Karen P. Steel - Publications, H-index & Citations

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Karen P. Steel

university of london

68H-index

289Paper Count

1.8WCitation Count

Published Papers 77

Publication Date

Limited Potential to Reverse Deafness Caused by Mutation of Myo7a

JARO-Journal of the Association for Research in Otolaryngology

IF2.3

2026-01-01

PREAI

Pentland, Daniel R.; Blackburn, Jack; Witting, Lauren; Kirwin, Darcey A.; Steel, Karen P.

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Large-scale audiometric phenotyping identifies distinct genes and pathways involved in hearing loss subtypes

Communications Biology

IF5.1

2025-10-31

OAAI

Samah Ahmed; Kenneth I. Vaden; Morag A. Lewis; Darren Leitao; Karen P. Steel; Judy R. Dubno; Britt I. Drögemöller

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The importance of accurate phenotyping in large-scale analyses of common disorders such as hearing loss

European Journal of Human Genetics

IF4.6

2025-09-27

OAAI

Morag A. Lewis; Bradley A. Schulte; Judy R. Dubno; Karen P. Steel

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Non-invasive testing to diagnose the underlying auditory pathology of hearing impairment

Hearing Research

IF2.5

2025-08-10

OAAI

Neil J Ingham; Karen P Steel

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Low level of expression of known deafness genes Kcne1, Kcnj10 or Col4a3 is sufficient to maintain hearing in mice

Hearing Research

IF2.5

2025-07-04

OAAI

Darcey A Kirwin; Nina Treder; Elisa Martelletti; Daniel R Pentland; Rechal Kumar; Neil J Ingham; Karen P Steel

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International Consortium on Ageing-Related Pathologies (ICCARP) Audiovestibular Group: fostering international consensus to refine International Classification of Diseases (ICD-11) codes for hearing loss across the life course

GeroScience

IF5.4

2025-06-28

OAAI

Dialechti Tsimpida; Michael A. Akeroyd; Barry L. Bentley; Shuvarthi Bhattacharjee; Michael R. Bowl; Emma Broome; Stuart R. G. Calimport; Sian Calvert; Gary Christopher; Tom Dening; Silvia Di Bonaventura; Ankita Goswami; Spyridon Gougousis; Paul J. Govaerts; Mini Gupta; Helen Henshaw; Robert T. R. Huckstepp; Vasiliki Maria Iliadou; Theano K. Koutsimani; Morag A. Lewis; Frank R. Lin; Cecilia Luisa Miotto; Lisa S. Nolan; Helen E. Nuttall; Chukwuebuka Prince Onyekere; Mukovhe Phanguphangu; Christopher J. Plack; Ramasamy S. Raghavan; Nicholas S. Reed; Konstantina Rova; Karen P. Steel; Robert J. Stokroos; De Wet Swanepoel; Agnieszka J. Szczepek; Susan L. Whitney

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A machine-learning-based approach to predict early hallmarks of progressive hearing loss

Hearing Research

IF2.5

2025-06-06

OAAI

Federico Ceriani; Joshua Giles; Neil J Ingham; Jing-Yi Jeng; Morag A Lewis; Karen P Steel; Mahnaz Arvaneh; Walter Marcotti

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Rescue of cochlear vascular pathology prevents sensory hair cell loss in Norrie disease

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2024-11-25

OAAI

Patel, Aara; Pauzuolyte, Valda; Ingham, Neil J.; Leong, Yeh Chwan; Berger, Wolfgang; Steel, Karen P.; Sowden, Jane C.

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Investigating the effects of a cryptic splice site in the En2 splice acceptor sequence used in the IKMC knockout-first alleles

Mammalian Genome

IF2.7

2024-10-01

OAAI

Nair, Prerna; Steel, Karen P.; Lewis, Morag A.

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Targeted genome editing restores auditory function in adult mice with progressive hearing loss caused by a human microRNA mutation

SCIENCE TRANSLATIONAL MEDICINE

IF14.6

2024-07-10

OAAI

Zhu, Wenliang; Du, Wan; Rameshbabu, Arun Prabhu; Armstrong, Ariel Miura; Silver, Stewart; Kim, Yehree; Wei, Wei; Shu, Yilai; Liu, Xuezhong; Lewis, Morag A.; Steel, Karen P.; Chen, Zheng-Yi

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Accurate phenotypic classification and exome sequencing allow identification of novel genes and variants associated with adult-onset hearing loss

PLOS GENETICS

IF3.7

2023-11-27

OAAI

Lewis, Morag A.; Schulte, Jennifer; Matthews, Lois; Vaden Jr, Kenneth I.; Steves, Claire J.; Williams, Frances M. K.; Schulte, Bradley A.; Dubno, Judy R.; Steel, Karen P.

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Systemic gene therapy rescues retinal dysfunction and hearing loss in a model of Norrie disease

EMBO MOLECULAR MEDICINE

IF8.3

2023-08-29

OAAI

Pauzuolyte, Valda; Patel, Aara; Wawrzynski, James R.; Ingham, Neil J.; Leong, Yeh Chwan; Karda, Rajvinder; Bitner-Glindzicz, Maria; Berger, Wolfgang; Waddington, Simon N.; Steel, Karen P.; Sowden, Jane C.

