gillis, Alexander; Mallet, Christophe; Singh, Paramjit; Jin, Aihua H.; Wang, Anna M.; Mohammadi, Sarasa A.; Stewart, Michael; Ratnayake, Ranjala; Fontaine, Frank; Lacey, Ernest; Piggott, Andrew M.; Du, Yan P.; Canals, Meritxell; Sessions, Richard B.; Kelly, Eamonn; Capon, Robert J.; Alewood, Paul F.; Christie, MacDonald J. Share Save Development of an N-Acyl Amino Acid That Selectively Inhibits the Glycine Transporter 2 To Produce Analgesia in a Rat Model of Chronic PainMostyn, Shannon N.; Rawling, Tristan; Mohammadi, Sarasa; Shimmon, Susan; Frangos, Zachary J.; Sarker, Subhodeep; Yousuf, Arsalan; Vetter, Irina; Ryan, Renae M.; Christie, Macdonald J.; Vandenbereg, Robert J. Share Save Share Save Novel analgesic ω-conotoxins from the vermivorous cone snail Conus moncuri provide new insights into the evolution of conopeptidesSousa, Silmara R.; McArthur, Jeffrey R.; Brust, Andreas; Bhola, Rebecca F.; Rosengren, K. Johan; Ragnarsson, Lotten; Dutertre, Sebastien; Alewood, Paul F.; Christie, Macdonald J.; Adams, David J.; Vetter, Irina; Lewis, Richard J. Share Save Multisite phosphorylation is required for sustained interaction with GRKs and arrestins during rapid μ-opioid receptor desensitizationMiess, Elke; Gondin, Arisbel B.; Yousuf, Arsalan; Steinborn, Ralph; Moesslein, Nadja; Yang, Yunshi; Goeldner, Martin; Ruland, Julia G.; Buenemann, Moritz; Krasel, Cornelius; Christie, MacDonald J.; Halls, Michelle L.; Schulz, Stefan; Canals, Meritxell Share Save Share Save Endosomal signaling of the receptor for calcitonin gene-related peptide mediates pain transmissionYarwood, Rebecca E.; Imlach, Wendy L.; Lieu, TinaMarie; Veldhuis, Nicholas A.; Jensen, Dane D.; Herenbrink, Carmen Klein; Aurelio, Luigi; Cai, Zhijian; Christie, MacDonald J.; Poole, Daniel P.; Porter, Christopher J. H.; McLean, Peter; Hicks, Gareth A.; Geppetti, Pierangelo; Halls, Michelle L.; Canals, Meritxell; Bunnett, Nigel W. Share Save Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain reliefJensen, Dane D.; Lieu, TinaMarie; Halls, Michelle L.; Veldhuis, Nicholas A.; Imlach, Wendy L.; Mai, Quynh N.; Poole, Daniel P.; Quach, Tim; Aurelio, Luigi; Conner, Joshua; Herenbrink, Carmen Klein; Barlow, Nicholas; Simpson, Jamie S.; Scanlon, Martin J.; Graham, Bimbil; McCluskey, Adam; Robinson, Phillip J.; Escriou, Virginie; Nassini, Romina; Materazzi, Serena; Geppetti, Pierangelo; Hicks, Gareth A.; Christie, Macdonald J.; Porter, Christopher J. H.; Canals, Meritxell; Bunnett, Nigel W. Share Save Pharmacological characterisation of the highly NaV1.7 selective spider venom peptide Pn3a (vol 7, 40883, 2017)Deuis, Jennifer R.; Dekan, Zoltan; Wingerd, Joshua S.; Smith, Jennifer J.; Munasinghe, Nehan R.; Bhola, Rebecca F.; Imlach, Wendy L.; Herzig, Volker; Armstrong, David A.; Rosengren, K. Johan; Bosmans, Frank; Waxman, Stephen G.; Dib-Hajj, Sulayman D.; Escoubas, Pierre; Minett, Michael S.; Christie, Macdonald J.; King, Glenn F.; Alewood, Paul F.; Lewis, Richard J.; Wood, John N.; Vetter, Irina Share Save The tarantula toxin β/δ-TRTX-Pre1a highlights the importance of the S1-S2 voltage-sensor region for sodium channel subtype selectivityWingerd, Joshua S.; Mozar, Christine A.; Ussing, Christine A.; Murali, Swetha S.; Chin, Yanni K. -Y.; Cristofori-Armstrong, Ben; Durek, Thomas; Gilchrist, John; Vaughan, Christopher W.; Bosmans, Frank; Adams, David J.; Lewis, Richard J.; Alewood, Paul F.; Mobli, Mehdi; Christie, Macdonald J.; Rash, Lachlan D. Share Save Pharmacological characterisation of the highly NaV1.7 selective spider venom peptide Pn3aDeuis, Jennifer R.; Dekan, Zoltan; Wingerd, Joshua S.; Smith, Jennifer J.; Munasinghe, Nehan R.; Bhola, Rebecca F.; Imlach, Wendy L.; Herzig, Volker; Armstrong, David A.; Rosengren, K. Johan; Bosmans, Frank; Waxman, Stephen G.; Dib-Hajj, Sulayman D.; Escoubas, Pierre; Minett, Michael S.; Christie, Macdonald J.; King, Glenn F.; Alewood, Paul F.; Lewis, Richard J.; Wood, John N.; Vetter, Irina Share Save Share Save Share Save 
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