Not logged in INVESTIGATION OF THE COMBINATION OF D2C7-IT WITH AN FC-ENGINEERED ANTI-HUMANCD40 MONOCLONAL ANTIBODY (2141-V11) WHEN ADMINISTERED INTRATUMORALLY VIA CONVECTION-ENHANCED DELIVERY (CED) FOLLOWED BY CERVICAL PERILYMPHATIC INJECTIONS (CPLIS) OF 2141-V11 COMPARED TO D2C7-IT CED MONOTHERAPY IN PATIENTS WITH RECURRENT GLIOBLASTOMA (RGBM) Desjardins, Annick; Chandramohan, Vidya; Herndon II, James E.; Bradbury, Claire; Shoaf, Madison; Peters, Katherine B.; Johnson, Margaret O.; Batich, Kristen; Low, Justin; Khasraw, Mustafa; Friedman, Allan H.; Friedman, Henry S.; Ashley, David M.; Grant, Gerald; Osorio, Juan; Ravetch, Jeffrey; Bigner, Darell D. Share Save
An assessment of the Tumor Monorail Device (TMD) for repeated sampling as part of a trial evaluating the combination of D2C7-IT and an Fc-engineered anti-CD40 monoclonal antibody (2141-V11) administered intratumorally via convection-enhanced delivery (CED) and cervical perilymphatic injections (CPLIs) of 2141-V11 in recurrent glioblastoma (rGBM) patients Desjardins, Annick; Chandramohan, Vidya; Mokarram, Nassir; Meehan, Sean; Sharma, Shaili; Herndon Ii, James E.; Shoaf, Madison; Peters, Katherine B.; Johnson, Margaret O.; Batich, Kristen; Low, Justin; Khasraw, Mustafa; Friedman, Allan H.; Friedman, Henry S.; Ashley, David M.; Grant, Gerald; Osorio, Juan; Ravetch, Jeffrey; Bellamkonda, Ravi; Bigner, Darell D. Share Save
Randomized phase 2 clinical trial of repeated intratumoral and cervical perilymphatic injections (CPLIs) of lerapolturev vs. lomustine in recurrent glioblastoma (rGBM): safety lead-in results Shoaf, Madison L.; Gromeier, Matthias; Brown, Michael C.; Buckley, Evan D.; Herndon II, James E.; Batich, Kristen; Johnson, Margaret O.; Khasraw, Mustafa; Low, Justin T.; Peters, Katherine B.; Friedman, Allan H.; Friedman, Henry S.; Ashley, David M.; Bigner, Darell D.; Desjardins, Annick Share Save
D2C7-IT IN COMBINATION WITH AN FC-ENGINEERED ANTI-HUMANCD40 MONOCLONAL ANTIBODY (2141-V11) ADMINISTERED INTRATUMORALLY VIA CONVECTION-ENHANCED DELIVERY (CED) FOLLOWED BY CERVICAL PERILYMPHATIC INJECTIONS (CPLIS) OF 2141-V11 IN PATIENTS WITH RECURRENT GLIOBLASTOMA (RGBM) Desjardins, Annick; Chandramohan, Vidya; Herndon, James E., II; Threatt, Stevie; Bullock, Chevelle; Bradbury, Claire; Johnson, Margaret O.; Khasraw, Mustafa; Low, Justin T.; Peters, Katherine B.; Shoaf, Madison; Landi, Daniel; Batich, Kristen; Friedman, Allan H.; Friedman, Henry S.; Ashley, David M.; Knorr, David; Osorio, Juan; Ravetch, Jeffrey; Bigner, Darell D. Share Save
REPEATED CONVECTION-ENHANCED DELIVERY (CED) INFUSION OF A POLIO/RHINOVIRUS RECOMBINANT (LERAPOLTUREV; LERA) IN RECURRENT GLIOBLASTOMA (RGBM) PATIENTS, FOLLOWED BY CERVICAL PERILYMPHATIC INJECTIONS OF LERA (LERA-CPLI) Desjardins, A.; Brown, M.; Shoaf, M.; Herndon, J. E.; Johnson, M. O.; Khasraw, M.; Low, J.; Peters, K. B.; Batich-Vaios, K.; Friedman, A. H.; Friedman, H. S.; Ashley, D. M.; Bigner, D. D.; Gromeier, M. Share Save
