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C. Dirk Keene

of medicine

84H-index
544Paper Count
4.0WCitation Count
Published Papers 207
Publication Date
Somatic mutations reveal the ontogeny of microglia in human aging
errNature
IF48.5
err2026-07-30
err0
PREAI
errJulia A. Belk; Yaowen Zhang; Emily E. Reilly; Quanming Shi; Daniel Dan Liu; Nicole Womack-Gambrel; Maarten van der Linde; Lisa Ma; Debasmita Paul; Alejandro Medina Enciso; Raja Kalluru; Jacob Weiss; Rui Li; Anna E. Eastman; Chunfang Zhu; Arnav Chakravarthy; Syed Bukhari; Dipabarna Bhattacharya; Suyash Raj; Daniel Richard; Simone Brioschi; Matthew R. Chrostek; Daniel C. Nachun; Christopher M. Arends; Jayakrishnan Gopakumar; Isak W. Tengesdal; Ademar Bynum; Shaneice Mitchell; Katalin Sandor; Wenxi Zhang; Badri N. Vardarajan; Inma Cobos; Donald E. Born; Robert B. West; Anne Brunet; Marco Colonna; Krishna L. Bharani; Hannes Vogel; Thomas J. Montine; Caitlin S. Latimer; Irving L. Weissman; Magdalena Matusiak; Jody E. Hooper; C. Dirk Keene; Howard Y. Chang; Siddhartha Jaiswal
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A multimodal adaptive optical microscope for in vivo imaging from molecules to organisms
err2026-05-22
err0
errOAAI
errTian-Ming Fu; Gaoxiang Liu; Daniel E. Milkie; Xiongtao Ruan; Frederik Görlitz; Yu Shi; Valentina Ferro; Nikita S. Divekar; Wei Wang; Harrison M. York; Velat Kilic; Matthew Mueller; Yajie Liang; Timothy A. Daugird; Maria Jose Gacha-Garay; Kathryn A. Larkin; Rebecca C. Adikes; Nathanael Harrison; Cyna Shirazinejad; Samara Williams; Jamison L. Nourse; Shu-Hsien Sheu; Liang Gao; Tongchao Li; Chandrani Mondal; Kemal Achour; Wilmene Hercule; Daniel R. Stabley; Kevin Emmerich; Peng Dong; David G. Drubin; Zhe J. Liu; Jeff S. Mumm; Minoru Koyama; Alison N. Killilea; Jose Javier Bravo-Cordero; C. Dirk Keene; Liqun Luo; Tomas Kirchhausen; Medha M. Pathak; Senthil Arumugam; James K. Nuñez; Ruixuan Gao; David Q. Matus; Benjamin L. Martin; Ian A. Swinburne; Eric Betzig; Wesley R. Legant; Srigokul Upadhyayula
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Heterogenous Neuropathology in a Pedigree with RAB39B-Related Parkinson's Disease
err2026-05-15
err0
PREAI
errCaitlin Latimer MD, PhD; Oswaldo Lorenzo-Betancor MD, PhD; Dong-Hui Chen MD, PhD; Kimmy Su MD, PhD; Marika Bogdani MD, PhD; Anna J. Park BS; Minsuh Kim BS; Joshua Weiss BS; Malia Callier HS; Ella H. Chiu HS; Sarah Fish BS; Jennifer L. Witt MD; Wendy H. Raskind MD, PhD; Marie Y. Davis MD, PhD; C. Dirk Keene MD, PhD; Cyrus P. Zabetian MD, MS
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Human hippocampal neurogenesis in adulthood, ageing and Alzheimer’s disease
errNature
IF48.5
err2026-02-25
err0
errOAAI
errAhmed Disouky; Mark A. Sanborn; K. R. Sabitha; Mostafa M. Mostafa; Ivan Alejandro Ayala; David A. Bennett; Yisha Lu; Yi Zhou; C. Dirk Keene; Sandra Weintraub; Tamar Gefen; M.-Marsel Mesulam; Changiz Geula; Mark Maienschein-Cline; Jalees Rehman; Orly Lazarov
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Single-cell multiomic human brain atlas reveals regulatory drivers of cortical regionality
err2026-02-21
err0
