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Esmethadone (REL-1017) in Patients With Major Depressive Disorder and Antidepressant Tachyphylaxis: An Exploratory Post Hoc Analysis From a Phase 3 Randomized Controlled Trial Guidetti, Clotilde; Papakostas, George I.; Pani, Luca; De Martin, Sara; Serra, Giulia; Apicella, Massimo; Kroger, Cornelia; Champasa, Paggard; Comai, Stefano; Mattarei, Andrea; Folli, Franco; Pappagallo, Marco; Manfredi, Paolo L.; Fava, Maurizio Share Save
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ANXIOLYTIC- AND PROCOGNITIVE-LIKE EFFECTS OF A 30-DAY CHRONIC TREATMENT WITH A LOW NON-PSYCHEDELIC DOSE OF PSILOCYBIN IN C57BL/6J MICE Nasini, Sofia; Tidei, Sara; Barzon, Benedetta; De Martin, Sara; Banzato, Marco; Mattarei, Andrea; Folli, Franco; Pappagallo, Marco; Manfredi, Paolo L.; Comai, Stefano Share Save
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Letter to the Editor regarding 'Unique pharmacodynamic properties and low abuse liability of the μ-opioid receptor ligand (S)-methadone' Pappagallo, Marco; Kosten, Thomas R.; Gorodetzky, Charles W.; Vocci, Frank J.; Sapienza, Frank L.; De Martin, Sara; Comai, Stefano; Mattarei, Andrea; Inturrisi, Charles E.; Manfredi, Paolo L. Share Save
Non-psychedelic doses of psilocybin as a novel therapeutic approach for MASLD De Martin, S.; Gabbia, D.; Colognesi, M.; Rinaldi, A.; Cascione, L.; Zanotto, I.; Sayaf, K.; Comai, S.; Mattarei, A.; Banzato, M.; Pasut, G.; Folli, F.; Centofanti, L.; Traversa, S.; Pappagallo, M.; Manfredi, P. L. Share Save
The novel uncompetitive NMDA receptor antagonist esmethadone (REL-1017) has no meaningful abuse potential in recreational drug users Shram, Megan J. J.; Henningfield, Jack E. E.; Apseloff, Glen; Gorodetzky, Charles W. W.; De Martin, Sara; Vocci, Frank L. L.; Sapienza, Frank L. L.; Kosten, Thomas R. R.; Huston, Jeff; Buchhalter, August; Ashworth, Judy; Lanier, Ryan; Folli, Franco; Mattarei, Andrea; Guidetti, Clotilde; Comai, Stefano; O'Gorman, Cedric; Traversa, Sergio; Inturrisi, Charles E. E.; Manfredi, Paolo L. L.; Pappagallo, Marco Share Save
Esmethadone-HCl (REL-1017): a promising rapid antidepressant Fava, Maurizio; Stahl, Stephen M. M.; De Martin, Sara; Mattarei, Andrea; Bettini, Ezio; Comai, Stefano; Alimonti, Andrea; Bifari, Francesco; Pani, Luca; Folli, Franco; Guidetti, Clotilde; Furlan, Alberto; Sgrignani, Jacopo; Locatelli, Patrizia; Cavalli, Andrea; O'Gorman, Cedric; Traversa, Sergio; Inturrisi, Charles E. E.; Pappagallo, Marco; Manfredi, Paolo L. L. Share Save
Pharmacological Comparative Characterization of REL-1017 (Esmethadone-HCl) and Other NMDAR Channel Blockers in Human Heterodimeric N-Methyl-D-Aspartate Receptors Bettini, Ezio; Stahl, Stephen M.; De Martin, Sara; Mattarei, Andrea; Sgrignani, Jacopo; Carignani, Corrado; Nola, Selena; Locatelli, Patrizia; Pappagallo, Marco; Inturrisi, Charles E.; Bifari, Francesco; Cavalli, Andrea; Alimonti, Andrea; Pani, Luca; Fava, Maurizio; Traversa, Sergio; Folli, Franco; Manfredi, Paolo L. Share Save
The N-Methyl-D-Aspartate Receptor Blocker REL-1017 (Esmethadone) Reduces Calcium Influx Induced by Glutamate, Quinolinic Acid, and Gentamicin Bettini, Ezio; De Martin, Sara; Mattarei, Andrea; Pappagallo, Marco; Stahl, Stephen M.; Bifari, Francesco; Inturrisi, Charles E.; Folli, Franco; Traversa, Sergio; Manfredi, Paolo L. Share Save
REL-1017 (esmethadone; d-methadone) does not cause reinforcing effect, physical dependence and withdrawal signs in Sprague Dawley rats Henningfield, Jack; Gauvin, David; Bifari, Francesco; Fant, Reginald; Shram, Megan; Buchhalter, August; Ashworth, Judy; Lanier, Ryan; Pappagallo, Marco; Inturrisi, Charles; Folli, Franco; Traversa, Sergio; Manfredi, Paolo L. Share Save
REL-1017 (Esmethadone) as Adjunctive Treatment in Patients With Major Depressive Disorder: A Phase 2a Randomized Double-Blind Trial Fava, Maurizio; Stahl, Stephen; Pani, Luca; De Martin, Sara; Pappagallo, Marco; Guidetti, Clotilde; Alimonti, Andrea; Bettini, Ezio; Mangano, Richard M.; Wessel, Thomas; de Somer, Marc; Caron, Judy; Vitolo, Ottavio V.; DiGuglielmo, Gina R.; Gilbert, Adam; Mehta, Hiren; Kearney, Morgan; Mattarei, Andrea; Gentilucci, Marco; Folli, Franco; Traversa, Sergio; Inturrisi, Charles E.; Manfredi, Paolo L. Share Save
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QTc interval prolongation associated with intravenous methadone Kornick, CA; Kilborn, MJ; Santiago-Palma, J; Schulman, G; Thaler, HT; Keefe, DL; Katchman, AN; Pezzullo, JC; Ebert, SN; Woosley, RL; Payne, R; Manfredi, PL Share Save
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