Recombinant polio-rhinovirus immunotherapy for recurrent paediatric high-grade glioma: a phase 1b trial Thompson, Eric M.; Landi, Daniel; Brown, Michael C.; Friedman, Henry S.; McLendon, Roger; Herndon II, James E.; Buckley, Evan; Bolognesi, Dani P.; Lipp, Eric; Schroeder, Kristin; Becher, Oren J.; Friedman, Allan H.; McKay, Zachary; Walter, Ashley; Threatt, Stevie; Jaggers, Denise; Desjardins, Annick; Gromeier, Matthias; Bigner, Darell; Ashley, David M. Share Save
Alternative lengthening of telomeres is associated with hypersensitivity to topoisomerase 1 inhibition in glioblastoma xenograft models Keir, Stephen T.; Liu, Heng; Low, Justin T.; Pirozzi, Christopher J.; Reynolds, Nathan; Lipp, Eric S.; Desjardins, Annick; Friedman, Henry S.; Khasraw, Mustafa; Bigner, Darell D.; Ashley, David M.; Waitkus, Matthew S. Share Save
Polio virotherapy targets the malignant glioma myeloid infiltrate with diffuse microglia activation engulfing the CNS Yang, Yuanfan; Brown, Michael C.; Zhang, Gao; Stevenson, Kevin; Mohme, Malte; Kornahrens, Reb; Bigner, Darell D.; Ashley, David M.; Lopez, Giselle Y.; Gromeier, Matthias Share Save
Immunotoxin-αCD40 therapy activates innate and adaptive immunity and generates a durable antitumor response in glioblastoma models Parker, Scott; McDowall, Charlotte; Sanchez-Perez, Luis; Osorio, Cristina; Duncker, Patrick C.; Briley, Aaron; Swartz, Adam M.; Herndon, James E.; Yu, Yen-Rei A.; McLendon, Roger E.; Tedder, Thomas F.; Desjardins, Annick; Ashley, David M.; Gunn, Michael Dee; Enterline, David S.; Knorr, David A.; Pastan, Ira H.; Nair, Smita K.; Bigner, Darell D.; Chandramohan, Vidyalakshmi Share Save
DISTRIBUTION AND VULNERABILITY OF TRANSCRIPTIONAL OUTPUTS ACROSS THE GENOME IN MYC-AMPLIFIED MEDULLOBLASTOMA CELLS Yang, Rui; Wang, Wenzhe; Dong, Meichen; Roso, Kristen; Bao, Xuhui; Pirozzi, Christopher; Bigner, Darell; Yan, Hai; Ashley, David; Zhabotynsky, Vasyl; Zou, Fei; He, Yiping Share Save
Viral infection of cells within the tumor microenvironment mediates antitumor immunotherapy via selective TBK1-IRF3 signaling Brown, Michael C.; Mosaheb, Mubeen M.; Mohme, Malte; McKay, Zachary P.; Holl, Eda K.; Kastan, Jonathan P.; Yang, Yuanfan; Beasley, Georgia M.; Hwang, E. Shelley; Ashley, David M.; Bigner, Darell D.; Nair, Smita K.; Gromeier, Matthias Share Save
Very low mutation burden is a feature of inflamed recurrent glioblastomas responsive to cancer immunotherapy Gromeier, Matthias; Brown, Michael C.; Zhang, Gao; Lin, Xiang; Chen, Yeqing; Wei, Zhi; Beaubier, Nike; Yan, Hai; He, Yiping; Desjardins, Annick; Herndon, James E., II; Varn, Frederick S.; Verhaak, Roel G.; Zhao, Junfei; Bolognesi, Dani P.; Friedman, Allan H.; Friedman, Henry S.; McSherry, Frances; Muscat, Andrea M.; Lipp, Eric S.; Nair, Smita K.; Khasraw, Mustafa; Peters, Katherine B.; Randazzo, Dina; Sampson, John H.; McLendon, Roger E.; Bigner, Darell D.; Ashley, David M. Share Save