errOAAI
errCarter R. Palmer; Jinghui Song; Bing Yang; Chien-Ju Chen; Dinh Diep; Kimberly Conklin; Nongluk Plongthongkum; Hannah S. Indralingam; Christine S. Liu; Joshua Kurtz; Qiwen Hu; Linnea Ransom; Anis Shahnaee; Annie Hiniker; Rebecca D. Hodge; C. Dirk Keene; Ed Lein; Peter Kharchenko; Nathan R. Zemke; Jerold Chun; Bing Ren; Kun Zhang
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Genetic modifiers of APOE-ε4-associated cognitive decline
err2026-02-20
err0
errOAAI
errAlex G. Contreras; Skylar Walters; Jaclyn M. Eissman; Derek B. Archer; Alexandra N. Regelson; Alaina Durant; Michelle Clifton; Subhabrata Mukherjee; Michael L. Lee; Seo-Eun Choi; Phoebe Scollard; Emily H. Trittschuh; Jesse Mez; William S. Bush; Brian W. Kunkle; Carlos Cruchaga; Adam C. Naj; Katherine A. Gifford; Murat Bilgel; Amanda B. Kuzma; Michael L. Cuccaro; Margaret A. Pericak-Vance; Lindsay A. Farrer; Li-San Wang; Gerard D. Schellenberg; Jonathan L. Haines; Angela L. Jefferson; Walter A. Kukull; C. Dirk Keene; Andrew J. Saykin; Paul M. Thompson; Eden R. Martin; Marilyn S. Albert; Sterling C. Johnson; Corinne D. Engelman; Luigi Ferrucci; David A. Bennett; Lisa L. Barnes; Julie A. Schneider; Reisa A. Sperling; Susan M. Resnick; Paul K. Crane; Logan Dumitrescu; Timothy J. Hohman
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APOE isoform-associated tau oligomer polymorphs differ in synaptotoxicity and seeding activity
err2025-12-13
err0
errOAAI
errNaomi Moreno; Nikita Shchankin; Leiana Fung; Nicha Puangmalai; Nemil Bhatt; Md Anzarul Haque; Yingxin Zhao; C. Dirk Keene; Agenor Limon; Rakez Kayed
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Transport of CCL2 across an induced pluripotent stem cell-derived in vitro model of the human blood-brain barrier is heparan sulfate-dependent
err2025-12-11
err0
PREAI
errWilliams, Lindsey M.; Fujimoto, Takashi; Damodarasamy, Mamatha; Weaver, Riley R.; Keene, C. Dirk; Banks, William A.; Reed, May J.; Erickson, Michelle A.
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Genome-wide association studies of TDP-43 proteinopathy and hippocampal sclerosis reveal shared genetic associations with APOE and TMEM106B
err2025-11-10
err0
errOAAI
errDana Godrich; Jeremy Pasteris; Eden R. Martin; Brian Kunkle; Adam C. Naj; Kara Hamilton; Hui Wang; Wan-Ping Lee; Logan Dumitrescu; Timothy J. Hohman; Richard Mayeux; Eric B. Larson; Paul K. Crane; C. Dirk Keene; Caitlin Latimer; Shubhabrata Mukherjee; Julia Kofler; M. Ilyas Kamboh; David A. Bennett; Laura Molina-Porcel; Gerard Schellenberg; Margaret A. Pericak-Vance; Michael Cuccaro; William K. Scott; Tatjana Rundek; Walter Kukull; Thomas Montine; Gary W. Beecham; the Alzheimer's Disease Genetics Consortium (ADGC)
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Digital neuropathology of neurodegenerative disorders: Foundations, research advances, and future directions
err2025-11-07
err0
errOAAI
errAaron M. Rosado; Juan C. Vizcarra; Shivam R. Rai Sharma; Cristopher Dirk Keene; Charles L. White III; Ain Kim; Shelley L. Forrest; Gabor G. Kovacs; Chen-Nee Chuah; Margaret E. Flanagan; Thomas M. Pearce; Brittany N. Dugger; David A. Gutman
