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A

Alfred C. Aplin

Department of Medicine

22H-index
45Paper Count
1.8KCitation Count
Published Papers 21
Publication Date
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Human islet amyloid polypeptide aggregation upregulates the mitochondrial cholesterol transport protein StAR and induces mitochondrial dysfunction in beta cells
errDiabetologia
IF10.2
err2026-05-20
err0
errOAAI
errMeghan F. Hogan; Rehana Akter; Alfred C. Aplin; Andrew T. Templin; Nathalie Esser; Daniel T. Meier; Brendy-Sue Fountaine; Joseph J. Castillo; Assam El-Osta; Rebecca L. Hull-Meichle; Sakeneh Zraika; Steven E. Kahn
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errSave
Tissue oxygenation stabilizes neovessels and mitigates hemorrhages in human atherosclerosis-induced angiogenesis
errANGIOGENESIS
IF9.2
err2022-08-10
err11
PREAI
errAplin, Alfred C.; Nicosia, Roberto F.
errShare
errSave
Islet amyloid polypeptide aggregation exerts cytotoxic and proinflammatory effects on the islet vasculature in mice
errDIABETOLOGIA
IF10.2
err2022-07-25
err13
errOAAI
errCastillo, Joseph J.; Aplin, Alfred C.; Hackney, Daryl J.; Hogan, Meghan F.; Esser, Nathalie; Templin, Andrew T.; Akter, Rehana; Kahn, Steven E.; Raleigh, Daniel P.; Zraika, Sakeneh; Hull, Rebecca L.
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The Proinflammatory but Not Cytotoxic Effect of A regated IAPP on Islet Endothelial Cells Requires TLR2/4 Signaling
errDIABETES
IF7.5
err2021-06-01
err0
PREAI
errCastillo, Joseph J.; Aplin, Alfred; Hogan, Meghan F.; Templin, Andrew T.; Esser, Nathalie; Akter, Rehana; Hull, Rebecca L.
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errSave
SGLT2-i improves markers of islet endothelia cell function in db/db diabetic mice
errJOURNAL OF ENDOCRINOLOGY
IF3.9
err2021-02-01
err12
errOAAI
errHogan, Meghan F.; Hackney, Daryl J.; Aplin, Alfred C.; Mundinger, Thomas O.; Larmore, Megan J.; Castillo, Joseph J.; Esser, Nathalie; Zraika, Sakeneh; Hull, Rebecca L.
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errSave
Hyaluronan Produced by Inflamed Islet Endothelial Cells Contributes to HIAPP Aggregation
errDIABETES
IF7.5
err2020-06-01
err0
PREAI
errCastillo, Joseph J.; Hogan, Meghan F.; Aplin, Alfred; Esser, Nathalie; Templin, Andrew T.; Hull, Rebecca L.
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errSave
The Tissue Plasminogen Activator (tPA)/Plasmin System Reduces Amyloid Formation by Cleaving Human Islet Amyloid Polypeptide (hIAPP)
errDIABETES
IF7.5
err2019-06-01
err0
PREAI
errEsser, Nathalie; Hogan, Meghan F.; Aplin, Alfred; Templin, Andrew T.; El-Osta, Sam; Raleigh, Daniel; Edgar, John S.; Zraika, Sakeneh; Hull, Rebecca L.; Kahn, Steven E.
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errSave
Islet Amyloid Deposition Is Cytotoxic to Islet Endothelial Cells
errDIABETES
IF7.5
err2019-06-01
err0
PREAI
errCastillo, Joseph J.; Hogan, Meghan F.; Aplin, Alfred; Hackney, Daryl J.; Hull, Rebecca L.
errShare
errSave
The plaque-aortic ring assay: a new method to study human atherosclerosis-induced angiogenesis
errANGIOGENESIS
IF9.2
err2019-04-09
err12
PREAI
errAplin, Alfred C.; Nicosia, Roberto F.
errShare
errSave
Treatment of Hyperglycemia with Empagliflozin, With or Without Metformin, Improves Islet Endothelial Cell Health and Insulin Secretion in db/db Diabetic Mice
errDIABETES
IF7.5
err2018-07-01
err0
PREAI
errHogan, Meghan F.; Hackney, Daryl J.; Aplin, Alfred; Mundinger, Thomas O.; Zraika, Sakeneh; Hull, Rebecca L.
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errSave
Consensus guidelines for the use and interpretation of angiogenesis assays
errANGIOGENESIS
IF9.2
err2018-05-15
err482
errOAAI
errNowak-Sliwinska, Patrycja; Alitalo, Kari; Allen, Elizabeth; Anisimov, Andrey; Aplin, Alfred C.; Auerbach, Robert; Augustin, Hellmut G.; Bates, David O.; van Beijnum, Judy R.; Bender, R. Hugh F.; Bergers, Gabriele; Bikfalvi, Andreas; Bischoff, Joyce; Boeck, Barbara C.; Brooks, Peter C.; Bussolino, Federico; Cakir, Bertan; Carmeliet, Peter; Castranova, Daniel; Cimpean, Anca M.; Cleaver, Ondine; Coukos, George; Davis, George E.; De Palma, Michele; Dimberg, Anna; Dings, Ruud P. M.; Djonov, Valentin; Dudley, Andrew C.; Dufton, Neil P.; Fendt, Sarah-Maria; Ferrara, Napoleone; Fruttiger, Marcus; Fukumura, Dai; Ghesquiere, Bart; Gong, Yan; Griffin, Robert J.; Harris, Adrian L.; Hughes, Christopher C. W.; Hultgren, Nan W.; Iruela-Arispe, M. Luisa; Irving, Melita; Jain, Rakesh