Genetically stable poliovirus vectors activate dendritic cells and prime antitumor CD8 T cell immunity Mosaheb, Mubeen M.; Dobrikova, Elena Y.; Brown, Michael C.; Yang, Yuanfan; Cable, Jana; Okada, Hideho; Nair, Smita K.; Bigner, Darell D.; Ashley, David M.; Gromeier, Matthias Share Save
MTAP Loss Promotes Stemness in Glioblastoma and Confers Unique Susceptibility to Purine Starvation Hansen, Landon J.; Sun, Ran; Yang, Rui; Singh, Simranjit X.; Chen, Lee H.; Pirozzi, Christopher J.; Moure, Casey J.; Hemphill, Carlee; Carpenter, Austin B.; Healy, Patrick; Ruger, Ryan C.; Chen, Chin-Pu J.; Greer, Paula K.; Zhao, Fangping; Spasojevic, Ivan; Grenier, Carole; Huang, Zhiqing; Murphy, Susan K.; McLendon, Roger E.; Friedman, Henry S.; Friedman, Allan H.; Herndonll, James E.; Sampson, John H.; Keir, Stephen T.; Bigner, Darell D.; Yan, Hai; He, Yiping Share Save
Improved efficacy against malignant brain tumors with EGFRwt/EGFRvIII targeting immunotoxin and checkpoint inhibitor combinations Chandramohan, Vidyalakshmi; Bao, Xuhui; Yu, Xin; Parker, Scott; McDowall, Charlotte; Yu, Yen-Rei; Healy, Patrick; Desjardins, Annick; Gunn, Michael D.; Gromeier, Matthias; Nair, Smita K.; Pastan, Ira H.; Bigner, Darell D. Share Save
MGMT: Immunohistochemical Detection in High-Grade Astrocytomas Lipp, Eric S.; Healy, Patrick; Austin, Alan; Clark, Alysha; Dalton, Tara; Perkinson, Kathryn; Herndon, James E.; Friedman, Henry S.; Friedman, Allan H.; Bigner, Darell D.; McLendon, Roger E. Share Save
Sensitive and rapid detection of TERT promoter and IDH mutations in diffuse gliomas Diplas, Bill H.; Liu, Heng; Yang, Rui; Hansen, Landon J.; Zachem, Alexis L.; Zhao, Fangping; Bigner, Darell D.; McLendon, Roger E.; Jiao, Yuchen; He, Yiping; Waitkus, Matthew S.; Yan, Hai Share Save
Inhibition of histone methyltransferase with novel epipolythiodioxopiperazines (ETP) alkaloids in pediatric high-grade glioma Dombrowski, Stephen; Abou-Antoun, Thamara; Mansour, Anthony; Arar, Rewa; Movassaghi, Mohammad; Murphy, Erin; Banerjee, Shuvojit; Li, Xiao-Nan; Houghton, Peter; Bigner, Darell; Carcaboso, Angel Montero; Rich, Jeremy; Recinos, Violette Share Save
Reversing the Warburg effect as a treatment for glioblastoma (vol 288, pg 9153, 2013) Poteet, Ethan; Choudhury, Gourav Roy; Winters, Ali; Li, Wenjun; Ryou, Myoung-Gwi; Liu, Ran; Tang, Lin; Ghorpade, Anuja; Wen, Yi; Yuan, Fang; Keir, Stephen T.; Yan, Hai; Bigner, Darell D.; Simpkins, James W.; Yang, Shao-Hua Share Save
Mutant allele quantification reveals a genetic basis for TP53 mutation-driven castration resistance in prostate cancer cells Lei, Kefeng; Sun, Ran; Chen, Lee H.; Diplas, Bill H.; Moure, Casey J.; Wang, Wenzhe; Hansen, Landon J.; Tao, Yulei; Chen, Xufeng; Chen, Chin-Pu Jason; Greer, Paula K.; Zhao, Fangping; Yan, Hai; Bigner, Darell D.; Huang, Jiaoti; He, Yiping Share Save
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