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Celebrating neuropathology's contributions to Alzheimer's Disease Research Centers
err2025-10-14
err0
errOAAI
errD. Luke Fischer; Lea T. Grinberg; Jared T. Ahrendsen; Thomas G. Beach; Kevin F. Bieniek; Rudolph J. Castellani; Rati Chkheidze; Inma Cobos; Mark Cohen; John F. Crary; Dennis W. Dickson; Brittany N. Dugger; Sara R. Dunlop; Kurt Farrell; Bernardino Ghetti; Mohammad Haeri; William Harrison; Elizabeth Head; Annie Hiniker; Eric J. Huang; Anita Huttner; Pouya Jamshidi; Alifiya Kapasi; C. Dirk Keene; Julia Kofler; Caitlin S. Latimer; Ann C. McKee; Karin Mente; Michael B. Miller; Thomas J. Montine; Meaghan Morris; Melissa E. Murray; Peter T. Nelson; Kathy L. Newell; Richard J. Perrin; Biswarathan Ramani; R. Ross Reichard; Subhojit Roy; Johannes C. M. Schlachetzki; William W. Seeley; Geidy E. Serrano; Salvatore Spina; Andrew F. Teich; Shih-Hsiu J. Wang; Thomas Wisniewski; Edward B. Lee
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Chronic traumatic encephalopathy neuropathologic change in the Late Effects of Traumatic Brain Injury project: Findings in a community autopsy cohort
err2025-10-01
err0
PREAI
errSelmanovic, Enna; Seifert, Alan C.; Delman, Bradley N.; Pruyser, Ariel; Thorn, Emma L.; Nolan, Amber L.; Keene, C. Dirk; Walker, Jamie M.; Crary, John F.; Hof, Patrick R.; Folkerth, Rebecca D.; Dams-O'Connor, Kristen
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Epigenomic profile of GBA1 in Parkinson’s disease
err2025-09-27
err0
PREAI
errEloise Berson; Raphael Zaghroun; Matteo Santoro; Syed Bukhari; David Seong; Chi-Hung Shu; Amalia Perna; Tomin James; Kathleen S. Montine; Geidy E. Serrano; Thomas G. Beach; C.Dirk Keene; Howard Y. Chang; M.Ryan Corces; Brenna Cholerton; Nima Aghaeepour; Thomas J. Montine
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The companion dog as a translational model for Alzheimer's disease: Development of a longitudinal research platform and post mortem protocols
err2025-09-25
err0
errOAAI
errStephanie McGrath; Emily Hull; Matthew D. Dunbar; Jena Prescott; Amber J. Keyser; Evan MacLean; Martin Darvas; Caitlin Latimer; Julie Moreno; Michael J. MacCoss; Mandy Kauffman; Paul Litwin; Marta Castelhano; Matt Kaeberlein; C. Dirk Keene; Dog Aging Project Consortium
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MicroRNA cargo in neuron-derived vesicles as peripheral biomarkers of brain insulin dysregulation
err2025-09-17
err0
errOAAI
errJacob Alexander Cleary; Ashish Kumar; Yixin Su; Sangeeta Singh; Fang-Chi Hsu; Suzanne Craft; William Harrison; C. Dirk Keene; Marjorie Howard; Kathleen M. Hayden; Mark A. Espeland; Jingzhong Ding; Gagan Deep
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Deep learning-based cell type profiles reveal signatures of Alzheimer's disease resilience and resistance
errBRAIN
IF11.7
err2025-09-01
err1
errOAAI
errBerson, Eloise; Perna, Amalia; Bukhari, Syed; Kim, Yeasul; Xue, Lei; Seong, David; Mataraso, Samson; Ghanem, Marc; Chang, Alan L.; Montine, Kathleen S.; Keene, C. Dirk; Kasowski, Maya; Aghaeepour, Nima; Montine, Thomas J.
