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M

Morgan Sheng

broad institute of mit and harvard

141H-index
365Paper Count
7.4WCitation Count
Published Papers 129
Publication Date
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Loss of schizophrenia risk gene XPO7 disrupts neuronal excitability and network regularity via altered Na+ channel dynamics in human neurons
errMolecular Psychiatry
IF10.1
err2026-04-15
err0
errOAAI
errLei Cui; Erkin Kurganov; Derek Hawes; Philipp Hornauer; Raozhou Lin; Yining Wang; Andreas Hierlemann; Morgan Sheng; Ralda Nehme; Jen Q. Pan
errShare
errSave
Impaired removal of dying brain cells by microglia in Gpr34 deficient mice
errJournal of Neuroinflammation
IF10.1
err2026-04-10
err0
errOAAI
errDiana G. Bohannon; Ana Geller; Sean K. Simmons; John A. Cintron; William E. Martenis; Katherine Stalnacker; Autumn Masse; Min Jee Kwon; Yan-Ling Zhang; Joshua Z. Levin; Prabhat S. Kunwar; Morgan Sheng
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errSave
Elevated synaptic PKA activity and abnormal striatal dopamine signaling in Akap11 mutant mice, a genetic model of schizophrenia and bipolar disorder
errNature Communications
IF15.7
err2025-11-28
err0
errOAAI
errBryan J. Song; Yang Ge; Ally Nicolella; Min Jee Kwon; Bart Lodder; Kevin Bonanno; Antia Valle-Tojeiro; Nolan D. Hartley; Kira Perzel Mandell; John Adeleye; Deeksha Misri; Chuhan Geng; Sahana Natarajan; Inès Picard; Nate Shepard; Alyssa Hall; Jiawen Tian; Sameer Aryal; Zohreh Farsi; Xiao-Man Liu; Nader Morshed; Naeem M. Nadaf; Horia Pribiag; Sean K. Simmons; D. R. Mani; Beth Stevens; Prabhat S. Kunwar; Zhanyan Fu; Evan Z. Macosko; Joshua Z. Levin; Bernardo L. Sabatini; Steven A. Carr; Borislav Dejanovic; Hasmik Keshishian; Adam J. Granger; Morgan Sheng
errShare
errSave
Meta-analysis of the brain transcriptomes of multiple genetic mouse models of schizophrenia highlights dysregulation in striatum and thalamus
errTranslational Psychiatry
IF6.2
err2025-09-29
err0
errOAAI
errKira A. Perzel Mandell; Sean K. Simmons; Ajay Nadig; Zohreh Farsi; Wei-Chao Huang; Sameer Aryal; Min Jee Kwon; Bryan Song; Kira Brenner; Nate Shepard; Ally A. Nicolella; Lesley D. O’Brien; Aron H. Lichtman; Joshua Z. Levin; Morgan Sheng
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errSave
Differential functional consequences of GRIN2A mutations associated with schizophrenia and neurodevelopmental disorders
errSCIENTIFIC REPORTS
IF3.9
err2024-02-02
err3
errOAAI
errShepard, Nate; Baez-Nieto, David; Iqbal, Sumaiya; Kurganov, Erkin; Budnik, Nikita; Campbell, Arthur J.; Pan, Jen Q.; Sheng, Morgan; Farsi, Zohreh
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errSave
Targeting synapse function and loss for treatment of neurodegenerative diseases
errNATURE REVIEWS DRUG DISCOVERY
IF101.8
err2023-11-27
err23
PREAI
errDejanovic, Borislav; Sheng, Morgan; Hanson, Jesse E.
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errSave
Brain-region-specific changes in neurons and glia and dysregulation of dopamine signaling in Grin2a mutant mice
errNEURON
IF15
err2023-11-01
err14
errOAAI
errFarsi, Zohreh; Nicolella, Ally; Simmons, Sean K.; Aryal, Sameer; Shepard, Nate; Brenner, Kira; Lin, Sherry; Herzog, Linnea; Moran, Sean P.; Stalnaker, Katherine J.; Shin, Wangyong; Gazestani, Vahid; Song, Bryan J.; Bonanno, Kevin; Keshishian, Hasmik; Carr, Steven A.; Pan, Jen Q.; Macosko, Evan Z.; Datta, Sandeep Robert; Dejanovic, Borislav; Kim, Eunjoon; Levin, Joshua Z.; Sheng, Morgan
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errSave
Btbd11 supports cell-type-specific synaptic function
errCELL REPORTS
IF6.9
err2023-06-01
err3
errOAAI
errBygrave, Alexei M.; Sengupta, Ayesha; Jackert, Ella P.; Ahmed, Mehroz; Adenuga, Beloved; Nelson, Erik; Goldschmidt, Hana L.; Johnson, Richard C.; Zhong, Haining; Yeh, Felix L.; Sheng, Morgan; Huganir, Richard L.
errShare
errSave
Deep proteomics identifies shared molecular pathway alterations in synapses of patients with schizophrenia and bipolar disorder and mouse model
errCELL REPORTS
IF6.9
err2023-05-01
err10
errOAAI
errAryal, Sameer; Bonanno, Kevin; Song, Bryan; Mani, D. R.; Keshishian, Hasmik; Carr, Steven A.; Sheng, Morgan; Dejanovic, Borislav
errShare
errSave
A synaptic molecular dependency network in knockdown of autism- and schizophrenia-associated genes revealed by multiplexed imaging
errCELL REPORTS
IF6.9
err2023-05-01
err7
errOAAI
errFalkovich, Reuven; Danielson, Eric W.; de Arce, Karen Perez; Wamhoff, Eike-C.; Strother, Juliana; Lapteva, Anna P.; Sheng, Morgan; Cottrell, Jeffrey R.; Bathe, Mark
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errSave
