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Consensus guidelines for the use and interpretation of angiogenesis assays
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DOI：10.1007/s10456-018-9613-x.png)
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Abstract
En 中文
The formation of new blood vessels, or angiogenesis, is a complex process that plays important roles in growth and development, tissue and organ regeneration, as well as numerous pathological conditions. Angiogenesis undergoes multiple discrete steps that can be individually evaluated and quantified by a large number of bioassays. These independent assessments hold advantages but also have limitations. This article describes in vivo, ex vivo, and in vitro bioassays that are available for the evaluation of angiogenesis and highlights critical aspects that are relevant for their execution and proper interpretation. As such, this collaborative work is the first edition of consensus guidelines on angiogenesis bioassays to serve for current and future reference.
Keywords:
Angiogenesis
Aortic ring
Endothelial cell migration
Proliferation
Microfluidic
Zebrafish
Chorioallantoic membrane (CAM)
Vascular network
Intussusceptive angiogenesis
Retinal vasculature
Corneal angiogenesis
Hindlimb ischemia
Myocardial angiogenesis
Recombinant proteins
Tip cells
Plug assay
Myocardial angiogenesis
Vessel co-option
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