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Accelerating biomedical discoveries in brain health through transformative neuropathology of aging and neurodegeneration
errNeuron
IF15
err2025-07-18
err0
errOAAI
errMelissa E. Murray; Colin Smith; Vilas Menon; C. Dirk Keene; Ed Lein; Michael Hawrylycz; Adriano Aguzzi; Brett Benedetti; Katja Brose; Kelsey Caetano-Anolles; Maria Inmaculada Cobos Sillero; John F. Crary; Philip L. De Jager; Arline Faustin; Margaret E. Flanagan; Ozgun Gokce; Seth G.N. Grant; Lea T. Grinberg; David A. Gutman; Elizabeth M.C. Hillman; Zhi Huang; David J. Irwin; David T. Jones; Alifiya Kapasi; Celeste M. Karch; Walter T. Kukull; Tammaryn Lashley; Edward B. Lee; Thomas Lehner; Laura Parkkinen; Maria Pedersen; Dominique Pritchett; Matthew H. Rutledge; Julie A. Schneider; William W. Seeley; Claire E. Shepherd; Tara L. Spires-Jones; Judith A. Steen; Margaret Sutherland; Sanja Vickovic; Bin Zhang; David J. Stewart; Michael J. Keiser; Jacob W. Vogel; Brittany N. Dugger; Hemali Phatnani
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Presence of Alzheimer's disease variants in circular RNA of <i>PSEN1</i> and <i>PSEN2</i>
err2025-06-16
err0
PREAI
errIan P Johnson; Tia M Peterson; Kathryn Gudsnuk; C Dirk Keene; Thomas D Bird; Suman Jayadev; Paul N Valdmanis; Meredith M Course
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Immunohistochemical evaluation of a trial of gantenerumab or solanezumab in dominantly inherited Alzheimer disease
err2025-06-03
err0
errOAAI
errCharles D. Chen; Erin E. Franklin; Yan Li; Nelly Joseph-Mathurin; Aime L. Burns; Diana A. Hobbs; Austin A. McCullough; Stephanie A. Schultz; Chengjie Xiong; Guoqiao Wang; Mario Masellis; Ging-Yuek Robin Hsiung; Serge Gauthier; Sarah B. Berman; Erik D. Roberson; Lawrence S. Honig; Roger Clarnette; John M. Ringman; James E. Galvin; William Brooks; Kazushi Suzuki; Sandra Black; Johannes Levin; Neelum T. Aggarwal; Mathias Jucker; Matthew P. Frosch; Julia K. Kofler; Charles White; C. Dirk Keene; Jie Chen; Alisha Daniels; Brian A. Gordon; Laura Ibanez; Celeste M. Karch; Jorge Llibre-Guerra; Eric McDade; John C. Morris; Charlene Supnet-Bell; Ricardo F. Allegri; Jae-Hong Lee; Gregory S. Day; Francisco Lopera; Jee Hoon Roh; Peter R. Schofield; Susan Mills; Tammie L. S. Benzinger; Randall J. Bateman; Richard J. Perrin
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Novel modelling approaches to elucidate the genetic architecture of resilience to Alzheimer's disease
errBRAIN
IF11.7
err2025-05-01
err0
PREAI
errPhillips, Jared M.; Dumitrescu, Logan C.; Archer, Derek B.; Regelson, Alexandra N.; Mukherjee, Shubhabrata; Lee, Michael L.; Choi, Seo-Eun; Scollard, Phoebe; Trittschuh, Emily H.; Kukull, Walter A.; Biber, Sarah; Mez, Jesse; Mahoney, Emily R.; Clifton, Michelle; Libby, Julia B.; Walters, Skylar; Bush, William S.; Engelman, Corinne D.; Lu, Qiongshi; Fardo, David W.; Widaman, Keith F.; Buckley, Rachel F.; Mormino, Elizabeth C.; Sanders, R. Elizabeth; Clark, Lindsay R.; Gifford, Katherine A.; Vardarajan, Badri; Cuccaro, Michael L.; Pericak-Vance, Margaret A.; Farrer, Lindsay A.; Wang, Li-San; Schellenberg, Gerard D.; Haines, Jonathan L.; Jefferson, Angela L.; Johnson, Sterling C.; Albert, Marilyn S.; Keene, C. Dirk; Saykin, Andrew J.; Risacher, Shannon L.; Larson, Eric B.; Sperling, Reisa A.; Mayeux, Richard; Goate, Alison M.; Renton, Alan E.; Marcora, Edoardo; Fulton-Howard, Brian; Patel, Tulsi; Bennett, David A.; Schneider, Julie A.; Barnes, Lisa L.; Cruchaga, Carlos; Hassenstab, Jason; Belloy, Michael E.; Andrews, Shea J.; Resnick, Susan M.; Bilgel, Murat; An, Yang; Beason-Held, Lori L.; Walker, Keenan A.; Duggan, Michael R.; Klinedinst, Brandon S.; Crane, Paul K.; Hohman, Timothy J.
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