Jeffrey J. Widrick - Publications, H-index & Citations

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Jeffrey J. Widrick

Harvard University

40H-index

139Paper Count

6.9KCitation Count

Published Papers 42

Publication Date

Conditional Dmd ablation in muscle and brain causes profound effects on muscle function and neurobehavior

Communications Biology

IF5.1

2025-12-02

OAAI

Muthukumar Karuppasamy; Katherine G. English; James R. Conner; Shelby N. Rorrer; Michael A. Lopez; David K. Crossman; Jodi R. Paul; Miguel A. Gutierrez-Monreal; Karen L. Gamble; Karyn A. Esser; Jeffrey J. Widrick; Louis M. Kunkel; Matthew S. Alexander

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Loss of adenylosuccinate synthetase 1 in mice recapitulates features of ADSS1 myopathy

HUMAN MOLECULAR GENETICS

IF3.2

2025-11-01

PREAI

Kim, Morgan E.; Yammine, Kathryn M.; Hickey, Emily T.; Matias, Catalina; Dubosclard, Lou C.; Widrick, Jeffrey J.; Brault, Jeffrey J.; Moghadaszadeh, Behzad; Beggs, Alan H.

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Identifying kinematic biomarkers of the dystrophic phenotype in a zebrafish model of Duchenne muscular dystrophy

Skeletal Muscle

IF4.4

2025-08-26

PREAI

Jeffrey J. Widrick; Matthias R. Lambert; Felipe de Souza Leite; Youngsook Lucy Jung; Junseok Park; James R. Conner; Eunjung Alice Lee; Alan H. Beggs; Louis M. Kunkel

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Dynamic regulation of inter-organelle communication by ubiquitylation controls skeletal muscle development and disease onset

ELIFE

IF0

2023-07-11

OAAI

Mansur, Arian; Joseph, Remi; Kim, Euri S.; Jean-Beltran, Pierre M.; Udeshi, Namrata D.; Pearce, Cadence; Jiang, Hanjie; Iwase, Reina; Milev, Miroslav P.; Almousa, Hashem A.; McNamara, Elyshia; Widrick, Jeffrey; Perez, Claudio; Ravenscroft, Gianina; Sacher, Michael; Cole, Philip A.; Carr, Steven A.; Gupta, Vandana A.

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Optimizing assays of zebrafish larvae swimming performance for drug discovery

EXPERT OPINION ON DRUG DISCOVERY

IF4.9

2023-05-15

PREAI

Widrick, Jeffrey J.; Lambert, Matthias R.; Kunkel, Louis M.; Beggs, Alan H.

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Electrical impedance myography detects age-related skeletal muscle atrophy in adult zebrafish

SCIENTIFIC REPORTS

IF3.9

2023-05-03

OAAI

Rutkove, Seward B.; Callegari, Santiago; Concepcion, Holly; Mourey, Tyler; Widrick, Jeffrey; Nagy, Janice A.; Nath, Anjali K.

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IMP2 Increases Mouse Skeletal Muscle Mass and Voluntary Activity by Enhancing Autocrine Insulin-Like Growth Factor 2 Production and Optimizing Muscle Metabolism

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-03

OAAI

Regue, Laura; Ji, Fei; Flicker, Daniel; Kramer, Dana; Pierce, William; Davidoff, Teekhon; Widrick, Jeffrey J.; Houstis, Nicholas; Minichiello, Liliana; Dai, Ning; Avruch, Joseph

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Dynamin-2 reduction rescues the skeletal myopathy of a SPEG-deficient mouse model

JCI INSIGHT

IF6.1

2022-08-08

OAAI

Li, Qifei; Lin, Jasmine; Widrick, Jeffrey J.; Luo, Shiyu; Li, Gu; Zhang, Yuanfan; Laporte, Jocelyn; Perrella, Mark A.; Liu, Xiaoli; Agrawal, Pankaj B.

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Skeletal Muscle Dysfunction in Experimental Pulmonary Hypertension Kosmas Kosmas1,2, Zoe Michael2,3, Fotios Spyropoulos1,2, Jeffrey Widrick2,4, Ravi Jasuja2, Aimilia Papathanasiou1,2, Helen Christou 1,21Department of Pediatric Newborn Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA 2Harvard Medical School, Boston, MA 02215, USA 3Department of Pediatrics, Boston Children's Hospital, Boston, MA 02215, USA 4Department of Genetics, Boston Children's Hospital, Boston, MA 02215, USA

FASEB JOURNAL

IF4.2

2022-05-13

PREAI

Kosmas, Kosmas; Michael, Zoe; Spyropoulos, Fotios; Widrick, Jeffrey; Jasuja, Ravi; Papathanasiou, Aimilia; Christou, Helen

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miR-486 is essential for muscle function and suppresses a dystrophic transcriptome

LIFE SCIENCE ALLIANCE

IF2.9

2022-05-05

OAAI

Samani, Adrienne; Hightower, Rylie M.; Reid, Andrea L.; English, Katherine G.; Lopez, Michael A.; Doyle, J. Scott; Conklin, Michael J.; Schneider, David A.; Bamman, Marcas M.; Widrick, Jeffrey J.; Crossman, David K.; Xie, Min; Jee, David; Lai, Eric C.; Alexander, Matthew S.

