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张培｜Pei Zhang
H-index:53
Citation Count:1.1万
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Biography
"1、教育经历 (1) 2012/09-2017/06， 中国药科大学， 药学院， 博士 (2) 2007/09-2011/06， 苏州大学， 药学院， 学士 2、工作经历 (1) 2022/07-至今， 中国药科大学， 药学院， 副教授 (2) 2021/01-2022/06， 中国药科大学， 药学院， 讲师 (3) 2019/08-2019/10， 卡罗林斯卡学院， 访问学者 (4) 2017/11-2020/11， 日本群马大学， 卡罗林斯卡学院海外实验室，博士后 (1)代谢组学分析新方法开发 (2)疾病代谢调控与药物靶标发现研究 1、科研项目 (1) 国家自然科学基金青年项目，82104117，基于游离N1-甲基腺苷溯源分析的非小细胞肺癌顺铂耐药机制研究，2022-01至2024-12，30万元，在研，主持 (2) 江苏省自然科学基金青年项目，BK20210427，m1A溯源分析及其与非小细胞肺癌顺铂耐药关联研究，2021-07至2024-06，20万元，在研，主持 (3) 日本学术振兴会（JSPS）科学研究费助成事业（KAKENHI）培育项目，18H06121/19K21239，Integrative Metabolomics and Exposomics Study of Severe Asthma in Adults，2018/04-2020/03，297.7万日元，已结题，主持 2、代表性科研成果 疾病代谢调控与药物靶标发现研究：针对急性肾损伤发生率高、机制不明、缺乏有效干预手段等问题，从代谢调控角度开展了系统探索，包括：①提出了代谢组学定量计算策略，量化评价了顺铂急性肾损的代谢轮廓变化（Chem Res Toxicol, 2016）；②首次揭示了急性肾损中，肾脏皮质和髓质代谢轮廓的敏感性差异（Sci Rep, 2017）；③针对顺铂急性肾损的个体化问题，构建了肾损伤综合分级体系，建立了急性肾损个体差异预测模型 (J Proteome Res, 2017)；④针对以上研究发现的潜在调控靶标，综合利用网络药理学、分子生物学等手段，发现了若干具有临床应用前景的肾损伤干预策略（专利ZL201811091172.9; Chem Res Toxicol, 2019; Chem Res Toxicol, 2021）。 1. Li, W.; # Zhang, P.; # Hou, X.; Tang, T.; Li, S.; Sun, R.; Zhang, Z.;* Xu, F.,* Twins labeling derivatization-based LC-MS/MS strategy for absolute quantification of paired prototypes and modified metabolites. Anal Chim Acta 2022, 1193, 339399. (IF: 6.558) 2. Liao, C.; Wang, D.; Qin, S.; Zhang, Y.; Chen, J.; Xu, R.; Xu, F.;* Zhang, P.,* Inflammatory-Dependent Bidirectional Effect of Bile Acids on NLRP3 Inflammasome and Its Role in Ameliorating CPT-11-Induced Colitis. Frontiers in pharmacology 2022, 13, 677738. 3. Lv, B.; Xu, R.; Xing, X.; Liao, C.; Zhang, Z.; Zhang, P.;* Xu, F.,* Discovery of Synergistic Drug Combinations for Colorectal Cancer Driven by Tumor Barcode Derived from Metabolomics \"Big Data\". Metabolites 2022, 12 (6). (IF: 5.581) 4. Zhang, Y.; Wang, D.; Lv, B.; Hou, X.; Liu, Q.; Liao, C.; Xu, R.; Zhang, Y.; Xu, F.;* Zhang, P.,* Oleic Acid and Insulin as Key Characteristics of T2D Promote Colorectal Cancer Deterioration in Xenograft Mice Revealed by Functional Metabolomics. Front Oncol 2021, 11, 685059. (IF: 6.244) 5. Hou, X.; # Zhang, P.; # Du, H.; Gao, Y.; Sun, R.; Qin, S.; Tian, Y.; Li, J.; Zhang, Y.; Chu, W.; Zhang, Z.;* Xu, F.,* Prevotella contributes to individual response of FOLFOX in colon cancer. Clin Transl Med 2021, 11 (9), e512. (IF: 11.492) 6. Tang, T.; # Zhang, P.; # Li, S.; Xu, D.; Li, W.; Tian, Y.; Jiao, Y.; Zhang, Z.;* Xu, F.,* Absolute Quantification of Acylcarnitines Using Integrated Tmt-PP Derivatization-Based LC-MS/MS and Quantitative Analysis of Multi-Components by a Single Marker Strategy. Anal Chem 2021, 93 (38), 12973-12980. (IF: 6.986) 7. Tan, B.; Chen, J.; Qin, S.; Liao, C.; Zhang, Y.; Wang, D.; Li, S.; Zhang, Z.; Zhang, P.;* Xu, F.,* Tryptophan Pathway-Targeted Metabolomics Study on the Mechanism and Intervention of Cisplatin-Induced Acute Kidney Injury in Rats. Chem Res Toxicol 2021, 34 (7), 1759-1768. (IF: 3.739) 8. Zhang, P.; Carlsten, C.; Chaleckis, R.; Hanhineva, K.; Huang, M.; Isobe, T.; Koistinen, V. M.; Meister, I.; Papazian, S.; Sdougkou, K.; Xie, H.; Martin, J. W.; Rappaport, S. M.; Tsugawa, H.; Walker, D. I.; Woodruff, T. J.; Wright, R. O.; Wheelock, C. E.,* Defining