K.; Kalluri, Raghu; Kalucka, Joanna; Kerbel, Robert S.; Kitajewski, Jan; Klaassen, Ingeborg; Kleinmann, Hynda K.; Koolwijk, Pieter; Kuczynski, Elisabeth; Kwak, Brenda R.; Marien, Koen; Melero-Martin, Juan M.; Munn, Lance L.; Nicosia, Roberto F.; Noel, Agnes; Nurro, Jussi; Olsson, Anna-Karin; Petrova, Tatiana V.; Pietras, Kristian; Pili, Roberto; Pollard, Jeffrey W.; Post, Mark J.; Quax, Paul H. A.; Rabinovich, Gabriel A.; Raica, Marius; Randi, Anna M.; Ribatti, Domenico; Ruegg, Curzio; Schlingemann, Reinier O.; Schulte-Merker, Stefan; Smith, Lois E. H.; Song, Jonathan W.; Stacker, Steven A.; Stalin, Jimmy; Stratman, Amber N.; Van de Velde, Maureen; van Hinsbergh, Victor W. M.; Vermeulen, Peter B.; Waltenberger, Johannes; Weinstein, Brant M.; Xin, Hong; Yetkin-Arik, Bahar; Yla-Herttuala, Seppo; Yoder, Mervin C.; Griffioen, Arjan W.
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errSave
Hyperactive FOXO1 results in lack of tip stalk identity and deficient microvascular regeneration during kidney injury
errBIOMATERIALS
IF12.9
err2017-10-01
err27
errOAAI
errDang, Lan T. H.; Aburatani, Takahide; Marsh, Graham A.; Johnson, Bryce G.; Alimperti, Stella; Yoon, Christine J.; Huang, Angela; Szak, Suzanne; Nakagawa, Naoki; Gomez, Ivan; Ren, Shuyu; Read, Sarah K.; Sparages, Chris; Aplin, Alfred C.; Nicosia, Roberto F.; Chen, Chris; Ligresti, Giovanni; Duffield, Jeremy S.
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errSave
Hypoxia paradoxically inhibits the angiogenic response of isolated vessel explants while inducing overexpression of vascular endothelial growth factor
errANGIOGENESIS
IF9.2
err2016-01-09
err12
PREAI
errAplin, Alfred C.; Nicosia, Roberto F.
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errSave
Regulation of angiogenesis, mural cell recruitment and adventitial macrophage behavior by Toll-like receptors
errANGIOGENESIS
IF9.2
err2013-10-04
err36
PREAI
errAplin, Alfred C.; Ligresti, Giovanni; Fogel, Eric; Zorzi, Penelope; Smith, Kelly; Nicosia, Roberto F.
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errSave
Macrophage-Derived Tumor Necrosis Factor-α Is an Early Component of the Molecular Cascade Leading to Angiogenesis in Response to Aortic Injury
errARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
IF7.4
err2011-05-01
err49
errOAAI
errLigresti, Giovanni; Aplin, Alfred C.; Zorzi, Penelope; Morishita, Ann; Nicosia, Roberto F.
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The rat aorta contains resident mononuclear phagocytes with proliferative capacity and proangiogenic properties
errJOURNAL OF LEUKOCYTE BIOLOGY
IF3.1
err2010-07-13
err28
errOAAI
errZorzi, Penelope; Aplin, Alfred C.; Smith, Kelly D.; Nicosia, Roberto F.
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errSave
MCP-1 promotes mural cell recruitment during angiogenesis in the aortic ring model
errANGIOGENESIS
IF9.2
err2010-06-23
err39
errOAAI
errAplin, Alfred C.; Fogel, Eric; Nicosia, Roberto F.
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errSave
Vascular regression and survival are differentially regulated by MT1-MMP and TIMPs in the aortic ring model of angiogenesis
errAMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
IF4.7
err2009-08-01
err67
errOAAI
errAplin, A. C.; Zhu, W. H.; Fogel, E.; Nicosia, R. F.
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errSave
Parstatin, the Cleaved Peptide on Proteinase-Activated Receptor 1 Activation, Is a Potent Inhibitor of Angiogenesis
errJOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
IF3.8
err2009-02-01
err41
PREAI
errZania, Panagiota; Gourni, Despina; Aplin, Alfred C.; Nicosia, Roberto F.; Flordellis, Christodoulos S.; Maragoudakis, Michael E.; Tsopanoglou, Nikos E.
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errSave
The angiogenic response of the aorta to injury and inflammatory cytokines requires macrophages
errJOURNAL OF IMMUNOLOGY
IF3.4
err2008-10-15
err41
errOAAI
errGelati, Maurizio; Aplin, Alfred C.; Fogel, Eric; Smith, Kelly D.; Nicosia, Roberto F.
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errSave

Research Directions

No research directions
Co-authors
Cooperation Journals
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Rakesh K. Jain
H-index: 200 · Papers: 1.7K
P
Peter Carmeliet
H-index: 192 · Papers: 1.4K
A
Adrian L. Harris
H-index: 187 · Papers: 2.1K
K
Kari Alitalo
H-index: 187 · Papers: 1.1K
N
Napoleone Ferrara
H-index: 156 · Papers: 389
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