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PDE10A Inhibition Reduces the Manifestation of Pathology in DMD Zebrafish and Represses the Genetic Modifier PITPNA

MOLECULAR THERAPY

IF12

2021-03-01

OAAI

Lambert, Matthias R.; Spinazzola, Janelle M.; Widrick, Jeffrey J.; Pakula, Anna; Conner, James R.; Chin, Janice E.; Owens, Jane M.; Kunkel, Louis M.

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The SINE Compound KPT-350 Blocks Dystrophic Pathologies in DMD Zebrafish and Mice

MOLECULAR THERAPY

IF12

2020-01-01

OAAI

Hightower, Rylie M.; Reid, Andrea L.; Gibbs, Devin E.; Wang, Yimin; Widrick, Jeffrey J.; Kunkel, Louis M.; Kastenschmidt, Jenna M.; Villalta, S. Armando; van Groen, Thomas; Chang, Hua; Gornisiewicz, Savanna; Landesman, Yosef; Tamir, Sharon; Alexander, Matthew S.

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Discovery of Novel Therapeutics for Muscular Dystrophies using Zebrafish Phenotypic Screens

JOURNAL OF NEUROMUSCULAR DISEASES

IF3.4

2019-09-03

OAAI

Widrick, Jeffrey J.; Kawahara, Genri; Alexander, Matthew S.; Beggs, Alan H.; Kunkel, Louis M.

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Follistatin-based ligand trap ACE-083 induces localized hypertrophy of skeletal muscle with functional improvement in models of neuromuscular disease

SCIENTIFIC REPORTS

IF3.9

2019-08-06

OAAI

Pearsall, R. S.; Davies, M., V; Cannel, M.; Li, J.; Widrick, J.; Mulivor, A. W.; Wallner, S.; Troy, M. E.; Spaits, M.; Liharska, K.; Sako, D.; Castonguay, R.; Keates, S.; Grinberg, A., V; Suragani, R. N. V. S.; Kumar, R.

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Transgenic zebrafish model of DUX4 misexpression reveals a developmental role in FSHD pathogenesis

HUMAN MOLECULAR GENETICS

IF3.2

2018-10-10

OAAI

Pakula, Anna; Lek, Angela; Widrick, Jeffrey; Mitsuhashi, Hiroaki; Gwilt, Katlynn M. Bugda; Gupta, Vandana A.; Rahimov, Fedik; Criscione, June; Zhang, Yuanfan; Gibbs, Devin; Murphy, Quinn; Manglik, Anusha; Mead, Lillian; Kunkel, Louis

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A limb-girdle muscula dystrophy 21 model of muscular dystrophy identifies corrective drug compounds for dystroglycanopathies

JCI INSIGHT

IF6.1

2018-09-20

OAAI

Serafini, Peter R.; Feyder, Michael J.; Hightower, Rylie M.; Garcia-Perez, Daniela; Vieira, Natassia M.; Lek, Angela; Gibbs, Devin E.; Moukha-Chafiq, Omar; Augelli-Szafran, Corinne E.; Kawahara, Genri; Widrick, Jeffrey J.; Kunkel, Louis M.; Alexander, Matthew S.

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RNA helicase, DDX27 regulates skeletal muscle growth and regeneration by modulation of translational processes

PLOS GENETICS

IF3.7

2018-03-08

OAAI

Bennett, Alexis H.; O'Donohue, Marie-Francoise; Gundry, Stacey R.; Chan, Aye T.; Widrick, Jeffrey; Drapers, Isabelle; Chakraborty, Anirban; Zhou, Yi; Zon, Leonard I.; Gleizes, Pierre-Emmanuel; Beggs, Alan H.; Gupta, Vandana A.

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SPEG-deficient skeletal muscles exhibit abnormal triad and defective calcium handling

HUMAN MOLECULAR GENETICS

IF3.2

2018-02-20

OAAI

Huntoon, Virginia; Widrick, Jeffrey J.; Sanchez, Colline; Rosen, Samantha M.; Kutchukian, Candice; Cao, Siqi; Pierson, Christopher R.; Liu, Xiaoli; Perrella, Mark A.; Beggs, Alan H.; Jacquemond, Vincent; Agrawal, Pankaj B.

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In Vivo DMD Gene Editing in Muscles and Muscle Stem Cells of Dystrophic Mice

MOLECULAR THERAPY

IF12

2016-05-01

OAAI

Tabebordbar, Mohammadsharif; Zhu, Kexian; Cheng, Jason; Widrick, Jeffrey; Yan, Winston; Xiao, Ru; Vandenberghe, Luk; Zhang, Feng; Wagers, Amy

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Dystrophic muscle improvement in zebrafish via increased heme oxygenase signaling (vol 23, pg 1869, 2014)

HUMAN MOLECULAR GENETICS

IF3.2

2015-06-01

OAAI

Kawahara, Genri; Gasperini, Molly J.; Myers, Jennifer A.; Widrick, Jeffrey J.; Eran, Alal; Serafini, Peter R.; Alexander, Matthew S.; Pletcher, Mathew T.; Morris, Carl A.; Kunkel, Louis M.

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Research Directions