the Scope of Exposome Studies and Research Needs from a Multidisciplinary Perspective. Environ Sci Tech Lett 2021, 8 (10), 839-852. (IF: 7.653) 9. Zhang, P.; Li, W.; Chen, J.; Li, R.; Zhang, Z.; Huang, Y.;* Xu, F.,* Branched-Chain Amino Acids as Predictors for Individual Differences of Cisplatin Nephrotoxicity in Rats: A Pharmacometabonomics Study. J Proteome Res 2017, 16 (4), 1753-1762. (IF: 3.950) 10. Zhang, P.; Chen, J.; Wang, Y.; Huang, Y.; Tian, Y.; Zhang, Z.;* Xu, F.,* Discovery of Potential Biomarkers with Dose- and Time-Dependence in Cisplatin-Induced Nephrotoxicity Using Metabolomics Integrated with a Principal Component-Based Area Calculation Strategy. Chem Res Toxicol 2016, 29 (5), 776-83. (IF: 3.278)"
Education
2012.09 – 2017.06
中国药科大学 博士 药学院
2007.09 – 2011.06
苏州大学 学士 药学院
Work Experience
2019.08 – 2019.10
卡罗林斯卡学院
访问学者
Honors & Awards
No content for now.
Gambogenic acid globally regulates translational processes in Nrf2-mutant esophageal squamous cell carcinoma by promoting Nrf2/MafG protein multimerization
gambogenic酸通过促进Nrf2/MafG蛋白多聚化，在全球范围内调节Nrf2突变型食管鳞状细胞癌中的翻译过程
Extinction-restraint intervention eradicates fear memory encoded in BLA engram cells via D2 receptor-mediated dopaminergic modulation from locus coeruleus
蓝斑通过D2受体介导的多巴胺能调控，灭绝-抑制干预通过消除杏仁核边缘区编码的记忆来消除恐惧记忆
Inhaled Virus-Mimicking Particles Elicit Dose-Dependent Immune Response against SARS-CoV-2 with Sex-Bias ACE2 Activity in Mice
吸入的病毒模拟颗粒在具有性别偏向性ACE2活性的小鼠中引发剂量依赖性抗SARS-CoV-2免疫反应
Nano Letters
IF9.1
Molecular and serologic analysis of linked blood donor and recipient samples to rule out transfusion-transmitted parvovirus B19 infection
通过关联献血者与受血者样本的分子与血清学分析排除输血传播的微小病毒B19感染
Integrated pathway analysis identifies prognostically relevant subtypes of glioblastoma characterized by abnormalities in multi-omics
整合通路分析识别出具有多组学异常特征的、在预后上具有相关性的胶质母细胞瘤亚型
Research on tracheal stenosis based on molecular biomarkers
基于分子生物标志物的气管狭窄研究
Resibufogenin ameliorates cerebral ischemia-reperfusion injury by modulating microglial redox homeostasis via Keap1-Nrf2-TFR1/ARE axis
Resibufogenin通过调节小胶质细胞氧化还原稳态，经由Keap1-Nrf2-TFR1/ARE轴改善脑缺血再灌注损伤。
Primary choroidal lymphoma with extrascleral extension and bone marrow involvement: a case report
原发性脉络膜淋巴瘤伴巩膜外扩展和骨髓受累：一例病例报告
Cannabinoid CB1 receptor in dopaminergic circuit from ventral tegmental area to nucleus accumbens links trait anxiety with reward learning
腹侧被盖区到 nucleus accumbens 的多巴胺能通路中的大麻素CB1受体将特质焦虑与奖励学习联系起来
Commentary: Correlation between different levels of thyroid autoantibodies and immune checkpoint inhibitor-associated thyroid dysfunction
评论：不同水平甲状腺自身抗体与免疫检查点抑制剂相关甲状腺功能障碍之间的相关性
Mechanically Compliant and Impedance Matching Hydrogel Bioelectronics for Low-Voltage Peripheral Neuromodulation
用于低压外周神经调节的机械顺应性和阻抗匹配水凝胶生物电子学
Advanced Materials
IF26.8
Deep Mining of Novel Acylated Polyamines by Integrated Prior-Knowledge-Guided Prediction and Chemical Isotope Labeling-Based Metabolomics
通过集成先验知识引导预测和基于化学同位素标记的代谢组学，深度挖掘新型酰化多胺。
Analytical Chemistry
IF6.7
Multiscale analysis on structural dynamics of fracture plugging zone: A visualization experiment study
多尺度分析断裂封堵区的结构动力学：一项可视化实验研究
Powder Technology
IF4.6
The role of dopaminergic neuronal clusters in governing division of labor in ants
多巴胺能神经元簇在调控蚂蚁劳动分工中的作用