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Insights into the pathophysiology of DFNA44 hearing loss associated with CCDC50 frameshift variants

DISEASE MODELS & MECHANISMS

IF3.3

2023-08-17

OAAI

Lachgar-Ruiz, Maria; Morin, Matias; Martelletti, Elisa; Ingham, Neil J.; Preite, Lorenzo; Lewis, Morag A.; de Castro, Luciana Santos Serrao; Steel, Karen P.; Moreno-Pelayo, Miguel Angel

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Reversal of an existing hearing loss by gene activation in Spns2 mutant mice

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2023-08-08

OAAI

Martelletti, Elisa; Ingham, Neil J.; Steel, Karen P.

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Mosaic complementation demonstrates a regulatory role for myosin VIIa in actin dynamics of stereocilia

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-27

OAAI

Prosser, Haydn M.; Rzadzinska, Agnieszka K.; Steel, Karen P.; Bradley, Allan

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The Effect of a Pex3 Mutation on Hearing and Lipid Content of the Inner Ear

CELLS

IF5.2

2022-10-13

OAAI

Kochaj, Rafael M.; Martelletti, Elisa; Ingham, Neil J.; Buniello, Annalisa; Sousa, Bebiana C.; Wakelam, Michael J. O.; Lopez-Clavijo, Andrea F.; Steel, Karen P.

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Mutations in MINAR2 encoding membrane integral NOTCH2-associated receptor 2 cause deafness in humans and mice

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2022-06-21

OAAI

Bademci, Guney; Lachgar-Ruiz, Maria; Deokar, Mangesh; Zafeer, Mohammad Faraz; Abad, Clemer; Baylan, Muzeyyen Yildirim; Ingham, Neil J.; Chen, Jing; Sineni, Claire J.; Vadgama, Nirmal; Karakikes, Ioannis; Guo, Shengru; Duman, Duygu; Singh, Nitu; Harlalka, Gaurav; Jain, Shirish P.; Chioza, Barry A.; Walz, Katherina; Steel, Karen P.; Nasir, Jamal; Tekin, Mustafa

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Targeted deletion of the RNA-binding protein Caprin1 leads to progressive hearing loss and impairs recovery from noise exposure in mice

SCIENTIFIC REPORTS

IF3.9

2022-02-14

OAAI

Nolan, Lisa S.; Chen, Jing; Goncalves, Ana-Claudia; Bullen, Anwen; Towers, Emily R.; Steel, Karen P.; Dawson, Sally J.; Gale, Jonathan E.

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The timing of auditory sensory deficits in Norrie disease has implications for intervention

JCI INSIGHT

IF6.1

2022-02-08

OAAI

Bryant, Dale; Pauzuolyte, Valda; Ingham, Neil J.; Patel, Aara; Pagarkar, Waheeda; Anderson, Lucy A.; Smith, Katie E.; Moulding, Dale A.; Leong, Yeh C.; Jafree, Daniyal J.; Long, David A.; Al-Yassin, Amina; Steel, Karen P.; Jagger, Daniel J.; Forge, Andrew; Berger, Wolfgang; Sowden, Jane C.; Bitner-Glindzicz, Maria

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A resource of targeted mutant mouse lines for 5,061 genes

NATURE GENETICS

IF31.8

2021-04-08

OAAI

Birling, Marie-Christine; Yoshiki, Atsushi; Adams, David J.; Ayabe, Shinya; Beaudet, Arthur L.; Bottomley, Joanna; Bradley, Allan; Brown, Steve D. M.; Buerger, Antje; Bushell, Wendy; Chiani, Francesco; Chin, Hsian-Jean Genie; Christou, Skevoulla; Codner, Gemma F.; DeMayo, Francesco J.; Dickinson, Mary E.; Doe, Brendan; Donahue, Leah Rae; Fray, Martin D.; Gambadoro, Alessia; Gao, Xiang; Gertsenstein, Marina; Gomez-Segura, Alba; Goodwin, Leslie O.; Heaney, Jason D.; Herault, Yann; de Angelis, Martin Hrabe; Jiang, Si-Tse; Justice, Monica J.; Kasparek, Petr; King, Ruairidh E.; Kuhn, Ralf; Lee, Ho; Lee, Young Jae; Liu, Zhiwei; Lloyd, K. C. Kent; Lorenzo, Isabel; Mallon, Ann-Marie; McKerlie, Colin; Meehan, Terrence F.; Fuentes, Violeta Munoz; Newman, Stuart; Nutter, Lauryl M. J.; Oh, Goo Taeg; Pavlovic, Guillaume; Ramirez-Solis, Ramiro; Rosen, Barry; Ryder, Edward J.; Santos, Luis A.; Schick, Joel; Seavitt, John R.; Sedlacek, Radislav; Seisenberger, Claudia; Seong, Je Kyung; Skarnes, William C.; Sorg, Tania; Steel, Karen P.; Tamura, Masaru; Tocchini-Valentini, Glauco P.; Wang, Chi-Kuang Leo; Wardle-Jones, Hannah; Wattenhofer-Donze, Marie; Wells, Sara; Wiles, Michael V.; Willis, Brandon J.; Wood, Joshua A.; Wurst, Wolfgang; Xu, Ying; Teboul, Lydia; Murray, Stephen A.

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Research Directions