The neuronal pentraxin Nptx2 regulates complement activity and restrains microglia-mediated synapse loss in neurodegeneration
errSCIENCE TRANSLATIONAL MEDICINE
IF14.6
err2023-03-29
err41
errOAAI
errZhou, Jiechao; Wade, Sarah D.; Graykowski, David; Xiao, Mei-Fang; Zhao, Binhui; Giannini, Lucia A. A.; Hanson, Jesse E.; van Swieten, John C.; Sheng, Morgan; Worley, Paul F.; Dejanovic, Borislav
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errSave
Mouse mutants in schizophrenia risk genes GRIN2A and AKAP11 show EEG abnormalities in common with schizophrenia patients
errTRANSLATIONAL PSYCHIATRY
IF6.2
err2023-03-13
err18
errOAAI
errHerzog, Linnea E.; Wang, Lei; Yu, Eunah; Choi, Soonwook; Farsi, Zohreh; Song, Bryan J.; Pan, Jen Q.; Sheng, Morgan
errShare
errSave
TREM2-dependent microglial function is essential for remyelination and subsequent neuroprotection
errGLIA
IF5.1
err2023-01-10
err21
errOAAI
errWang, Yuanyuan; Kyauk, Roxanne V.; Shen, Yun-An A.; Xie, Luke; Reichelt, Mike; Lin, Han; Jiang, Zhiyu; Ngu, Hai; Shen, Kimberle; Greene, Jacob J.; Sheng, Morgan; Yuen, Tracy J.
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errSave
Optogenetic polymerization and assembly of electrically functional polymers for modulation of single-neuron excitability
errSCIENCE ADVANCES
IF12.5
err2022-12-09
err10
errOAAI
errSessler, Chanan D.; Zhou, Yiming; Wang, Wenbo; Hartley, Nolan D.; Fu, Zhanyan; Graykowski, David; Sheng, Morgan; Wang, Xiao; Liu, Jia
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errSave
Complement C1q-dependent excitatory and inhibitory synapse elimination by astrocytes and microglia in Alzheimer's disease mouse models
errNATURE AGING
IF19.4
err2022-09-20
err101
errOAAI
errDejanovic, Borislav; Wu, Tiffany; Tsai, Ming-Chi; Graykowski, David; Gandham, Vineela D.; Rose, Christopher M.; Bakalarski, Corey E.; Ngu, Hai; Wang, Yuanyuan; Pandey, Shristi; Rezzonico, Mitchell G.; Friedman, Brad A.; Edmonds, Rose; De Maziere, Ann; Rakosi-Schmidt, Raphael; Singh, Tarjinder; Klumperman, Judith; Foreman, Oded; Chang, Michael C.; Xie, Luke; Sheng, Morgan; Hanson, Jesse E.
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errSave
NMDA receptor-dependent prostaglandin-endoperoxide synthase 2 induction in neurons promotes glial proliferation during brain development and injury
errCELL REPORTS
IF6.9
err2022-03-01
err8
errOAAI
errZhou, Jia; Geng, Yang; Su, Tonghui; Wang, Qiuyan; Ren, Yongfei; Zhao, Jing; Fu, Chaoying; Weber, Martin; Lin, Han; Kaminker, Joshua S.; Liu, Nan; Sheng, Morgan; Chen, Yelin
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errSave
TREM2-independent oligodendrocyte, astrocyte, and T cell responses to tau and amyloid pathology in mouse models of Alzheimer disease
errCELL REPORTS
IF6.9
err2021-12-01
err39
errOAAI
errLee, Seung-Hye; Rezzonico, Mitchell G.; Friedman, Brad A.; Huntley, Melanie H.; Meilandt, William J.; Pandey, Shristi; Chen, Ying-Jiun J.; Easton, Amy; Modrusan, Zora; Hansen, David, V; Sheng, Morgan; Bohlen, Christopher J.
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errSave
Trem2 restrains the enhancement of tau accumulation and neurodegeneration by β-amyloid pathology
errNEURON
IF15
err2021-04-01
err147
errOAAI
errLee, Seung-Hye; Meilandt, William J.; Xie, Luke; Gandham, Vineela D.; Ngu, Hai; Barck, Kai H.; Rezzonico, Mitchell G.; Imperio, Jose; Lalehzadeh, Guita; Huntley, Melanie A.; Stark, Kimberly L.; Foreman, Oded; Carano, Richard A. D.; Friedman, Brad A.; Sheng, Morgan; Easton, Amy; Bohlen, Christopher J.; Hansen, David V.
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errSave
Multiple sclerosis risk gene Mertk is required for microglial activation and subsequent remyelination
errCELL REPORTS
IF6.9
err2021-03-01
err74
errOAAI
errShen, Kimberle; Reichelt, Mike; Kyauk, Roxanne, V; Ngu, Hai; Shen, Yun-An A.; Foreman, Oded; Modrusan, Zora; Friedman, Brad A.; Sheng, Morgan; Yuen, Tracy J.
errShare
errSave
PCDH7 interacts with GluN1 and regulates dendritic spine morphology and synaptic function
errSCIENTIFIC REPORTS
IF3.9
err2020-07-02
err21
errOAAI
errWang, Yuanyuan; Campbell, Meghan Kerrisk; Tom, Irene; Foreman, Oded; Hanson, Jesse E.; Sheng, Morgan
errShare
errSave

Research Directions

No research directions
Co-authors
Cooperation Journals
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Steven P. Gygi
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T
Thomas C. Südhof
H-index: 192 · Papers: 751
K
Karl Deisseroth
H-index: 182 · Papers: 634
P
Phillip A. Sharp
H-index: 173 · Papers: 638
L
Lily Yeh Jan
H-index: 170 · Papers: 599
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