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J

John F. Hancock

University of Texas Health Science Center

84H-index
283Paper Count
2.7WCitation Count
Published Papers 145
Publication Date
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Glycosphingolipids regulate phosphatidylserine transport machinery that operates at ER-PM contact sites
errNature Communications
IF15.7
err2026-06-12
err0
errOAAI
errRitchel Gannaban; Sher Ali; Wei Chen; Melanie Nguyen; Li Lai; Travis I. Moore; Yubin Zhou; John F. Hancock; Junchen Liu
errShare
errSave
DIRAS3-derived cyclic peptides disrupt KRAS-RAF interaction and KRAS nanoclustering, suppressing KRAS-driven pancreatic and ovarian tumors
erriScience
IF4.1
err2025-10-04
err0
errOAAI
errJoshua P. Gray; Gamze Bildik; Ha-Neul Kim; Margie N. Sutton; Jing Wang; Amarachi O. Osuji; Nefeli Batistatou; Hailing Yang; Weiqun Mao; Zhi Tan; Geneviève M.C. Gasmi-Seabrook; Junchen Liu; John F. Hancock; Christopher B. Marshall; Joshua A. Kritzer; Mitsuhiko Ikura; Robert C. Bast; Steven W. Millward; Zhen Lu
errShare
errSave
Terraforming the KRAS lipid landscape
errNature Chemical Biology
IF13.7
err2025-09-15
err0
PREAI
errYong Zhou; John F. Hancock
errShare
errSave
MTMR regulates KRAS function by controlling plasma membrane levels of phospholipids
errJOURNAL OF CELL BIOLOGY
IF6.4
err2025-05-02
err0
PREAI
errLange, Taylor E.; Naji, Ali; van der Hoeven, Ransome; Liang, Hong; Zhou, Yong; Hammond, Gerald R. V.; Hancock, John F.; Cho, Kwang-jin
errShare
errSave
Differential Lipid Binding Specificities of RAP1A and RAP1B are Encoded by the Amino Acid Sequence of the Membrane Anchors
errJOURNAL OF THE AMERICAN CHEMICAL SOCIETY
IF15.6
err2024-07-13
err1
errOAAI
errAraya, Mussie K.; Chen, Wei; Ke, Yuepeng; Zhou, Yubin; Gorfe, Alemayehu A.; Hancock, John F.; Liu, Junchen
errShare
errSave
DIRAS3 inhibits oncogenic RAS signaling and RAS-dependent cell growth driven by prevalent KRAS hot spot mutations
errCANCER RESEARCH
IF16.6
err2024-03-22
err0
PREAI
errBildik, Gamze; Liu, Junchen; Mao, Weiqun; Yang, Hailing; Hancock, John F.; Bast, Robert C.; Lu, Zhen
errShare
errSave
Direct Modulators of K-Ras-Membrane Interactions
errACS CHEMICAL BIOLOGY
IF3.8
err2023-08-14
err7
errOAAI
errMorstein, Johannes; Shrestha, Rebika; Van, Que N.; Lopez, Cesar A.; Arora, Neha; Tonelli, Marco; Liang, Hong; Chen, De; Zhou, Yong; Hancock, John F.; Stephen, Andrew G.; Turbyville, Thomas J.; Shokat, Kevan M.
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errSave
Consensus on the RAS dimerization hypothesis: Strong evidence for lipid-mediated clustering but not for G-domain-mediated interactions
errMOLECULAR CELL
IF16.6
err2023-04-01
err23
errOAAI
errSimanshu, Dhirendra K.; Philips, Mark R.; Hancock, John F.
errShare
errSave
14-3-3 facilitates Ras-dependent Raf-1 activation in vitro and in vivo
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-28
err137
errOAAI
errRoy, S; McPherson, RA; Apolloni, A; Yan, J; Lane, A; Clyde-Smith, J; Hancock, JF
errShare
errSave
H-Ras signaling and K-Ras signaling are differentially dependent on endocytosis
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-27
err139
errOAAI
errRoy, S; Wyse, B; Hancock, JF
errShare
errSave
Individual palmitoyl residues serve distinct roles in H-ras trafficking, microlocalization, and signaling
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-27
err208
errOAAI
errRoy, S; Plowman, S; Rotblat, B; Prior, IA; Muncke, C; Grainger, S; Parton, RG; Henis, YI; Kloog, Y; Hancock, JF
errShare
errSave
Identifying optimal lipid raft characteristics required to promote nanoscale protein-protein interactions on the plasma membrane
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-27
err189
errOAAI
errNicolau, DV; Burrage, K; Parton, RG; Hancock, JF
errShare
errSave
H-ras but not K-ras traffics to the plasma membrane through the exocytic pathway
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-27
err416
errOAAI
errApolloni, A; Prior, IA; Lindsay, M; Parton, RG; Hancock, JF
errShare
errSave
Three separable domains regulate GTP-dependent association of H-ras with the plasma membrane
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-27
err152
errOAAI
errRotblat, B; Prior, IA; Muncke, C; Parton, RG; Kloog, Y; Henis, YI; Hancock, JF
errShare
errSave
Electrostatic interactions positively regulate K-ras nanocluster formation and function
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-27
err103
errOAAI
errPlowman, Sarah J.; Ariotti, Nicholas; Goodall, Andrew; Parton, Robert G.; Hancock, John F.
errShare
errSave
Epidermal Growth Factor Receptor Activation Remodels the Plasma Membrane Lipid Environment To Induce Nanocluster Formation
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-20
err87
errOAAI
errAriotti, Nicholas; Liang, Hong; Xu, Yufei; Zhang, Yueqiang; Yonekubo, Yoshiya; Inder, Kerry; Du, Guangwei; Parton, Robert G.; Hancock, John F.; Plowman, Sarah J.
errShare
errSave
Signal Integration by Lipid-Mediated Spatial Cross Talk between Ras Nanoclusters
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-20
err118
errOAAI
errZhou, Yong; Liang, Hong; Rodkey, Travis; Ariotti, Nicholas; Parton, Robert G.; Hancock, John F.
errShare
errSave
Temporal Production of the Signaling Lipid Phosphatidic Acid by Phospholipase D2 Determines the Output of Extracellular Signal-Regulated Kinase Signaling in Cancer Cells
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-20
err100
errOAAI
errZhang, Feng; Wang, Ziqing; Lu, Maryia; Yonekubo, Yoshiya; Liang, Xiao; Zhang, Yueqiang; Wu, Ping; Zhou, Yong; Grinstein, Sergio; Hancock, John F.; Du, Guangwei
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errSave
Fendiline Inhibits K-Ras Plasma Membrane Localization and Blocks K-Ras Signal Transmission
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-20
err96
errOAAI
errvan der Hoeven, Dharini; Cho, Kwang-jin; Ma, Xiaoping; Chigurupati, Sravanthi; Parton, Robert G.; Hancock, John F.
errShare
errSave
Therapeutic Levels of the Hydroxmethylglutaryl-Coenzyme A Reductase Inhibitor Lovastatin Activate Ras Signaling via Phospholipase D2
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-20
err35
errOAAI
errCho, Kwang-jin; Hill, Michelle M.; Chigurupati, Sravanthi; Du, Guangwei; Parton, Robert G.; Hancock, John F.
errShare
errSave

Research Directions

No research directions
Co-authors
Cooperation Journals
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A
Anil K. Sood
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Mien‐Chie Hung
H-index: 163 · Papers: 1.5K
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Ignacio I. Wistuba
H-index: 153 · Papers: 2.8K
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Robert G. Parton
H-index: 149 · Papers: 705
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