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James Douglas Engel

university of michigan

78H-index
290Paper Count
2.3WCitation Count
Published Papers 82
Publication Date
LSD1 inhibition ameliorates congenital dyserythropoietic anemia type II
err2026-03-25
err0
PREAI
errLei Yu; Yu Wang; Richard King; Greggory Myers; Kaiwen Deng; Beth McGee; Ann Friedman; Ginette Balbin-Cuesta; Zesen Lin; Claire Drysdale; Xiaofang Liu; Joseph C. Min; Claire Kerpet; Yuanfang Guan; Patrick J. Gallagher; Ayse Bilge Ozel; Aaron Robida; James Douglas Engel; Rami Khoriaty
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Novel, potent, and orally bioavailable LSD1 inhibitors induce fetal hemoglobin synthesis in a sickle cell disease mouse model
errBlood
IF23.1
err2025-05-09
err0
PREAI
errYu Wang; Lei Yu; Kaiwen Deng; Mathivanan Packiarajan; Angelo Aguilar; Sojin An; Xiaofang Liu; Greggory Myers; Hoon Oh; Sharon A. Singh; Uhn-soo Cho; Shaomeng Wang; Yuanfang Guan; Andrew D. White; Rami Khoriaty; James Douglas Engel
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A genome-wide screen identifies genes required for erythroid differentiation
err2025-04-12
err0
errOAAI
errMyers, Greggory; Friedman, Ann; Yu, Lei; Pourmandi, Narges; Kerpet, Claire; Ito, Masaki A.; Saba, Rilie; Tang, Vi; Ozel, Ayse Bilge; Bergin, Ingrid L.; Johnson, Craig N.; Ku, Chia-Jui; Wang, Yu; Balbin-Cuesta, Ginette; Lim, Kim-Chew; Lin, Zesen; Drysdale, Claire; Mcgee, Beth; Kurita, Ryo; Nakamura, Yukio; Liu, Xiaofang; Siemieniak, David; Singh, Sharon A.; Lyssiotis, Costas A.; Maillard, Ivan; Weisman, Lois S.; Engel, James Douglas; Khoriaty, Rami
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The abundance of the short GATA1 isoform affects megakaryocyte differentiation and leukemic predisposition in mice
err2024-02-26
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errOAAI
errIshihara, Daishi; Hasegawa, Atsushi; Hirano, Ikuo; Engel, James Douglas; Yamamoto, Masayuki; Shimizu, Ritsuko
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Strain-dependent modifiers exacerbate familial leukemia caused by GATA1-deficiency
err2024-02-26
err0
errOAAI
errHirano, Ikuo; Abe, Kanako; Engel, James Douglas; Yamamoto, Masayuki; Shimizu, Ritsuko
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Murine erythroid differentiation kinetics in vivo under normal and anemic stress conditions
err2023-09-27
err1
errOAAI
errMyers, Greggory; Wang, Yu; Wang, Qing; Friedman, Ann; Sanchez-Martinez, Alejandra; Liu, Xiaofang; Sharon, Singh A.; Lim, Kim-Chew; Khoriaty, Rami; Engel, James Douglas; Yu, Lei
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Linear distance from the locus control region determines ε-globin transcriptional activity
err2023-04-01
err11
errOAAI
errShimotsuma, Motoshi; Matsuzaki, Hitomi; Tanabe, Osamu; Campbell, Andrew D.; Engel, James Douglas; Fukamizu, Akiyoshi; Tanimoto, Keiji
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Reconstitution of human β-globin locus control region hypersensitive sites in the absence of chromatin assembly
err2023-03-28
err50
errOAAI
errLeach, KM; Nightingale, K; Igarashi, K; Levings, PP; Engel, JD; Becker, PB; Bungert, J
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GATA motifs regulate early hematopoietic lineage-specific expression of the Gata2 gene
err2023-03-27
err82
errOAAI
errKobayashi-Osaki, M; Ohneda, O; Suzuki, N; Minegishi, N; Yokomizo, T; Takahashi, S; Lim, KC; Engel, JD; Yamamoto, M
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Identification of cis-regulatory sequences in the human angiotensinogen gene by transgene coplacement and site-specific recombination
err2023-03-27
err17
errOAAI
errShimizu, T; Oishi, T; Omori, A; Sugiura, A; Hirota, K; Aoyama, H; Saito, T; Sugaya, T; Kon, Y; Engel, JD; Fukamizu, A; Tanimoto, K
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MafG sumoylation is required for active transcriptional repression
err2023-03-27
err52
errOAAI
errMotohashi, Hozumi; Katsuoka, Fumiki; Miyoshi, Chika; Uchimura, Yasuhiro; Saitoh, Hisato; Francastel, Claire; Engel, James Douglas; Yamamoto, Masayuki
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MafB is essential for renal development and F4/80 expression in macrophages
err2023-03-27
err193
errOAAI
errMoriguchi, Takashi; Hamada, Michito; Morito, Naoki; Terunuma, Tsumoru; Hasegawa, Kazuteru; Zhang, Chuan; Yokomizo, Tomomasa; Esaki, Ritsuko; Kuroda, Etsushi; Yoh, Keigyou; Kudo, Takashi; Nagata, Michio; Greaves, David R.; Engel, James Douglas; Yamamoto, Masayuki; Takahashi, Satoru
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MafA is a key regulator of glucose-stimulated insulin secretion
err2023-03-27
err514
errOAAI
errZhang, C; Moriguchi, T; Kajihara, M; Esaki, R; Harada, A; Shimohata, H; Oishi, H; Hamada, M; Morito, N; Hasegawa, K; Kudo, T; Engel, JD; Yamamoto, M; Takahashi, S
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Disruption of the Hbs1l-Myb Locus Causes Hereditary Persistence of Fetal Hemoglobin in a Mouse Model
err2023-03-21
err39
errOAAI
errSuzuki, Mikiko; Yamazaki, Hiromi; Mukai, Harumi Y.; Motohashi, Hozumi; Shi, Lihong; Tanabe, Osamu; Engel, James Douglas; Yamamoto, Masayuki
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UG4 Enhancer-Driven GATA-2 and Bone Morphogenetic Protein 4 Complementation Remedies the CAKUT Phenotype in Gata2 Hypomorphic Mutant Mice
err2023-03-20
err22
errOAAI
errAinoya, Keiko; Moriguchi, Takashi; Ohmori, Shin'ya; Souma, Tomokazu; Takai, Jun; Morita, Masanobu; Chandler, Kelly J.; Mortlock, Douglas P.; Shimizu, Ritsuko; Engel, James Douglas; Lim, Kim-Chew; Yamamoto, Masayuki
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Nuclear Receptors TR2 and TR4 Recruit Multiple Epigenetic Transcriptional Corepressors That Associate Specifically with the Embryonic β-Type Globin Promoters in Differentiated Adult Erythroid Cells
err2023-03-20
err131
errOAAI
errCui, Shuaiying; Kolodziej, Katarzyna E.; Obara, Naoshi; Amaral-Psarris, Alexandra; Demmers, Jeroen; Shi, Lihong; Engel, James Douglas; Grosveld, Frank; Strouboulis, John; Tanabe, Osamu
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